Mechanisms of mucus secretion in the airways

References

• Li Y, Martin LD, Spizz G, Adler KB. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 2001; 276: 40982–90
   PubMed Web of Science ®Google Scholar
• Singer M, Vargaftig BB, Martin LD, Li Y, Adler KB. A MARCKS-related peptide blocks mucus hypersecretion in a murine model of asthma. Nat Med 2004; 10: 193–6
   PubMed Web of Science ®Google Scholar
• Seykora JT, Myatt MM, Allen LAH, Ravetch JV, Aderem A. Molecular determinants of the myristoyl-electrostatic switch of MARCKS. J Biol Chem 1996; 271: 18797–802
   PubMed Web of Science ®Google Scholar
• Koch H, Hoffmann K, Brose N. Definition of Munc-13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J 2000; 349: 247–53
   PubMed Web of Science ®Google Scholar
• Thelen M, Rosen A, Nairn AC, Aderem A. Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane. Nature 1991; 351: 320–2
   PubMed Web of Science ®Google Scholar
• Arbuzova A, Schmitz AAP, Vergeres G. Cross-talk unfolded: MARCKS proteins. Biochem J 2002; 362: 1–12
   PubMed Web of Science ®Google Scholar
• Vergeres G, Manenti S, Weber T, Sturzinger C. The myristoyl moiety of myristoylated alanine rich C kinase substrate and MARCKS related protein is embedded in the membrane. J Biol Chem 1995; 25: 19879–87
   Google Scholar
• Aderem A. The MARCKS brothers: a family of protein kinase C substrates. Cell 1992; 71: 713–6
   PubMed Web of Science ®Google Scholar
• Aderem A. The MARCKS family of protein kinase C substrates. Biochem Soc Trans 1995; 23: 587–91
   PubMedGoogle Scholar
• Salli U, Stormshak F. Prostaglandin F2alpha-activated protein kinase C alpha phosphorylates myristoylated alanine-rich C kinase substrate protein in bovine luteal cells. Endocrine 2001; 16: 83–8
   PubMedGoogle Scholar
• Salli U, Supanic S, Stormshak F. Phosphorylation of myristoylated alanine rich C kinase substrate (MARCKS) protein is associated with bovine luteal oxytocin exocytosis. Biol Reprod 2000; 63: 12–20
   PubMedGoogle Scholar
• Akita Y, Kawasaki H, Ohno S, Suzuki K, Kawashima S. Involvement of protein kinase C epsilon in thyrotropin-releasing hormone-stimulated phosphorylation of the myristoylated alanine-rich C kinase substrate in rat pituitary clonal cells. Electrophoresis 2000; 21: 452–9
   PubMedGoogle Scholar
• Liu JP, Engler D, Funder JW, Robinson PJ. Arginine vasopressin (AVP) causes the reversible phosphorylation of the myristoylated alanine-rich C-kinase substrate (MARCKS) protein in the ovine anterior pituitary: evidence that MARCKS phosphorylation is associated with adrenocorticotropin (ACTH) secretion. Mol Cell Endocrinol 1994; 101: 247–56
   PubMedGoogle Scholar
• Rose SD, Lejen T, Zhang L, Trifaro JM. Chromaffin cell F-actin disassembly and potentiation of catecholamine release in response to protein kinase C activation by phorbol esters is mediated through myristoylated alanine-rich C kinase substrate phosphorylation. J Biol Chem 2001; 276: 36757–63
   PubMedGoogle Scholar
• Trifaro J, Rose SD, Lejen T, Elzagallaai A. Two pathways control chromaffin cell cortical F-actin dynamics during exocytosis. Biochimie 2000; 82: 339–52
   PubMed Web of Science ®Google Scholar
• Calle R, Ganesan S, Smallwood JI, Rasmussen H. Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets. J Biol Chem 1992; 267: 18723–7
   PubMedGoogle Scholar
• Raufman JP, Malhotra R, Xie Q, Raffaniello RD. Expression and phosphorylation of a MARCKS-like protein in gastric chief cells: further evidence for modulation of pepsinogen secretion by interaction of Ca + 2/calmodulin with protein kinase C. J Cell Biochem 1997; 1: 514–23
   Google Scholar
• Vaughan PF, Walker JH, Peers C. The regulation of neurotransmitter secretion by protein kinase C. J Mol Neurobiol 1998; 18: 125–55
   PubMedGoogle Scholar
• Yang H, Wang X, Sumners C, Raizada MK. Obligatory role of protein kinase C beta and MARCKS in vesicular trafficking in living neurons. Hypertension 2002; 39: 567–72
   PubMedGoogle Scholar
• Walaas SI, Sefland I. Modulation of calcium-evoked [3H] noradrenaline release from permeabilized cerebrocortical synaptosomes by the MARCKS protein, calmodulin and the actin cytoskeleton. Neurochem Int 2000; 36: 581–93
   PubMedGoogle Scholar
• Elzagallaai A, Rose SD, Trifaro JM. Platelet secretion induced by phorbol ester stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation. Blood 2000; 95: 894–902
   PubMed Web of Science ®Google Scholar
• Cremona O, De Camilli P. Phosphoinositides in membrane traffic at the synapse. J Cell Sci 2001; 114: 1041–52
   PubMed Web of Science ®Google Scholar
• Martin TFJ. PI(4,5)P2 regulation of surface membrane traffic. Curr Opin Cell Biol 2001; 13: 493–9
   PubMed Web of Science ®Google Scholar
• Arbuzova A, Wang L, Wang J, Hangyas-Mihalyne G, Murray D, Honig B, et al. Membrane binding of peptides containing both basic and aromatic residues. Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS. Biochemistry 2000; 39: 10330–9
   PubMedGoogle Scholar
• Wang J, Arbuzova A, Hangyas-Mihalyne G, McLaughlin S. The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidyl 4,5 biphosphate. J Biol Chem 2001; 276: 5012–9
   PubMedGoogle Scholar
• Laux T, Fukami K, Thelen M, Golub T, Frey D, Caroni P. GAP43, MARCKS and CAP23 modulate PI(4,5)P2 at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol 2000; 149: 1455–71
   PubMed Web of Science ®Google Scholar
• Park J, Fang S, Adler KB. Cysteine String Protein is involved in mucin secretion from normal human bronchial epithelial (NHBE) cells in vitro. Proc Am Thorac Soc 2005; 2: A215
   Google Scholar
• Fang S, Park J, Adler KB. Small interfering RNA's directed against MARCKS protein and Heat Shock Protein 70 (Hsp70) attenuate mucin secretion in human airway epithelial cells in vitro. Am J Respir Crit Care Med 2004; 169: A712
   PubMedGoogle Scholar
• Resh MD. Membrane interactions of pp60v-src: a model for myristylated tyrosine protein kinases. Oncogene 1990; 5: 1437–44
   PubMed Web of Science ®Google Scholar
• Manenti S, Sorokine O, Van Dorsselaer A, Taniguchi H. Affinity purification and characterization of myristoylated alanine-rich protein kinase C substrate (MARCKS) from bovine brain. Comparison of the cytoplasmic and the membrane-bound forms. J Biol Chem 1992; 267: 22310–5
   PubMedGoogle Scholar
• Wu R, Zhao YH, Plopper CG, Chang MMJ, Chmiel K, Cross JJ, et al. Differential expression of stress proteins in nonhuman primate lung and conducting airway after ozone exposure. Am J Physiol 1999; 277: L511–22
   Google Scholar
• Vignola AM, Chanez P, Polla BS, Vic P, Godard P, Bousquet J. Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis. Am J Respir Cell Mol Biol 1995; 13: 683–91
   PubMed Web of Science ®Google Scholar
• Agarraberes FA, Dice JF. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 2001; 114: 2491–9
   PubMed Web of Science ®Google Scholar
• Spizz G, Blackshear P. Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme. J Biol Chem 1997; 272: 23833–42
   PubMedGoogle Scholar
• Terlecky SR, Dice JF. Polypeptide import and degradation by isolated lysosomes. J Biol Chem 1993; 268: 23490–5
   PubMed Web of Science ®Google Scholar
• Cuervo AM, Dice JF. Lysosomes, a meeting point of proteins, chaperones and proteases. J Mol Med 1998; 76: 6–121
   PubMed Web of Science ®Google Scholar
• Mastrogiacomo A, Parsons SM, Zampighi GA, Jenden DJ, Umbach JA, Gundersen CB. Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels. Science 1994; 263: 981–2
   PubMed Web of Science ®Google Scholar
• Braun JE, Scheller RH. CSP: cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Neuropharmacology 1995; 34: 1361–9
   PubMedGoogle Scholar
• Tobaben S, Thakur P, Fernendez-Chacon R, Sudhof TC, Rettig J, Stahl B. A trimeric protein complex functions as a synaptic chaperone machine. Neuron 2001; 31: 987–99
   PubMed Web of Science ®Google Scholar
• Brown H, Larsson O, Branstrom R, Yang S-N, Leibiger B, Leibiger I, et al. Cysteine string protein in an insulin secretory granule-associated protein regulating beta cell exocytosis. EMBO J 1998; 17: 5048–58
   PubMedGoogle Scholar
• Zhang H, Kelley WL, Chamberlain LH, Burgoyne RD, Lang J. Mutational analysis of cysteine-string protein function in insulin exocytosis. J Cell Sci 1999; 112: 1345–51
   PubMedGoogle Scholar
• Stahl B, Tobaaben S, Sudhof TC. Two distinct domains in hsc70 are essential for the interaction with the synaptic vesicle cysteine string protein. Eur J Cell Biol 1999; 78: 375–81
   PubMedGoogle Scholar
• Zhang H, Peters KW, Sun F, Marino CRF, Lang J, Burgoyne RD, et al. Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem 2002; 277: 28948–58
   PubMedGoogle Scholar
• Park J, Fang S, Gruber AD, Adler KB. MARCKS protein interaction with the “secretory module” regulates airway mucin secretion. Am J Respir Crit Care Med 2004; 169: A535
   Google Scholar
• Cuervo AM, Terlecky SR, Dice JF, Knecht E. Selective binding and uptake of ribonuclease A and glyceraldehydes-3-phosphate dehydrogenase by isolated rat liver lysosomes. J Biol Chem 1994; 269: 26374–380
   PubMed Web of Science ®Google Scholar
• Chen YA, Scheller RH. SNARE-mediated membrane fusion. Nat Rev Mol Cell Biol 2001; 2: 98–106
   PubMed Web of Science ®Google Scholar
• An SJ, Hansen NJ, Hodel A, Jahn R, Edwardson JM. Analysis of the association of syncollin with the membrane of the pancreatic zymogen granule. J Biol Chem 2000; 275: 11306–11
   PubMed Web of Science ®Google Scholar
• Feng D, Flaumenhaft R, Bandeira-Melo C, Weller P, Dvorak AM. Ultrastructural localization of vesicle-associated membrane protein(s) to specialized membrane structures in human pericytes, vascular smooth muscle cells, endothelial cells, neutrophils, and eosinophils. J Histochem Cytochem 2001; 49: 293–304
   PubMedGoogle Scholar
• Kalus I, Hodel A, Koch A, Kleene R, Edwardson JM, Schrader M. Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains. Biochem J 2002; 362: 433–42
   PubMed Web of Science ®Google Scholar
• Hansen NJ, Antonin W, Edwardson JM. Identification of SNARE's involved in regulated exocytosis in the pancreatic acinar cell. J Biol Chem 1999; 274: 22871–6
   PubMed Web of Science ®Google Scholar
• Hodel A, Edwardson JM. Targeting of the zymogen-granule protein syncollin in AR42J and AtT-20 cells. Biochem J 2000; 350: 637–43
   PubMedGoogle Scholar
• Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, et al. Soluble SNF attachment protein receptors (SNARE's) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. J Immunol 2000; 164: 5850–7
   PubMed Web of Science ®Google Scholar
• Houng A, Polgar J, Reed GL. Munc18-syntaxin complexes and exocytosis in human platelets. J Biol Chem 2003; 278: 19627–33
   PubMed Web of Science ®Google Scholar
• Reed GL, Houng AK, Fitzgerald ML. Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion. Blood 1999; 93: 2617–26
   PubMed Web of Science ®Google Scholar
• Polgar J, Chung SH, Reed GL. Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Blood 2002; 100: 1081–3
   PubMed Web of Science ®Google Scholar
• Steegmaier M, Lee KC, Prekeris R, Scheller RH. SNARE protein trafficking in polarized MDCK cells. Traffic 2001; 1: 553–60
   Google Scholar
• Scales SJ, Hesser BA, Masuda ES, Scheller RH. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. J Biol Chem 2002; 277: 28271–9
   PubMedGoogle Scholar
• Zhang W, Khan A, Ostgenson CG, Berggren PO, Efendic S, Meister B. Down-regulated expression of exocytotic proteins in pancreatic islets of diabetic GK rats. Biochem Biophys Res Commun 2002; 291: 1038–44
   PubMed Web of Science ®Google Scholar
• Zhang W, Efanov A, Yang SN, Fried G, Kolare S, Brown H, et al. Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta-cell. J Biol Chem 2000; 275: 4152–7
   PubMedGoogle Scholar
• Naren AP, Di A, Cormet-Boyaka E, Boyaka PN, McGhee JR, Zhou W, et al. Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(−) currents. J Clin Invest 2000; 105: 377–86
   PubMedGoogle Scholar
• Gaisano HY, Ghai M, Malkus PN, Sheu L, Bouquillon A, Bennett MK, et al. Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells. Mol Biol Cell 1996; 7: 2019–27
   PubMed Web of Science ®Google Scholar
• Smith CA, Reynolds SD, Peredo CE, Evans C, Dickey BF, Frizzell RA, et al. Components of the regulated secretory pathway specific to clara cell secretory protein (CCSP) expressing cells. Am J Respir Crit Care Med 2003; 167: A17
   Google Scholar
• Tuvim M, Alcorn J, Agrawal A, Dickson A, Nguyen J, Dickey BF. Munc18B regulates surfactant secretion in T2 cells. Am J Respir Crit Care Med 2003; 167: A395
   PubMedGoogle Scholar
• Agrawal A, Evans CM, Nigam R, Mixides G, Tuvim M, Koo JS, et al. The exocytotic protein Munc 18-2 is selectively upregulated during goblet cell metaplasia of airway epithelium in vivo and in vitro. Am J Respir Crit Care Med 2003; 167: A454
   Google Scholar