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Research Article

Resting-state brain network properties mediate the association between the oxytocin receptor gene and interdependence

, , , &
Pages 296-310 | Received 29 May 2019, Published online: 14 Jan 2020

References

  • Achard, S., & Bullmore, E. (2007). Efficiency and Cost of Economical Brain Functional Networks. PLoS Computational Biology, 3(2), e17.
  • Achard, S., Salvador, R., Whitcher, B., Suckling, J., & Bullmore, E. D. (2006). A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. Journal of Neuroscience, 26(1), 63-72. doi:10.1523/JNEUROSCI.3874-05.2006
  • Adams, G., & Markus, H. R. (2004). Toward a Conception of Culture Suitable for a Social Psychology of Culture. In M. Schaller & C. S. Crandall (Eds.), The psychological foundations of culture (pp. 335–360). Mahwah, NJ, US: Lawrence Erlbaum Associates Publishers.
  • Aiken, L. S., West, S. G., & Reno, R. R. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
  • Armstrong, E. (1991). The limbic system and culture: An allometric analysis of the neocortex and limbic nuclei. Human Nature, 2(2), 117–136.
  • Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3(2), 128–134.
  • Baroncini, M., Jissendi, P., Balland, E., Besson, P., Pruvo, J.-P., Francke, J.-P., … Prevot, V. (2012). MRI atlas of the human hypothalamus. NeuroImage, 59(1), 168–180.
  • Bassett, D. S., & Sporns, O. (2017). Network neuroscience. Nature Neuroscience, 20(3), 353–364.
  • Bhanji, J. P., & Delgado, M. R. (2014). The social brain and reward: Social information processing in the human striatum: Social brain and reward. Wiley Interdisciplinary Reviews: Cognitive Science, 5(1), 61–73.
  • Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., … Milham, M. P. (2010). Toward discovery science of human brain function. Proceedings of the National Academy of Sciences, 107(10), 4734–4739.
  • Boyd, R., & Richerson, P. J. (1983). The cultural transmission of acquired variation: Effects on genetic fitness. Journal of Theoretical Biology, 100(4), 567–596.
  • Bullmore, E., & Bassett, D. S. (2011). Brain graphs: Graphical models of the human brain connectome. Annual Review of Clinical Psychology, 7, 113–140.
  • Bullmore, E., & Sporns, O. (2009). Complex brain networks: Graph theoretical analysis of structural and functional systems. Nature Reviews. Neuroscience, 10(3), 186–198.
  • Chiao, J. Y., & Blizinsky, K. D. (2010). Culture–gene coevolution of individualism–collectivism and the serotonin transporter gene. Proceedings of the Royal Society B: Biological Sciences, 277(1681), 529–537.
  • Cohen, A. B. (2009). Many forms of culture. American Psychologist, 64(3), 194.
  • Cole, D. M., Smith, S. M., & Beckmann, C. F. (2010). Advances and pitfalls in the analysis and interpretation of resting-state FMRI data. Frontiers in Systems Neuroscience, 4, 8.
  • Davey, C. G., Pujol, J., & Harrison, B. J. (2016). Mapping the self in the brain’s default mode network. Neuroimage, 132, 390–397.
  • de Greck, M., Shi, Z., Wang, G., Zuo, X., Yang, X., Wang, X., … Han, S. (2012). Culture modulates brain activity during empathy with anger. NeuroImage, 59(3), 2871–2882.
  • Epstein, R., DeYoe, E. A., Press, D. Z., Rosen, A. C., & Kanwisher, N. (2001). Neuropsychological evidence for a topographical learning mechanism in parahippocampal cortex. Cognitive Neuropsychology, 18(6), 481–508.
  • Fox, M. D., Zhang, D., Snyder, A. Z., & Raichle, M. E. (2009). The Global Signal and Observed Anticorrelated Resting State Brain Networks. Journal of Neurophysiology, 101(6), 3270–3283.
  • Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996). Movement-Related effects in fMRI time-series. Magnetic Resonance in Medicine, 35(3), 346–355.
  • Gao, Q., Xu, Q., Duan, X., Liao, W., Ding, J., Zhang, Z., … Chen, H. (2013). Extraversion and neuroticism relate to topological properties of resting-state brain networks. Frontiers in Human Neuroscience, 7. doi:10.3389/fnhum.2013.00257
  • Gimpl, G., & Fahrenholz, F. (2001). The Oxytocin Receptor System: Structure, Function, and Regulation. Physiological Reviews, 81(2), 629–683.
  • Gutchess, A. H., & Indeck, A. (2009). Cultural influences on memory. In Progress in Brain Research (Vol, 178, 137–150.
  • Han, S. (2017). The Sociocultural Brain: A Cultural Neuroscience Approach to Human Nature. Oxford, UK: Oxford University Press.
  • Han, S., & Humphreys, G. (2016). Self-construal: A cultural framework for brain function. Current Opinion in Psychology, 8, 10–14.
  • Han, S., & Ma, Y. (2014). Cultural differences in human brain activity: A quantitative meta-analysis. NeuroImage, 99, 293–300.
  • Han, S., & Ma, Y. (2015). A Culture–Behavior–Brain Loop Model of Human Development. Trends in Cognitive Sciences, 19(11), 666–676.
  • Han, S., & Northoff, G. (2008). Culture-sensitive neural substrates of human cognition: A transcultural neuroimaging approach. Nature Reviews Neuroscience, 9(8), 646–654.
  • Han, S., & Northoff, G. (2009). Understanding the self: A cultural neuroscience approach. Progress in Brain Research, 178, 203–212.
  • Han, S., Northoff, G., Vogeley, K., Wexler, B. E., Kitayama, S., & Varnum, M. E. W. (2013). A Cultural Neuroscience Approach to the Biosocial Nature of the Human Brain. Annual Review of Psychology, 64(1), 335–359.
  • Hayes, A. F. (2009). Beyond Baron and Kenny: Statistical Mediation Analysis in the New Millennium. Communication Monographs, 76(4), 408–420.
  • He, Y., Dagher, A., Chen, Z., Charil, A., Zijdenbos, A., Worsley, K., & Evans, A. (2009). Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain, 132(12), 3366–3379.
  • Hedden, T., Ketay, S., Aron, A., Markus, H. R., & Gabrieli, J. D. E. (2008). Cultural Influences on Neural Substrates of Attentional Control. Psychological Science, 19(1), 12–17.
  • Humphries, M. D., Gurney, K., & Prescott, T. J. (2006). The brainstem reticular formation is a small-world, not scale-free, network. Proceedings of the Royal Society B: Biological Sciences, 273(1585), 503–511.
  • Inoue, T., Kimura, T., Azuma, C., Inazawa, J., Takemura, M., Kikuchi, T., … Saji, F. (1994). Structural organization of the human oxytocin receptor gene. The Journal of Biological Chemistry, 269(51), 32451–32456.
  • Ivancovsky, T., Kleinmintz, O., Lee, J., Kurman, J., & Shamay‐Tsoory, S. G. (2018). The neural underpinnings of cross‐cultural differences in creativity. Human Brain Mapping, 39(11), 4493–4508.
  • Ivancovsky, T., Shamay-Tsoory, S., Lee, J., Morio, H., & Kurman, J. (2019). A dual process model of generation and evaluation: A theoretical framework to examine cross-cultural differences in the creative process. Personality and Individual Differences, 139, 60–68.
  • Iyengar, S. S., & Lepper, M. R. (1999). Rethinking the value of choice: A cultural perspective on intrinsic motivation. Journal of Personality and Social Psychology, 76(3), 349–366.
  • Ji, G.-J., Yu, Y., Miao, -H.-H., Wang, Z.-J., Tang, Y.-L., & Liao, W. (2017). Decreased Network Efficiency in Benign Epilepsy with Centrotemporal Spikes. Radiology, 283(1), 186–194.
  • Kim, B., Sung, Y. S., & McClure, S. M. (2012). The neural basis of cultural differences in delay discounting. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1589), 650–656.
  • Kim, H. S., & Sasaki, J. Y. (2014). Cultural Neuroscience: Biology of the Mind in Cultural Contexts. Annual Review of Psychology, 65(1), 487–514.
  • Kim, H. S., Sherman, D. K., Mojaverian, T., Sasaki, J. Y., Park, J., Suh, E. M., & Taylor, S. E. (2011). Gene–Culture Interaction: Oxytocin Receptor Polymorphism (OXTR) and Emotion Regulation. Social Psychological and Personality Science, 2(6), 665–672.
  • Kitayama, S., & Park, J. (2014). Error-related brain activity reveals self-centric motivation: Culture matters. Journal of Experimental Psychology: General, 143(1), 62–70.
  • Kogan, A., Saslow, L. R., Impett, E. A., Oveis, C., Keltner, D., & Rodrigues Saturn, S. (2011). Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proceedings of the National Academy of Sciences, 108(48), 19189–19192.
  • Kremer, I., Bachner-Melman, R., Reshef, A., Broude, L., Nemanov, L., Gritsenko, I., … Ebstein, R. P. (2005). Association of the Serotonin Transporter Gene With Smoking Behavior. American Journal of Psychiatry, 162(5), 924–930.
  • Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., … Lipsky, R. H. (2012). Oxytocin Receptor Genetic Variation Promotes Human Trust Behavior. Frontiers in Human Neuroscience, 6. doi:10.3389/fnhum.2012.00004
  • Liang, X., He, Y., Salmeron, B. J., Gu, H., Stein, E. A., & Yang, Y. (2015). Interactions between the salience and default-mode networks are disrupted in cocaine addiction. Journal of Neuroscience, 35(21),8081–8090.
  • Liang, X., Zou, Q., He, Y., & Yang, Y. (2015). Topologically reorganized connectivity architecture of default-mode, executive-control, and salience networks across working memory task loads. Cerebral Cortex, 26(4), 1501–1511.
  • Liu, Y., Liang, M., Zhou, Y., He, Y., Hao, Y., Song, M., … Jiang, T. (2008). Disrupted small-world networks in schizophrenia. Brain, 131(4), 945–961.
  • Lumsden, C. J., & Wilson, E. O. (2005). Genes, mind, and culture: The coevolutionary process. Singapore: World Scientific.
  • Luo, S., & Han, S. (2014). The association between an oxytocin receptor gene polymorphism and cultural orientations. Culture and Brain, 2(1), 89–107.
  • Luo, S., Li, B., Ma, Y., Zhang, W., Rao, Y., & Han, S. (2015a). Oxytocin receptor gene and racial ingroup bias in empathy-related brain activity. NeuroImage, 110, 22–31.
  • Luo, S., Ma, Y., Liu, Y., Li, B., Wang, C., Shi, Z., … Han, S. (2015b). Interaction between oxytocin receptor polymorphism and interdependent culture values on human empathy. Social Cognitive and Affective Neuroscience, 10(9), 1273–1281.
  • Luo, S., Zhang, T., Li, W., Yu, M., Hein, G., & Han, S. (2019). Interactions between oxytocin receptor gene and intergroup relationship on empathic neural responses to others’ pain. Social Cognitive and Affective Neuroscience, 14(5), 505–517.
  • Luo, S., Zhu, Y., Xu, Y., & Kong, Q. (2017). The oxytocinergic system modulates sadistic context-dependent empathy in humans. Scientific Reports, 7(1), 12463.
  • Ma, Y., Bang, D., Wang, C., Allen, M., Frith, C., Roepstorff, A., & Han, S. (2014a). Sociocultural patterning of neural activity during self-reflection. Social Cognitive and Affective Neuroscience, 9(1), 73–80.
  • Ma, Y., Wang, C., Li, B., Zhang, W., Rao, Y., & Han, S. (2014b). Does self-construal predict activity in the social brain network? A genetic moderation effect. Social Cognitive and Affective Neuroscience, 9(9), 1360–1367.
  • Ma-Kellams, C., & Blascovich, J. (2012). Inferring the emotions of friends versus strangers: The role of culture and self-construal. Personality and Social Psychology Bulletin, 38(7), 933–945.
  • Malenka, R., Nestler, E., & Hyman, S. (2009). Reinforcement and addictive disorders. In Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd., pp. 364–375). New York: McGraw-Hill Medical.
  • Markus, H. R., & Kitayama, S. (2003). Models of agency: Sociocultural diversity in the construction of action. In V. Murphy-Berman & J. J. Berman (Eds.), Nebraska symposium on motivation: Cross-cultural differences in perspectives on the self (Vol. 49, pp. 1–57). Lincoln & London: University of Nebraska Press.
  • Markus, H. R., & Kitayama, S. (1991). Culture and the self: Implications for cognition, emotion, and motivation. Psychological Review, 98(2), 224.
  • Mattay, V. S., & Goldberg, T. E. (2004). Imaging genetic influences in human brain function. Current Opinion in Neurobiology, 14(2), 239–247.
  • Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12(9), 524–538.
  • Montagrin, A., Saiote, C., & Schiller, D. (2018). The social hippocampus: M ONTAGRIN ET AL. Hippocampus, 28(9), 672–679.
  • Mu, Y., Kitayama, S., Han, S., & Gelfand, M. J. (2015). How culture gets embrained: Cultural differences in event-related potentials of social norm violations. Proceedings of the National Academy of Sciences, 112(50), 15348–15353.
  • Murphy, K., Birn, R. M., Handwerker, D. A., Jones, T. B., & Bandettini, P. A. (2009). The impact of global signal regression on resting state correlations: Are anti-correlated networks introduced?. NeuroImage, 44(3), 893–905.
  • Na, K.-S., Won, E., Kang, J., Kim, A., Choi, S., Kim, Y.-K., … Ham, B.-J. (2018). Interaction effects of oxytocin receptor gene polymorphism and depression on hippocampal volume. Psychiatry Research: Neuroimaging, 282, 18–23.
  • Owen, S. F., Tuncdemir, S. N., Bader, P. L., Tirko, N. N., Fishell, G., & Tsien, R. W. (2013). Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons. Nature, 500(7463), 458–462.
  • Preacher, K. J., & Hayes, A. F. (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods, 40(3), 879–891.
  • Puglia, M. H., Lillard, T. S., Morris, J. P., & Connelly, J. J. (2015). Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain. Proceedings of the National Academy of Sciences, 112(11), 3308–3313.
  • Rasetti, R., & Weinberger, D. R. (2011). Intermediate phenotypes in psychiatric disorders. Current Opinion in Genetics & Development, 21(3), 340–348.
  • Richerson, P. J., Boyd, R., & Henrich, J. (2010). Gene-culture coevolution in the age of genomics. Proceedings of the National Academy of Sciences of the United States of America, 107, 8985–8992. Retrieved from https://doi.org/10.1073/pnas.0914631107
  • Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., … Koellinger, P. D. (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340(6139), 1467–1471.
  • Rodrigues, S. M., Saslow, L. R., Garcia, N., John, O. P., & Keltner, D. (2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proceedings of the National Academy of Sciences, 106(50), 21437–21441.
  • Rubin, R. D., Watson, P. D., Duff, M. C., & Cohen, N. J. (2014). The role of the hippocampus in flexible cognition and social behavior. Frontiers in Human Neuroscience, 8. doi:10.3389/fnhum.2014.00742
  • Rubinov, M., & Sporns, O. (2010). Complex network measures of brain connectivity: Uses and interpretations. NeuroImage, 52(3), 1059–1069.
  • Rucker, D. D., Preacher, K. J., Tormala, Z. L., & Petty, R. E. (2011). Mediation Analysis in Social Psychology: Current Practices and New Recommendations: Mediation Analysis in Social Psychology. Social and Personality Psychology Compass, 5(6), 359–371.
  • Rudie, J. D., Brown, J. A., Beck-Pancer, D., Hernandez, L. M., Dennis, E. L., Thompson, P. M., … Dapretto, M. (2013). Altered functional and structural brain network organization in autism. NeuroImage: Clinical, 2, 79–94.
  • Saad, Z. S., Gotts, S. J., Murphy, K., Chen, G., Jo, H. J., Martin, A., & Cox, R. W. (2012). Trouble at rest: How correlation patterns and group differences become distorted after global signal regression. Brain Connectivity, 2(1), 25-32. doi:10.1089/brain.2012.0080
  • Schneider-Hassloff, H., Straube, B., Jansen, A., Nuscheler, B., Wemken, G., Witt, S. H., … Kircher, T. (2016). Oxytocin receptor polymorphism and childhood social experiences shape adult personality, brain structure and neural correlates of mentalizing. NeuroImage, 134, 671–684.
  • Schoemann, A. M., Boulton, A. J., & Short, S. D. (2017). Determining power and sample size for simple and complex mediation models. Social Psychological and Personality Science, 8(4), 379-386. doi: 10.1177/1948550617715068
  • Scoville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology. Neurosurgery, and Psychiatry, 20(1), 11–21.
  • Singelis, T. M. (1994). The Measurement of Independent and Interdependent Self-Construals. Personality and Social Psychology Bulletin, 20(5), 580–591.
  • Skuse, D. H., & Gallagher, L. (2009). Dopaminergic-neuropeptide interactions in the social brain. Trends in Cognitive Sciences, 13(1), 27–35.
  • Smith, K. E., Porges, E. C., Norman, G. J., Connelly, J. J., & Decety, J. (2014). Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others. Social Neuroscience, 9(1), 1–9.
  • Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009). Ventral pallidum roles in reward and motivation. Behavioural Brain Research, 196(2), 155–167.
  • Tomizawa, K., Iga, N., Lu, Y.-F., Moriwaki, A., Matsushita, M., Li, S.-T., … Matsui, H. (2003). Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nature Neuroscience, 6(4), 384–390.
  • Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., … Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences, 107(31), 13936–13941.
  • Tsai, J. L., Miao, F. F., Seppala, E., Fung, H. H., & Yeung, D. Y. (2007). Influence and adjustment goals: Sources of cultural differences in ideal affect. Journal of Personality and Social Psychology, 92(6), 1102. https://psycnet.apa.org/doi/10.1037/0022-3514.92.6.1102
  • Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., … Joliot, M. (2002). Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain. NeuroImage, 15(1), 273–289.
  • van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010). Exploring the brain network: A review on resting-state fMRI functional connectivity. European Neuropsychopharmacology, 20(8), 519–534.
  • van den Heuvel, M. P., Stam, C. J., Kahn, R. S., & Hulshoff Pol, H. E. (2009). Efficiency of Functional Brain Networks and Intellectual Performance. Journal of Neuroscience, 29(23), 7619–7624.
  • Wang, J. (2010). Graph-based network analysis of resting-state functional MRI. Frontiers in Systems Neuroscience. doi:10.3389/fnsys.2010.00016
  • Wang, J., Qin, W., Liu, B., Wang, D., Zhang, Y., Jiang, T., & Yu, C. (2013). Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects. NeuroImage, 81, 199–204.
  • Wang, J., Wang, X., Xia, M., Liao, X., Evans, A., & He, Y. (2015). GRETNA: A graph theoretical network analysis toolbox for imaging connectomics. Frontiers in Human Neuroscience, 9. doi:10.3389/fnhum.2015.00386
  • Wang, J., Zuo, X., Dai, Z., Xia, M., Zhao, Z., Zhao, X., … He, Y. (2013). Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer’s Disease. Biological Psychiatry, 73(5), 472–481.
  • Wang, Q. (2001). Culture effects on adults’ earliest childhood recollection and self-description: Implications for the relation between memory and the self. Journal of Personality and Social Psychology, 81(2), 220.
  • Wang, Y., Fan, L., Zhu, Y., Yang, J., Wang, C., Gu, L., & Luo, S. (2019). Neurogenetic mechanisms of self-compassionate mindfulness: The role of oxytocin-receptor genes. Mindfulness, 10, 1792–1802. doi:10.1007/s12671-019-01141-7
  • Watts, D. J., & Strogatz, S. H. (1998). Collective dynamics of ‘small-world’ networks. Nature, 393(6684), 440–442.
  • Yan, C., & Zang, Y. (2010). DPARSF. A MATLAB Toolbox for “Pipeline” Data Analysis of Resting-State fMRI. Frontiers in Systems Neuroscience, 4, 13.
  • Yarkoni, T., Poldrack, R. A., Nichols, T. E., Van Essen, D. C., & Wager, T. D. (2011). Large-scale automated synthesis of human functional neuroimaging data. Nature Methods, 8(8), 665. doi: 10.1038/nmeth.1635
  • Zhang, L., Zhang, Y., Li, L., Li, Z., Li, W., Ma, N., … Lu, G. (2011). Different white matter abnormalities between the first-episode, treatment-naive patients with posttraumatic stress disorder and generalized anxiety disorder without comorbid conditions. Journal of Affective Disorders, 133(1–2), 294–299.
  • Zhao, X., Lynch, J. G., & Chen, Q. (2010). Reconsidering Baron and Kenny: Myths and Truths about Mediation Analysis. Journal of Consumer Research, 37(2), 197–206.
  • Zhu, Y., Zhang, L., Fan, J., & Han, S. (2007). Neural basis of cultural influence on self-representation. NeuroImage, 34(3), 1310–1316.

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