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Review

The role of endoscopy in eosinophilic esophagitis: from diagnosis to therapy

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1135-1149 | Received 23 Feb 2017, Accepted 11 Aug 2017, Published online: 17 Aug 2017

References

  • Lucendo AJ, Molina-Infante J, Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J. 2017;5(3):335–358.
  • Attwood SE, Smyrk TC, Demeester TR, et al. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci. 1993;38(1):109–116.
  • Menard-Katcher P, Marks KL, Liacouras CA, et al. The natural history of eosinophilic oesophagitis in the transition from childhood to adulthood. Aliment Pharmacol Ther. 2013;37(1):114–121.
  • Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut. 2007;56(5):615–620.
  • Kidambi T, Toto E, Ho N, et al. Temporal trends in the relative prevalence of dysphagia etiologies from 1999-2009. World J Gastroenterol. 2012;18(32):4335–4341.
  • Arias A, Pérez-Martínez I, Tenías JM, et al. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2016;43(1):3–15.
  • Giriens B, Yan P, Safroneeva E, et al. Escalating incidence of eosinophilic esophagitis in Canton of Vaud, Switzerland, 1993-2013: a population-based study. Allergy Eur J Allergy Clin Immunol. 2015;70(12):1633–1639.
  • Arias A, Lucendo AJ. Prevalence of eosinophilic oesophagitis in adult patients in a central region of Spain. Eur J Gastroenterol Hepatol. 2013;25(2):208–212.
  • Larsson H, Bergman K, Finizia C, et al. Dysphagia and health-related quality of life in patients with eosinophilic esophagitis: a long-term follow-up. Eur Arch Otorhinolaryngol. 2015;272(12):3833–3839.
  • Savarino E, Tolone S, Caccaro R, et al. Clinical, endoscopic, histological and radiological characteristics of Italian patients with eosinophilic oesophagitis. Dig Liver Dis. 2015;47(12):1033–1038.
  • Miehlke S, Hruz P, Vieth M, et al. A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of eosinophilic oesophagitis. Gut. 2016;65(3):390–399.
  • Van Rhijn BD, Verheij J, Smout AJPM, et al. Rapidly increasing incidence of eosinophilic esophagitis in a large cohort. Neurogastroenterol Motil. 2013;25(1):47–e5.
  • Dellon ES, Jensen ET, Martin CF, et al. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12(4):589–596.e1.
  • Soto-Solís R, Santana-de Anda K, González-Uribe N, et al. How to improve the diagnosis of eosinophilic esophagitis: experience from a case series in Mexico. Rev Gastroenterol Mex. 2017;82(1):5–12.
  • de Sá CC, Kishi HS, Silva-Werneck AL, et al. Eosinophilic esophagitis in patients with typical gastroesophageal reflux disease symptoms refractory to proton pump inhibitor. Clinics. 2011;66(4):557–561.
  • Elias MK, Kopacova J, Arora AS, et al. The diagnosis of esophageal eosinophilia is not increased in the summer months. Dysphagia. 2015;30(1):67–73.
  • Fujishiro H, Amano Y, Kushiyama Y, et al. Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients. J Gastroenterol. 2011;46(9):1142–1144.
  • Shi YN, Sun SJ, Xiong LS, et al. Prevalence, clinical manifestations and endoscopic features of eosinophilic esophagitis: a pathological review in China. J Dig Dis. 2012;13(6):304–309.
  • Assiri AM, Saeed A. Incidence and diagnostic features of eosinophilic esophagitis in a group of children with dysphagia and gastroesophageal reflux disease. Saudi Med J. 2014;35(3):292–297.
  • Al-Hussaini A, Semaan T, El Hag I. Eosinophilic esophagitis in a developing country: is it different from developed countries? Gastroenterol Res Pract. 2013;2013:526037.
  • Ferreira CT, Goldani HA. Contribution of endoscopy in the management of eosinophilic esophagitis. World J Gastrointest Endosc. 2012;4(8):347–355.
  • Kim HP, Vance RB, Shaheen NJ, et al. The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis. Clin Gastroenterol Hepatol. 2012;10(9):988–996.
  • Molina-Infante J, Gonzalez-Cordero PL, Arias A, et al. Update on dietary therapy for eosinophilic esophagitis in children and adults. Expert Rev Gastroenterol Hepatol. 2017;11(2):115–123.
  • Kelly KJ, Lazenby AJ, Rowe PC, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503–1512.
  • Arias Á, González-Cervera J, Tenias JM, et al. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology. 2014;146(7):1639–1648.
  • Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4(9):1097–1102.
  • Lucendo AJ, Arias Á, González-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: a prospective study on the food cause of the disease. J Allergy Clin Immunol. 2013;131(3):797–804.
  • Molina-Infante J, Bredenoord AJ, Cheng E, et al. Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut. 2016;65(3):521–531.
  • Lucendo AJ, Arias Á, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2016;14(1):13–22.e1.
  • Sawas T, Dhalla S, Sayyar M, et al. Systematic review with meta-analysis: pharmacological interventions for eosinophilic oesophagitis. Aliment Pharmacol Ther. 2015;41(9):797–806.
  • Chuang M-Y, Chinnaratha MA, Hancock DG, et al. Topical steroid therapy for the treatment of eosinophilic esophagitis (EoE): a systematic review and meta-analysis. Clin Transl Gastroenterol. 2015;6(3). DOI:10.1038/ctg.2015.9.
  • Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128(1):3–20.
  • González-Castillo S, Arias Á, Lucendo AJ. Treatment of eosinophilic esophagitis: how should we manage the disease? J Clin Gastroenterol. 2010;44(10):663–671.
  • Martín De Carpi J, Gómez Chiari M, Castejón Ponce E, et al. Increasing diagnosis of eosinophilic esophagitis in Spain. An Pediatr. 2005;62(4):333–339.
  • Schoepfer AM, Safroneeva E, Bussmann C, et al. Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology. 2013;145(6):1230–1236.
  • Lucendo AJ, Arias T, Molina-Infante J, et al. Diagnostic and therapeutic management of eosinophilic oesophagitis in children and adults: results from a Spanish registry of clinical practice. Dig Liver Dis. 2013;45(7):562–568.
  • Lucendo AJ, Pascual-Turrión JM, Navarro M, et al. Endoscopic, bioptic, and manometric findings in eosinophilic esophagitis before and after steroid therapy: a case series. Endoscopy. 2007;39(9):765–771.
  • Liacouras CA, Spergel JM, Ruchelli E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3(12):1198–1206.
  • Müller S, Pühl S, Vieth M, et al. Analysis of symptoms and endoscopic findings in 117 patients with histological diagnoses of eosinophilic esophagitis. Endoscopy. 2007;39(4):339–344.
  • Hirano I, Moy N, Heckman MG, et al. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut. 2013;62(4):489–495.
  • Dellon ES, Cotton CC, Gebhart JH, et al. Accuracy of the eosinophilic esophagitis endoscopic reference score in diagnosis and determining response to treatment. Clin Gastroenterol Hepatol. 2016;14(1):31–39.
  • Van Rhijn BD, Warners MJ, Curvers WL, et al. Evaluating the endoscopic reference score for eosinophilic esophagitis: moderate to substantial intra- and interobserver reliability. Endoscopy. 2014;46(12):1049–1055.
  • Nurko S, Teitelbaum JE, Husain K, et al. Association of Schatzki ring with eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2004 abril de;38(4):436–441.
  • Müller M, Eckardt AJ, Fisseler-Eckhoff A, et al. Endoscopic findings in patients with Schatzki rings: evidence for an association with eosinophilic esophagitis. World J Gastroenterol. 2012;18(47):6960–6966.
  • Müller S. Key findings ineosinophilic esophagitis. Verdauungskra nkheiten. 2010;28(3):100–104.
  • Towbin AJ, Diniz LO. Schatzki ring in pediatric and young adult patients. Pediatr Radiol. 2012 diciembre de;42(12):1437–1440.
  • Moawad FJ, Dellon ES, Achem SR, et al. Effects of race and sex on features of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2016;14(1):23–30.
  • Okimoto E, Ishimura N, Okada M, et al. Specific locations of linear furrows in patients with esophageal eosinophilia. Dig Endosc. 2017;29(1):49–56.
  • Prasad GA, Talley NJ, Romero Y, et al. Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study. Am J Gastroenterol. 2007;102(12):2627–2632.
  • Mackenzie SH, Go M, Chadwick B, et al. Eosinophilic oesophagitis in patients presenting with dysphagia - a prospective analysis. Aliment Pharmacol Ther. 2008;28(9):1140–1146.
  • van Rhijn BD, Verheij J, Smout AJPM, et al. The endoscopic reference score shows modest accuracy to predict histologic remission in adult patients with eosinophilic esophagitis. Neurogastroenterol Motil. 2016;28(11):1714–1722.
  • Rodríguez-Sánchez J, Barrio-Andrés J, Nantes Castillejo O, et al. The endoscopic reference score shows modest accuracy to predict either clinical or histological activity in adult patients with eosinophilic oesophagitis. Aliment Pharmacol Ther. 2017;45(2):300–309.
  • Ricker J, Mcnear S, Cassidy T, et al. Routine screening for eosinophilic esophagitis in patients presenting with dysphagia. Ther Adv Gastroenterol. 2011;4(1):27–35.
  • Schoepfer AM, Panczak R, Zwahlen M, et al. How do gastroenterologists assess overall activity of eosinophilic esophagitis in adult patients? Am J Gastroenterol. 2015;110(3):402–414.
  • Schoepfer AM, Straumann A, Panczak R, et al. Development and validation of a symptom-based activity index for adults with eosinophilic esophagitis. Gastroenterology. 2014;147(6):1255–1266.e21.
  • Safroneeva E, Straumann A, Coslovsky M, et al. Symptoms have modest accuracy in detecting endoscopic and histologic remission in adults with eosinophilic esophagitis. Gastroenterology. 2016;150(3):581–590e4.
  • Dellon ES, Gibbs WB, Fritchie KJ, et al. Clinical, endoscopic, and histologic findings distinguish eosinophilic esophagitis from gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2009;7(12):1305–1313.
  • Dellon ES, Rusin S, Gebhart JH, et al. A clinical prediction tool identifies cases of eosinophilic esophagitis without endoscopic biopsy: a prospective study. Am J Gastroenterol. 2015 septiembre de;110(9):1347–1354.
  • Hori K, Watari J, Fukui H, et al. Do endoscopic features suggesting eosinophilic esophagitis represent histological eosinophilia? Dig Endosc. 2014;26(2):156–163.
  • Saffari H, Peterson KA, Fang JC, et al. Patchy eosinophil distributions in an esophagectomy specimen from a patient with eosinophilic esophagitis: implications for endoscopic biopsy. J Allergy Clin Immunol. 2012 septiembre de;130(3):798–800.
  • Dellon ES, Speck O, Woodward K. The patchy nature of esophageal eosinophilia in eosinophilic esophagitis: insights from pathology samples from a clinical trial. Gastroenterology. 2012;142(Suppl):Su–1129.
  • Gonsalves N, Policarpio-Nicolas M, Zhang Q, et al. Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis. Gastrointest Endosc. 2006;64(3):313–319.
  • Shah A, Kagalwalla AF, Gonsalves N, et al. Histopathologic variability in children with eosinophilic esophagitis. Am J Gastroenterol. 2009;104(3):716–721.
  • Nielsen JA, Lager DJ, Lewin M, et al. The optimal number of biopsy fragments to establish a morphologic diagnosis of eosinophilic esophagitis. Am J Gastroenterol. 2014;109(4):515–520.
  • Salek J, Clayton F, Vinson L, et al. Endoscopic appearance and location dictate diagnostic yield of biopsies in eosinophilic oesophagitis. Aliment Pharmacol Ther. 2015;41(12):1288–1295.
  • Lucendo AJ, Navarro M, Comas C, et al. Immunophenotypic characterization and quantification of the epithelial inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellular mechanisms of the disease and the immunologic capacity of the esophagus. Am J Surg Pathol. 2007;31(4):598–606.
  • Hill CA, Ramakrishna J, Fracchia MS, et al. Prevalence of eosinophilic esophagitis in children with refractory aerodigestive symptoms. JAMA Otolaryngol Head Neck Surg. 2013;139(9):903–905.
  • Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Sponsored by the American gastroenterological association (AGA) institute and North American society of pediatric gastroenterol. Gastroenterology. 2007;133(4):1342–1363.
  • Dellon ES, Speck O, Woodward K, et al. Distribution and variability of esophageal eosinophilia in patients undergoing upper endoscopy. Mod Pathol Off J US Can Acad Pathol Inc. 2015;28(3):383–390.
  • Dellon ES, Aderoju A, Woosley JT, et al. Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review. Am J Gastroenterol. 2007;102(10):2300–2313.
  • Collins MH, Martin LJ, Alexander ES, et al. Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring. Dis Esophagus. 2017;30(3):1–8.
  • Kaur S, Rosen JM, Kriegermeier AA, et al. Utility of gastric and duodenal biopsies during follow-up endoscopy in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2017. [Epub ahead of print]. DOI:10.1097/MPG.0000000000001528
  • Lucendo AJ, De Rezende L, González-Castillo S, et al. Chromoendoscopy with Indigo-Carmine improves the recognition of endoscopic mucosal findings in adult eosinophilic esophagitis. Gastroenterology. 2009;136(Suppl 1):S1874.
  • Peery AF, Cao H, Dominik R, et al. Variable reliability of endoscopic findings with white-light and narrow-band imaging for patients with suspected eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2011;9(6):475–480.
  • Lee BE, Kim GH. Magnifying endoscopy with narrow band imaging and endoscopic ultrasonography for assessing eosinophilic esophagitis. J Neurogastroenterol Motil. 2013;19(1):104–106.
  • Tanaka K, Rubio CA, Dlugosz A, et al. Narrow-band imaging magnifying endoscopy in adult patients with eosinophilic esophagitis/esophageal eosinophilia and lymphocytic esophagitis. Gastrointest Endosc. 2013;78(4):659–664.
  • Hirano I. Therapeutic end points in eosinophilic esophagitis: is elimination of esophageal eosinophils enough? Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2012;10(7):750–752.
  • Straumann A. The natural history and complications of eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2008;18(1):99–118.
  • Lucendo AJ, Arias A, De Rezende LC, et al. Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: a prospective study. J Allergy Clin Immunol. 2011;128(5):1037–1046.
  • Dellon ES, Kim HP, Sperry SLW, et al. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc. 2014;79(4):577–585.e4.
  • Debrosse CW, Franciosi JP, King EC, et al. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011;128(1):132–138.
  • Lucendo AJ, Arias-González L, Arias Á, et al. Determinant factors of quality of life in adult patients with eosinophilic esophagitis. United Eur Gastroenterol J. 2017. DOI:10.1177/2050640617707095
  • Lucendo AJ, Arias Á, González-Cervera J, et al. Dual response to dietary/topical steroid and proton pump inhibitor therapy in adult patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016;137(3):931–934.
  • Sodikoff J, Hirano I. Proton pump inhibitor-responsive esophageal eosinophilia does not preclude food-responsive eosinophilic esophagitis. J Allergy Clin Immunol. 2016;137(2):631–633.
  • Saligram S, McGrath K. The safety of a strict wire-guided dilation protocol for eosinophilic esophagitis. Eur J Gastroenterol Hepatol. 2014;26(7):699–703.
  • Ally MR, Dias J, Veerappan GR, et al. Safety of dilation in adults with eosinophilic esophagitis. Dis Esophagus. 2013;26(3):241–245.
  • Lucendo AJ. Cellular and molecular immunological mechanisms in eosinophilic esophagitis: an updated overview of their clinical implications. Expert Rev Gastroenterol Hepatol. 2014;8(6):669–685.
  • Mangla S, Goldin AH, Singal G, et al. Endoscopic features and eosinophil density are associated with food impaction in adults with esophageal eosinophilia. Dig Dis Sci. 2016;61(9):2578–2584.
  • Alexander JA, Jung KW, Arora AS, et al. Swallowed fluticasone improves histologic but not symptomatic response of adults with eosinophilic esophagitis. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2012;10(7):742–749.e1.
  • Gupta SK, Vitanza JM, Collins MH. Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2015;13(1):66–76.e3.
  • Dohil R, Newbury R, Fox L, et al. Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized, placebo-controlled trial. Gastroenterology. 2010;139(2):418–429.e1.
  • Butz BK, Wen T, Gleich GJ, et al. Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology. 2014;147(2):324–333.e5.
  • Moawad FJ, Veerappan GR, Dias JA, et al. Randomized controlled trial comparing aerosolized swallowed fluticasone to esomeprazole for esophageal eosinophilia. Am J Gastroenterol. 2013;108(3):366–372.
  • Schoepfer AM, Gschossmann J, Scheurer U, et al. Esophageal strictures in adult eosinophilic esophagitis: dilation is an effective and safe alternative after failure of topical corticosteroids. Endoscopy. 2008;40(2):161–164.
  • Runge TM, Eluri S, Cotton CC, et al. Outcomes of esophageal dilation in eosinophilic esophagitis: safety, efficacy, and persistence of the fibrostenotic phenotype. Am J Gastroenterol. 2016;111(2):206–213.
  • Desai TK, Stecevic V, Chang C-H, et al. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005;61(7):795–801.
  • Sperry SLW, Crockett SD, Miller CB, et al. Esophageal foreign-body impactions: epidemiology, time trends, and the impact of the increasing prevalence of eosinophilic esophagitis. Gastrointest Endosc. 2011;74(5):985–991.
  • Runge TM, Eluri S, Cotton CC, et al. Causes and outcomes of esophageal perforation in eosinophilic esophagitis. J Clin Gastroenterol. 2016. [Epub ahead of print]. DOI:10.1097/MCG.0000000000000718
  • Straumann A, Bussmann C, Zuber M, et al. Eosinophilic esophagitis: analysis of food impaction and perforation in 251 adolescent and adult patients. Clin Gastroenterol Hepatol. 2008;6(5):598–600.
  • El-Matary W, El-Hakim H, Popel J. Eosinophilic esophagitis in children needing emergency endoscopy for foreign body and food bolus impaction. Pediatr Emerg Care. 2012;28(7):611–613.
  • Hurtado CW, Furuta GT, Kramer RE. Etiology of esophageal food impactions in children. J Pediatr Gastroenterol Nutr. 2011;52(1):43–46.
  • Alrazzak BA, Al-Subu A, Elitsur Y. Etiology and management of esophageal impaction in children: a review of 11 years. Avicenna J Med. 2013;3(2):33–36.
  • Muir AB, Merves J, Liacouras CA. Role of endoscopy in diagnosis and management of pediatric eosinophilic esophagitis. Gastrointest Endosc Clin N Am. 2016;26(1):187–200.
  • Thimmapuram J, Oosterveen S, Grim R. Use of glucagon in relieving esophageal food bolus impaction in the era of eosinophilic esophageal infiltration. Dysphagia. 2013;28(2):212–216.
  • Lipka S, Kumar A, Richter JE. Impact of diagnostic delay and other risk factors on eosinophilic esophagitis phenotype and esophageal diameter. J Clin Gastroenterol. 2016;50(2):134–140.
  • Chehade M, Sampson HA, Morotti RA, et al. Esophageal subepithelial fibrosis in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2007;45(3):319–328.
  • Aceves SS, Newbury RO, Dohil R, et al. Esophageal remodeling in pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2007 enero de;119(1):206–212.
  • Straumann A, Conus S, Degen L, et al. Long-term budesonide maintenance treatment is partially effective for patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2011;9(5):400–409.e1.
  • Mishra A, Wang M, Pemmaraju VR, et al. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008 enero de;134(1):204–214.
  • Moawad FJ, Cheatham JG, Dezee KJ. Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis. Aliment Pharmacol Ther. 2013;38(7):713–720.
  • Moawad F, Molina-Infante J, Lucendo AJ, et al. Endoscopic dilation is highly effective and safe and effective in improving clinical symptoms in eosinophilic esophagitis in children and adults: a systematic review and meta-analysis. Aliment Pharmacol Ther. 2017;46(2):96–105.
  • Schoepfer AM, Gonsalves N, Bussmann C, et al. Esophageal dilation in eosinophilic esophagitis: effectiveness, safety, and impact on the underlying inflammation. Am J Gastroenterol. 2010;105(5):1062–1070.
  • Dellon ES, Gibbs WB, Rubinas TC, et al. Esophageal dilation in eosinophilic esophagitis: safety and predictors of clinical response and complications. Gastrointest Endosc. 2010;71(4):706–712.
  • Lipka S, Keshishian J, Boyce HW, et al. The natural history of steroid-naïve eosinophilic esophagitis in adults treated with endoscopic dilation and proton pump inhibitor therapy over a mean duration of nearly 14 years. Gastrointest Endosc. 2015;80(4):592–598.
  • Colizzo JM, Clayton SB, Richter JE. Intrabolus pressure on high-resolution manometry distinguishes fibrostenotic and inflammatory phenotypes of eosinophilic esophagitis. Dis Esophagus. 2016;29(6):551–557.
  • Gentile N, Katzka D, Ravi K, et al. Oesophageal narrowing is common and frequently under-appreciated at endoscopy in patients with oesophageal eosinophilia. Aliment Pharmacol Ther. 2014;40(11–12):1333–1340.
  • Kwiatek MA, Hirano I, Kahrilas PJ, et al. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology. 2011;140(1):82–90.
  • Nicodème F, Hirano I, Chen J, et al. Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2013;11(9):1101–1107.
  • ChenJW, Pandolfino JE, Lin Z, et al. Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis. Endoscopy. 2016;48(9):873. [French comment on article].
  • Zuber-Jerger I, Ratiu N, Kullman F. Long-lasting effect of endoscopic dilatation of an esophageal stenosis due to eosinophilic esophagitis. J Gastrointestin Liver Dis. 2006;15(2):167–170.
  • Roberts-Thomson IC. Images of interest. Gastrointestinal: eosinophilic esophagitis. J Gastroenterol Hepatol. 2005;20(8):1299.
  • Vasilopoulos S, Murphy P, Auerbach A, et al. The small-caliber esophagus: an unappreciated cause of dysphagia for solids in patients with eosinophilic esophagitis. Gastrointest Endosc. 2002;55(1):99–106.
  • Hirano I. Dilation in eosinophilic esophagitis: to do or not to do? Gastrointest Endosc. 2010 abril de;71(4):713–714.
  • Eisenbach C, Merle U, Schirmacher P, et al. Perforation of the esophagus after dilation treatment for dysphagia in a patient with eosinophilic esophagitis. Endoscopy. 2006;38(Suppl 2):E43–E44.
  • Rajagopalan J, Triadafilopoulos G. Ring(s)-related esophageal meat bolus impaction: biopsy first, dilate later. Dis Esophagus Off J Int Soc Dis Esophagus. 2009;22(5):E14–E16.
  • Lucendo AJ, Friginal-Ruiz AB, Rodríguez B. Boerhaave’s syndrome as the primary manifestation of adult eosinophilic esophagitis. Two case reports and a review of the literature. Dis Esophagus Off J Int Soc Dis Esophagus. 2011;24(2):E11–E15.
  • Riou PJ, Nicholson AG, Pastorino U. Esophageal rupture in a patient with idiopathic eosinophilic esophagitis. Ann Thorac Surg. 1996;62(6):1854–1856.
  • Liguori G, Cortale M, Cimino F, et al. Circumferential mucosal dissection and esophageal perforation in a patient with eosinophilic esophagitis. World J Gastroenterol. 2008;14(5):803–804.
  • Fontillón M, Lucendo AJ. Transmural eosinophilic infiltration and fibrosis in a patient with non-traumatic Boerhaave’s syndrome due to eosinophilic esophagitis. Am J Gastroenterol. 2012;107(11):1762.
  • Sgouros SN, Bergele C, Mantides A. Eosinophilic esophagitis in adults: what is the clinical significance? Endoscopy. 2006;38(5):515–520.
  • Lucendo AJ, De Rezende L. Endoscopic dilation in eosinophilic esophagitis: a treatment strategy associated with a high risk of perforation. Endoscopy. 2007;39(4):376.
  • Rothenberg ME, Mishra A, Brandt EB, et al. Gastrointestinal eosinophils. Immunol Rev. 2001;179:139–155.
  • Landres RT, Kuster GG, Strum WB. Eosinophilic esophagitis in a patient with vigorous achalasia. Gastroenterology. 1978;74(6):1298–1301.
  • Jackson WE, Mehendiratta V, Palazzo J, et al. Boerhaave’s syndrome as an initial presentation of eosinophilic esophagitis: a case series. Ann Gastroenterol Q Publ Hell Soc Gastroenterol. 2013;26(2):166–169.
  • Prasad GA, Arora AS. Spontaneous perforation in the ringed esophagus. Dis Esophagus Off J Int Soc Dis Esophagus. 2005;18(6):406–409.
  • Kaplan M, Mutlu EA, Jakate S, et al. Endoscopy in eosinophilic esophagitis: «feline» esophagus and perforation risk. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2003;1(6):433–437.
  • Benítez Cantero JM, Ángel JM, Rodríguez Perálvarez M, et al. Esophageal perforation following a biopsy in a patient with eosinophilic esophagitis. Gastroenterol Hepatol. 2011;34(7):460–463.
  • Jung KW, Gundersen N, Kopacova J, et al. Occurrence of and risk factors for complications after endoscopic dilation in eosinophilic esophagitis. Gastrointest Endosc. 2011;73(1):15–21.
  • Cohen MS, Kaufman AB, Palazzo JP, et al. An audit of endoscopic complications in adult eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2007;5(10):1149–1153.
  • Robles-Medranda C, Villard F, Le Gall C, et al. Severe dysphagia in children with eosinophilic esophagitis and esophageal stricture: an indication for balloon dilation? J Pediatr Gastroenterol Nutr. 2010;50(5):516–520.
  • Kay M, Wyllie R. Direct endoscopic dilation in patients with eosinophilic esophagitis. Gastrointest Endosc. 2011 febrero;73(2):409. author reply 409.
  • Menard-Katcher C, Furuta GT, Kramer RE. Dilation of pediatric eosinophilic esophagitis - adverse events and short term outcomes. J Pediatr Gastroenterol Nutr. 2016;64(5):701–706.
  • Nantes Castillejo O, Zozaya JM, Jiménez-Pérez FJ, et al. Incidence and characteristics of eosinophilic esophagitis in adults. An Sist Sanit Navar. 2009;32(2):227–234.
  • Swan MP, Donnellan F, Kandel G. Safe and effective dilatation in eosinophilic esophagitis: the tale of two subgroups. Gastrointest Endosc. 2011;73(2):408. author reply 408-409.
  • Kagalwalla AF, Shah A, Li BUK, et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr. 2011;53(2):145–149.
  • Gonsalves N, Yang G-Y, Doerfler B, et al. Elimination diet effectively treats eosinophilic esophagitis in adults; Food reintroduction identifies causative factors. Gastroenterology. 2012;142(7):1451–1459.e1.
  • Dellon ES, Rusin S, Gebhart JH, et al. Utility of a noninvasive serum biomarker panel for diagnosis and monitoring of eosinophilic esophagitis: a prospective study. Am J Gastroenterol. 2015;110(6):821–827.
  • Furuta GT, Kagalwalla AF, Lee JJ, et al. The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis. Gut. 2013;62(10):1395–1405.
  • Katzka DA, Geno DM, Ravi A, et al. Accuracy, safety, and tolerability of tissue collection by cytosponge vs endoscopy for evaluation of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2015;13(1):77–83.

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