Understanding COPD-overlap syndromes

References

• Venables PJ. Mixed connective tissue disease. Lupus. 2006;15(3):132–137.
   PubMed Web of Science ®Google Scholar
• Kaji M, Fujiwara Y, Shiba M, et al. Prevalence of overlaps between GERD, FD and IBS and impact on health-related quality of life. J Gastroenterol Hepatol. 2010;25(6):1151–1156.
   PubMed Web of Science ®Google Scholar
• Lohse AW, zum Buschenfelde KH, Franz B, et al. Characterization of the overlap syndrome of primary biliary cirrhosis (PBC) and autoimmune hepatitis: evidence for it being a hepatitic form of PBC in genetically susceptible individuals. Hepatology. 1999;29(4):1078–1084.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Chronic obstructive pulmonary disease (COPD). [cited 2016 Nov 16]. Available from: http://www.who.int/mediacentre/factsheets/fs315/en/
   Google Scholar
• Minino AM, Murphy SL, Xu J, et al. Deaths: final data for 2008. National Vital Stat Rep. 2011;59(10):1–126.
   Google Scholar
• World Health Organization. Global Health Observatory (GHO) data - Top 10 causes of death. [cited 2017 Feb 2]. Available from: http://www.who.int/gho/mortality_burden_disease/causes_death/top_10/en/
   Google Scholar
• Lopez-Campos JL, Ruiz-Ramos M, Soriano JB. Mortality trends in chronic obstructive pulmonary disease in Europe, 1994-2010: a joinpoint regression analysis. Lancet Respir Med. 2014;2(1):54–62.
   PubMed Web of Science ®Google Scholar
• Tan WC, Ng TP. COPD in Asia: where east meets west. Chest. 2008;133(2):517–527.
   PubMed Web of Science ®Google Scholar
• To T, Zhu J, Larsen K, et al. Progression from asthma to chronic obstructive pulmonary disease. Is air pollution a risk factor? Am J Respir Crit Care Med. 2016;194(4):429–438.
   PubMed Web of Science ®Google Scholar
• Oxman AD, Muir DC, Shannon HS, et al. Occupational dust exposure and chronic obstructive pulmonary disease. A systematic overview of the evidence. Am Rev Respir Dis. 1993;148(1):38–48.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Chronic Obstructive Lung Disease. GOLD 2017 global strategy for the diagnosis, management and prevention of COPD. [cited 2017 Feb 2]. Available from: http://goldcopd.org/gold-2017-global-strategy-diagnosis-management-prevention-copd/
   Google Scholar
• Global Initiative for Asthma. 2016 GINA report, global strategy for asthma management and prevention. [cited 2016 Nov 19]. Available from: http://ginasthma.org/2016-gina-report-global-strategy-for-asthma-management-and-prevention/
   Google Scholar
• Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med. 2015;373(13):1241–1249.
   PubMed Web of Science ®Google Scholar
• Orie NGM SH, De Vries K, Tammeling GJ, et al. The host factor in bronchitis. Bronchitis. Assen (Ed. The Netherlands: Royal Van Gorcum; 1961. p. 43–59.
   Google Scholar
• Vermeire PA, Pride NB. A “splitting” look at chronic nonspecific lung disease (CNSLD): common features but diverse pathogenesis. Eur Respir J. 1991;4(4):490–496.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Against the Dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases. Am J Respir Crit Care Med. 2006;174(3):240–243;discussion 243–244.
   Web of Science ®Google Scholar
• Postma DS, Weiss ST, van den Berge M, et al. Revisiting the Dutch hypothesis. J Allergy Clin Immunol. 2015;136(3):521–529.
   PubMed Web of Science ®Google Scholar
• Sluiter HJ, Koeter GH, de Monchy JG, et al. The Dutch hypothesis (chronic non-specific lung disease) revisited. Eur Respir J. 1991;4(4):479–489.
   PubMed Web of Science ®Google Scholar
• Sin DD, Miravitlles M, Mannino DM, et al. What is asthma-COPD overlap syndrome? Towards a consensus definition from a round table discussion. Eur Respir J. 2016;48(3):664–673.
   PubMed Web of Science ®Google Scholar
• Kiljander T, Helin T, Venho K, et al. Prevalence of asthma-COPD overlap syndrome among primary care asthmatics with a smoking history: a cross-sectional study. NPJ Primary Care Respir Med. 2015;25:15047.
   PubMed Web of Science ®Google Scholar
• Golpe R, Sanjuan Lopez P, Cano Jimenez E, et al. Distribution of clinical phenotypes in patients with chronic obstructive pulmonary disease caused by biomass and tobacco smoke. Arch Bronconeumol. 2014;50(8):318–324.
   PubMed Web of Science ®Google Scholar
• Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir Res. 2011;12:127.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Soriano JB, Ancochea J, et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status. Respir Med. 2013;107(7):1053–1060.
   PubMed Web of Science ®Google Scholar
• Miravitlles M, Soriano JB, Garcia-Rio F, et al. Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities. Thorax. 2009;64(10):863–868.
   PubMed Web of Science ®Google Scholar
• Tho NV, Park HY, Nakano Y. Asthma-COPD overlap syndrome (ACOS): a diagnostic challenge. Respirology. 2016;21(3):410–418.
   PubMed Web of Science ®Google Scholar
• Caillaud D, Chanez P, Escamilla R, et al. Asthma-COPD overlap syndrome (ACOS) vs ‘pure’ COPD: a distinct phenotype? Allergy. 2017;72(1):137–145.
   PubMed Web of Science ®Google Scholar
• Cosio BG, Soriano JB, López-Campos JL, et al. Defining the asthma-COPD overlap syndrome in a COPD cohort. Chest. 2016;149(1):45–52.
   PubMed Web of Science ®Google Scholar
• Sorino C, Pedone C, Scichilone N. Fifteen-year mortality of patients with asthma-COPD overlap syndrome. Eur J Intern Med. 2016;34:72–77.
   PubMed Web of Science ®Google Scholar
• Lange P, Colak Y, Ingebrigtsen TS, et al. Long-term prognosis of asthma, chronic obstructive pulmonary disease, and asthma-chronic obstructive pulmonary disease overlap in the Copenhagen City Heart study: a prospective population-based analysis. Lancet Respir Med. 2016;4(6):454–462.
   PubMed Web of Science ®Google Scholar
• McShane PJ, Naureckas ET, Tino G, et al. Non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med. 2013;188(6):647–656.
   PubMed Web of Science ®Google Scholar
• Pasteur MC, Bilton D, Hill AT. British Thoracic Society Non CFBGG.British Thoracic Society guideline for non-CF bronchiectasis. Thorax. 2010;65(7):577.
   PubMed Web of Science ®Google Scholar
• Barker AF. Bronchiectasis. N Engl J Med. 2002;346(18):1383–1393.
   PubMed Web of Science ®Google Scholar
• Agusti A, Calverley PM, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res. 2010;11:122.
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia MA, Soler-Cataluna JJ, Donat Sanz Y, et al. Factors associated with bronchiectasis in patients with COPD. Chest. 2011;140(5):1130–1137.
   PubMed Web of Science ®Google Scholar
• Patel IS, Vlahos I, Wilkinson TM, et al. Bronchiectasis, exacerbation indices, and inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170(4):400–407.
   PubMed Web of Science ®Google Scholar
• O’Brien C, Guest PJ, Hill SL, et al. Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care. Thorax. 2000;55(8):635–642.
   PubMed Web of Science ®Google Scholar
• Bafadhel M, Umar I, Gupta S, et al. The role of CT scanning in multidimensional phenotyping of COPD. Chest. 2011;140(3):634–642.
   PubMed Web of Science ®Google Scholar
• Gursel G. Does coexistence with bronchiectasis influence intensive care unit outcome in patients with chronic obstructive pulmonary disease? Heart Lung. 2006;35(1):58–65.
   PubMed Web of Science ®Google Scholar
• De Soyza A, McDonnell MJ, Goeminne PC et al. Bronchiectasis Rheumatoid overlap syndrome (BROS) is an independent risk factor for mortality in patients with bronchiectasis: A multicentre cohort study. Chest.  2017;1-29. doi:10.1016/j.chest.2016.12.024.
   Google Scholar
• Cottin V, Nunes H, Brillet PY, et al. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005;26(4):586–593.
   PubMed Web of Science ®Google Scholar
• Ryerson CJ, Hartman T, Elicker BM, et al. Clinical features and outcomes in combined pulmonary fibrosis and emphysema in idiopathic pulmonary fibrosis. Chest. 2013;144(1):234–240.
   PubMed Web of Science ®Google Scholar
• Chilosi M, Poletti V, Rossi A. The pathogenesis of COPD and IPF: distinct horns of the same devil? Respir Res. 2012;13:3.
   PubMed Web of Science ®Google Scholar
• Epstein LJ, Kristo D, Strollo PJ Jr., et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;5(3):263–276.
   PubMed Web of Science ®Google Scholar
• Calverley PM, Brezinova V, Douglas NJ, et al. The effect of oxygenation on sleep quality in chronic bronchitis and emphysema. Am Rev Respir Dis. 1982;126(2):206–210.
   PubMed Web of Science ®Google Scholar
• Flenley DC. Sleep in chronic obstructive lung disease. Clin Chest Med. 1985;6(4):651–661.
   PubMed Web of Science ®Google Scholar
• Sanders MH, Newman AB, Haggerty CL, et al. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med. 2003;167(1):7–14.
   PubMed Web of Science ®Google Scholar
• Mermigkis C, Kopanakis A, Foldvary-Schaefer N, et al. Health-related quality of life in patients with obstructive sleep apnoea and chronic obstructive pulmonary disease (overlap syndrome). Int J Clin Pract. 2007;61(2):207–211.
   PubMed Web of Science ®Google Scholar
• He B-T, Lu G, Xiao S-C, et al. Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD. Thorax. 2017;72(3):256–262.
   PubMed Web of Science ®Google Scholar
• Marin JM, Soriano JB, Carrizo SJ, et al. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med. 2010;182(3):325–331.
   PubMed Web of Science ®Google Scholar
• Machado MC, Vollmer WM, Togeiro SM, et al. CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD. Eur Respir J. 2010;35(1):132–137.
   PubMed Web of Science ®Google Scholar
• Hawrylkiewicz I, Sliwinski P, Gorecka D, et al. Pulmonary haemodynamics in patients with OSAS or an overlap syndrome. Monaldi Arch Chest Dis. 2004;61(3):148–152.
   PubMedGoogle Scholar
• Sharma B, Neilan TG, Kwong RY, et al. Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea. COPD. 2013;10(1):4–10.
   PubMedGoogle Scholar
• Hurst JR, Elborn JS, De Soyza A, et al. COPD-bronchiectasis overlap syndrome. Eur Respir J. 2015;45(2):310–313.
   PubMed Web of Science ®Google Scholar
• King TE Jr, Bradford WZ, Castro-Bernardini S, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2083–2092.
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia MA, Soler-Cataluna JJ, Catalan-Serra P, et al. Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis. Chest. 2012;141(2):461–468.
   PubMed Web of Science ®Google Scholar
• Cazzola M, Rogliani P. Do we really need asthma-chronic obstructive pulmonary disease overlap syndrome? J Allergy Clin Immunol. 2016;138(4):977–983.
   PubMed Web of Science ®Google Scholar
• Cameron SJ, Lewis KE, Huws SA et al. Metagenomic Sequencing of the Chronic Obstructive Pulmonary Disease Upper Bronchial Tract Microbiome Reveals Functional Changes Associated with Disease Severity. PLoS One. 2016;1-16. doi:10.1371/journal.pone.0149095.
   Google Scholar
• Rogers GB, Zain NM, Bruce KD, et al. A novel microbiota stratification system predicts future exacerbations in bronchiectasis. Ann Am Thorac Soc. 2014;11(4):496–503.
   PubMedGoogle Scholar
• Cameron SJ, Lewis KE, Huws SA, et al. Metagenomic sequencing of the chronic obstructive pulmonary disease upper bronchial tract microbiome reveals functional changes associated with disease severity. PLoS One. 2016;11(2):e0149095.
   PubMed Web of Science ®Google Scholar
• Budden KF, Gellatly SL, Wood DLA et al. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Micro. 201715(1):55-63.
   Google Scholar
• Han MK, Zhou Y, Murray S, et al. Lung microbiome and disease progression in idiopathic pulmonary fibrosis: an analysis of the COMET study. Lancet Respir Med. 2014;2(7):548–556.
   PubMed Web of Science ®Google Scholar
• Yii AC, Koh MS, Lapperre TS, et al. The emergence of Aspergillus species in chronic respiratory disease. Front Biosci (Schol Ed). 2017;9:127–138.
   PubMedGoogle Scholar
• Miravitlles M, Huerta A, Fernandez-Villar JA, et al. Generic utilities in chronic obstructive pulmonary disease patients stratified according to different staging systems. Health Qual Life Outcomes. 2014;12:120.
   PubMed Web of Science ®Google Scholar
• Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir Res. 2011;12(1):127–127.
   PubMedGoogle Scholar
• Gatheral T, Kumar N, Sansom B, et al. COPD-related bronchiectasis; independent impact on disease course and outcomes. COPD. 2014;11(6):605–614.
   PubMedGoogle Scholar
• Mao B, Lu HW, Li MH, et al. The existence of bronchiectasis predicts worse prognosis in patients with COPD. Sci Rep. 2015;5:10961.
   PubMed Web of Science ®Google Scholar
• Jin J, Yu W, Li S, et al. Factors associated with bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease. Medicine (Baltimore). 2016;95(29):e4219.
   PubMed Web of Science ®Google Scholar
• Akagi T, Matsumoto T, Harada T, et al. Coexistent emphysema delays the decrease of vital capacity in idiopathic pulmonary fibrosis. Respir Med. 2009;103(8):1209–1215.
   PubMed Web of Science ®Google Scholar
• Schmidt SL, Nambiar AM, Tayob N, et al. Pulmonary function measures predict mortality differently in IPF versus combined pulmonary fibrosis and emphysema. Eur Respir J. 2011;38(1):176–183.
   PubMed Web of Science ®Google Scholar
• Kim YJ, Shin SH, Park JW, et al. Annual change in pulmonary function and clinical characteristics of combined pulmonary fibrosis and emphysema and idiopathic pulmonary fibrosis: over a 3-year follow-up. Tuberc Respir Dis (Seoul). 2014;77(1):18–23.
   PubMedGoogle Scholar
• Wurst KE, Laurent SS, Hinds D, et al. Disease Burden of Patients with Asthma/COPD Overlap in a US Claims Database: Impact of ICD-9 Coding-based Definitions. COPD: Journal of Chronic Obstructive Pulmonary Disease. 2017;1-10. doi:10.1080/15412555.2016.1257598.
   Google Scholar
• Fu JJ, Gibson PG, Simpson JL, et al. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome. Respiration. 2014;87(1):63–74.
   PubMed Web of Science ®Google Scholar
• Izquierdo-Alonso JL, Rodriguez-Gonzalezmoro JM, De Lucas-Ramos P, et al. Prevalence and characteristics of three clinical phenotypes of chronic obstructive pulmonary disease (COPD). Respir Med. 2013;107(5):724–731.
   PubMed Web of Science ®Google Scholar
• Kessler R, Chaouat A, Schinkewitch P, et al. The obesity-hypoventilation syndrome revisited: a prospective study of 34 consecutive cases. Chest. 2001;120(2):369–376.
   PubMed Web of Science ®Google Scholar
• Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med. 2014;189(5):576–585.
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia MA, de Gracia J, Vendrell Relat M, et al. Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score. Eur Respir J. 2014;43(5):1357–1367.
   PubMed Web of Science ®Google Scholar
• Du Q, Jin J, Liu X, et al. Bronchiectasis as a comorbidity of chronic obstructive pulmonary disease: a systematic review and meta-analysis. PLoS One. 2016;11(3):e0150532.
   PubMed Web of Science ®Google Scholar
• Mannino DM. Coexisting asthma and COPD: confused clinicians or poor prognosticator? Chest. 2008;134(1):1–2.
   PubMed Web of Science ®Google Scholar
• Andersen H, Lampela P, Nevanlinna A, et al. High hospital burden in overlap syndrome of asthma and COPD. Clin Respir J. 2013;7(4):342–346.
   PubMed Web of Science ®Google Scholar
• Milanese M, Di Marco F, Corsico AG, et al. Asthma control in elderly asthmatics. An Italian observational study. Respir Med. 2014;108(8):1091–1099.
   PubMed Web of Science ®Google Scholar
• Kumbhare S, Pleasants R, Ohar JA, et al. Characteristics and prevalence of asthma/chronic obstructive pulmonary disease overlap in the United States. Ann Am Thorac Soc. 2016;13(6):803–810.
   PubMed Web of Science ®Google Scholar
• Ding B, DiBonaventura M, Karlsson N, et al. Asthma-chronic obstructive pulmonary disease overlap syndrome in the urban Chinese population: prevalence and disease burden using the 2010, 2012, and 2013 China National Health and Wellness Surveys. Int J Chron Obstruct Pulmon Dis. 2016;11:1139–1150.
   PubMedGoogle Scholar
• Kim MA, Noh CS, Chang YJ, et al. Asthma and COPD overlap syndrome is associated with increased risk of hospitalisation. Int J Tuberculosis Lung Dis. 2015;19(7):864–869.
   PubMed Web of Science ®Google Scholar
• Gerhardsson de Verdier M, Andersson M, Kern DM, et al. Asthma and chronic obstructive pulmonary disease overlap syndrome: doubled costs compared with patients with asthma alone. Value Health. 2015;18(6):759–766.
   PubMed Web of Science ®Google Scholar
• Yeh JJ, Wang YC, Kao CH. Asthma-chronic obstructive pulmonary disease overlap syndrome associated with risk of pulmonary embolism. PLoS One. 2016;11(9):e0162483.
   PubMed Web of Science ®Google Scholar
• Yeh JJ, Wang YC, Kao CH. Asthma-chronic obstructive pulmonary diseases overlap syndrome increases the risk of incident tuberculosis: a national cohort study. PLoS One. 2016;11(7):e0159012.
   PubMed Web of Science ®Google Scholar
• Chaouat A, Weitzenblum E, Krieger J, et al. Association of chronic obstructive pulmonary disease and sleep apnea syndrome. Am J Respir Crit Care Med. 1995;151(1):82–86.
   PubMed Web of Science ®Google Scholar
• Doyle TJ, Washko GR, Fernandez IE, et al. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012;185(7):756–762.
   PubMed Web of Science ®Google Scholar
• Menezes AM, Montes de Oca M, Perez-Padilla R, et al. Increased risk of exacerbation and hospitalization in subjects with an overlap phenotype: COPD-asthma. Chest. 2014;145(2):297–304.
   PubMed Web of Science ®Google Scholar
• Cottin V, Nunes H, Mouthon L, et al. Combined pulmonary fibrosis and emphysema syndrome in connective tissue disease. Arthritis Rheum. 2011;63(1):295–304.
   PubMed Web of Science ®Google Scholar
• Ravensberg AJ, Slats AM, van Wetering S, et al. CD8(+) T cells characterize early smoking-related airway pathology in patients with asthma. Respir Med. 2013;107(7):959–966.
   PubMed Web of Science ®Google Scholar
• Wenzel SE, Szefler SJ, Leung DY, et al. Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med. 1997;156(3 Pt 1):737–743.
   PubMed Web of Science ®Google Scholar
• Yii ACA, Tan GL, Tan KL, et al. Fixed airways obstruction among patients with severe asthma: findings from the Singapore General Hospital-Severe Asthma Phenotype Study. BMC Pulm Med. 2014;14(1):191.
   PubMed Web of Science ®Google Scholar
• Brightling CE, Monteiro W, Ward R, et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2000;356(9240):1480–1485.
   PubMed Web of Science ®Google Scholar
• Christenson SA, Steiling K, van den Berge M, et al. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;191(7):758–766.
   PubMed Web of Science ®Google Scholar
• Tashkin DP, Altose MD, Connett JE, et al. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1802–1811.
   PubMed Web of Science ®Google Scholar
• Gelb AF, Yamamoto A, Verbeken EK, et al. Unraveling the pathophysiology of the asthma-COPD overlap syndrome: unsuspected mild centrilobular emphysema is responsible for loss of lung elastic recoil in never smokers with asthma with persistent expiratory airflow limitation. Chest. 2015;148(2):313–320.
   PubMed Web of Science ®Google Scholar
• Chinn S, Jarvis D, Luczynska CM, et al. An increase in bronchial responsiveness is associated with continuing or restarting smoking. Am J Respir Crit Care Med. 2005;172(8):956–961.
   PubMed Web of Science ®Google Scholar
• Chaudhuri R, Livingston E, McMahon AD, et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med. 2003;168(11):1308–1311.
   PubMed Web of Science ®Google Scholar
• Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of Lung Health Study participants after 11 years. Am J Respir Crit Care Med. 2002;166(5):675–679.
   PubMed Web of Science ®Google Scholar
• To T, Zhu J, Larsen K, et al. Progression from asthma to chronic obstructive pulmonary disease. Is air pollution a risk factor? Am J Respir Crit Care Med. 2016;194(4):429–438.
   PubMed Web of Science ®Google Scholar
• Jamieson DB, Matsui EC, Belli A, et al. Effects of allergic phenotype on respiratory symptoms and exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188(2):187–192.
   PubMed Web of Science ®Google Scholar
• Fattahi F, ten Hacken NH, Lofdahl CG, et al. Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study. Respir Res. 2013;14:10.
   PubMed Web of Science ®Google Scholar
• King PT. The pathophysiology of bronchiectasis. Int J Chron Obstruct Pulmon Dis. 2009;4:411–419.
   PubMedGoogle Scholar
• Cole PJ. Inflammation: a two-edged sword–the model of bronchiectasis. Eur J Respir Dis Suppl. 1986;147:6–15.
   PubMedGoogle Scholar
• Salvi SS, Barnes PJ. Chronic obstructive pulmonary disease in non-smokers. Lancet. 2009;374(9691):733–743.
   PubMed Web of Science ®Google Scholar
• Whiteley M, Bangera MG, Bumgarner RE, et al. Gene expression in Pseudomonas aeruginosa biofilms. Nature. 2001;413(6858):860–864.
   PubMed Web of Science ®Google Scholar
• Pappalettera M, Aliberti S, Castellotti P, et al. Bronchiectasis: an update. Clin Respir J. 2009;3(3):126–134.
   PubMed Web of Science ®Google Scholar
• Garcia-Vidal C, Almagro P, Romani V, et al. Pseudomonas aeruginosa in patients hospitalised for COPD exacerbation: a prospective study. Eur Respir J. 2009;34(5):1072–1078.
   PubMed Web of Science ®Google Scholar
• Almagro P, Salvado M, Garcia-Vidal C, et al. Pseudomonas aeruginosa and mortality after hospital admission for chronic obstructive pulmonary disease. Respiration. 2012;84(1):36–43.
   PubMed Web of Science ®Google Scholar
• Groenewegen KH, Wouters EF. Bacterial infections in patients requiring admission for an acute exacerbation of COPD; a 1-year prospective study. Respir Med. 2003;97(7):770–777.
   PubMed Web of Science ®Google Scholar
• Patel IS, Seemungal TAR, Wilks M, et al. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax. 2002;57(9):759–764.
   PubMed Web of Science ®Google Scholar
• American Thoracic Society, European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003;168(7):818–900.
   PubMed Web of Science ®Google Scholar
• Cuvelier A, Muir JF, Hellot MF, et al. Distribution of alpha(1)-antitrypsin alleles in patients with bronchiectasis. Chest. 2000;117(2):415–419.
   PubMed Web of Science ®Google Scholar
• Shin MS, Ho KJ. Bronchiectasis in patients with alpha 1-antitrypsin deficiency. A rare occurrence? Chest. 1993;104(5):1384–1386.
   PubMed Web of Science ®Google Scholar
• Parr DG, Guest PG, Reynolds JH, et al. Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med. 2007;176(12):1215–1221.
   PubMed Web of Science ®Google Scholar
• Chotirmall SH, Al-Alawi M, McEnery T, et al. Alpha-1 proteinase inhibitors for the treatment of alpha-1 antitrypsin deficiency: safety, tolerability, and patient outcomes. Ther Clin Risk Manag. 2015;11:143–151.
   PubMed Web of Science ®Google Scholar
• Dawkins PA, Dawkins CL, Wood AM, et al. Rate of progression of lung function impairment in alpha1-antitrypsin deficiency. Eur Respir J. 2009;33(6):1338–1344.
   PubMed Web of Science ®Google Scholar
• Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol. 2014;76:493–513.
   PubMed Web of Science ®Google Scholar
• Navaratnam V, Fleming KM, West J, et al. The rising incidence of idiopathic pulmonary fibrosis in the U.K. Thorax. 2011;66(6):462–467.
   PubMed Web of Science ®Google Scholar
• Kohansal R, Martinez-Camblor P, Agusti A, et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am J Respir Crit Care Med. 2009;180(1):3–10.
   PubMed Web of Science ®Google Scholar
• Murray MA, Chotirmall SH. The impact of immunosenescence on pulmonary disease. Mediators Inflamm. 2015;692546:2015.
   Google Scholar
• Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128–1138.
   PubMed Web of Science ®Google Scholar
• Kim S, Clark S, Camargo CA Jr. Mortality after an emergency department visit for exacerbation of chronic obstructive pulmonary disease. COPD. 2006;3(2):75–81.
   PubMedGoogle Scholar
• Faner R, Rojas M, Macnee W, et al. Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2012;186(4):306–313.
   PubMed Web of Science ®Google Scholar
• MacNee W. Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2005;2(1):50–60.
   PubMedGoogle Scholar
• Rahman I, Skwarska E, Henry M, et al. Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis. Free Radic Biol Med. 1999;27(1–2):60–68.
   PubMed Web of Science ®Google Scholar
• Rode L, Bojesen SE, Weischer M, et al. Short telomere length, lung function and chronic obstructive pulmonary disease in 46,396 individuals. Thorax. 2013;68(5):429–435.
   PubMed Web of Science ®Google Scholar
• Dai J, Cai H, Zhuang Y, et al. Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population. Respirology. 2015;20(1):122–128.
   PubMed Web of Science ®Google Scholar
• Diaz de Leon A, Cronkhite JT, Katzenstein AL, et al. Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations. PLoS One. 2010;5(5):e10680.
   PubMed Web of Science ®Google Scholar
• Liu T, Ullenbruch M, Young Choi Y, et al. Telomerase and telomere length in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2013;49(2):260–268.
   PubMed Web of Science ®Google Scholar
• Naikawadi RP, Disayabutr S, Mallavia B, et al. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016;1(14):e86704.
   PubMed Web of Science ®Google Scholar
• Alder JK, Guo N, Kembou F, et al. Telomere length is a determinant of emphysema susceptibility. Am J Respir Crit Care Med. 2011;184(8):904–912.
   PubMed Web of Science ®Google Scholar
• Armanios MY, Chen JJ, Cogan JD, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356(13):1317–1326.
   PubMed Web of Science ®Google Scholar
• Tsakiri KD, Cronkhite JT, Kuan PJ, et al. Adult-onset pulmonary fibrosis caused by mutations in telomerase. Proc Natl Acad Sci USA. 2007;104(18):7552–7557.
   PubMed Web of Science ®Google Scholar
• Mieczkowski B, Ezzie ME. Update on obstructive sleep apnea and its relation to COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:349–362.
   PubMed Web of Science ®Google Scholar
• Poulain M, Doucet M, Major GC, et al. The effect of obesity on chronic respiratory diseases: pathophysiology and therapeutic strategies. CMAJ. 2006;174(9):1293–1299.
   PubMed Web of Science ®Google Scholar
• Taranto-Montemurro L, Messineo L, Perger E, et al. Cardiac sympathetic hyperactivity in patients with chronic obstructive pulmonary disease and obstructive sleep apnea. COPD. 2016;13(6):706–711.
   PubMedGoogle Scholar
• Ganga HV, Nair SU, Puppala VK, et al. Risk of new-onset atrial fibrillation in elderly patients with the overlap syndrome: a retrospective cohort study. J Geriatr Cardiol. 2013;10(2):129–134.
   PubMedGoogle Scholar
• Chaouat A, Weitzenblum E, Krieger J, et al. Pulmonary hemodynamics in the obstructive sleep apnea syndrome. Results in 220 consecutive patients. Chest. 1996;109(2):380–386.
   PubMed Web of Science ®Google Scholar
• Hurst JR, Perera WR, Wilkinson TM, et al. Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006;173(1):71–78.
   PubMed Web of Science ®Google Scholar
• Ryan S, Taylor CT, McNicholas WT. Predictors of elevated nuclear factor-kappaB-dependent genes in obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2006;174(7):824–830.
   PubMed Web of Science ®Google Scholar
• Takabatake N, Nakamura H, Abe S, et al. The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1179–1184.
   PubMed Web of Science ®Google Scholar
• Yokoe T, Minoguchi K, Matsuo H, et al. Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure. Circulation. 2003;107(8):1129–1134.
   PubMed Web of Science ®Google Scholar
• Lavie L. Obstructive sleep apnoea syndrome–an oxidative stress disorder. Sleep Med Rev. 2003;7(1):35–51.
   PubMed Web of Science ®Google Scholar
• Loebinger MR, Wells AU, Hansell DM, et al. Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur Respir J. 2009;34(4):843–849.
   PubMed Web of Science ®Google Scholar
• Ashley SL, Jegal Y, Moore TA, et al. gamma-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014;307(3):L219–230.
   PubMed Web of Science ®Google Scholar
• Edwards MR, Bartlett NW, Hussell T, et al. The microbiology of asthma. Nat Rev Microbiol. 2012;10(7):459–471.
   PubMed Web of Science ®Google Scholar
• Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260–270.
   PubMed Web of Science ®Google Scholar
• Budden KF, Gellatly SL, Wood DLA et al. Emerging pathogenic links between microbiota and the gut-lung axis. Nat Rev Micro. 2017;15(1):55-63.
   Google Scholar
• Chotirmall SH, Burke CM. Aging and the microbiome: implications for asthma in the elderly? Expert Rev Respir Med. 2015;9(2):125–128.
   PubMed Web of Science ®Google Scholar
• Morris A, Beck JM, Schloss PD, et al. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013;187(10):1067–1075.
   PubMed Web of Science ®Google Scholar
• Segal LN, Alekseyenko AV, Clemente JC, et al. Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation. Microbiome. 2013;1(1):19.
   PubMed Web of Science ®Google Scholar
• Denning DW, Pashley C, Hartl D, et al. Fungal allergy in asthma-state of the art and research needs. Clin Transl Allergy. 2014;4:14.
   PubMed Web of Science ®Google Scholar
• Chotirmall SH, Gellatly SL, Budden KF, et al. Microbiomes in respiratory health and disease: an Asia-Pacific perspective. Respirology. 2017;22(2):240–250.
   PubMed Web of Science ®Google Scholar
• Al-Alawi M, Hassan T, Chotirmall SH. Advances in the diagnosis and management of asthma in older adults. Am J Med. 2014;127(5):370–378.
   PubMed Web of Science ®Google Scholar
• Chotirmall SH, Watts M, Branagan P, et al. Diagnosis and management of asthma in older adults. J Am Geriatr Soc. 2009;57(5):901–909.
   PubMed Web of Science ®Google Scholar
• Kobayashi S, Hanagama M, Yamanda S, et al. Inflammatory biomarkers in asthma-COPD overlap syndrome. Int J Chron Obstruct Pulmon Dis. 2016;11:2117–2123.
   PubMed Web of Science ®Google Scholar
• Goto T, Camargo CA, Hasegawa K. Fractional exhaled nitric oxide levels in asthma-COPD overlap syndrome: analysis of the National Health and Nutrition Examination Survey, 2007-2012. Int J Chron Obstruct Pulmon Dis. 2016;11:2149–2155.
   PubMed Web of Science ®Google Scholar
• Chen F-J, Huang X-Y, Liu Y-L, et al. Importance of fractional exhaled nitric oxide in the differentiation of asthma-COPD overlap syndrome, asthma, and COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2385–2390.
   PubMed Web of Science ®Google Scholar
• Altenburg J, de Graaff CS, Stienstra Y, et al. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial. JAMA. 2013;309(12):1251–1259.
   PubMed Web of Science ®Google Scholar
• Crockett AJ, Cranston JM, Moss JR, et al. A review of long-term oxygen therapy for chronic obstructive pulmonary disease. Respir Med. 2001;95(6):437–443.
   PubMed Web of Science ®Google Scholar
• Richeldi L, du Bois RM, Raghu G, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–2082.
   PubMed Web of Science ®Google Scholar
• McNicholas WT, Strohl KP, White D et al. Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep. 1999;22(5):667-689.
   Google Scholar
• Bateman ED, Reddel HK, van Zyl-Smit RN, et al. The asthma–COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases? Lancet Respir Med. 2015;3(9):719–728.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Asthma-COPD overlap. Chest. 2016;149(1):7–8.
   PubMed Web of Science ®Google Scholar
• Jfm VB, Román-Rodríguez M, Palmer JF, et al. Comorbidome, pattern, and impact of asthma-COPD overlap syndrome in real life. Chest. 2016;149(4):1011–1020.
   PubMed Web of Science ®Google Scholar
• Ishiura Y, Fujimura M, Shiba Y, et al. A comparison of the efficacy of once-daily fluticasone furoate/vilanterole with twice-daily fluticasone propionate/salmeterol in asthma-COPD overlap syndrome. Pulm Pharmacol Ther. 2015;35:28–33.
   PubMed Web of Science ®Google Scholar
• Maltby S, Gibson PG, Powell H, et al. Omalizumab treatment response in a population with severe allergic asthma and overlapping COPD. Chest. 2017;151(1):78–89.
   PubMed Web of Science ®Google Scholar
• Pasteur MC, Bilton D, Hill AT. British Thoracic Society Bronchiectasis non CFGG. British Thoracic Society guideline for non-CF bronchiectasis. Thorax. 2010;65(Suppl 1):i1–58.
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia MA, Soler-Cataluna JJ, Perpina-Tordera M, et al. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest. 2007;132(5):1565–1572.
   PubMed Web of Science ®Google Scholar
• Washko GR, Hunninghake GM, Fernandez IE, et al. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011;364(10):897–906.
   PubMed Web of Science ®Google Scholar
• Cottin V, Le Pavec J, Prevot G, et al. Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome. Eur Respir J. 2010;35(1):105–111.
   PubMed Web of Science ®Google Scholar
• Seeger W, Adir Y, Barbera JA, et al. Pulmonary hypertension in chronic lung diseases. J Am Coll Cardiol. 2013;62(25 Suppl):D109–D116.
   PubMed Web of Science ®Google Scholar
• Weitzenblum E, Chaouat A, Kessler R, et al. Overlap syndrome: obstructive sleep apnea in patients with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2008;5(2):237–241.
   PubMedGoogle Scholar
• Kohnlein T, Windisch W, Kohler D, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014;2(9):698–705.
   PubMed Web of Science ®Google Scholar
• Agusti A, Bel E, Thomas M, et al. Treatable traits: toward precision medicine of chronic airway diseases. Eur Respir J. 2016;47(2):410–419.
   PubMed Web of Science ®Google Scholar
• Lange P, Celli B, Agusti A, et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N Engl J Med. 2015;373(2):111–122.
   PubMed Web of Science ®Google Scholar