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Review

Update on iron supplementation in patients with cancer-related anemia

Pages 505-514 | Received 23 Feb 2024, Accepted 28 Jun 2024, Published online: 02 Jul 2024

References

  • Gilreath JA, Stenehjem DD, Rodgers GM. Diagnosis and treatment of cancer-related anemia. Am J Hematol. 2014;89(2):203–212. doi: 10.1002/ajh.23628
  • Andrews NC. Forging a field: the golden age of iron biology. Blood. 2008;112(2):219–230. doi: 10.1182/blood-2007-12-077388
  • Pantopoulos K, Porwal SK, Tartakoff A, et al. Mechanisms of mammalian iron homeostasis. Biochemistry. 2012;51(29):5705–5724. doi: 10.1021/bi300752r
  • Gilreath JA, Rodgers GM. How I treat cancer-associated anemia. Blood. 2020;136(7):801–813. doi: 10.1182/blood.2019004017
  • Camaschella C. Disorders of iron homeostasis: iron deficiency and overload. In: Hoffman R, Benz E, Silverstein L, et al., editors. Hematology: basic principles and practice. 8th ed. Philadelphia: Elsevier; 2023. p. 483–497.
  • Avni T, Bieber A, Grossman A, et al. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin Proc. 2015;90(1):12–23. doi: 10.1016/j.mayocp.2014.10.007
  • Auerbach M, Ballard H, Trout JR, et al. Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter open-label, randomized trial. JCO. 2004;24(7):1301–1307. doi: 10.1200/JCO.2004.08.119
  • Rodgers GM, Gilreath JA. The role of intravenous iron in the treatment of anemia associated with cancer and chemotherapy. Acta Haematol. 2019;142(1):13–20. doi: 10.1159/000496967
  • Kim YT, Kim SW, Yoon BS, et al. Effect of intravenously administered iron sucrose on the prevention of anemia in the cervical cancer patients treated with concurrent chemoradiotherapy. Gynecol Oncol. 2007;105(1):199–204. doi: 10.1016/j.ygyno.2006.11.014
  • Dangsuwan P, Manchana T. Blood transfusion reduction with intravenous iron in gynecologic cancer patients receiving chemotherapy. Gynecol Oncol. 2010;116(3):522–525. doi: 10.1016/j.ygyno.2009.12.004
  • Abdel-Razeq H, Abbasi S, Saadi I, et al. Intravenous iron monotherapy for the treatment of non-iron-deficiency anemia in cancer patients undergoing chemotherapy: a pilot study. Drug Des Devel Ther. 2013;7:939–944. doi: 10.2147/DDDT.S45674
  • Athibovonsuk P, Manchana T, Sirisabya N. Prevention of blood transfusion with intravenous iron in gynecologic cancer patients receiving platinum based chemotherapy. Gynecol Oncol. 2013;131(3):679–682. doi: 10.1016/j.ygyno.2013.09.028
  • Steinmetz T, Tschechne B, Harlin O, et al. Clinical experience with ferric carboxymaltose in the treatment of cancer-and chemotherapy-associated anaemia. Ann Oncol. 2013;24(2):475–482. doi: 10.1093/annonc/mds338
  • Hedenus M, Karlsson T, Ludwig H, et al. Intravenous iron alone resolves anemia in patients with functional iron deficiency and lymphoid malignancies undergoing chemotherapy. Med Oncol. 2014;31(12):302. doi: 10.1007/s12032-014-0302-3
  • Birgegard G, Henry D, Glaspy J, et al. A randomized noninferiority trial of intravenous iron isomaltoside versus oral iron sulfate in patients with nonmyeloid malignancies and anemia receiving chemotherapy: the PROFOUND trial. Pharmacotherapy. 2016;36(4):402–414. doi: 10.1002/phar.1729
  • Vadhan-Raj S, Dahl NV, Bernard K, et al. Efficacy and safety of IV ferumoxytol for iron deficiency anemia in patients with cancer. J Blood Med. 2017;8:199–209. doi: 10.2147/JBM.S138474
  • Jang JH, Kim Y, Park S, et al. Efficacy of intravenous iron treatment for chemotherapy-induced anemia: a prospective phase II pilot clinical trial in South Korea. PLoS Med. 2020;17(6). doi: 10.1371/journal.pmed.1003091
  • Makharadze T, Boccia R, Krupa A, et al. Efficacy and safety of ferric carboxymaltose infusion in reducing anemia in patients receiving chemotherapy for nonmyeloid malignancies: a randomized, p lacebo-controlled study (IRON - CLAD). Am J Hematol. 2021;96(12):1639–1646. doi: 10.1002/ajh.26376
  • Hedenus M, Birgegard G, Nasman P, et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia. 2007;21(4):627–632. doi: 10.1038/sj.leu.2404562
  • Henry DH, Dahl NV, Auerbach M, et al. Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncology. 2007;12(2):231–242. doi: 10.1634/theoncologist.12-2-231
  • Bastit L, Vandebroek A, Altintas S, et al. Randomized multicenter, controlled trial comparing the efficacy and safety of darbepoetin alpha administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. J Clin Oncol. 2008;26(10):1611–1618. doi: 10.1200/JCO.2006.10.4620
  • Pedrazzoli P, Farris A, Del Prete S, et al. Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alpha. J Clin Oncol. 2008;26(10):1619–1625. doi: 10.1200/JCO.2007.12.2051
  • Auerbach M, Silberstein PT, Webb RT, et al. Darbepoetin alfa 300 or 500 μg once every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. Am J Hematol. 2010;85(9):655–663. doi: 10.1002/ajh.21779
  • Steensma DP, Sloan JA, Dakhil SR, et al. Phase III randomized study of the effects of parenteral iron, oral iron, or no iron supplementation on the erythropoietic response to darbepoetin alfa for patients with chemotherapy-associated anemia. J Clin Oncol. 2011;29(1):97–105. doi: 10.1200/JCO.2010.30.3644
  • Rodgers GM, Auerbach M, Cella D, et al. High-molecular weight iron dextran: a wolf in sheep’s clothing? J Am Soc Nephrol. 2008;19(5):833–834. doi: 10.1681/ASN.2008030255
  • Dave CV, Brittenham GM, Carson JL, et al. Risks for anaphylaxis with intravenous iron formulations. A retrospective cohort study. Ann Intern Med. 2022;175(5):656–664. doi: 10.7326/M21-4009
  • Al-Samkari H, Glaspy JA, Means RT, et al. Risks for anaphylaxis with intravenous iron formulations. Ann Intern Med. 2022;175(11):W143. doi: 10.7326/L22-0282
  • Pollock RF, Biggar P. Indirect methods of comparison of the safety of ferric derisomaltose, iron sucrose and ferric carboxymaltose in the treatment of iron deficiency anemia. Expert Rev Hematol. 2020;13(2):187–195. doi: 10.1080/17474086.2020.1709437
  • Arastu AH, Elstrott BK, Martens KL, et al. Analysis of adverse events and intravenous iron infusion formulations in adults with and without prior infusion reactions. JAMA Netw Open. 2022;5(3):e224488. doi: 10.1001/jamanetworkopen.2022.4488
  • Griffiths EA, Roy V, Bachiashvili K, et al. Hematopoietic growth factors. NCCN guidelines version 3. 2024 [cited 2024 May 11]. Available from: nccn.org
  • Bohlius J, Bohkle K, Castelli R, et al. Management of cancer-associated anemia with erythropoiesis-stimulating agents: ASCO/ASH clinical practice guideline update. Blood Adv. 2019;3(8):1197–1210. doi: 10.1182/bloodadvances.2018030387
  • Bolton-Maggs PH, Cohen H. Serious hazards of transfusion (SHOT) haemovigilance and progress is improving transfusion safety. Br J Haematol. 2013;163(3):303–314. doi: 10.1111/bjh.12547
  • Hendrickson JE, Roubinian NH, Chowdhury D, et al. Incidence of transfusion reactions: a multicenter study utilizing systemic active surveillance and expert adjudication. Transfusion. 2016;56(10):2587–2596. doi: 10.1111/trf.13730 13730.
  • Khorana AA, Francis CW, Blumberg N, et al. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008;168(21):2377–2381. doi: 10.1001/archinte.168.21.2377
  • Jahn MR, Andreasen HB, Futterer S, et al. A comparative study of the physicochemical properties of iron isomaltoside 1000 (Monofer®), a new intravenous iron preparation and its clinical implications. Eur J Pharm Biopharm. 2011;78(3):480–491. doi: 10.1016/j.ejpb.2011.03.016
  • Alsaleh NB, Brown JM. Engineered nanomaterials and type 1 allergic hypersensitivity reactions. Front Immunol. 2020;11: Article 222, 1–14. doi: 10.3389/fimmu.2020.00222
  • Rampton D, Folkersen J, Fishbane S, et al. Hypersensitivity reaction to intravenous iron: guidance for risk minimization and management. Haematologica. 2014;99(11):1671–1676. doi: 10.3324/haematol.2014.111492
  • Fishbane S, Ungureanu VD, Maesaka JK, et al. The safety of intravenous iron dextran in hemodialysis patients. Am J Kidney Dis. 1996;28(4):529–534. doi: 10.1016/S0272-6386(96)90463-1
  • Auerbach M, Ballard H, Glaspy J. Clinical update: intravenous iron for anaemia. Lancet. 2007;369(9572):1502–1504. doi: 10.1016/S0140-6736(07)60689-8
  • Montandon SV, Fajt ML, Petrov AA. A safe and novel desensitization protocol with ferric carboxymaltose to treat iron deficiency anemia. Curr Drug Saf. 2016;11(2):145–148. doi: 10.2174/1574886311666151209114203
  • Steinmetz T, Schroder J, Plath M, et al. Antianemic treatment of cancer patients in German routine practice: data from a prospective cohort study—the tumor anemia registry. Anemia. 2016;2016:1–9. doi: 10.1155/2016/8057650
  • Hufnagel DH, Mehta ST, Ezekwe C, et al. Prevalence of anemia and compliance with NCCN guidelines for evaluation and treatment of anemia in patients with gynecologic cancer. J Natl Compr Canc Netw. 2021;19:513–520. doi: 10.6004/jnccn.2020.7638
  • Aapro M, Beguin Y, Bokemeyer C, et al. Management of anaemia and iron deficiency in patients with cancer: ESMO clinical practice guidelines. Ann Oncol. 2018;29(Suppl 4):iv96–iv110. doi: 10.1093/annonc/mdx758
  • De Loughery TG. Safety of oral and intravenous iron. Acta Haematol. 2019;142(1):8–12. doi: 10.1159/000496966
  • Kelsey SM, Hider RC, Bloor JR, et al. Absorption at low and therapeutic doses of ferric maltol, a novel ferric iron compound, in iron-deficient subjects using a single dose iron absorption test. J Clin Pharm Ther. 1991;16(2):117–122. doi: 10.1111/j.1365-2710.1991.tb00292.x
  • Pergola PE, Kopyt NP. Oral ferric maltol for the treatment of iron-deficiency anemia in patients with CKD: a randomized trial and open-label extension. AJKD. 2021;78(6):846–856. doi: 10.1053/j.ajkd.2021.03.020
  • Gasche C, Ahmad T, Tulassay Z, et al. Ferric maltol is effective in correcting iron deficiency anemia in patients with inflammatory bowel disease: results from a phase-3 clinical trial program. Inflamm Bowel Dis. 2015;21:579–588. doi: 10.1097/MIB.0000000000000314
  • Howaldt S, Domenech E, Martinez N, et al. Long term effectiveness of oral ferric maltol vs intravenous ferric carboxylmaltose for the treatment of iron-deficiency anemia in patients with inflammatory bowel disease: a randomized controlled noninferiority trial. Inflamm Bowel Dis. 2022;28(3):373–384. doi: 10.1093/ibd/izab073
  • Gomez-Ramirez S, Brilli E, Tarantino G, et al. Sucrosomial® iron: an updated review of its clinical efficacy for the treatment of iron deficiency. Pharmaceuticals (Basel). 2023;16(6):847. doi: 10.3390/ph16060847
  • Pantopoulos K. Oral iron supplementation: new formulations, old questions. Haematologica. 2024 Apr 11. doi: 10.3324/haematol2024.284967
  • Mueller MM, van Remoortel H, Meybohm P, et al. Patient blood management: recommendations from the 2018 Frankfurt consensus conference. JAMA. 2019;321(10):983–997. doi: 10.1001/jama.2019.0554
  • Fein S, Alonso D, Menendez M, et al. Overcoming the obstacles that prevent identification and treatment of women who have iron deficiency. In: Abstracts of the American Society of Hematology; 2023 Dec; San Diego, CA USA. 2023.
  • Steensma DP, Sloan JA, Loprinzi CL. Reply to M. Aapro et al. J Clin Oncol. 2011;29(17):e527–528. doi: 10.1200/JCO.2011.35.4597

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