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Meta-analysis

Pomalidomide combined with dexamethasone for the treatment of relapsed/refractory multiple myeloma: a systematic review and meta-analysis

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Pages 127-134 | Received 24 Oct 2023, Accepted 15 Feb 2024, Published online: 05 Mar 2024

References

  • Moreau P, San Miguel J, Sonneveld P, et al. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(suppl_4):iv52–iv61. doi: 10.1093/annonc/mdx096
  • Van de Donk NWCJ, Pawlyn C, Yong KL. Multiple myeloma. Lancet. 2021;397(10272):410–427. doi: 10.1016/S0140-6736(21)00135-5
  • Zhu YX, Braggio E, Shi CX, et al. Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide. Blood. 2011;118(18):4771–4779. doi: 10.1182/blood-2011-05-356063
  • Ito T, Ando H, Suzuki T, et al. Identification of a primary target of thalidomide teratogenicity. Science. 2010;327(5971):1345–1350. doi: 10.1126/science.1177319
  • Krönke J, Udeshi ND, Narla A, et al. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014;343(6168):301. doi: 10.1126/science.1244851
  • Lu G, Middleton RE, Sun H, et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of ikaros proteins. Science. 2014;343(6168):305. doi: 10.1126/science.1244917
  • Zou Y, Ma X, Yu H, et al. Carfilzomib/Pomalidomide single-agent or in combination with other agents for the management of relapsed/refractory multiple myeloma: a meta-analysis of 37 trials. Oncotarget. 2017;8(24):39805–39817. doi: 10.18632/oncotarget.10768
  • Richardson PG, Siegel DS, Vij R, et al. Pomalidomide alone or in combination with low-dose dexamethasone in relapsed and refractory multiple myeloma: a randomized phase 2 study. Blood. 2014;123(12):1826–1832. doi: 10.1182/blood-2013-11-538835
  • San Miguel JF, Weisel KC, Song KW, et al. Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma. Haematologica. 2015;100(10):1334–1339. doi: 10.3324/haematol.2015.125864
  • Mushtaq A, Iftikhar A, Hassan H, et al. Pomalidomide-based regimens for treatment of relapsed and relapsed/refractory multiple myeloma: systematic review and meta-analysis of phase 2 and 3 clinical trials. Clin Lymphoma Myeloma Leuk. 2019;19(7):447–461. doi: 10.1016/j.clml.2019.04.003
  • Richardson PG, Oriol A, Beksac M, et al. Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20(6):781–794. doi: 10.1016/S1470-2045(19)30152-4
  • Highsmith KN, Chen SE, Horowitz S. Carfilzomib and pomalidomide: recent advances in the treatment of multiple myeloma. Pharmacotherapy. 2014;34(9):927–940. doi: 10.1002/phar.1463
  • Bringhen S, Mina R, Cafro AM, et al. Once-weekly carfilzomib, pomalidomide, and low-dose dexamethasone for relapsed/refractory myeloma: a phase I/II study. Leukemia. 2018;32(8):1803–1807. doi: 10.1038/s41375-018-0024-1
  • Voorhees PM, Suman VJ, Tuchman SA, et al. A phase I/II study of ixazomib, pomalidomide, and dexamethasone for lenalidomide and proteasome inhibitor refractory multiple myeloma (alliance A061202). Am J Hematol. 2021;96(12):1595–1603. doi: 10.1002/ajh.26361
  • Dimopoulos M, Schjesvold F, Doronin V, et al. Oral ixazomib-dexamethasone versus oral pomalidomide-dexamethasone for lenalidomide-refractory, proteasome inhibitor-exposed multiple myeloma (MM) patients: a global, multicenter, randomized, open-label, phase 2 trial. J Clin Oncol. 2021;39(15_suppl):8020. doi: 10.1200/JCO.2021.39.15_suppl.8020
  • Pierceall WE, Amatangelo MD, Bahlis NJ, et al. Immunomodulation in pomalidomide, dexamethasone, and daratumumab-treated patients with relapsed/refractory multiple myeloma. Clin Cancer Res. 2020;26(22):5895–5902. doi: 10.1158/1078-0432.CCR-20-1781
  • Chari A, Suvannasankha A, Fay JW, et al. Daratumumab plus pomalidomide and dexamethasone in relapsed and/or refractory multiple myeloma. Blood. 2017;130(8):974–981. doi: 10.1182/blood-2017-05-785246
  • Siegel DS, Schiller GJ, Samaras C, et al. Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment. Leukemia. 2020;34(12):3286–3297. doi: 10.1038/s41375-020-0813-1
  • Nooka AK, Joseph NS, Kaufman JL, et al. Clinical efficacy of daratumumab, pomalidomide, and dexamethasone in patients with relapsed or refractory myeloma: utility of re-treatment with daratumumab among refractory patients. Cancer. 2019;125(17):2991–3000. doi: 10.1002/cncr.32178
  • Mikhael J, Richardson P, Usmani SZ, et al. A phase 1b study of isatuximab plus pomalidomide/dexamethasone in relapsed/refractory multiple myeloma. Blood. 2019;134(2):123–133. doi: 10.1182/blood-2019-02-895193

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