Mass production of stem cell derived human hepatocytes for experimental medicine

References

• Nicolas CT, Wang Y, Nyberg SL. Cell therapy in chronic liver disease. Curr Opin Gastroenterol. 2016;32(3):189–194.
   PubMed Web of Science ®Google Scholar
• Fox IJ, Chowdhury JR, Kaufman SS, et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med. 1998;338:1422–1426.
   PubMed Web of Science ®Google Scholar
• Forbes SJ, Gupta S, Dhawan A. Cell therapy for liver disease: from liver transplantation to cell factory. J Hepatol. 2015;62:S157–69.
   PubMed Web of Science ®Google Scholar
• Weber A, Delgado J-P, Parouchev A, et al. Primate hepatic foetal progenitor cells and their therapeutic potential. Pathol Biol (Paris). 2006;54:58–63.
   PubMed Web of Science ®Google Scholar
• Terrace JD, Currie IS, Hay DC, et al. Progenitor cell characterization and location in the developing human liver. Stem Cells Dev. 2007;16:771–778.
   PubMed Web of Science ®Google Scholar
• Lu W-Y, Bird TG, Boulter L, et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol. 2015;17:971–983.
   PubMed Web of Science ®Google Scholar
• Boulter L, Lu W-Y, Forbes SJ. Differentiation of progenitors in the liver: a matter of local choice. J Clin Invest. 2013;123:1867–1873.
   PubMed Web of Science ®Google Scholar
• Huch M, Gehart H, Van Boxtel R, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell. 2015;160:299–312.
   PubMed Web of Science ®Google Scholar
• Hay DC, Zhao D, Ross A, et al. Direct differentiation of human embryonic stem cells to hepatocyte-like cells exhibiting functional activities. Cloning Stem Cells. 2007;9:51–62.
   PubMedGoogle Scholar
• Hay DC, Fletcher J, Payne C, et al. Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Proc Natl Acad Sci U S A. 2008;105:12301–12306.
   PubMed Web of Science ®Google Scholar
• Thomson JA, Itskovitz-Eldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147.
   PubMed Web of Science ®Google Scholar
• Rodin S, Antonsson L, Niaudet C, et al. Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment. Nat Commun. 2014;5:3195.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–872.
   PubMed Web of Science ®Google Scholar
• Hochedlinger K, Jaenisch R. Induced pluripotency and epigenetic reprogramming. Cold Spring Harb Perspect Biol. 2015;7(12):pii:a019448.
   Google Scholar
• Hannoun Z, Steichen C, Dianat N, et al. The potential of induced pluripotent stem cell derived hepatocytes. J Hepatol. 2016;pii:S0168–8278(16)00158-6. doi:10.1016/j.jhep.2016.02.025. [Epub ahead of print].
   PubMedGoogle Scholar
• Carpenter MK, Rao MS. Concise review: making and using clinically compliant pluripotent stem cell lines. Stem Cells Transl Med. 2015;4:381–388.
   PubMed Web of Science ®Google Scholar
• Crook JM, Peura TT, Kravets L, et al. The generation of six clinical-grade human embryonic stem cell lines. Cell Stem Cell. 2007;1:490–494.
   PubMed Web of Science ®Google Scholar
• Canham MA, Van Deusen A, Brison DR, et al. The molecular karyotype of 25 clinical-grade human embryonic stem cell lines. Sci Rep. 2015;5:17258.
   PubMed Web of Science ®Google Scholar
• Baghbaderani BA, Tian X, Neo BH, et al. cGMP-manufactured human induced pluripotent stem cells are available for pre-clinical and clinical applications. Stem Cell Rep. 2015;5:647–659.
   PubMed Web of Science ®Google Scholar
• Wang J, Hao J, Bai D, et al. Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions. Stem Cell Res Ther. 2015;6:223.
   PubMed Web of Science ®Google Scholar
• Zhou X, Sun P, Lucendo-Villarin B, et al. Modulating innate immunity improves hepatitis C virus infection and replication in stem cell-derived hepatocytes. Stem Cell Rep. 2014;3:204–214.
   PubMed Web of Science ®Google Scholar
• Szkolnicka D, Farnworth SL, Lucendo-Villarin B, et al. Accurate prediction of drug-induced liver injury using stem cell-derived populations. Stem Cells Transl Med. 2014;3:141–148.
   PubMed Web of Science ®Google Scholar
• Medine CN, Lucendo-Villarin B, Storck C, et al. Developing high-fidelity hepatotoxicity models from pluripotent stem cells. Stem Cells Transl Med. 2013;2:505–509.
   PubMed Web of Science ®Google Scholar
• Rashid ST, Corbineau S, Hannan N, et al. Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells. J Clin Invest. 2010;120:3127–3136.
   PubMed Web of Science ®Google Scholar
• Sampaziotis F, Segeritz C-P, Vallier L. Potential of human induced pluripotent stem cells in studies of liver disease. Hepatology. 2015;62:303–311.
   PubMed Web of Science ®Google Scholar
• Choi SM, Kim Y, Shim JS, et al. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology. 2013;57:2458–2468.
   PubMed Web of Science ®Google Scholar
• Szkolnicka D, Lucendo-Villarin B, Moore JK, et al. Reducing hepatocyte injury and necrosis in response to paracetamol using noncoding RNAs. Stem Cells Transl Med. 2016 Apr 7;sctm.2015-0117. doi:10.5966/sctm.2015-0117
   PubMedGoogle Scholar
• Rashidi H, Alhaque S, Szkolnicka D, et al. shear stress modulation of hepatocyte-like cell function. Arch Toxicol. 2016 Mar 15. doi:10.1007/s00204-016-1689-8
   PubMedGoogle Scholar
• Yusa K, Rashid ST, Strick-Marchand H, et al. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011;478:391–394.
   PubMed Web of Science ®Google Scholar
• Lucendo Villarin B, Rashidi H, Cameron K, etal. Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering. J Mater Chem B. 2016. doi:10.1039/C6TB00331A. [Epub ahead of print].
   Google Scholar
• Szkolnicka D, Hay DC. Advances in generating hepatocytes from pluripotent stem cells for translational medicine. Stem Cells. 2016. doi:10.1002/stem.2368.
   PubMedGoogle Scholar
• Cameron K, Tan R, Schmidt-Heck W, et al. Recombinant laminins drive the differentiation and self-organization of hESC-derived hepatocytes. Stem Cell Rep. 2015;5:1250–1262.
   PubMed Web of Science ®Google Scholar
• Villarin BL, Cameron K, Szkolnicka D, et al. Polymer supported directed differentiation reveals a unique gene signature predicting stable hepatocyte performance. Adv Healthc Mater. 2015;4:1820–1825.
   PubMed Web of Science ®Google Scholar
• Hay DC, Pernagallo S, Diaz-Mochon JJ, et al. Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Stem Cell Res. 2011;6:92–102.
   PubMed Web of Science ®Google Scholar
• Chen Y-F, Tseng C-Y, Wang H-W, et al. Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology. 2012;55:1193–1203.
   PubMed Web of Science ®Google Scholar
• Woo D-H, Kim S-K, Lim H-J, et al. Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice. Gastroenterology. 2012;142:602–611.
   PubMed Web of Science ®Google Scholar
• Touboul T, Hannan NR, Corbineau S, et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology. 2010;51:1754–1765.
   PubMed Web of Science ®Google Scholar
• Nagamoto Y, Takayama K, Ohashi K, et al. Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure. J Hepatol. 2016;64:1068–1075.
   PubMed Web of Science ®Google Scholar
• Takebe T, Sekine K, Enomura M, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature. 2013;499:481–484.
   PubMed Web of Science ®Google Scholar
• Song W, Lu Y-C, Frankel AS, et al. Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation. Sci Rep. 2015;5:16884.
   PubMed Web of Science ®Google Scholar
• Godoy P, Schmidt-Heck W, Natarajan K, et al. Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. J Hepatol. 2015;63:934–942.
   PubMed Web of Science ®Google Scholar