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Original Research

Frontline combination of dasatinib and low-intensity chemotherapy in adults with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia

ORCID Icon, , , , , , , , , , & ORCID Icon show all
Pages 173-180 | Received 19 Sep 2023, Accepted 19 Mar 2024, Published online: 24 Apr 2024

References

  • Daver N, Thomas D, Ravandi F, et al. Final report of a phase II study of imatinib mesylate with hyper-CVAD for the front-line treatment of adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Haematologica. 2015 May;100(5):653–661. doi: 10.3324/haematol.2014.118588
  • Ravandi F, O’Brien SM, Cortes JE, et al. Long-term follow-up of a phase 2 study of chemotherapy plus dasatinib for the initial treatment of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer. 2015 Dec 1;121(23):4158–4164. doi: 10.1002/cncr.29646
  • Short NJ, Kantarjian HM, Ravandi F, et al. Long-term safety and efficacy of hyper-CVAD plus ponatinib as frontline therapy for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 2019;134(Supplement_1):283–283. doi: 10.1182/blood-2019-125146
  • Jabbour E, Haddad FG, Short NJ, et al. Treatment of adults with Philadelphia chromosome-positive acute lymphoblastic leukemia-from intensive chemotherapy combinations to chemotherapy-free regimens: a review. JAMA Oncol. 2022 Sep 1;8(9):1340–1348. doi: 10.1001/jamaoncol.2022.2398
  • Ravandi F, Othus M, O’Brien SM, et al. US intergroup study of chemotherapy plus dasatinib and allogeneic stem cell transplant in Philadelphia chromosome positive ALL. Blood Adv. 2016 Dec 27;1(3):250–259. doi: 10.1182/bloodadvances.2016001495
  • Liu B, Wang Y, Zhou C, et al. Nilotinib combined with multi-agent chemotherapy in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a single-center prospective study with long-term follow-up. Ann Hematol. 2019 Mar;98(3):633–645. doi: 10.1007/s00277-019-03594-1
  • Kim DY, Joo YD, Lim SN, et al. Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia. Blood. 2015 Aug 6;126(6):746–756. doi: 10.1182/blood-2015-03-636548
  • Kantarjian H, Short NJ, Jain N, et al. Frontline combination of ponatinib and hyper-CVAD in Philadelphia chromosome-positive acute lymphoblastic leukemia: 80-months follow-up results. Am J Hematol. 2023 Mar;98(3):493–501. doi: 10.1002/ajh.26816
  • Short N, Kantarjian H, Jain N, et al. Ponatinib and Blinatumomab for patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a subgroup analysis from a phase II study. Blood. 2022;140(Supplement 1):513–515. doi: 10.1182/blood-2022-157775
  • Foa R, Bassan R, Elia L, et al. Long-term results of the dasatinib-blinatumomab protocol for adult Philadelphia-positive ALL. J Clin Oncol. 2023;42(8):881–885. doi: 10.1200/JCO.23.01075 Dec 21:JCO2301075.
  • Martinelli G, Papayannidis C, Piciocchi A, et al. INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia. Blood Adv. 2022 Mar 22;6(6):1742–1753. doi: 10.1182/bloodadvances.2021004821
  • Wieduwilt MJ, Yin J, Wetzler M, et al. Dasatinib and dexamethasone followed by hematopoietic cell transplantation for adults with Ph-positive ALL. Blood Adv. 2021 Nov 23;5(22):4691–4700. doi: 10.1182/bloodadvances.2021004813
  • Ribera JM, Garcia-Calduch O, Ribera J, et al. Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood Adv. 2022 Sep 27;6(18):5395–5402. doi: 10.1182/bloodadvances.2022007764
  • Liu D, Zhao J, Song Y, et al. Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia. J Hematol Oncol. 2019 Feb 8;12(1):15. doi: 10.1186/s13045-019-0703-z
  • Wang J, Jiang Q, Xu L-P, et al. Allogeneic stem cell transplantation versus tyrosine kinase inhibitors combined with chemotherapy in patients with Philadelphia chromosome–positive acute lymphoblastic leukemia. Biology Of Blood And Marrow Transplantation. 2018;24(4):741–750. doi: 10.1016/j.bbmt.2017.12.777
  • Cortes JE, Kim DW, Pinilla-Ibarz J, et al. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. N Engl J Med. 2013 Nov 7;369(19):1783–1796. doi: 10.1056/NEJMoa1306494
  • Nicolini FE, Basak GW, Kim DW, et al. Overall survival with ponatinib versus allogeneic stem cell transplantation in Philadelphia chromosome-positive leukemias with the T315I mutation. Cancer. 2017 Aug 1;123(15):2875–2880. doi: 10.1002/cncr.30558
  • Gu B, Shi BY, Zhang X, et al. Allogeneic haematopoietic stem cell transplantation improves outcome of adults with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia entering remission following CD19 chimeric antigen receptor T cells. Bone Marrow Transplant. 2021 Jan;56(1):91–100. doi: 10.1038/s41409-020-0982-6

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