Oxytocin increases eye-gaze towards novel social and non-social stimuli

References

• Abu-Akel, A., Palgi, S., Klein, E., Decety, J., & Shamay-Tsoory, S. (2015). Oxytocin increases empathy to pain when adopting the other-but not the self-perspective. Social Neuroscience, 10(1), 7–15.
   Google Scholar
• Alnaes, D., Sneve, M. H., Espeseth, T., Endestad, T., van de Pavert, S. H., & Laeng, B. (2014). Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus. Journal of Vision, 14(4). doi:10.1167/14.13.11
   Google Scholar
• Alvares, G. A., Chen, N. T., Balleine, B. W., Hickie, I. B., & Guastella, A. J. (2012). Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males. Psychoneuroendocrinology, 37(12), 2022–2031.
   Google Scholar
• Amadei, E. A., Johnson, Z. V., Kwon, Y. J., Shpiner, A. C., Saravanan, V., Mays, W. D., & Young, L. J. (2017). Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles. Nature, 546(7657), 297–301.
   Google Scholar
• Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proceedings of the National Academy of Sciences, 107(9), 4389–4394.
   Google Scholar
• Auyeung, B., Lombardo, M., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J., & Sipple, J. (2015). Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism. Translational Psychiatry, 5(2), e507.
   Google Scholar
• Bakermans-Kranenburg, M., & Van Ijzendoorn, M. (2013). Sniffing around oxytocin: Review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Translational Psychiatry, 3(5), e258.
   Google Scholar
• Bartoń, K. (2013). MuMIn: Multi-model inference. R package version 1.9. 13. The Comprehensive R Archive Network (CRAN), Vienna, Austria.
   Google Scholar
• Barton, R. A. (1998). Visual specialization and brain evolution in primates. [10.1098/rspb.1998.0523]. Proceedings of the royal society of London Series B: Biological Sciences, 265(1409), p 1933.
   Google Scholar
• Behnia, B., Heinrichs, M., Bergmann, W., Jung, S., Germann, J., Schedlowski, M., & Kruger, T. H. (2014). Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples. Hormones and Behavior, 65(3), 308–318.
   Google Scholar
• Blaicher, W., Gruber, D., Bieglmayer, C., Blaicher, A. M., Knogler, W., & Huber, J. C. (1999). The role of oxytocin in relation to female sexual arousal. Gynecologic and Obstetric Investigation, 47(2), 125–126.
   Google Scholar
• Borrow, A. P., & Cameron, N. M. (2012). The role of oxytocin in mating and pregnancy. Hormones and Behavior, 61(3), 266–276.
   Google Scholar
• Bosch, O. J., Dabrowska, J., Modi, M. E., Johnson, Z. V., Keebaugh, A. C., Barrett, C. E., & Rainnie, D. G. (2016). Oxytocin in the nucleus accumbens shell reverses CRFR2-evoked passive stress-coping after partner loss in monogamous male prairie voles. Psychoneuroendocrinology, 64, 66–78.
   Google Scholar
• Bosch, O. J., & Young, L. J. (2017). Oxytocin and social relationships: From attachment to bond disruption.In Hurlemann R., Grinevich V. (Eds.), Behavioral Pharmacology of Neuropeptides: Oxytocin. Current Topics in Behavioral Neurosciences, vol 35. Springer, Cham
   Google Scholar
• Bradley, M. M., Miccoli, L., Escrig, M. A., & Lang, P. J. (2008). The pupil as a measure of emotional arousal and autonomic activation. Psychophysiology, 45(4), 602–607.
   Google Scholar
• Burri, A., Heinrichs, M., Schedlowski, M., & Kruger, T. H. (2008). The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology, 33(5), 591–600.
   Google Scholar
• Cardoso, C., Orlando, M. A., Brown, C. A., & Ellenbogen, M. A. (2014). Oxytocin and enhancement of the positive valence of social affiliation memories: An autobiographical memory study. Social Neuroscience, 9(2), 186–195.
   Google Scholar
• Carter, C. S. (1998). Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology, 23(8), 779–818.
   Google Scholar
• Cavanaugh, J., Mustoe, A. C., Taylor, J. H., & French, J. A. (2014). Oxytocin facilitates fidelity in well-established marmoset pairs by reducing sociosexual behavior toward opposite-sex strangers. Psychoneuroendocrinology, 49, 1–10.
   Google Scholar
• de Boer, A., van Buel, E. M., & Ter Horst, G. J. (2012). Love is more than just a kiss: A neurobiological perspective on love and affection. Neuroscience, 201, 114–124.
   Google Scholar
• de Jong, T. R., Menon, R., Bludau, A., Grund, T., Biermeier, V., Klampfl, S. M., & Neumann, I. D. (2015). Salivary oxytocin concentrations in response to running, sexual self-stimulation, breastfeeding and the TSST: The Regensburg Oxytocin Challenge (ROC) study. Psychoneuroendocrinology, 62, 381–388.
   Google Scholar
• Dijksterhuis, A., & Bargh, J. A. (2001). The perception-behavior expressway: Automatic effects of social perception on social behavior. Advances in Experimental Social Psychology, 33, 1–40.
   Google Scholar
• Ditzen, B., Nater, U. M., Schaer, M., La Marca, R., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2012). Sex-specific effects of intranasal oxytocin on autonomic nervous system and emotional responses to couple conflict. Social Cognitive and Affective Neuroscience, 8(8), 897–902.
   Google Scholar
• Ditzen, B., Palm-Fischbacher, S., Gossweiler, L., Stucky, L., & Ehlert, U. (2017). Effects of stress on women’s preference for male facial masculinity and their endocrine correlates. Psychoneuroendocrinology, 82, 67–74.
   Google Scholar
• Ditzen, B., Schaer, M., Bodenmann, G., Gabriel, B., Ehlert, U., & Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biological Psychiatry, 65(9), 728–731.
   Google Scholar
• Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S., & Heinrichs, M. (2013). Intranasal oxytocin increases covert attention to positive social cues. Psychological Medicine, 43(08), 1747–1753.
   Google Scholar
• Domes, G., Steiner, A., Porges, S. W., & Heinrichs, M. (2013). Oxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger. Psychoneuroendocrinology, 38(7), 1198–1202.
   Google Scholar
• Eckstein, M., Becker, B., Scheele, D., Scholz, C., Preckel, K., Schlaepfer, T. E., & Hurlemann, R. (2015). Oxytocin facilitates the extinction of conditioned fear in humans. Biological Psychiatry, 78(3), 194–202.
   Google Scholar
• Eckstein, M., Markett, S., Kendrick, K. M., Ditzen, B., Liu, F., Hurlemann, R., & Becker, B. (2017). Oxytocin differentially alters resting state functional connectivity between amygdala subregions and emotional control networks: Inverse correlation with depressive traits. NeuroImage, 149, 458–467.
   Google Scholar
• Feldman, R. (2012). Oxytocin and social affiliation in humans. Hormones and Behavior, 61(3), 380–391.
   Google Scholar
• Feldman, R. (2017). The neurobiology of human attachments. Trends in Cognitive Sciences, 21(2), 80–99.
   Google Scholar
• Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016). Oxytocin pathway genes: Evolutionary ancient system impacting on human affiliation, sociality, and psychopathology. Biological Psychiatry, 79(3), 174–184.
   Google Scholar
• Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000). Social amnesia in mice lacking the oxytocin gene. Nature Genetics, 25(3), 284–288.
   Google Scholar
• Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014). The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta). Psychoneuroendocrinology, 45, 128–141.
   Google Scholar
• Freeman, S. M., & Young, L. J. (2016). Comparative perspectives on oxytocin and vasopressin receptor research in rodents and primates: Translational implications. Journal of Neuroendocrinology, 28(4). doi:10.1111/jne.12382
   Google Scholar
• Gamer, M., Schmitz, A. K., Tittgemeyer, M., & Schilbach, L. (2013). The human amygdala drives reflexive orienting towards facial features. Current Biology, 23(20), R917–918.
   Google Scholar
• Gordon, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2010). Oxytocin and the development of parenting in humans. Biological Psychiatry, 68(4), 377–382.
   Google Scholar
• Guastella, A. J., Carson, D. S., Dadds, M. R., Mitchell, P. B., & Cox, R. E. (2009). Does oxytocin influence the early detection of angry and happy faces? Psychoneuroendocrinology, 34(2), 220–225.
   Google Scholar
• Guastella, A. J., & Hickie, I. B. (2016). Oxytocin treatment, circuitry, and autism: A critical review of the literature placing oxytocin into the autism context. Biological Psychiatry, 79(3), 234–242.
   Google Scholar
• Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 63(1), 3–5.
   Google Scholar
• Hubble, K., Daughters, K., Manstead, A. S., Rees, A., Thapar, A., & van Goozen, S. H. (2017). Oxytocin reduces face processing time but leaves recognition accuracy and eye-gaze unaffected. Journal of the International Neuropsychological Society : JINS, 23(1), 23–33.
   Google Scholar
• Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., & Maier, W. (2010). Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. Journal of Neuroscience, 30(14), 4999–5007.
   Google Scholar
• Hurlemann, R., & Scheele, D. (2016). Dissecting the role of oxytocin in the formation and loss of social relationships. Biological Psychiatry, 79(3), 185–193.
   Google Scholar
• Insel, T. R., & Young, L. J. (2001). Opinion: The neurobiology of attachment. Nature Reviews Neuroscience, 2(2), 129.
   Google Scholar
• Itier, R. J., & Batty, M. (2009). Neural bases of eye and gaze processing: The core of social cognition. Neuroscience & Biobehavioral Reviews, 33(6), 843–863.
   Google Scholar
• Itti, L., & Koch, C. (2001). Computational modelling of visual attention. Nature Reviews. Neuroscience, 2(3), 194–203.
   Google Scholar
• Johnson, Z. V., & Young, L. J. (2015). Neurobiological mechanisms of social attachment and pair bonding. Current Opinion in Behavioral Sciences, 3, 38–44.
   Google Scholar
• Johnson, Z. V., & Young, L. J. (2017). Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience. Neuroscience & Biobehavioral Reviews, 76, 87–98.
   Google Scholar
• Kemp, A. H., & Guastella, A. J. (2010). Oxytocin: Prosocial behavior, social salience, or approach-related behavior? Biological Psychiatry, 67(6), e33–e34.
   Google Scholar
• Keverne, E. B., & Kendrick, K. M. (1992). Oxytocin facilitation of maternal behavior in sheepa. Annals of the New York Academy of Sciences, 652(1), 83–101.
   Google Scholar
• Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2012). Oxytocin enhances pupil dilation and sensitivity to ‘hidden’emotional expressions. Social Cognitive and Affective Neuroscience, 8(7), 741–749.
   Google Scholar
• Lim, M. M., & Young, L. J. (2006). Neuropeptidergic regulation of affiliative behavior and social bonding in animals. Hormones and Behavior, 50(4), 506–517.
   Google Scholar
• Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012). Intranasal oxytocin enhances emotion recognition from dynamic facial expressions and leaves eye-gaze unaffected. Psychoneuroendocrinology, 37(4), 475–481.
   Google Scholar
• Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016). Oxytocin and social adaptation: Insights from neuroimaging studies of healthy and clinical populations. Trends in Cognitive Sciences, 20(2), 133–145.
   Google Scholar
• Moresi, S., Adam, J. J., Rijcken, J., Van Gerven, P. W. M., Kuipers, H., & Jolles, J. (2008). Pupil dilation in response preparation. International Journal of Psychophysiology, 67(2), 124–130.
   Google Scholar
• Muin, D. A., Wolzt, M., Marculescu, R., Rezaei, S. S., Salama, M., Fuchs, C., & Bayerle-Eder, M. (2015). Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: A randomized trial. Fertility and Sterility, 104(3), 715–723. e714.
   Google Scholar
• Murphy, P. R., O’Connell, R. G., O’Sullivan, M., Robertson, I. H., & Balsters, J. H. (2014). Pupil diameter covaries with BOLD activity in human locus coeruleus. Human Brain Mapping, 35(8), 4140–4154.
   Google Scholar
• Numan, M., & Young, L. J. (2016). Neural mechanisms of mother–Infant bonding and pair bonding: Similarities, differences, and broader implications. Hormones and Behavior, 77, 98–112.
   Google Scholar
• Nummenmaa, L., & Calder, A. J. (2009). Neural mechanisms of social attention. Trends in Cognitive Sciences, 13(3), 135–143.
   Google Scholar
• Oettl, -L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., & Young, W. S. (2016). Oxytocin enhances social recognition by modulating cortical control of early olfactory processing. Neuron, 90(3), 609–621.
   Google Scholar
• Pinheiro, J., Bates, D., DebRoy, S., & Sarkar, D. (2014). R Core Team (2014) nlme: linear and nonlinear mixed effects models. R package version 3.1-117. Retrieved from: See http://CRAN. R-project. org/package= nlme
   Google Scholar
• Preckel, K., Scheele, D., Eckstein, M., Maier, W., & Hurlemann, R. (2015). The influence of oxytocin on volitional and emotional ambivalence. Social Cognitive and Affective Neuroscience, 10(7), 987–993.
   Google Scholar
• Prehn, K., Kazzer, P., Lischke, A., Heinrichs, M., Herpertz, S. C., & Domes, G. (2013). Effects of intranasal oxytocin on pupil dilation indicate increased salience of socioaffective stimuli. Psychophysiology, 50(6), 528–537.
   Google Scholar
• Rilling, J. K., & Young, L. J. (2014). The biology of mammalian parenting and its effect on offspring social development. Science, 345(6198), 771–776.
   Google Scholar
• Rosler, L., End, A., & Gamer, M. (2017). Orienting towards social features in naturalistic scenes is reflexive. PLoS One, 12(7), e0182037.
   Google Scholar
• Ross, H. E., Freeman, S. M., Spiegel, L. L., Ren, X., Terwilliger, E. F., & Young, L. J. (2009). Variation in oxytocin receptor density in the nucleus accumbens has differential effects on affiliative behaviors in monogamous and polygamous voles. Journal of Neuroscience, 29(5), 1312–1318.
   Google Scholar
• Rupp, H. A., & Wallen, K. (2007). Relationship between testosterone and interest in sexual stimuli: The effect of experience. Hormones and Behavior, 52(5), 581–589.
   Google Scholar
• Scheele, D., Plota, J., Stoffel-Wagner, B., Maier, W., & Hurlemann, R. (2015). Hormonal contraceptives suppress oxytocin-induced brain reward responses to the partner’s face. Social Cognitive and Affective Neuroscience, 11(5), 767–774.
   Google Scholar
• Scheele, D., Striepens, N., Güntürkün, O., Deutschländer, S., Maier, W., Kendrick, K. M., & Hurlemann, R. (2012). Oxytocin modulates social distance between males and females. Journal of Neuroscience, 32(46), 16074–16079.
   Google Scholar
• Scheele, D., Wille, A., Kendrick, K. M., Stoffel-Wagner, B., Becker, B., Güntürkün, O., & Hurlemann, R. (2013). Oxytocin enhances brain reward system responses in men viewing the face of their female partner. Proceedings of the National Academy of Sciences, 110(50), 20308–20313.
   Google Scholar
• Shahrestani, S., Kemp, A. H., & Guastella, A. J. (2013). The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: A meta-analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 38(10), 1929–1936.
   Google Scholar
• Skuse, D. H., & Gallagher, L. (2009). Dopaminergic-neuropeptide interactions in the social brain. Trends in Cognitive Sciences, 13(1), 27–35.
   Google Scholar
• Striepens, N., Kendrick, K. M., Hanking, V., Landgraf, R., Wüllner, U., Maier, W., & Hurlemann, R. (2013). Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Scientific Reports, 3. doi:10.1038/srep03440
   Google Scholar
• Symons, D. (1995). Beauty is in the adaptations of the beholder: The evolutionary psychology of human female sexual attractiveness. In Abramson, P. R., & Pinkerton, S. D. (Eds.), Sexual nature/sexual culture  (80-118). University of Chicago Press.
   Google Scholar
• Thienel, M., Heinrichs, M., Fischer, S., Ott, V., Born, J., & Hallschmid, M. (2014). Oxytocin’s impact on social face processing is stronger in homosexual than heterosexual men. Psychoneuroendocrinology, 39, 194–203.
   Google Scholar
• Tops, M., Huffmeijer, R., Linting, M., Grewen, K. M., Light, K. C., Koole, S. L., & van IJzendoorn, M. H. (2013). The role of oxytocin in familiarization-habituation responses to social novelty. Frontiers in Psychology, 4. doi:10.3389/fpsyg.2013.00186
   Google Scholar
• Unkelbach, C., Guastella, A. J., & Forgas, J. P. (2008). Oxytocin selectively facilitates recognition of positive sex and relationship words. Psychological Science, 19(11), 1092–1094.
   Google Scholar
• Veenema, A. H., & Neumann, I. D. (2008). Central vasopressin and oxytocin release: Regulation of complex social behaviours. Progress in Brain Research, 170, 261–276.
   Google Scholar
• Veening, J., De Jong, T., Waldinger, M., Korte, S., & Olivier, B. (2015). The role of oxytocin in male and female reproductive behavior. European Journal of Pharmacology, 753, 209–228.
   Google Scholar
• Wallen, K. (1995). The evolution of female sexual desire. In Abramson, P. R., & Pinkerton, S. D. (Eds.), Sexual nature/sexual culture  (57–79). University of Chicago Press.
   Google Scholar
• Wallen, K., & Rupp, H. A. (2010). Women’s interest in visual sexual stimuli varies with menstrual cycle phase at first exposure and predicts later interest. Hormones and Behavior, 57(2), 263–268.
   Google Scholar
• Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., & Westberg, L. (2012). Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior. Biological Psychiatry, 71(5), 419–426.
   Google Scholar
• Walum, H., Waldman, I. D., & Young, L. J. (2016). Statistical and methodological considerations for the interpretation of intranasal oxytocin studies. Biological Psychiatry, 79(3), 251–257.
   Google Scholar
• Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2012). Oxytocin administration to parent enhances infant physiological and behavioral readiness for social engagement. Biological Psychiatry, 72(12), 982–989.
   Google Scholar
• White‐Traut, R., Watanabe, K., Pournajafi‐Nazarloo, H., Schwertz, D., Bell, A., & Carter, C. S. (2009). Detection of salivary oxytocin levels in lactating women. Developmental Psychobiology, 51(4), 367–373.
   Google Scholar
• Young, L. J. (2015). Oxytocin, social cognition and psychiatry. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 40(1), 243–244.
   Google Scholar
• Zekveld, A. A., Heslenfeld, D. J., Johnsrude, I. S., Versfeld, N. J., & Kramer, S. E. (2014). The eye as a window to the listening brain: Neural correlates of pupil size as a measure of cognitive listening load. NeuroImage, 101, 76–86.
   Google Scholar
• Zhang, Y., Deiter, F., Jung, S., Heinrichs, M., Schedlowski, M., & Krüger, H. (2015). Differential effects of intranasal oxytocin administration on sexual functions in healthy females: A laboratory setting. European Psychiatry, 30, 264.
   Google Scholar