An overview of interventions for constipation in adults

References

• WGO practice guideline – constipation. WGO. Milwaukee, Wisconsin: World gastroenterology organization. [ Cited Feb 2020]. Available at: https://www.worldgastroenterology.org/guidelines/global-guidelines/constipation
   Google Scholar
• Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009;136(3):741–754.
   PubMed Web of Science ®Google Scholar
• Mugie SM, Benninga MA, Di Lorenzo C. Epidemiology of constipation in children and adults: a systematic review. Best Pract Res Clin Gastroenterol. 2011;25(1):3–18.
   PubMed Web of Science ®Google Scholar
• Gallegos-Orozco JF, Foxx-Orenstein AE, Sterler SM, et al. Chronic constipation in the elderly. Am J Gastroenterol. 2012;107(1):18–25.
   PubMed Web of Science ®Google Scholar
• Bharucha AE, Pemberton JH, Locke GR. American gastroenterological association technical review on constipation. Gastroenterology. 2013;144(1):218–238.
   PubMed Web of Science ®Google Scholar
• Gunter F. Chronic functional constipation in infants and children. Handb Exp Pharmacol. 2019;1–20.
   Google Scholar
• Rao SS, Tuteja AK, Vellema T, et al. Dyssynergic defecation: demographics, symptoms, stool patterns, and quality of life. J Clin Gastroenterol. 2004;38(8):680–685.
   PubMed Web of Science ®Google Scholar
• Rao SS, Ozturk R, Stessman M. Investigation of the pathophysiology of fecal seepage. Am J Gastroenterol. 2004;99(11):2204–2209.
   PubMed Web of Science ®Google Scholar
• Locke III GR, Zinsmeister AR, Fett SL, et al. Overlap of gastrointestional symptom complexes in a US community. Neurogastroenterol Motility. 2005;17(1):29–34.
   PubMed Web of Science ®Google Scholar
• Forootan M, Bagheri N, Darvishi M. Chronic constipation: A review of literature. Medicine (Baltimore). 2018;97(20).
   Web of Science ®Google Scholar
• Simren M, Palsson OS, Whitehead WE. Update on Rome IV criteria for colorectal disorders: implications for clinical practice. Curr Gastroenterol Rep. 2017;19(4):15.
   PubMedGoogle Scholar
• Black CJ, Ford AC. Chronic idiopathic constipation in adults: epidemiology, pathophysiology, diagnosis and clinical management. Med J Aust. 2018;209(2):86–91.
   PubMed Web of Science ®Google Scholar
• Wald A, Scarpignato C, Kamm MA, et al. The burden of constipation on quality of life: results of a multinational survey. Aliment Pharmacol Ther. 2007;26(2):227–236.
   PubMed Web of Science ®Google Scholar
• Lembo A, Camilleri M. Chronic constipation. N Engl J Med. 2013;349(14):1360–1368.
   Google Scholar
• Lee BE, Kim GH. How to perform and interpret balloon expulsion test. J Neurogastroenterol Motil. 2014;20(3):407.
   PubMed Web of Science ®Google Scholar
• Shin A, Camilleri M, Nadeau A, et al. Interpretation of overall colonic transit in defecation disorders in males and females. Neurogastroenterol Motility. 2013;25(6):502–e369.
   PubMed Web of Science ®Google Scholar
• Sharma A, Constipation: RS. Pathophysiology and Current Therapeutic Approaches. Handb Exp Pharmacol. 2017;239:59–74.
   PubMedGoogle Scholar
• Rao SS. Dyssynergic defecation. Gastroenterol Clin North Am. 2001;1;30(1):97–114.
   PubMed Web of Science ®Google Scholar
• Roque MV, Bouras EP. Epidemiology and management of chronic constipation in elderly patients. Clin Interv Aging. 2015;10:919.
   PubMed Web of Science ®Google Scholar
• Salles N. Basic mechanisms of the aging gastrointestinal tract. Dig Dis. 2007;25(2):112–117.
   PubMed Web of Science ®Google Scholar
• Orr WC, Chen CLIV. Clinical and physiological aspects of gastrointestinal motility and aging. Am J Physiol Gastrointest Liver Physiol. 2001;283(6):1226–1231.
   Web of Science ®Google Scholar
• Saha L. Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine. World J Gastroenterol. 2014;20(22):6759–6773.
   PubMed Web of Science ®Google Scholar
• Wald A. Constipation: advances in diagnosis and treatment. Jama. 2016;315(2):185–191.
   PubMed Web of Science ®Google Scholar
• Saad RJ, Rao SS, Koch KL, et al. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol. 2010;105(2):403–411.
   PubMed Web of Science ®Google Scholar
• Tantiphlachiva K, Rao P, Attaluri A, et al. Digital rectal examination is a useful tool for identifying patients with dyssynergia. Clin Gastroenterol Hepatol. 2010;8(11):955–960.
   PubMed Web of Science ®Google Scholar
• Rao SS, Meduri K. What is necessary to diagnose constipation?. Best Pract Res Clin Gastroenterol. 2011;25(1):127–140.
   PubMed Web of Science ®Google Scholar
• Coffin B, Caussé C. Constipation assessment scales in adults: a literature review including the new Bowel Function Index. Expert Rev Gastroenterol Hepatol. 2011;5(5):601–613.
   PubMed Web of Science ®Google Scholar
• Rao SS, Ozturk R, Laine L. Clinical utility of diagnostic tests for constipation in adults: a systematic review. Am J Gastroenterol. 2005;100(7):1605–1615..
   PubMed Web of Science ®Google Scholar
• Singh P, Seo Y, Ballou S, et al. Pelvic floor symptom related distress in chronic constipation correlates with a diagnosis of irritable bowel syndrome with constipation and constipation severity but not pelvic floor dyssynergia. J Neurogastroenterol Motil. 2019;25(1):129.
   PubMed Web of Science ®Google Scholar
• Brandt LJ, Prather CM, Quigley EMM, et al.. Systematic review on the management of chronic constipation in North America. Am J Gastroenterol. 2005;100.
   Web of Science ®Google Scholar
• Kim ER, Rhee PL. How to interpret a functional or motility test - colon transit study. J Neurogastroenterol Motil. 2012;18(1):94–99.
   PubMed Web of Science ®Google Scholar
• Saad RJ, Hasler WL. A technical review and clinical assessment of the wireless motility capsule. Gastroenterol Hepatol. 2011;7(12):795–804.
   Google Scholar
• Rao SSC, Kuo B, McCallum RW, et al. Investigation of Colonic and Whole-Gut Transit With Wireless Motility Capsule and Radiopaque Markers in Constipation. Clin Gastroenterol Hepatol. 2009;7(5):537–544.
   PubMed Web of Science ®Google Scholar
• Rao SS, Sadeghi P, Beaty J, et al. Ambulatory 24-h colonic manometry in healthy humans. Am J Physiol Gastrointest Liver Physiol. 2001;280(4):629–639.
   PubMed Web of Science ®Google Scholar
• Wald A. Pathophysiology, diagnosis and current management of chronic constipation. Nat Clin Pract Gastroenterol Hepatol. 2006;3(2):90–100..
   PubMedGoogle Scholar
• Tantawy SA, Kamel DM, Abdelbasset WK, et al.. Effects of a proposed physical activity and diet control to manage constipation in middle-aged obese women. Dig Dis Sci. 2017;10,513.
   Google Scholar
• Loening-Baucke VA, Miele E, Staiano A. Fiber (glucomannan) is beneficial in the treatment of childhood constipation. Pediatrics. 2004;113(3):259–264.
   PubMed Web of Science ®Google Scholar
• Castillejo G, Bulló M, Anguera A, et al. A controlled, randomized, double-blind trial to evaluate the effect of a supplement of cocoa husk that is rich in dietary fiber on colonic transit in constipated pediatric patients. Pediatrics. 2006;118(3):641–648.
   Web of Science ®Google Scholar
• Kokke FT, Scholtens PA, Alles MS, et al. A dietary fiber mixture versus lactulose in the treatment of childhood constipation: a double-blind randomized controlled trial. J Pediatr Gastroenterol Nutr. 2008;47(5):592–597.
   PubMed Web of Science ®Google Scholar
• Lacy BE. Update on the management of chronic idiopathic constipation. Am J Manag Care. 2019;25(4Suppl):S55–62..
   PubMedGoogle Scholar
• Shen L, Huang C, Lu X, et al. Lower dietary fibre intake, but not total water consumption, is associated with constipation: a population‐based analysis. J Hum Nutr Diet. 2019;32(4):422–431.
   PubMed Web of Science ®Google Scholar
• O’Grady J, Shanahan F. Dietary Fiber and Gastrointestinal Disease: an Evolving Story. Curr Gastroenterol Rep. 2018;20(12):59.
   PubMedGoogle Scholar
• Cabrera AM, Rodríguez RM, Díaz ML, et al. Fecal incontinence in older patients. A narrative review. Cirugía Española (English Edition). 2018;96(3):131–137.
   Google Scholar
• Hosseini A, Nikfar S, Abdollahi M. Are probiotics effective in management of irritable bowel syndrome?. Arch Med Sci. 2012;8(3):403.
   PubMed Web of Science ®Google Scholar
• Martoni CJ, Evans M, Chow CT, et al. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20(9):435–446.
   PubMed Web of Science ®Google Scholar
• Sotoudegan F, Daniali M, Hassani S, et al.. Reappraisal of probiotics’ safety in human. Food Chem Toxicol. 2019.
   PubMed Web of Science ®Google Scholar
• Yang DH, Myung SJ, Jung KW, et al. Anorectal function and the effect of biofeedback therapy in ambulatory spinal cord disease patients having constipation. Scand J Gastroenterol. 2010;45(11):1281–1288.
   PubMed Web of Science ®Google Scholar
• Iacona R, Ramage L, Malakounides G. Current state of neuromodulation for constipation and fecal incontinence in children: a systematic review. Eur J Pediatr Surg. 2019.
   Web of Science ®Google Scholar
• Regueiro M, Velayos F, Greer JB, et al. American Gastroenterological Association Institute technical review on the management of Crohn’s disease after surgical resection. Gastroenterology. 2017;152(1):277–295.
   PubMed Web of Science ®Google Scholar
• Paré P, Fedorak RN. Systematic Review of Stimulant and Nonstimulant Laxatives for the Treatment of Functional constipation. Can J Gastroenterol Hepatol. 2014;28.
   PubMed Web of Science ®Google Scholar
• Ruby CM, Fillenbaum GG, Kuchibhatla MN, et al. Laxative Use in the Community-Dwelling Elderly. Am J Geriatric Pharmacother. 2003;1(1):11–17.
   PubMedGoogle Scholar
• Whorwell PJ. Availability of over-the-counter laxatives should not be restricted. Bmj. 2019;9:364–l51.
   Google Scholar
• Alsalimy N, Madi L, Awaisu A. Efficacy and safety of laxatives for chronic constipation in long-term care settings: A systematic review. J Clin Pharm Ther. 2018;43(5):595–605.
   PubMed Web of Science ®Google Scholar
• Offia A. Laxative prescribing in primary care: age, gender and product analysis. Acute Pain. 2019;27:10.
   Google Scholar
• American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol. 2005;100:1–4.
   PubMed Web of Science ®Google Scholar
• Ramkumar D, Rao SS. Efficacy and safety of traditional medical therapies for chronic constipation: systematic review. Am J Gastroenterol. 2005;100(4):936–971.
   PubMed Web of Science ®Google Scholar
• Attaluri A, Donahoe R, Valestin J, et al. Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Aliment Pharmacol Ther. 2011;33(7):822–828.
   PubMed Web of Science ®Google Scholar
• Rhodes FA, Carty E. Laxatives: a rational approach to prescribing. Br J Hosp Med. 2014;75(Sup8):114–118.
   Google Scholar
• Leung L, Riutta T, Kotecha J, et al. Chronic constipation: an evidence-based review. J Am Board Family Med. 2011;24(4):436–451.
   PubMed Web of Science ®Google Scholar
• Passmore AP, Wilson-Davies K, Stoker C, et al. Chronic constipation in long stay elderly patients: a comparison of lactulose and a senna-fibre combination. BMJ. 1993;307(6907):769–771.
   PubMed Web of Science ®Google Scholar
• Currie GP. Lactulose/senna. Reactions. 2007;10:114210.
   Google Scholar
• Rafati MR, Karami H, Salehifar E, et al. Clinical efficacy and safety of polyethylene glycol 3350 versus liquid paraffin in the treatment of pediatric functional constipation. Daru. 2011;19(2):154.
   PubMed Web of Science ®Google Scholar
• Camilleri M. Guanylate cyclase C agonists: emerging gastrointestinal therapies and actions. Gastroenterology. 2015;148(3):483–487.
   PubMed Web of Science ®Google Scholar
• Lin JE, Snook AE, Li P, et al.. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. PloS One. 2012;7(2).
   Web of Science ®Google Scholar
• Busby RW, Bryant AP, Bartolini WP, et al. Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur J Pharmacol. 2010;649(1–3):328–335.
   PubMed Web of Science ®Google Scholar
• Forest Laboratories. Phase 2 randomized, double-blind, placebo-controlled, parallel group trial of linaclotide administered to patients with opioid-induced constipation receiving chronic opioid treatment for non-cancer pain. In: clinicaltrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2000; [2020 Feb]. Available from: https://clinicaltrials.gov/ct2/show/study/NCT02270983?term=linaclotide&cond=constipation&draw=2&rank=4 NLM Identifier: NCT02270983.
   Google Scholar
• Bassotti G, Usai-Satta P, Bellini M. Linaclotide for the treatment of chronic constipation. Expert Opin Pharmacother. 2018;19(11):1261–1266.
   PubMed Web of Science ®Google Scholar
• Highlights of Prescribing Information Trulance® (plecanatide). FDA. Washington, DC: Food and Drug Administration (FDA, or the Agency), 2017. [Cited Feb 2020]. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208745s001lbl.pdf.
   Google Scholar
• Rao SS. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018;11:1756284818777945.
   Web of Science ®Google Scholar
• Jr PB M, Koltun WD, Wiener GJ, et al. A randomized phase III clinical trial of plecanatide, a uroguanylin analog, in patients with chronic idiopathic constipation. Am J Gastroenterol. 2017;112(4):613.
   PubMed Web of Science ®Google Scholar
• Lacy BE, Levy LC. Lubiprostone: a novel treatment for chronic constipation. Clin Interv Aging. 2008;3(2):357.
   PubMed Web of Science ®Google Scholar
• Johanson JF, Ueno R. Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double‐blind, placebo‐controlled, dose‐ranging study to evaluate efficacy and safety. Aliment Pharmacol Ther. 2007;25(11):1351–1361.
   PubMed Web of Science ®Google Scholar
• Daniali M, Nikfar S, Abdollahi M. An overview of the efficacy and safety of prucalopride for the treatment of chronic idiopathic constipation. Expert Opin Pharmacother. 2019;20(17):2073–2080.
   PubMed Web of Science ®Google Scholar
• Spierings EL, Rauck R, Brewer R, et al. Long‐Term Safety and Efficacy of Lubiprostone in Opioid‐induced Constipation in Patients with Chronic Noncancer Pain. Pain Pract. 2016;16(8):985–993.
   PubMed Web of Science ®Google Scholar
• Gonzalez-Martinez MA, Ortiz-Olvera NX, Mendez-Navarro J. Novel pharmacological therapies for management of chronic constipation. J Clin Gastroenterol. 2014;48(1):21.
   PubMed Web of Science ®Google Scholar
• Mozaffari S, Didari T, Nikfar S, et al.. Phase II drugs under clinical investigation for the treatment of chronic constipation. Expert Opin Investig Drugs. 2014;23(11):1485–1497.
   PubMed Web of Science ®Google Scholar
• Wong BS, Camilleri M. Elobixibat for the treatment of constipation. Expert Opin Investig Drugs. 2013;22(2):277–284.
   PubMed Web of Science ®Google Scholar
• Nakajima A, Seki M, Taniguchi S, et al.. Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial. Lancet Gastroenterol Hepatol. 2018;3(8):537–547.
   PubMed Web of Science ®Google Scholar
• DeBoer M. The use of ghrelin and ghrelin receptor agonists as a treatment for animal models of disease: efficacy and mechanism. Curr Pharm Des. 2012;18(31):4779–4799.
   PubMed Web of Science ®Google Scholar
• Mosińska P, Zatorski H, Storr M, et al. Future treatment of constipation-associated disorders: role of relamorelin and other ghrelin receptor agonists. J Neurogastroenterol Motil. 2017;23(2):171.
   PubMed Web of Science ®Google Scholar
• Markham A. Tenapanor: first Approval. Drugs. 2019;79(17):1897–1903.
   PubMed Web of Science ®Google Scholar
• Block GA, Rosenbaum DP, Leonsson-Zachrisson M, et al. Effect of Tenapanor on Serum Phosphate in Patients Receiving Hemodialysis.. J Am Soc Nephrol. 2017;28(6):1933–1942.
   PubMed Web of Science ®Google Scholar
• Taghavi SA, Shabani S, Mehramiri A, et al. Colchicine is effective for short-term treatment of slow transit constipation: a double-blind placebo-controlled clinical trial. Int J Colorectal Dis. 2010;25(3):389–394.
   PubMed Web of Science ®Google Scholar
• Kirchner J. Use of Colchicine in Patients with Severe Constipation. Am Fam Physician. 1999;59(4):975.
   Google Scholar
• Cytotec® (misoprostol). FDA. Washington, DC: Food and Drug Administration (FDA, or the Agency). [Cited Feb 2020]. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/19268slr037.pdf.
   Google Scholar
• Bharucha AE. Treatment of severe and intractable constipation. Curr Treat Options Gastroenterol. 2004;7(4):291–298.
   PubMedGoogle Scholar
• Nelson AD, Camilleri M. Opioid-induced constipation: advances and clinical guidance. Ther Adv Chronic Dis. 2016;7(2):121–134.
   PubMed Web of Science ®Google Scholar
• Wald A. Bile acids and bowel function: do they play a role in constipation-associated irritable bowel syndrome?. Clin Gastroenterol Hepatol. 2018;16(4):486–487.
   PubMed Web of Science ®Google Scholar
• Palmer RH. Bile Acid Deficiency and Constipation. Clin Gastroenterol Hepatol. 2018;16(8):1363–1364..
   PubMed Web of Science ®Google Scholar
• Pacilli M, Pallot D, Andrews A, et al. Use of Peristeen® transanal colonic irrigation for bowel management in children: a single-center experience. J Pediatr Surg. 2014;49(2):269–272.
   PubMed Web of Science ®Google Scholar
• Corbett P, Denny A, Dick K, et al. Peristeen integrated transanal irrigation system successfully treats faecal incontinence in children. J Pediatr Urol. 2014;10(2):219–222.
   PubMed Web of Science ®Google Scholar
• Siminas S, Losty PD. Current surgical management of pediatric idiopathic constipation. Ann Surg. 2015;262(6):925–933.
   PubMed Web of Science ®Google Scholar
• Poddar U. Approach to constipation in children. Indian Pediatr. 2016;53(4):319–327.
   PubMed Web of Science ®Google Scholar
• Liu Z, Yan S, Wu J, et al. Acupuncture for chronic severe functional constipation: a randomized trial. Ann Intern Med. 2016;165(11):761–769.
   PubMed Web of Science ®Google Scholar
• Matsumoto-Miyazaki J, Asano Y, Takei H, et al. Acupuncture for Chronic Constipation in Patients with Chronic Disorders of Consciousness After Severe Traumatic Brain Injury. Med Acupuncture. 2019;31(4):218–223.
   PubMed Web of Science ®Google Scholar
• Nyrop KA, Palsson OS, Levy RL, et al. Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain. Aliment Pharmacol Ther. 2007;26(2):237–248.
   PubMed Web of Science ®Google Scholar
• McCormick D. Managing costs and care for chronic idiopathic constipation. Am J Manag Care. 2019;25(4):63–69.
   Web of Science ®Google Scholar
• Albu A, Farcas A, David L, et al. The economic burden of constipation therapy. Med Pharm Rep. 2019;92(3):261–264.
   PubMedGoogle Scholar
• Acosta A, Camilleri M, Kolar G, et al. Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial. Clin Gastroenterol Hepatol. 2015;13(13):2312–2319.
   PubMed Web of Science ®Google Scholar
• Merchan C, Altshuler D, Papadopoulos J. Methylnaltrexone versus naloxone for opioid-induced constipation in the medical intensive care unit. Ann Pharmacother. 2017;51(3):203–208.
   PubMed Web of Science ®Google Scholar
• Daniali M, Nikfar S, Abdollahi M. Evaluating naloxegol for the treatment of opioid-induced constipation. Expert Opin Pharmacother. DOI:10.1080/14656566.2020.1735354
   Web of Science ®Google Scholar
• Mozaffari S, Nikfar S, Abdollahi M. Methylnaltrexone bromide for the treatment of opioid-induced constipation. Expert Opin Pharmacother. 2018;19(10):1127–1135.
   PubMed Web of Science ®Google Scholar
• Markham A. Naldemedine: first global approval. Drugs. 2017;77(8):923–927.
   PubMed Web of Science ®Google Scholar