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ORIGINAL ARTICLES

Effects of phosphodiesterase inhibition in sepsis

, , , , & , FACS , MD , PhD
Pages 115-121 | Published online: 11 Jul 2009

References

  • Endres S, Fulle JJ, Sinha B, Stoll D, Dinarello CA, Gerzer R, et al. Cyclic nucleotides differentially regulate the synthesis of tumour necrosis factor-alpha and interleukin-1 beta by human mononuclear cells. Immunology 1991; 72: 56–60
  • Porter JM, Cutler BS, Lee BY, Reich T, Reichle FA, Scogin JT, et al. Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double-blind trial with objective assessment of chronic occlusive arterial disease patients. Am Heart J 1982; 104: 66–72
  • Hoffmann H, Markewitz A, Kreuzer E, Reichert K, Jochum M, Faist E. Pentoxifylline decreases the incidence of multiple organ failure in patients after major cardiothoracic surgery. Shock 1998; 9: 235–40
  • Staubach KH, Schroder J, Stuber F, Gehrke K, Traumann E, Zabel P. Effect of pentoxifylline decreases the incidence of severe sepsis: results of a randomized, double-blind, placebo-controlled study. Arch Surg 1998; 133: 94–100
  • Lauterbach R, Zembala M. Pentoxifylline reduces plasma tumor necrosis factor-alpha concentration in premature infants with sepsis. Eur J Pediatr 1996; 155: 404–9
  • Windsor AC, Mullen PG, Fowler AA, Sugerman HJ. Role of the neutrophil in adult respiratory distress syndrome. Br J Surg 1993; 80: 10–17
  • Karlsson A, Dahlgren C. Assembly and activation of the neutrophil NADPH oxidase in granule membranes. Antioxidants Redox Signal 2002; 4: 49–60
  • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990; 249: 1431–3
  • Nick JA, Avdi NJ, Young SK, Lehman LA, McDonald PP, Frasch SC, et al. Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J Clin Invest 1999; 103: 851–8
  • Coimbra R, Loomis W, Melbostad H, Tobar M, Porcides RD, Hoyt DB. LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline. J Trauma 2004; 57: 1157–63
  • Nick JA, Avdi NJ, Gerwins P, Johnson GL, Worthen GS. Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and fMLP. J Clin Invest 1997; 99: 975–86
  • Wientjes FB, Segal AW. NADPH oxidase and the respiratory burst. Cell Biol 1995; 270: 7420–6
  • El Benna J, Faust LP, Babior BM. The phosphorylation of the respiratory burst oxidase component p47 phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases. J Biol Chem 1994; 94: 815–23
  • Zu YL, Qi J, Gilchrist A, Fernandez GA, Vazquez-Abad D, Kreutzer DL, et al. p38 MAPK activation is required for human neutrophil function triggered by TNF-alpha or fMLP stimulation. J Immunol 1989; 160: 1982–99
  • Coimbra R, Melbostad H, Loomis W, Tobar M, Hoyt DB. Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia. J Trauma 2005; 59: 575–82
  • Neumann B, Machleidt T, Lifka A, Pfeffer K, Vestweber D, Mak TW, et al. Crucial role of 55-kilodalton TNF receptor in TNF-induced adhesion molecule expression and leukocyte organ infiltration. J Immunol 1996; 156: 1587–93
  • Yada-Langui MM, Coimbra R, Lancellotti C, Mimica I, Garcia C, Correia N, et al. Hypertonic saline and pentoxifylline prevent lung injury and bacterial translocation after hemorrhagic shock. Shock 2000; 14: 594–8
  • Michetti C, Coimbra R, Hoyt DB, Loomis W, Junger W, Wolf P. Pentoxifylline reduces acute lung injury in chronic endotoxemia. J Surg Res 2003; 115: 92–9
  • Simons RK, Junger WG, Loomis WH, Hoyt DB. Acute lung injury in endotoxemic rats is associated with sustained circulating IL-6 levels and intrapulmonary CINC activity and neutrophil recruitment—role of circulating TNF-alpha and IL-beta?. Shock 1996; 6: 39–45
  • Suwa T, Hogg JC, Klut ME, Hards J, van Eeden SF. Interleukin-6 changes the deformability of neutrophils and increases their sequestration in the lung. Am J Respir Crit Care Med 2001;163:970–6.
  • Koo DJ, Yoo P, Cioffi WG, Bland KI, Chaudry IH, Wang P. Mechanism of the beneficial effects of pentoxifylline during sepsis: maintenance of adrenomedullin responsiveness and downregulation of proinflammatory cytokines. J Surg Res 2000;91:70–6.
  • Calkins CM, Heimbach JK, Bensard DD, Song Y, Raeburn CD, Meng X, et al. TNF receptor I mediates chemokine production and neutrophil accumulation in the lung following systemic lipopolysaccharide. J Surg Res 2001; 101: 232–37
  • Basit A, Reutershan J, Morris MA, Solga M, Rose CE, Ley K. ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Am J Physiol Lung Cell Mol Physiol 2006;291:L200–7.
  • Coimbra R, Melbostad H, Loomis W, Porcides RD, Wolf P, Tobar M, et al. LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. J Trauma 2006; 60: 115–25
  • Nakamura T, Ebihara I, Shimada N, Shoji H, Koide H. Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte nRNA concentrations in patients with septic shock: effect of fiber-immobilized polymyxin B treatment. Am J Respir Cell Mol Biol 1998; 316: 355–60
  • De Oliveira Martins J, Meyer-Pflug AR, Alba-Loureiro TC, Melbostad H, Costa da Cruz JW, Coimbra R, et al. Modulation of lipopolysaccharide-induced acute lung inflammation: role of insulin. Shock 2006; 25: 260–6
  • Garrean S, Gao XP, Brovkovych V, Shimizu J, Zhao YY, Vogel SM, et al. Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol 2006; 177: 4853–60
  • Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, et al. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996; 24: 1285–92
  • Cheng DS, Han W, Chen SM. Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway. J Immunol 2007; 178: 6504–13
  • Coimbra R, Porcides R, Melbostad H, Loomis W, Tobar M, Hoyt DB, et al. Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia. Surg Infect 2005; 6: 73–85
  • Sener G, Arbak S, Kurtaran P, Gedik N, Yegen BC. Estrogen protects the liver and intestines against sepsis-induced injury in rats. J Surg Res 2005; 128: 70–8
  • Lawson JA, Burns AR, Farhood A, Lynn Bajt M, Collins RG, Smith CW, et al. Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice. Hepatology 2000; 32: 990–8
  • Thiemermann C, Ruetten H, Wu CC, Vane JR. The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase. Br J Pharmacol 1995; 116: 2845–51
  • Li J, Billiar TR. Determinants of nitric oxide protection and toxicity in liver. Am J Physiol 1999; 276: G1069–73
  • Chen T, Zamora R, Zuckerbraun B, Billiar TR, et al. Role of nitric oxide in liver injury. Curr Mol Med 2003; 3: 519–26
  • Matejovic M, Krouzecky A, Martinkova V, Rokyta R, Jr, Kralova H, Treska V, et al. Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock 2004; 21: 458–65
  • Christman JW, Lancaster LF, Blackwell TS. Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 1998; 24: 1131–8

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