The role of MicroRNAs in COPD muscle dysfunction and mass loss: implications on the clinic

Reference

• Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187:347–365.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Soler-Cataluna JJ, Calle M, et al. Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. Arch Bronconeumol. 2012;48(7):247–57. doi:10.1016/j.arbres.2012.04.001.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Soler-Cataluna JJ, Calle M, et al. Spanish Guideline for COPD (GesEPOC). Update 2014. Arch Bronconeumol. 2014;50(Suppl 1):1–16. doi:10.1016/S0300-2896(14)70070-5
   Google Scholar
• Anker SD, Ponikowski P, Varney S, et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet. 1997;349:1050–1053.
   PubMed Web of Science ®Google Scholar
• Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12:489–495.
   PubMed Web of Science ®Google Scholar
• Gielen S, Adams V, Mobius-Winkler S, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol. 2003;42:861–868.
   PubMed Web of Science ®Google Scholar
• Gielen S, Adams V, Linke A, et al. Exercise training in chronic heart failure: correlation between reduced local inflammation and improved oxidative capacity in the skeletal muscle. Eur J Cardiovasc Prev Rehabil. 2005;12:393–400.
   PubMedGoogle Scholar
• Marquis K, Debigare R, Lacasse Y, et al. Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002;166:809–813.
   PubMed Web of Science ®Google Scholar
• Seymour JM, Spruit MA, Hopkinson NS, et al. The prevalence of quadriceps weakness in COPD and the relationship with disease severity. Eur Respir J. 2010;36:81–88.
   PubMed Web of Science ®Google Scholar
• Shrikrishna D, Patel M, Tanner RJ, et al. Quadriceps wasting and physical inactivity in patients with COPD. Eur Respir J. 2012;40:1115–1122.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Sznajder JI. Epigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction. J Appl Physiol. 2013;114:1263–1272.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Gea J. Epigenetics and muscle dysfunction in chronic obstructive pulmonary disease. Transl Res. 2015;165:61–73.
   PubMed Web of Science ®Google Scholar
• Donaldson A, Natanek SA, Lewis A, et al. Increased skeletal muscle-specific microRNA in the blood of patients with COPD. Thorax. 2013;68:1140–1149.
   PubMed Web of Science ®Google Scholar
• Lewis A, Riddoch-Contreras J, Natanek SA, et al. Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD. Thorax. 2012;67:26–34.
   PubMed Web of Science ®Google Scholar
• Puig-Vilanova E, Ausin P, Martinez-Llorens J, et al. Do epigenetic events take place in the vastus lateralis of patients with mild chronic obstructive pulmonary disease? PLoS One. 2014;9:e102296.
   PubMed Web of Science ®Google Scholar
• Puig-Vilanova E, Aguilo R, Rodriguez-Fuster A, et al. Epigenetic mechanisms in respiratory muscle dysfunction of patients with chronic obstructive pulmonary disease. PLoS One. 2014;9:e111514.
   PubMed Web of Science ®Google Scholar
• Puig-Vilanova E, Martinez-Llorens J, Ausin P, et al. Quadriceps muscle weakness and atrophy are associated with a differential epigenetic profile in advanced COPD. Clin Sci (Lond). 2015;128:905–921.
   PubMed Web of Science ®Google Scholar
• Terruzzi I, Senesi P, Montesano A, et al. Genetic polymorphisms of the enzymes involved in DNA methylation and synthesis in elite athletes. Physiol Genomics. 2011;43:965–973.
   PubMed Web of Science ®Google Scholar
• Timmons JA, Knudsen S, Rankinen T, et al. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol. 1985;2010(108):1487–1496.
   Google Scholar
• Gosselink R, Troosters T, Decramer M. Peripheral muscle weakness contributes to exercise limitation in COPD. Am J Respir Crit Care Med. 1996;153:976–980.
   PubMed Web of Science ®Google Scholar
• Swallow EB, Reyes D, Hopkinson NS, et al. Quadriceps strength predicts mortality in patients with moderate to severe chronic obstructive pulmonary disease. Thorax. 2007;62:115–120.
   PubMed Web of Science ®Google Scholar
• Patel MS, Natanek SA, Stratakos G, et al. Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;190:350–352.
   PubMed Web of Science ®Google Scholar
• Levine S, Bashir MH, Clanton TL, et al. COPD elicits remodeling of the diaphragm and vastus lateralis muscles in humans. J Appl Physiol. 2013;114:1235–1245.
   PubMed Web of Science ®Google Scholar
• Gea J, Agusti A, Roca J. Pathophysiology of muscle dysfunction in COPD. J Appl Physiol. 2013;114:1222–1234.
   PubMed Web of Science ®Google Scholar
• Mador MJ, Bozkanat E. Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Respir Res. 2001;2:216–224.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Schols AM, Polkey MI, et al. Cytokine profile in quadriceps muscles of patients with severe COPD. Thorax. 2008;63:100–107.
   PubMed Web of Science ®Google Scholar
• Fermoselle C, Rabinovich R, Ausin P, et al. Does oxidative stress modulate limb muscle atrophy in severe COPD patients? Eur Respir J. 2012;40:851–862.
   PubMed Web of Science ®Google Scholar
• Testelmans D, Crul T, Maes K, et al. Atrophy and hypertrophy signalling in the diaphragm of patients with COPD. Eur Respir J. 2010;35:549–556.
   PubMed Web of Science ®Google Scholar
• Marin-Corral J, Minguella J, Ramirez-Sarmiento AL, et al. Oxidised proteins and superoxide anion production in the diaphragm of severe COPD patients. Eur Respir J. 2009;33:1309–1319.
   PubMed Web of Science ®Google Scholar
• Ottenheijm CA, Heunks LM, Li YP, et al. Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;174:997–1002.
   PubMed Web of Science ®Google Scholar
• Ottenheijm CA, Lawlor MW, Stienen GJ, et al. Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Hum Mol Genet. 2011;20:2015–2025.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Bustamante V, Cejudo P, et al. Guidelines for the evaluation and treatment of muscle dysfunction in patients with chronic obstructive pulmonary disease. Arch Bronconeumol. 2015;51:384–395.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Gea J. Respiratory and limb muscle dysfunction in COPD. COPD. 2015;12:413–426.
   PubMedGoogle Scholar
• Barreiro E, Gea J. Molecular and biological pathways of skeletal muscle dysfunction in chronic obstructive pulmonary disease. Chron Respir Dis. 2016 Forthcoming.
   PubMedGoogle Scholar
• Maltais F, Decramer M, Casaburi R, et al. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014;189:e15–e62.
   PubMed Web of Science ®Google Scholar
• Puig-Vilanova E, Rodriguez DA, Lloreta J, et al. Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer. Free Radic Biol Med. 2015;79:91–108.
   PubMed Web of Science ®Google Scholar
• Lexell J, Downham D. What is the effect of ageing on type 2 muscle fibres? J Neurol Sci. 1992;107:250–251.
   PubMed Web of Science ®Google Scholar
• Kelsen SG, Ference M, Kapoor S. Effects of prolonged undernutrition on structure and function of the diaphragm. J Appl Physiol. 1985;58(4):1354–1359.
   PubMed Web of Science ®Google Scholar
• Dekhuijzen PN, Decramer M. Steroid-induced myopathy and its significance to respiratory disease: a known disease rediscovered. Eur Respir J. 1992;5:997–1003.
   PubMed Web of Science ®Google Scholar
• Puente-Maestu L, Perez-Parra J, Godoy R, et al. Abnormal mitochondrial function in locomotor and respiratory muscles of COPD patients. Eur Respir J. 2009;33:1045–1052.
   PubMed Web of Science ®Google Scholar
• Puente-Maestu L, Tejedor A, Lazaro A, et al. Site of mitochondrial reactive oxygen species production in skeletal muscle of chronic obstructive pulmonary disease and its relationship with exercise oxidative stress. Am J Respir Cell Mol Biol. 2012;47:358–362.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Ferrer D, Sanchez F, et al. Inflammatory cells and apoptosis in respiratory and limb muscles of patients with COPD. J Appl Physiol. 2011;111:808–817.
   PubMed Web of Science ®Google Scholar
• Baar K. Epigenetic control of skeletal muscle fibre type. Acta Physiol (Oxf). 2010;199:477–487.
   PubMed Web of Science ®Google Scholar
• Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31:27–36.
   PubMed Web of Science ®Google Scholar
• Lawless MW, O’Byrne KJ, Gray SG. Targeting oxidative stress in cancer. Expert Opin Ther Targets. 2010;14:1225–1245.
   PubMed Web of Science ®Google Scholar
• Zykovich A, Hubbard A, Flynn JM, et al. Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell. 2014;13:360–366.
   PubMed Web of Science ®Google Scholar
• Jin L, Jiang Z, Xia Y, et al. Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs. BMC Genomics. 2014;15:653.
   PubMedGoogle Scholar
• Livshits G, Gao F, Malkin I, et al. Contribution of heritability and epigenetic factors to skeletal muscle mass variation in United Kingdom twins. J Clin Endocrinol Metab. 2016;101:2450–2459.
   PubMed Web of Science ®Google Scholar
• Rzehak P, Saffery R, Reischl E, et al. Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-Study. PLoS One. 2016;11:e0155554.
   PubMed Web of Science ®Google Scholar
• Alamdari N, Aversa Z, Castillero E, et al. Acetylation and deacetylation–novel factors in muscle wasting. Metabolism. 2013;62:1–11.
   PubMed Web of Science ®Google Scholar
• Chen LF, Greene WC. Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. J Mol Med (Berl). 2003;81:549–557.
   PubMed Web of Science ®Google Scholar
• Sadoul K, Boyault C, Pabion M, et al. Regulation of protein turnover by acetyltransferases and deacetylases. Biochimie. 2008;90:306–312.
   PubMed Web of Science ®Google Scholar
• Seigneurin-Berny D, Verdel A, Curtet S, et al. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol. 2001;21:8035–8044.
   PubMed Web of Science ®Google Scholar
• Scroggins BT, Robzyk K, Wang D, et al. An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol Cell. 2007;25:151–159.
   PubMed Web of Science ®Google Scholar
• Jacobs SA, Khorasanizadeh S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002;295:2080–2083.
   PubMed Web of Science ®Google Scholar
• Taverna SD, Ilin S, Rogers RS, et al. Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 2006;24:785–796.
   PubMed Web of Science ®Google Scholar
• Cote J, Richard S. Tudor domains bind symmetrical dimethylated arginines. J Biol Chem. 2005;280:28476–28483.
   PubMed Web of Science ®Google Scholar
• Huang Y, Fang J, Bedford MT, et al. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science. 2006;312:748–751.
   PubMed Web of Science ®Google Scholar
• Angulo M, Lecuona E, Sznajder JI. Role of microRNAs in lung disease. Arch Bronconeumol. 2012;48:325–330.
   PubMed Web of Science ®Google Scholar
• Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase II. Embo J. 2004;23:4051–4060.
   PubMed Web of Science ®Google Scholar
• Perdiguero E, Sousa-Victor P, Ballestar E, et al. Epigenetic regulation of myogenesis. Epigenetics. 2009;4:541–550.
   PubMed Web of Science ®Google Scholar
• Kurihara Y, Watanabe Y. Arabidopsis micro-RNA biogenesis through Dicer-like 1 protein functions. Proc Natl Acad Sci U S A. 2004;101:12753–12758.
   PubMed Web of Science ®Google Scholar
• Hutvagner G. Small RNA asymmetry in RNAi: function in RISC assembly and gene regulation. FEBS Lett. 2005;579:5850–5857.
   PubMed Web of Science ®Google Scholar
• O’Rourke JR, Georges SA, Seay HR, et al. Essential role for Dicer during skeletal muscle development. Dev Biol. 2007;311:359–368.
   PubMed Web of Science ®Google Scholar
• Chen JF, Mandel EM, Thomson JM, et al. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2006;38:228–233.
   PubMed Web of Science ®Google Scholar
• Kim HK, Lee YS, Sivaprasad U, et al. Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol. 2006;174:677–687.
   PubMed Web of Science ®Google Scholar
• Koutsoulidou A, Mastroyiannopoulos NP, Furling D, et al. Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle. BMC Dev Biol. 2011;11:34.
   PubMed Web of Science ®Google Scholar
• Deato MD, Marr MT, Sottero T, et al. MyoD targets TAF3/TRF3 to activate myogenin transcription. Mol Cell. 2008;32:96–105.
   PubMed Web of Science ®Google Scholar
• Nakaj0ima N, Takahashi T, Kitamura R, et al. MicroRNA-1 facilitates skeletal myogenic differentiation without affecting osteoblastic and adipogenic differentiation. Biochem Biophys Res Commun. 2006;350:1006–1012.
   PubMed Web of Science ®Google Scholar
• Elia L, Contu R, Quintavalle M, et al. Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions. Circulation. 2009;120:2377–2385.
   PubMed Web of Science ®Google Scholar
• Anderson C, Catoe H, Werner R. MIR-206 regulates connexin43 expression during skeletal muscle development. Nucleic Acids Res. 2006;34:5863–5871.
   PubMed Web of Science ®Google Scholar
• Dey BK, Gagan J, Dutta A. miR-206 and -486 induce myoblast differentiation by downregulating Pax7. Mol Cell Biol. 2011;31:203–214.
   PubMed Web of Science ®Google Scholar
• Crist CG, Montarras D, Pallafacchina G, et al. Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A. 2009;106:13383–13387.
   PubMed Web of Science ®Google Scholar
• Naguibneva I, Ameyar-Zazoua M, Polesskaya A, et al. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol. 2006;8:278–284.
   PubMed Web of Science ®Google Scholar
• Wang H, Garzon R, Sun H, et al. NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008;14:369–381.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhou L, Jiang P, et al. Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Mol Ther. 2012;20:1222–1233.
   PubMed Web of Science ®Google Scholar
• Rao PK, Kumar RM, Farkhondeh M, et al. Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A. 2006;103:8721–8726.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Samal E, Srivastava D. Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature. 2005;436:214–220.
   PubMed Web of Science ®Google Scholar
• Wu H, Rothermel B, Kanatous S, et al. Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. Embo J. 2001;20:6414–6423.
   PubMed Web of Science ®Google Scholar
• Ikeda S, He A, Kong SW, et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009;29:2193–2204.
   PubMed Web of Science ®Google Scholar
• Barreiro E, Peinado VI, Galdiz JB, et al. Cigarette smoke-induced oxidative stress: A role in chronic obstructive pulmonary disease skeletal muscle dysfunction. Am J Respir Crit Care Med. 2010;182:477–488.
   PubMed Web of Science ®Google Scholar
• Lewis A, Lee JY, Donaldson AV, et al. Increased expression of H19/miR-675 is associated with a low fat-free mass index in patients with COPD. J Cachexia Sarcopenia Muscle. 2016 Forthcoming.
   PubMed Web of Science ®Google Scholar
• Ellis PD, Martin KM, Rickman C, et al. Increased actin polymerization reduces the inhibition of serum response factor activity by Yin Yang 1. Biochem J. 2002;364:547–554.
   PubMed Web of Science ®Google Scholar
• Wang H, Hertlein E, Bakkar N, et al. NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007;27:4374–4387.
   PubMed Web of Science ®Google Scholar
• Natanek SA, Riddoch-Contreras J, Marsh GS, et al. Yin Yang 1 expression and localisation in quadriceps muscle in COPD. Arch Bronconeumol. 2011;47:296–302.
   PubMed Web of Science ®Google Scholar
• Liu N, Williams AH, Maxeiner JM, et al. microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice. J Clin Invest. 2012;122:2054–2065.
   PubMed Web of Science ®Google Scholar
• Orozco-Levi M, Lloreta J, Minguella J, et al. Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:1734–1739.
   PubMed Web of Science ®Google Scholar
• McCarthy JJ, Esser KA. MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol. 2007;102:306–313.
   PubMed Web of Science ®Google Scholar