Bariatric venous thromboembolism prophylaxis: an update on the literature

References

• Holländer SW, Sifft A, Hess S, et al. Identifying the bariatric patient at risk for pulmonary embolism: prospective clinical trial using duplex sonography and blood screening. Obes Surg. 2015;25(11):2011–2017.
   PubMed Web of Science ®Google Scholar
• Nguyen NT, Masoomi H, Magno CP, et al. Trends in use of bariatric surgery, 2003–2008. J Am Coll Surg. 2011;213(2):261–266.
   PubMed Web of Science ®Google Scholar
• Aminian A, Andalib A, Khorgami Z, et al. Who should get extended thromboprophylaxis after bariatric surgery? A risk assessment tool to guide indications for post-discharge pharmacoprophylaxis. Ann Surg. 2017;265(1):143–150.
   PubMed Web of Science ®Google Scholar
• Froehling DA, Daniels PR, Mauck KF, et al. Incidence of venous thromboembolism after bariatric surgery: a population-based cohort study. Obes Surg. 2013;23(11):1874–1879.
   PubMed Web of Science ®Google Scholar
• Hamad GG, Choban PS. Enoxaparin for thromboprophylaxis in morbidly obese patients undergoing bariatric surgery: findings of the prophylaxis against VTE outcomes in bariatric surgery patients receiving enoxaparin (PROBE) study. Obes Surg. 2005;15(10):1368–1374.
   PubMed Web of Science ®Google Scholar
• Lentz SR. Thrombosis in the setting of obesity or inflammatory bowel disease. Blood. 2016;128(20):2388–2394.
   PubMed Web of Science ®Google Scholar
• Ageno W, Becattini C, Brighton T, et al. Cardiovascular risk factors and venous thromboembolism. Circulation. 2008;117(1):93–102.
   PubMed Web of Science ®Google Scholar
• Finks JF, English WJ, Carlin AM, et al. Predicting risk for venous thromboembolism with bariatric surgery: results from the Michigan bariatric surgery collaborative. Ann Surg. 2012;255(6):1100–1104.
   PubMed Web of Science ®Google Scholar
• Jamal MH, Corcelles R, Shimizu H, et al. Thromboembolic events in bariatric surgery: a large multi-institutional referral center experience. Surg Endosc. 2015;29(2):376–380.
   PubMed Web of Science ®Google Scholar
• Helm MC, Simon K, Higgins R, et al. Perioperative complications increase the risk of venous thromboembolism following bariatric surgery. Am J Surg. 2017;214(6):1135–1140.
   PubMed Web of Science ®Google Scholar
• Merkow RP, Bilimoria KY, McCarter MD, et al. Post-discharge venous thromboembolism after cancer surgery: extending the case for extended prophylaxis. Ann Surg. 2011;254(1):131–137.
   PubMed Web of Science ®Google Scholar
• Kucher N, Koo S, Quiroz R, et al. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005;352(10):969–977.
   PubMed Web of Science ®Google Scholar
• Rogers SO Jr., Kilaru RK, Hosokawa P, et al. Multivariable predictors of postoperative venous thromboembolic events after general and vascular surgery: results from the patient safety in surgery study. J Am Coll Surg. 2007;204(6):1211–1221.
   PubMed Web of Science ®Google Scholar
• Caprini JA. Thrombosis risk assessment as a guide to quality patient care. Dis Mon. 2005;51(2–3):70–78.
   PubMed Web of Science ®Google Scholar
• Pannucci CJ, Laird S, Dimick JB, et al. A validated risk model to predict 90-day VTE events in postsurgical patients. Chest. 2014;145(3):567–573.
   PubMed Web of Science ®Google Scholar
• Scarborough JE, Cox MW, Mureebe L, et al. A novel scoring system for predicting postoperative venous thromboembolic complications in patients after open aortic surgery. J Am Coll Surg. 2012;214(4):620–6. discussion 7–8.
   PubMed Web of Science ®Google Scholar
• Bahl V, Hu HM, Henke PK, et al. A validation study of a retrospective venous thromboembolism risk scoring method. Ann Surg. 2010;251(2):344–350.
   PubMed Web of Science ®Google Scholar
• Caprini JA, Arcelus JI, Hasty JH, et al. Clinical assessment of venous thromboembolic risk in surgical patients. Semin Thromb Hemost. 1991;17(Suppl 3):304–312.
   PubMed Web of Science ®Google Scholar
• Pannucci CJ, Swistun L, MacDonald JK, et al. Individualized venous thromboembolism risk stratification using the 2005 caprini score to identify the benefits and harms of chemoprophylaxis in surgical patients: a meta-analysis. Ann Surg. 2017;265(6):1094–1103.
   PubMed Web of Science ®Google Scholar
• Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):e227S–e77S.
   PubMed Web of Science ®Google Scholar
• Overby DW, Kohn GP, Cahan MA, et al. Prevalence of thrombophilias in patients presenting for bariatric surgery. Obes Surg. 2009;19(9):1278–1285.
   PubMed Web of Science ®Google Scholar
• Dang JT, Switzer N, Delisle M, et al. Predicting venous thromboembolism following laparoscopic bariatric surgery: development of the BariClot tool using the MBSAQIP database. Surg Endosc. 2019;33(3):821–831.
   PubMed Web of Science ®Google Scholar
• Miranda S, Le Cam-Duchez V, Benichou J, et al. Adjusted value of thromboprophylaxis in hospitalized obese patients: A comparative study of two regimens of enoxaparin: the ITOHENOX study. Thromb Res. 2017;155:1–5.
   PubMed Web of Science ®Google Scholar
• Birkmeyer NJ, Finks JF, Carlin AM, et al. Comparative effectiveness of unfractionated and low-molecular-weight heparin for prevention of venous thromboembolism following bariatric surgery. Arch Surg. 2012;147(11):994–998.
   PubMedGoogle Scholar
• Steele KE, Canner J, Prokopowicz G, et al. The EFFORT trial: preoperative enoxaparin versus postoperative fondaparinux for thromboprophylaxis in bariatric surgical patients: a randomized double-blind pilot trial. Surg Obesity Related Dis. 2015;11(3):672–683.
   PubMed Web of Science ®Google Scholar
• Abuoglu HH, Muftuoglu MAT, Odabasi M. A new protocol for venous thromboembolism prophylaxis in bariatric surgery. Obes Surg. 2019;29(2):729–734.
   PubMed Web of Science ®Google Scholar
• Shin S, Harthan EF. Safety and efficacy of the use of institutional unfractionated heparin protocols for therapeutic anticoagulation in obese patients: a retrospective chart review. Blood Coagul Fibrinolysis. 2015;26(6):655–660.
   PubMed Web of Science ®Google Scholar
• Ikesaka R, Delluc A, Le Gal G, et al. Efficacy and safety of weight-adjusted heparin prophylaxis for the prevention of acute venous thromboembolism among obese patients undergoing bariatric surgery: a systematic review and meta-analysis. Thromb Res. 2014;133(4):682–687.
   PubMed Web of Science ®Google Scholar
• Simoneau M-D, Vachon A, Picard F. Effect of prophylactic dalteparin on anti-factor Xa levels in morbidly obese patients after bariatric surgery. Obes Surg. 2010;20(4):487–491.
   PubMed Web of Science ®Google Scholar
• Tseng E, Kolesar E, Handa P, et al. Weight-adjusted tinzaparin for the prevention of venous thromboembolism after bariatric surgery. J Thromb Haemost. 2018;16(10):2008–2015.
   PubMed Web of Science ®Google Scholar
• Scholten DJ, Hoedema RM, Scholten SE. A comparison of two different prophylactic dose regimens of low molecular weight heparin in bariatric surgery. Obes Surg. 2002;12(1):19–24.
   PubMed Web of Science ®Google Scholar
• Paige JT, Gouda BP, Gaitor-Stampley V, et al. No correlation between anti-factor Xa levels, low-molecular-weight heparin, and bleeding after gastric bypass. Surg Obesity Related Dis. 2007;3(4):469–475.
   PubMed Web of Science ®Google Scholar
• Nutescu EA, Spinler SA, Wittkowsky A, et al. Low-molecular-weight heparins in renal impairment and obesity: available evidence and clinical practice recommendations across medical and surgical settings. Ann Pharmacother. 2009;43(6):1064–1083.
   PubMed Web of Science ®Google Scholar
• Sacha GL, Greenlee KM, Ketz JM. The use of anti-factor Xa monitoring in a selection of patients receiving enoxaparin at a large academic medical center. J Thromb Thrombolysis. 2016;42(4):479–485.
   PubMed Web of Science ®Google Scholar
• Wei MY, Ward SM. The anti-factor Xa range for low molecular weight heparin thromboprophylaxis. Hematol Rep. 2015;7(4).
   PubMed Web of Science ®Google Scholar
• Egan G, Ensom MH. Measuring anti–factor Xa activity to monitor low-molecular-weight heparin in obesity: a critical review. Can J Hosp Pharm. 2015;68(1):33.
   PubMedGoogle Scholar
• Celik F, Huitema AD, Hooijberg JH, et al. Fixed-dose enoxaparin after bariatric surgery: the influence of body weight on peak anti-Xa levels. Obes Surg. 2015;25(4):628–634.
   PubMed Web of Science ®Google Scholar
• Schijns W, Deenen M, Aarts E, et al. The effect of obesity on Anti-Xa concentrations in bariatric patients. Obes Surg. 2018;28(7):1997–2005.
   PubMed Web of Science ®Google Scholar
• Gaborit B, Moulin P-A, Bege T, et al. Lean body weight is the best scale for venous thromboprophylaxis algorithm in severely obese patients undergoing bariatric surgery. Pharmacol Res. 2018;131:211–217.
   PubMed Web of Science ®Google Scholar
• Brophy DF, Martin EJ, Gehr TW, et al. Enhanced anticoagulant activity of enoxaparin in patients with ESRD as measured by thrombin generation time. Am J Kidney Diseases. 2004;44(2):270–277.
   PubMed Web of Science ®Google Scholar
• Imberti D, Baldini E, Pierfranceschi MG, et al. Prophylaxis of venous thromboembolism with low molecular weight heparin in bariatric surgery: a prospective, randomised pilot study evaluating two doses of parnaparin (BAFLUX Study). Obes Surg. 2014;24(2):284–291.
   PubMed Web of Science ®Google Scholar
• Borkgren-Okonek MJ, Hart RW, Pantano JE, et al. Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity. Surg Obes Relat Dis. 2008;4(5):625–631.
   PubMed Web of Science ®Google Scholar
• Kothari SN, Lambert PJ, Mathiason MA, et al. A comparison of thromboembolic and bleeding events following laparoscopic gastric bypass in patients treated with prophylactic regimens of unfractionated heparin or enoxaparin. Am J Surg. 2007;194(6):709–711.
   PubMed Web of Science ®Google Scholar
• Singh K, Podolsky ER, Um S, et al. Evaluating the safety and efficacy of BMI-based preoperative administration of low-molecular-weight heparin in morbidly obese patients undergoing Roux-en-Y gastric bypass surgery. Obes Surg. 2012;22(1):47–51.
   PubMed Web of Science ®Google Scholar
• Cossu ML, Pilo L, Piseddu G, et al. Prophylaxis of venous thromboembolism in bariatric surgery. Chirurgia Ital. 2007;59(3):331–335.
   PubMedGoogle Scholar
• Ojo P, Asiyanbola B, Valin E, et al. Post discharge prophylactic anticoagulation in gastric bypass patient-how safe? Obes Surg. 2008;18(7):791–796.
   PubMed Web of Science ®Google Scholar
• Heffline MS. Preventing vascular complications after gastric bypass. J Vasc Nurs. 2006;24(2): 50–54. quiz 5.
   PubMedGoogle Scholar
• Hakeam HA, Al-Sanea N. Effect of major gastrointestinal tract surgery on the absorption and efficacy of direct acting oral anticoagulants (DOACs). J Thromb Thrombolysis. 2017;43(3):343–351.
   PubMed Web of Science ®Google Scholar
• Frantzides CT, Welle SN, Ruff TM, et al. Routine anticoagulation for venous thromboembolism prevention following laparoscopic gastric bypass. JSLS. 2012;16(1):33.
   PubMed Web of Science ®Google Scholar
• Clements RH, Yellumahanthi K, Ballem N, et al. Pharmacologic prophylaxis against venous thromboembolic complications is not mandatory for all laparoscopic Roux-en-Y gastric bypass procedures. J Am Coll Surg. 2009;208(5):917–921.
   PubMed Web of Science ®Google Scholar
• Moaad F, Zakhar B, Anton K, et al. Is LMWH sufficient for anticoagulant prophylaxis in bariatric surgery? Prospective study. Obes Surg. 2017;27(9):2331–2337.
   PubMed Web of Science ®Google Scholar
• Raftopoulos I, Martindale C, Cronin A, et al. The effect of extended post-discharge chemical thromboprophylaxis on venous thromboembolism rates after bariatric surgery: a prospective comparison trial. Surg Endosc. 2008;22(11):2384–2391.
   PubMed Web of Science ®Google Scholar
• Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):e419S–e96S.
   PubMed Web of Science ®Google Scholar
• ASMBS updated position statement on prophylactic measures to reduce the risk of venous thromboembolism in bariatric surgery patients. Surg Obes Relat Dis. 2013;9(4):493–497.
   PubMed Web of Science ®Google Scholar
• Martin K, Beyer-Westendorf J, Davidson B, et al. Use of the direct oral anticoagulants in obese patients: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14(6):1308–1313.
   PubMed Web of Science ®Google Scholar
• Afshari A, Ageno W, Ahmed A, et al. European Guidelines on perioperative venous thromboembolism prophylaxis: executive summary. Eur J Anaesthesiol. 2018;35(2):77–83.
   PubMed Web of Science ®Google Scholar
• Comes RF, Mismetti P, Afshari A. European guidelines on perioperative venous thromboembolism prophylaxis: inferior vena cava filters. Eur J Anaesthesiol. 2018;35(2):108–111.
   PubMed Web of Science ®Google Scholar
• Lalama JT, Feeney ME, Vandiver JW, et al. Assessing an enoxaparin dosing protocol in morbidly obese patients. J Thromb Thrombolysis. 2015;39(4):516–521.
   PubMed Web of Science ®Google Scholar
• Rondina MT, Wheeler M, Rodgers GM, et al. Weight-based dosing of enoxaparin for VTE prophylaxis in morbidly obese, medically-Ill patients. Thromb Res. 2010;125(3):220–223.
   PubMed Web of Science ®Google Scholar
• Freeman A, Horner T, Pendleton RC, et al. Prospective comparison of three enoxaparin dosing regimens to achieve target anti‐factor Xa levels in hospitalized, medically ill patients with extreme obesity. Am J Hematol. 2012;87(7):740–743.
   PubMed Web of Science ®Google Scholar
• Becattini C, Agnelli G, Manina G, et al. Venous thromboembolism after laparoscopic bariatric surgery for morbid obesity: clinical burden and prevention. Surg Obes Relat Dis. 2012;8(1):108–115.
   PubMed Web of Science ®Google Scholar
• Winegar DA, Sherif B, Pate V, et al. Venous thromboembolism after bariatric surgery performed by bariatric surgery center of excellence participants: analysis of the bariatric outcomes longitudinal database. Surg Obesity Related Dis. 2011;7(2):181–188.
   PubMed Web of Science ®Google Scholar
• Sapala JA, Wood MH, Schuhknecht MP, et al. Fatal pulmonary embolism after bariatric operations for morbid obesity: a 24-year retrospective analysis. Obes Surg. 2003;13(6):819–825.
   PubMed Web of Science ®Google Scholar
• Sugerman HJ, Sugerman EL, Wolfe L, et al. Risks and benefits of gastric bypass in morbidly obese patients with severe venous stasis disease. Ann Surg. 2001;234(1):41.
   PubMed Web of Science ®Google Scholar
• Kalfarentzos F, Yarmenitis S, Kehagias I, et al. Prophylaxis of venous thromboembolism using two different doses of low-molecular-weight heparin (nadroparin) in bariatric surgery: a prospective randomized trial. Obes Surg. 2001;11(6):670–676.
   PubMed Web of Science ®Google Scholar