Insulin, glucose control and multiple organ dysfunction syndrome

References

• Thorell A, Nygren J, Ljungqvist O. Insulin resistance: a marker of surgical stress. Curr Opin Clin Nutr Met Care 1999; 21: 69–78
   Google Scholar
• McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycaemia. Crit Care Clin 2001; 17: 107–24
   PubMed Web of Science ®Google Scholar
• Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab 2001; 15: 533–51
   PubMed Web of Science ®Google Scholar
• Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. J Clin Invest 2004; 9: 1187–95
   Google Scholar
• Marik PE, Raghaven M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intensive Care Med 2004; 30: 748–56
   PubMed Web of Science ®Google Scholar
• Turina M, Christ-Crain M, Polk HC, Jr. Diabetes and hyperglycemia: strict glycemic control. Crit Care Med 2006; 34(Suppl 9)S291–300
   Google Scholar
• Van den Berghe G, de Zegher F, Bouillon R. Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 1998; 83: 1827–34
   PubMed Web of Science ®Google Scholar
• Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000; 355: 773–8
   PubMed Web of Science ®Google Scholar
• Deedwania P, Kosiborod M, Barrett E, Ceriello A, Isley W, Mazzone T, et al. Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 2008; 117: 1610–9
   PubMed Web of Science ®Google Scholar
• Muhlestein JB, Anderson JL, Horne BD, Lavasani F, Allen Maycock CA, Bair TL, et al. Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention. Am Heart J 2003; 146: 351–8
   PubMed Web of Science ®Google Scholar
• Doenst T, Wijeysundera D, Karkouti K, Zechner C, Maganti M, Rao V, et al. Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 2005; 13: 1144e1–e7
   Google Scholar
• Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, Williams BA, et al. Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc 2005; 80: 862–6
   PubMed Web of Science ®Google Scholar
• Barsheshet A, Garty M, Grossman E, Sandach A, Lewis BS, Gottlieb S, et al. Admission blood glucose level and mortality among hospitalized nondiabetic patients with heart failure. Arch Intern Med 2006; 166: 1613–9
   Google Scholar
• Baker EH, Janaway CH, Philips BJ, Brennan AL, Baines DL, Wood DM, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006; 61: 284–9
   PubMed Web of Science ®Google Scholar
• Capes SE, Hunt D, Malmberg K, Pathak P, Gerstein H. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001; 32: 2426–32
   PubMed Web of Science ®Google Scholar
• Baird TA, Parsons MW, Phanh T, Butcher KS, Desmond PM, Tress BM, et al. Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome. Stroke 2003; 34: 2208–14
   PubMed Web of Science ®Google Scholar
• Gentile NT, Seftchick MW, Huynh T, Kruus LK, Gaughan J. Decreased mortality by normalizing blood glucose after acute ischemic stroke. Acad Emerg Med 2006; 13: 174–80
   PubMed Web of Science ®Google Scholar
• Stead LG, Gilmore RM, Bellolio MF, Mishra S, Bhagra A, Vaidyanathan L, et al. Hyperglycemia as an independent predictor of worse outcome in non-diabetic patients presenting with acute ischemic stroke. Neurocrit Care 2008;Mar 21 [ Epub ahead of print].
   Google Scholar
• Yendamuri S, Fulda GJ, Tinkoff GH. Admission hyperglycemia as a prognostic indicator in trauma. J Trauma 2003; 55: 33–8
   PubMedGoogle Scholar
• Laird AM, Miller PR, Kilgo PD, Meredith JW, Chang MC. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004; 56: 1058–62
   PubMedGoogle Scholar
• Sung J, Bochicchio GV, Joshi M, Bochicchio K, Tracy K, Scalea TM. Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005; 59: 80–3
   PubMedGoogle Scholar
• Bochicchio GV, Joshi M, Bochicchio KM, Pyle A, Johnson SB, Meyer W, et al. Early hyperglycemic control is important in critically injured trauma patients. J Trauma 2007; 63: 1353–9
   Google Scholar
• Jeremitsky E, Omert LA, Dunham CM, Wilberger J, Rodriguez A. The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005; 58: 47–50
   PubMed Web of Science ®Google Scholar
• Yang SY, Zhang S, Wang ML. Clinical significance of admission hyperglycemia and factors related to it in patients with acute severe head injury. Surg Neurol 1995; 44: 373–7
   Google Scholar
• Gore DC, Chinkes D, Heggers J, Herndon DN, Wolf SE, Desai M. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma 2001; 51: 540–4
   PubMedGoogle Scholar
• Holm C, Horbrand F, Mayr M, von Donnersmarck GH, Muhlbauer W. Acute hyperglycaemia following thermal injury: friend or foe?. Resuscitation 2004; 60: 71–7
   PubMed Web of Science ®Google Scholar
• Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003; 78: 1471–8
   PubMed Web of Science ®Google Scholar
• Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA 2003; 290: 2041–7
   PubMed Web of Science ®Google Scholar
• Bochicchio GV, Sung J, Joshi M, Bochicchio K, Johnson SB, Meyer W, et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005; 58: 921–4
   PubMedGoogle Scholar
• Cheung NW, Napier B, Zaccaria C, Fletcher JP. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care 2005; 28: 2367–71
   PubMed Web of Science ®Google Scholar
• Ammori JB, Sigakis M, Englesbe MJ, O'Reilly M, Pelletier SJ. Effect of intraoperative hyperglycemia during liver transplantation. J Surg Res 2007; 140: 227–33
   Google Scholar
• Lin LY, Lin HC, Lee PC, Ma WY, Lin HD. Hyperglycemia correlates with outcomes in patients receiving total parenteral nutrition. Am J Med 2007; 333: 261–5
   Google Scholar
• Mangano CM, Diamondstone LS, Ramsay JG, Aggarwal A, Herskowitz A, Mangano DT. Renal dysfunction after myocardial revascularization: risk factors, adverse outcomes, and hospital resource utilization. The Multicenter Study of Perioperative Ischemia Research Group. Ann Intern Med 1998; 128: 194–203
   PubMed Web of Science ®Google Scholar
• Turcot DB, Kiernan FJ, McKay RG, Grey NJ, Boden W, Perdrizet GA. Acute hyperglycemia: implications for contrast-induced nephropathy during cardiac catheterization. Diabetes Care 2004; 27: 620–1
   Google Scholar
• Suematsu Y, Sato H, Ohtsuka T, Kotsuka Y, Araki S, Takamoto S. Predictive risk factors for delayed extubation in patients undergoing coronary artery bypass grafting. Heart Vessels 2000; 15: 214–20
   Google Scholar
• Bruno A, Williams LS, Kent TA. How important is hyperglycemia during acute brain infarction?. Neurologist 2004; 10: 195–200
   Google Scholar
• Alvarez-Sabin J, Molina CA, Ribo M, Arenillas JF, Montaner J, Huertas R, et al. Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion. Stroke 2004; 35: 2493–8
   PubMed Web of Science ®Google Scholar
• Losert H, Sterz F, Roine RO, Holzer M, Martens P, Cerchiari E, et al. Strict normoglycaemic blood glucose levels in the therapeutic management of patients within 12h after cardiac arrest might not be necessary. Resuscitation 2008; 76: 214–20
   PubMed Web of Science ®Google Scholar
• Rovlias A, Kotsou S. The influence of hyperglycaemia on neurological outcome in patients with severe head injury. Neurosurgery 2000; 46: 335–43
   PubMed Web of Science ®Google Scholar
• Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007; 33: 1876–91
   PubMed Web of Science ®Google Scholar
• Leijten FS, De Weerd AW, Poortvliet DC, De Ridder VA, Ulrich C, Harink-De Weerd JE. Critical illness polyneuropathy in multiple organ dysfunction syndrome and weaning from the ventilator. Intensive Care Med 1996; 22: 856–61
   Google Scholar
• The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–86.
   PubMed Web of Science ®Google Scholar
• Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) study. JAMA 2003;290:2159–67.
   PubMed Web of Science ®Google Scholar
• UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837–53.
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359–67
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters P, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006; 354: 449–61
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wouters PJ, Bouillon R, Weekers F, Verwaest C, Schetz M. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003; 31: 359–66
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Wilmer A, Milants I, Wouters PJ, Bouckaert B, Bruyninckx F, et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit versus harm. Diabetes 2006; 55: 3151–9
   PubMed Web of Science ®Google Scholar
• Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36: 296–327
   PubMed Web of Science ®Google Scholar
• Schultz MJ, de Graaff MJ, Kuiper MA, Spronk PE. The new Surviving Sepsis Campaign recommendations on glucose control should be reconsidered. Intensive Care Med 2008; 34: 779–80
   Google Scholar
• Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125–39
   PubMed Web of Science ®Google Scholar
• NCT 00107601. Available from: www.clinicaltrials.gov.
   Google Scholar
• NCT 00220987 Available from: www.clinicaltrials.gov.
   Google Scholar
• Krinsley JS. Effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Mayo Clin Proc 2004; 79: 992–1000
   PubMed Web of Science ®Google Scholar
• Reed CC, Stewart RM, Sherman M, Myers JG, Corneille MG, Larson N, et al. Intensive insulin protocol improves glucose control and is associated with a reduction in intensive care unit mortality. J Am Coll Surg 2007; 204: 1048–55
   PubMed Web of Science ®Google Scholar
• Scalea TM, Bochicchio GV, Bochicchio KM, Johnson SB, Joshi M, Pyle A. Tight glycemic control in critically injured trauma patients. Ann Surg 2007; 246: 605–12
   Web of Science ®Google Scholar
• Lazar HL, Chipkin SR, Fitzgerald CA, Bao Y, Cabral H, Apstein CS. Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events. Circulation 2004; 109: 1497–502
   PubMed Web of Science ®Google Scholar
• Furnary AP, Wu Y, Bookin SO. Effect of hyperglycemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project. Endocr Pract 2004; 10(Suppl 2)21–33
   PubMedGoogle Scholar
• Honiden S, Schultz A, Im SA, Nierman DM, Gong MN. Early versus late intravenous insulin administration in critically ill patients. Intensive Care Med 2008; 34: 881–7
   PubMed Web of Science ®Google Scholar
• Lacherade JC, Jabre P, Bastuji-Garin S, Grimaldi D, Fangio P, Théron V, et al. Failure to achieve glycemic control despite intensive insulin therapy in a medical ICU: incidence and influence on ICU mortality. Intensive Care Med 2007; 33: 814–21
   Google Scholar
• Gale SC, Sicoutris C, Reilly PM, Schwab CW, Gracias VH. Poor glycemic control is associated with increased mortality in critically ill trauma patients. Am Surg 2007; 73: 454–60
   PubMed Web of Science ®Google Scholar
• Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes 2006; 55: 1096–105
   PubMed Web of Science ®Google Scholar
• Heuer JG, Sharma GR, Zhang T, Ding C, Bailey DL, Stephens EJ, et al. Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness. J Trauma 2006; 60: 865–72
   Google Scholar
• Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol P, Waldenstrom A, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995; 26: 57–65
   PubMed Web of Science ®Google Scholar
• Malmberg K, Ryden L, Hamsten A, Herlitz J, Waldenstrom A, Wedel H. Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI Study Group. Diabetes Insulin-Glucose in Acute Myocardial Infarction. Eur Heart J 1996; 17: 1337–44
   PubMedGoogle Scholar
• Diaz R, Paolasso EA, Piegas LS, Tajer CD, Moreno MG, Corvalan R, et al. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group. Circulation 1998; 98: 2227–34
   PubMed Web of Science ®Google Scholar
• Mehta SR, Yusuf S, Diaz R, Zhu J, Pais P, Xavier D, et al. The CREATE-ECLA Trial Group Investigators. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction. The CREATE-ECLA randomized controlled trial. JAMA 2005; 293: 437–46
   PubMed Web of Science ®Google Scholar
• Cheung NW, Wong VW, McLean M. The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction. Diabetes Care 2006; 29: 765–70
   PubMed Web of Science ®Google Scholar
• Malmberg K, Ryden L, Wedel H, Birkeland K, Bootsma A, Dickstein K, et al. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur Heart J 2005; 26: 650–61
   PubMed Web of Science ®Google Scholar
• Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 1994; 343: 155–8
   PubMed Web of Science ®Google Scholar
• Lazar HL. Alterations in myocardial metabolism in the diabetic myocardium. Semin Thorac Cardiovasc Surg 2006; 18: 289–92
   Google Scholar
• Van den Berghe G. Insulin vs. strict blood glucose control to achieve a survival benefit after AMI?. Eur Heart J 2005; 26: 639–41
   Google Scholar
• Su H, Sun X, Ma H, Zhang HF, Yu QJ, Huang C, et al. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol 2007; 293: E629–35
   PubMed Web of Science ®Google Scholar
• Blondet JJ, Beilman GJ. Glycemic control and prevention of perioperative infection. Curr Opin Crit Care 2007; 13: 421–7
   PubMed Web of Science ®Google Scholar
• Turina M, Fry DE, Polk HC, Jr. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med 2005; 33: 1624–33
   PubMed Web of Science ®Google Scholar
• Grey NJ, Perdrizet GA. Reduction of nosocomial infections in the surgical intensive-care unit by strict glycemic control. Endocr Pract 2004; 10(Suppl 2)46–52
   Google Scholar
• Bilotta F, Spinelli A, Giovannini F, Doronzio A, Delfini R, Rosa G. The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with acute subarachnoid hemorrhage: a randomized prospective pilot trial. J Neurosurg Anesthesiol 2007; 19: 156–60
   Google Scholar
• Weekers F, Gifulietti A, Michalaki M, Coopmans W, Van Herck E, Mathieu C, et al. Metabolic, endocrine and immune effects of stress hyperglycaemia in a rabbit model of prolonged critical illness. Endocrinology 2003; 144: 5329–38
   PubMed Web of Science ®Google Scholar
• Van den Berghe G, Schoonheydt K, Becx P, Bruyninckx F, Wouters PJ. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology 2005; 64: 1348–53
   PubMed Web of Science ®Google Scholar
• Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, et al. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med 2007; 175: 480–9
   PubMed Web of Science ®Google Scholar
• Gray CS, Hildreth AJ, Sandercock PA, O'Connell JE, Johnston DE, Cartlidge NE, et al. Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol 2007; 6: 397–406
   PubMed Web of Science ®Google Scholar
• Donelly M, Condron C, Murray P, Bouchier-Hayes D. Modulation of the glycemic response using insulin attenuates the pulmonary response in an animal trauma model. J Trauma 2007; 63: 351–7
   Google Scholar
• Fioretto P, Bruseghin M, Berto I, Gallina P, Manzato E, Mussap M. Renal protection in diabetes: role of glycemic control. J Am Soc Nephrol 2006; 17(Suppl 2)S86–9
   Google Scholar
• Schetz M, Vanhorebeek I, Wouters P, Wilmer A, Vandenberghe G. Tight glycemic control protects the kidney of critically ill patients. J Am Soc Nephrol 2008; 19: 571–8
   PubMed Web of Science ®Google Scholar
• Bothe W, Olschewski M, Beyersdorf F, Doenst T. Glucose-insulin-potassium in cardiac surgery: a meta-analysis. Ann Thorac Surg 2004; 78: 1650–7
   Google Scholar
• Quinn DW, Pagano D, Bonser RS, Rooney SJ, Graham TR, Wilson IC, et al. Improved myocardial protection during coronary artery surgery with glucose-insulin-potassium: a randomized controlled trial. J Thorac Cardiovasc Surg 2006; 131: 34–42
   Web of Science ®Google Scholar
• Gandhi GY, Nuttall GA, Abel MD, Mullany CJ, Schaff HV, O'Brien PC, et al. Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery: a randomized trial. Ann Intern Med 2007; 146: 233–43
   PubMed Web of Science ®Google Scholar
• Allen KV, Frier BM. Nocturnal hypoglycemia: clinical manifestations and therapeutic strategies toward prevention. Endocr Pract 2003; 9: 530–43
   PubMedGoogle Scholar
• Mackenzie I, Ingle S, Zaidi S, Buczaski S. Hypoglycemia? So what!. Intensive Care Med 2006; 32: 620–1
   Google Scholar
• Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med 2007; 35: 2262–7
   PubMed Web of Science ®Google Scholar
• Vriesendorp TM, DeVries JH, van Santen S, Moeniralam HS, de Jonge E, Roos YB, et al. Evaluation of short-term consequences of hypoglycemia in an intensive care unit. Crit Care Med 2006; 34: 2714–8
   PubMed Web of Science ®Google Scholar
• , Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research GroupJacobson AM, Musen G, Ryan CM, Silvers N, Cleary P, et al. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med 2007;356:1842–52.
   PubMed Web of Science ®Google Scholar
• Suh SW, Gum ET, Hamby AM, Chan PH, Swanson RA. Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. J Clin Invest 2007; 117: 910–8
   PubMed Web of Science ®Google Scholar
• Hirsch IB, Brownlee M. Should minimal blood glucose variability become the gold standard of glycemic control?. J Diabetes Complications 2005; 19: 178–81
   PubMed Web of Science ®Google Scholar
• Egi M, Bellomo R, Stachowski E, French CJ, Hart G, Stow P. Circadian rhythm of blood glucose values in critically ill patients. Crit Care Med 2007; 35: 416–21
   Google Scholar
• Remick DG. Pathophysiology of sepsis. Am J Pathol 2007; 170: 1435–44
   PubMed Web of Science ®Google Scholar
• Marshall JC. Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction. Crit Care Med 2001; 29(Suppl)S99–106
   Google Scholar
• Grune T, Berger MM. Markers of oxidative stress in ICU clinical settings: present and future. Curr Opin Clin Nutr Metab Care 2006; 9: 712–7
   Google Scholar
• Crimi R, Ignarro J, Napoli C. Microcirculation and oxidative stress. Free Radic Res 2007; 41: 1364–75
   PubMed Web of Science ®Google Scholar
• Motoyama T, Okamoto K, Kukita I, Hamaguchi M, Kinoshita Y, Ogawa H. Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome. Crit Care Med 2003; 31: 1048–52
   PubMed Web of Science ®Google Scholar
• Eaton S. The biochemical basis of antioxidant therapy in critical illness. Proc Nutr Soc 2006; 65: 242–9
   PubMed Web of Science ®Google Scholar
• Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction. Blood 2003; 101: 3765–77
   PubMed Web of Science ®Google Scholar
• Matsuda N, Hattori Y. Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction. J Smooth Muscle Res 2007; 43: 117–37
   Google Scholar
• Singer M. Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit Care Med 2007; 35(Suppl)S441–8
   Google Scholar
• Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360: 219–23
   PubMed Web of Science ®Google Scholar
• Orrenius S, Gogvadze V, Zhivotovsky B. Mitochondrial oxidative stress; implications for cell death. Annu Rev Pharmacol Toxicol 2007; 47: 143–83
   PubMed Web of Science ®Google Scholar
• Bayir H, Kagian VE. Bench-to-bedside review: mitochondrial injury, oxidative stress and apoptosis—there is nothing more practical than a good theory. Crit Care 2008; 12: 206
   PubMed Web of Science ®Google Scholar
• Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813–20
   PubMed Web of Science ®Google Scholar
• Ceriello A. Oxidative stress and diabetes-associated complications. Endocr Pract 2006; 12(Suppl 1)60–2
   PubMedGoogle Scholar
• Choi SW, Benzie IFF, Ma SW, Strain JJ, Hannigan BM. Acute hyperglycemia and oxidative stress: direct cause and effect?. Free Radic Biol Med 2008; 44: 1217–31
   PubMed Web of Science ®Google Scholar
• Allen DA, Yaqoob MM, Harwood SM. Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem 2005; 16: 705–13
   PubMed Web of Science ®Google Scholar
• Pacher P, Obrosova IG, Mabley JG, Szabo C. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr Med Chem 2005; 12: 267–75
   PubMed Web of Science ®Google Scholar
• Liaudet L. Poly(adenosine 5′-diphosphate) ribose polymerase activation as a cause of metabolic dysfunction in critical illness. Curr Opin Clin Nutr Metab Care 2002; 5: 175–84
   Google Scholar
• Horvath EM, Benko R, Gero D, Kiss L, Szabo C. Treatment with insulin inhibits poly(ADP-ribose)polymerase in a rat model of endotoxemia. Life Sci 2008; 82: 205–9
   Google Scholar
• Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?. J Clin Endocrinol Metab 2001; 86: 3257–65
   PubMed Web of Science ®Google Scholar
• Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P. Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J Clin Endocrinol Metab 2002; 87: 1419–22
   PubMed Web of Science ®Google Scholar
• Aljada A, Friedman J, Ghanim H, Mohanty P, Hofmeyer D, Chaudhuri A, et al. Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism 2006; 55: 1177–85
   PubMed Web of Science ®Google Scholar
• Pickkers P, Hoedemaekers A, Netea MG, de Galan BE, Smits P, van der Hoeven JG, et al. Hypothesis: normalisation of cytokine dysbalance explains the favourable effects of strict glucose regulation in the critically ill. Neth J Med 2004; 62: 143–50
   Google Scholar
• Dandona P, Chaudhuri A, Mohanty P, Ghanim H. Anti-inflammatory effects of insulin. Curr Opin Clin Nutr Metab Care 2007; 10: 511–7
   PubMedGoogle Scholar
• Lafuente N, Matesanz N, Azcutia V, Romacho T, Nevado J, Rodríguez-Mañas L, et al. The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning. J Hypertens 2008; 26: 478–85
   Google Scholar
• Iwasaki Y, Kambayashi M, Asai M, Yoshida M, Nigawara T, Hashimoto K. High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro. J Diabetes Complications 2007; 21: 56–62
   Google Scholar
• Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003; 88: 1082–8
   PubMed Web of Science ®Google Scholar
• Wong VW, McLean M, Boyages SC, Cheung NW. C-reactive protein levels following acute myocardial infarction: effect of insulin infusion and tight glycemic control. Diabetes Care 2004; 27: 2971–3
   PubMed Web of Science ®Google Scholar
• Langouche L, Van Horebeek I, Vlasselaers D, Vander Perre S, Wouters P, Skogstrand K, et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005; 115: 2277–86
   PubMed Web of Science ®Google Scholar
• Hoedemaekers CW, Pickkers P, Netea MG, van Deuren M, Van der Hoeven JG. Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial. Crit Care 2005; 9: R790–7
   Google Scholar
• Vanhorebeek I, Peeters RP, Vander Perre S, Jans I, Wouters PJ, Skogstrand K, et al. Cortisol response to critical illness: effect of intensive insulin therapy. J Clin Endocrinol Metab 2006; 91: 3803–13
   PubMed Web of Science ®Google Scholar
• Brix-Christensen V, Andersen SK, Andersen R, Mengel A, Dyhr T, Andersen NT, et al. Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model. Anesthesiology 2004; 100: 861–70
   PubMed Web of Science ®Google Scholar
• Brix-Christensen V, Gjedsted J, Andersen SK, Vestergaard C, Nielsen J, Rix T, et al. Inflammatory response during hyperglycemia and hyperinsulinemia in a porcine endotoxemic model: the contribution of essential organs. Acta Anaesthesiol Scand 2005; 49: 991–8
   Google Scholar
• Jeschke MG, Klein D, Bolder U, Einspanier R. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Endocrinology 2004; 145: 4089–3
   Google Scholar
• Schalkwijk CG, Stehouwer CD. Vascular complications in diabetes mellitus: the role of endothelial dysfunction. Clin Sci (Lond) 2005; 109: 143–59
   PubMed Web of Science ®Google Scholar
• Martini SR, Kent TA. Hyperglycemia in acute ischemic stroke: a vascular perspective. J Cerebr Blood Flow Metab 2007; 27: 435–51
   PubMed Web of Science ®Google Scholar
• Kado S, Wakatsuki T, Yamamoto M, Nagata N. Expression of intercellular adhesion molecule-1 induced by high glucose concentrations in human aortic endothelial cells. Life Sci 2001; 68: 727–37
   PubMed Web of Science ®Google Scholar
• Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, et al. Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 2005; 183: 259–67
   PubMed Web of Science ®Google Scholar
• Puente Navazo MD, Chettab K, Duhault J, Koenig-Berard E, McGregor JL. Glucose and insulin modulate the capacity of endothelial cells (HUVEC) to express P-selectin and bind a monocytic cell line (U937). Thromb Haemost 2001; 86: 680–5
   Google Scholar
• Morigi M, Angioletti S, Imberti B, Donadelli R, Micheletti G, Figliuzzi M, et al. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. J Clin Invest 1998; 101: 1905–15
   PubMed Web of Science ®Google Scholar
• Ceriello A, Falleti E, Motz E, Taboga C, Tonutti L, Ezsol Z, et al. Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress. Horm Metab Res 1998; 30: 146–9
   PubMed Web of Science ®Google Scholar
• Marfella R, Esposito K, Giunta R, Coppola G, De Angelis L, Farzati B, et al. Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia. Circulation 2000; 101: 2247–51
   PubMed Web of Science ®Google Scholar
• Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. J Clin Endocrinol Metab 2000; 85: 2572–5
   PubMed Web of Science ®Google Scholar
• Ding Y, Vaziri ND, Coulson R, Kamanna VS, Roh DD. Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression. Am J Physiol Endocrinol Metab 2000; 279: E11–7
   PubMed Web of Science ®Google Scholar
• Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, et al. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 1999; 34: 146–54
   PubMed Web of Science ®Google Scholar
• Park JY, Takahara N, Gabriele A, Chou E, Naruse K, Suzuma K, et al. Induction of endothelin-1 expression by glucose. An effect of protein kinase C activation. Diabetes 2000; 49: 1239–48
   PubMed Web of Science ®Google Scholar
• Montagnani M, Chen H, Barr VA, Quon MJ. Insulin-stimulated activation of eNOS is independent of Ca2 +  but requires phosphorylation by Akt at Ser(1179). J Biol Chem 2001; 276: 30392–8
   PubMed Web of Science ®Google Scholar
• Krzyzanowska K, Mittermayer F, Wolzt M, Schernthaner G. Asymmetric dimethylarginine predicts cardiovascular events in patients with type 2 diabetes. Diabetes Care 2007; 30: 1834–9
   PubMed Web of Science ®Google Scholar
• Nijveldt RJ, Teerlink T, van Leeuwen PA. The asymmetric dimethylarginine (ADMA)-multiple organ failure hypothesis. Clin Nutr 2003; 22: 99–104
   PubMed Web of Science ®Google Scholar
• Siroen MPC, van Leeuwen PAM, Nijveldt RJ, Teerlink T, Wouters PJ, Van den Berghe G. Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality?. Crit Care Med 2005; 33: 504–10
   Google Scholar
• Ellger B, Richir MC, van Leeuwen PA, Debaveye Y, Langouche L, Vanhorebeek I, et al. Glycemic control modulates arginine- and ADMA-levels during critical illness by preserving DDAH-activity. Endocrinology 2008; 149: 3148–57
   PubMed Web of Science ®Google Scholar
• Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. Am J Clin Nutr 2004; 80: 51–7
   PubMed Web of Science ®Google Scholar
• Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, et al. Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation 2004; 109: 849–54
   PubMed Web of Science ®Google Scholar
• Gentile NT, Vaidyula VR, Kanamalla U, DeAngelis M, Gaughan J, Rao AK. Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia. Thromb Haemost 2007; 98: 1007–13
   Google Scholar
• Boden G, Rao AK. Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation. Curr Diab Rep 2007; 7: 223–7
   PubMedGoogle Scholar
• Slaughter TF. Hemostasis and glycemic control in the cardiac surgical patient. Semin Cardiothorac Vasc Anesth 2006; 10: 176–9
   Google Scholar
• Langouche L, Meersseman W, Vander Perre S, Milants I, Wouters P, Hermans G, et al. Effect of insulin therapy on coagulation and fibrinolysis in medical intensive care patients. Crit Care Med 2008; 36: 1475–80
   PubMed Web of Science ®Google Scholar
• Stegenga ME, van der Crabben SN, Blumer RM, Levi M, Meijers JC, Serlie MJ, et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 2008; 112: 82–9
   PubMed Web of Science ®Google Scholar
• Kim J, Wei Y, Sowers JR. Role of mitochondrial dysfunction in insulin resistance. Circ Res 2008; 102: 401–14
   PubMed Web of Science ®Google Scholar
• Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters, Van den Berghe G. Strict blood glucose control with insulin in critically ill patients protects hepatocytic mitochondrial ultrastructure and function. Lancet 2005;365:53–9.
   PubMed Web of Science ®Google Scholar
• Rosca MG, Monnier VM, Szweda LI, Weiss MF. Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal. Am J Physiol Renal Physiol 2002; 283: F52–9
   PubMed Web of Science ®Google Scholar
• de Arriba SG, Stuchbury G, Yarin J, Burnell J, Loske C, Münch G. Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells—protection by carbonyl scavengers. Neurobiol Aging 2007; 28: 1044–50
   PubMed Web of Science ®Google Scholar
• Crouser ED, Julian MW, Joshi MS, Bauer JA, Wewers MD, Hart JM, et al. Cyclosporin A ameliorates mitochondrial ultrastructural injury in the ileum during acute endotoxemia. Crit Care Med 2002; 30: 2722–8
   PubMed Web of Science ®Google Scholar
• Allen DA, Yaqoob MM, Harwood SM. Mechanisms of high glucose-induced apoptosis and its relationship to diabetic complications. J Nutr Biochem 2005; 16: 705–13
   PubMed Web of Science ®Google Scholar
• Gao F, Gao E, Yue T, Ohlstein EH, Lopez BL, Christopher TA, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the role of PI3-kinase, Akt and eNOS phosphorylation. Circulation 2002; 105: 1497–502
   PubMed Web of Science ®Google Scholar
• Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001; 89: 1191–8
   PubMed Web of Science ®Google Scholar
• Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G. Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 2004; 89: 219–26
   PubMed Web of Science ®Google Scholar
• Pittas AG, Siegel RD, Lau J. Insulin therapy for critically ill hospitalized patients: a meta-analysis of randomized controlled trials. Arch Intern Med 2004; 164: 2005–11
   PubMedGoogle Scholar
• Langouche L, Vander Perre S, Wouters PJ, D'Hoore A, Hansen TK, Van den Berghe G. Effect of intensive insulin therapy on insulin sensitivity in the critically ill. J Clin Endocrinol Metab 2007; 92: 3890–7
   Google Scholar
• Klip A, Tsakiridis T, Marette A, Ortiz PA. Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. FASEB J 1994; 8: 43–53
   PubMed Web of Science ®Google Scholar
• Pekala P, Marlow M, Heuvelman D, Connolly D. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor alfa, but not by insulin. J Biol Chem 1990; 265: 18051–4
   PubMed Web of Science ®Google Scholar
• Shikman AR, Brinson DC, Valbracht J, Lotz MK. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 2001; 167: 7001–8
   Google Scholar
• Quinn LA, McCumbee WD. Regulation of glucose transport by angiotensin II and glucose in cultured vascular smooth muscle cells. J Cell Physiol 1998; 177: 94–102
   Google Scholar
• Clerici C, Matthay MA. Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 2000; 88: 1890–6
   Google Scholar
• Sanchez-Alvarez R, Tabernero A, Medina JM. Endothelin-1 stimulates the translocation and upregulation of glucose transporter and hexokinase in astrocytes: relationship with gap junctional communication. J Neurochem 2004; 89: 703–14
   PubMed Web of Science ®Google Scholar