Recognizing, quantifying and managing patient-ventilator asynchrony in invasive and noninvasive ventilation

References

• Sassoon CS, Foster GT. Patient-ventilator asynchrony. Curr Opin Crit Care. 2001;7(1):28–33.
   PubMedGoogle Scholar
• Thille AW, Rodriguez P, Cabello B, et al. Patient-ventilator asynchrony during assisted mechanical ventilation. Intensive Care Med. 2006;32(10):1515–1522.
   PubMed Web of Science ®Google Scholar
• Chao DC, Scheinhorn DJ, Stearn-Hassenpflug M. Patient-ventilator trigger asynchrony in prolonged mechanical ventilation. Chest. 1997;112(6):1592–1599.
   PubMed Web of Science ®Google Scholar
• de Wit M, Miller KB, Green DA, et al. Ineffective triggering predicts increased duration of mechanical ventilation. Crit Care Med. 2009;37(10):2740–2745.
   PubMed Web of Science ®Google Scholar
• Blanch L, Villagra A, Sales B, et al. Asynchronies during mechanical ventilation are associated with mortality. Intensive Care Med. 2015;41(4):633–641.
   PubMed Web of Science ®Google Scholar
• Georgopoulos D, Prinianakis G, Kondili E. Bedside waveforms interpretation as a tool to identify patient-ventilator asynchronies. Intensive Care Med. 2006;32(1):34–47.
   PubMed Web of Science ®Google Scholar
• Longhini F, Colombo D, Pisani L, et al. Efficacy of ventilator waveform observation for detection of patient-ventilator asynchrony during NIV: a multicentre study. ERJ Open Res. 2017;3:4.
   Google Scholar
• Parthasarathy S, Jubran A, Tobin MJ. Cycling of inspiratory and expiratory muscle groups with the ventilator in airflow limitation. Am J Respir Crit Care Med. 1998;158(5 Pt 1):1471–1478.
   PubMed Web of Science ®Google Scholar
• Leung P, Jubran A, Tobin MJ. Comparison of assisted ventilator modes on triggering, patient effort, and dyspnea. Am J Respir Crit Care Med. 1997;155(6):1940–1948.
   PubMed Web of Science ®Google Scholar
• Vaschetto R, Cammarota G, Colombo D, et al. Effects of propofol on patient-ventilator synchrony and interaction during pressure support ventilation and neurally adjusted ventilatory assist. Crit Care Med. 2014;42(1):74–82.
   PubMed Web of Science ®Google Scholar
• De Wit M, Pedram S, Best AM, et al. Observational study of patient-ventilator asynchrony and relationship to sedation level. J Crit Care. 2009;24(1):74–80.
   PubMed Web of Science ®Google Scholar
• Imanaka H, Nishimura M, Takeuchi M, et al. Autotriggering caused by cardiogenic oscillation during flow-triggered mechanical ventilation. Crit Care Med. 2000;28(2):402–407.
   PubMed Web of Science ®Google Scholar
• Vignaux L, Tassaux D, Jolliet P. Performance of noninvasive ventilation modes on ICU ventilators during pressure support: a bench model study. Intensive Care Med. 2007;33(8):1444–1451.
   PubMed Web of Science ®Google Scholar
• Chanques G, Kress JP, Pohlman A, et al. Impact of ventilator adjustment and sedation-analgesia practices on severe asynchrony in patients ventilated in assist-control mode. Crit Care Med. 2013;41(9):2177–2187.
   PubMed Web of Science ®Google Scholar
• Vignaux L, Vargas F, Roeseler J, et al. Patient-ventilator asynchrony during non-invasive ventilation for acute respiratory failure: a multicenter study. Intensive Care Med. 2009;35(5):840–846.
   PubMed Web of Science ®Google Scholar
• Mauri T, Bellani G, Grasselli G, et al. Patient-ventilator interaction in ARDS patients with extremely low compliance undergoing ECMO: a novel approach based on diaphragm electrical activity. Intensive Care Med. 2013;39(2):282–291.
   PubMed Web of Science ®Google Scholar
• Tassaux D, Michotte JB, Gainnier M, et al. Expiratory trigger setting in pressure support ventilation: from mathematical model to bedside. Crit Care Med. 2004;32(9):1844–1850.
   PubMed Web of Science ®Google Scholar
• Tokioka H, Tanaka T, Ishizu T, et al. The effect of breath termination criterion on breathing patterns and the work of breathing during pressure support ventilation. Anesth Analg. 2001;92(1):161–165.
   PubMed Web of Science ®Google Scholar
• Calderini E, Confalonieri M, Puccio PG, et al. Patient-ventilator asynchrony during noninvasive ventilation: the role of expiratory trigger. Intensive Care Med. 1999;25(7):662–667.
   PubMed Web of Science ®Google Scholar
• Cammarota G, Olivieri C, Costa R, et al. Noninvasive ventilation through a helmet in postextubation hypoxemic patients: physiologic comparison between neurally adjusted ventilatory assist and pressure support ventilation. Intensive Care Med. 2011;37(12):1943–1950.
   PubMed Web of Science ®Google Scholar
• Akoumianaki E, Lyazidi A, Rey N, et al. Mechanical ventilation-induced reverse-triggered breaths: a frequently unrecognized form of neuromechanical coupling. Chest. 2013;143(4):927–938.
   PubMed Web of Science ®Google Scholar
• Colombo D, Cammarota G, Alemani M, et al. Efficacy of ventilator waveforms observation in detecting patient-ventilator asynchrony. Crit Care Med. 2011;39(11):2452–2457.
   PubMed Web of Science ®Google Scholar
• Sinderby C, Liu S, Colombo D, et al. An automated and standardized neural index to quantify patient-ventilator interaction. Crit Care. 2013;17(5):R239.
   PubMed Web of Science ®Google Scholar
• Vaporidi K, Babalis D, Chytas A, et al. Clusters of ineffective efforts during mechanical ventilation: impact on outcome. Intensive Care Med. 2017;43(2):184–191.
   PubMed Web of Science ®Google Scholar
• Demoule A, Clavel M, Rolland-Debord C, et al. Neurally adjusted ventilatory assist as an alternative to pressure support ventilation in adults: a French multicentre randomized trial. Intensive Care Med. 2016;42(11):1723–1732.
   PubMed Web of Science ®Google Scholar
• Navalesi P, Longhini F. No harm, no benefit: should we give up with neurally adjusted ventilatory assist? Intensive Care Med. 2016;42(11):1770–1771.
   PubMed Web of Science ®Google Scholar
• Chen CW, Lin WC, Hsu CH, et al. Detecting ineffective triggering in the expiratory phase in mechanically ventilated patients based on airway flow and pressure deflection: feasibility of using a computer algorithm. Crit Care Med. 2008;36(2):455–461.
   PubMed Web of Science ®Google Scholar
• Blanch L, Sales B, Montanya J, et al. Validation of the Better Care (R) system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study. Intensive Care Med. 2012;38(5):772–780.
   PubMed Web of Science ®Google Scholar
• Mulqueeny Q, Ceriana P, Carlucci A, et al. Automatic detection of ineffective triggering and double triggering during mechanical ventilation. Intensive Care Med. 2007;33(11):2014–2018.
   PubMed Web of Science ®Google Scholar
• Gutierrez G, Ballarino GJ, Turkan H, et al. Automatic detection of patient-ventilator asynchrony by spectral analysis of airway flow. Crit Care. 2011;15(4):R167.
   PubMed Web of Science ®Google Scholar
• Navalesi P. On the imperfect synchrony between patient and ventilator. Crit Care. 2011;15(4):181.
   PubMed Web of Science ®Google Scholar
• Younes M, Brochard L, Grasso S, et al. A method for monitoring and improving patient: ventilator interaction. Intensive Care Med. 2007;33(8):1337–1346.
   PubMed Web of Science ®Google Scholar
• Kondili E, Alexopoulou C, Xirouchaki N, et al. Estimation of inspiratory muscle pressure in critically ill patients. Intensive Care Med. 2010;36(4):648–655.
   PubMed Web of Science ®Google Scholar
• Navalesi P, Longhini F. Neurally adjusted ventilatory assist. Curr Opin Crit Care. 2015;21(1):58–64.
   PubMed Web of Science ®Google Scholar
• Rolland-Debord C, Bureau C, Poitou T, et al. Prevalence and prognosis impact of patient-ventilator asynchrony in early phase of weaning according to two detection methods. Anesthesiology. 2017;127(6):989–997.
   PubMed Web of Science ®Google Scholar
• Vignaux L, Grazioli S, Piquilloud L, et al. Optimizing patient-ventilator synchrony during invasive ventilator assist in children and infants remains a difficult task*. Pediatr Crit Care Med. 2013;14(7):e316–e325.
   PubMed Web of Science ®Google Scholar
• Blokpoel RG, Burgerhof JG, Markhorst DG, et al. Patient-ventilator asynchrony during assisted ventilation in children. Pediatr Crit Care Med. 2016;17(5):e204–e211.
   PubMed Web of Science ®Google Scholar
• Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017;50:2.
   Web of Science ®Google Scholar
• Squadrone E, Frigerio P, Fogliati C, et al. Noninvasive vs. invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance. Intensive Care Med. 2004;30(7):1303–1310.
   PubMed Web of Science ®Google Scholar
• Elliott MW. The interface: crucial for successful noninvasive ventilation. Eur Respir J. 2004;23(1):7–8.
   PubMed Web of Science ®Google Scholar
• Nava S, Navalesi P, Carlucci A. Non-invasive ventilation. Minerva Anestesiol. 2009;75(1–2):31–36.
   PubMed Web of Science ®Google Scholar
• Tobin MJ, Jubran A, Laghi F. Patient-ventilator interaction. Am J Respir Crit Care Med. 2001;163(5):1059–1063.
   PubMed Web of Science ®Google Scholar
• Kondili E, Prinianakis G, Georgopoulos D. Patient-ventilator interaction. Br J Anaesth. 2003;91(1):106–119.
   PubMed Web of Science ®Google Scholar
• Hess DR. Patient-ventilator interaction during noninvasive ventilation. Respir Care. 2011;56(2):153–165; discussion 165–157.
   Web of Science ®Google Scholar
• Costa R, Navalesi P, Antonelli M, et al. Physiologic evaluation of different levels of assistance during noninvasive ventilation delivered through a helmet. Chest. 2005;128(4):2984–2990.
   PubMed Web of Science ®Google Scholar
• Doorduin J, Sinderby CA, Beck J, et al. Automated patient-ventilator interaction analysis during neurally adjusted non-invasive ventilation and pressure support ventilation in chronic obstructive pulmonary disease. Crit Care. 2014;18(5):550.
   PubMed Web of Science ®Google Scholar
• Schwarz SB, Magnet FS, Windisch W. Impact of home mechanical ventilation on sleep quality. Curr Opin Pulm Med. 2017;23(6):500–505.
   PubMed Web of Science ®Google Scholar
• Fanfulla F, Taurino AE, Lupo ND, et al. Effect of sleep on patient/ventilator asynchrony in patients undergoing chronic non-invasive mechanical ventilation. Respir Med. 2007;101(8):1702–1707.
   PubMed Web of Science ®Google Scholar
• Ramsay M, Mandal S, Suh ES, et al. Parasternal electromyography to determine the relationship between patient-ventilator asynchrony and nocturnal gas exchange during home mechanical ventilation set-up. Thorax. 2015;70(10):946–952.
   PubMed Web of Science ®Google Scholar
• Cuvelier A, Achour L, Rabarimanantsoa H, et al. A noninvasive method to identify ineffective triggering in patients with noninvasive pressure support ventilation. Respiration. 2010;80(3):198–206.
   PubMed Web of Science ®Google Scholar
• Thille AW, Cabello B, Galia F, et al. Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation. Intensive Care Med. 2008;34(8):1477–1486.
   PubMed Web of Science ®Google Scholar
• Colombo D, Cammarota G, Bergamaschi V, et al. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure. Intensive Care Med. 2008;34(11):2010–2018.
   PubMed Web of Science ®Google Scholar
• Nava S, Navalesi P. Bronchodilators and mechanical ventilation in COPD patients. Emptying, pumping or both? Intensive Care Med. 1999;25(11):1206–1208.
   PubMed Web of Science ®Google Scholar
• Appendini L, Patessio A, Zanaboni S, et al. Physiologic effects of positive end-expiratory pressure and mask pressure support during exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1994;149(5):1069–1076.
   PubMed Web of Science ®Google Scholar
• Tassaux D, Gainnier M, Battisti A, et al. Impact of expiratory trigger setting on delayed cycling and inspiratory muscle workload. Am J Respir Crit Care Med. 2005;172(10):1283–1289.
   PubMed Web of Science ®Google Scholar
• Costa R, Navalesi P, Cammarota G, et al. Remifentanil effects on respiratory drive and timing during pressure support ventilation and neurally adjusted ventilatory assist. Respir Physiol Neurobiol. 2017;244:10–16.
   PubMed Web of Science ®Google Scholar
• Conti G, Ranieri VM, Costa R, et al. Effects of dexmedetomidine and propofol on patient-ventilator interaction in difficult-to-wean, mechanically ventilated patients: a prospective, open-label, randomised, multicentre study. Crit Care. 2016;20(1):206.
   PubMedGoogle Scholar
• Navalesi P, Hernandez P, Wongsa A, et al. Proportional assist ventilation in acute respiratory failure: effects on breathing pattern and inspiratory effort. Am J Respir Crit Care Med. 1996;154(5):1330–1338.
   PubMed Web of Science ®Google Scholar
• Giannouli E, Webster K, Roberts D, et al. Response of ventilator-dependent patients to different levels of pressure support and proportional assist. Am J Respir Crit Care Med. 1999;159(6):1716–1725.
   PubMed Web of Science ®Google Scholar
• Xirouchaki N, Kondili E, Vaporidi K, et al. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support. Intensive Care Med. 2008;34(11):2026–2034.
   PubMed Web of Science ®Google Scholar
• Liu L, Xia F, Yang Y, et al. Neural versus pneumatic control of pressure support in patients with chronic obstructive pulmonary diseases at different levels of positive end expiratory pressure: a physiological study. Crit Care. 2015;19:244.
   PubMed Web of Science ®Google Scholar
• Longhini F, Ferrero F, De Luca D, et al. Neurally adjusted ventilatory assist in preterm neonates with acute respiratory failure. Neonatology. 2015;107(1):60–67.
   PubMed Web of Science ®Google Scholar
• Beck J, Emeriaud G, Liu Y, et al. Neurally-adjusted ventilatory assist (NAVA) in children: a systematic review. Minerva Anestesiol. 2016;82(8):874–883.
   PubMed Web of Science ®Google Scholar
• Vignaux L, Tassaux D, Carteaux G, et al. Performance of noninvasive ventilation algorithms on ICU ventilators during pressure support: a clinical study. Intensive Care Med. 2010;36(12):2053–2059.
   PubMed Web of Science ®Google Scholar
• Marjanovic NS, De Simone A, Jegou G, et al. A new global and comprehensive model for ICU ventilator performances evaluation. Ann Intensive Care. 2017;7(1):68.
   PubMedGoogle Scholar
• Carteaux G, Lyazidi A, Cordoba-Izquierdo A, et al. Patient-ventilator asynchrony during noninvasive ventilation: a bench and clinical study. Chest. 2012;142(2):367–376.
   PubMed Web of Science ®Google Scholar
• Moerer O, Harnisch LO, Herrmann P, et al. Patient-ventilator interaction during noninvasive ventilation in simulated COPD. Respir Care. 2016;61(1):15–22.
   PubMed Web of Science ®Google Scholar
• Gay PC, Hess DR, Hill NS. Noninvasive proportional assist ventilation for acute respiratory insufficiency. Comparison with pressure support ventilation. Am J Respir Crit Care Med. 2001;164(9):1606–1611.
   PubMed Web of Science ®Google Scholar
• Fernandez-Vivas M, Caturla-Such J, Gonzalez de la Rosa J, et al. Noninvasive pressure support versus proportional assist ventilation in acute respiratory failure. Intensive Care Med. 2003;29(7):1126–1133.
   PubMed Web of Science ®Google Scholar
• Piquilloud L, Tassaux D, Bialais E, et al. Neurally adjusted ventilatory assist (NAVA) improves patient-ventilator interaction during non-invasive ventilation delivered by face mask. Intensive Care Med. 2012;38(10):1624–1631.
   PubMed Web of Science ®Google Scholar
• Schmidt M, Dres M, Raux M, et al. Neurally adjusted ventilatory assist improves patient-ventilator interaction during postextubation prophylactic noninvasive ventilation. Crit Care Med. 2012;40(6):1738–1744.
   PubMed Web of Science ®Google Scholar
• Bertrand PM, Futier E, Coisel Y, et al. Neurally adjusted ventilatory assist vs. pressure support ventilation for noninvasive ventilation during acute respiratory failure: a crossover physiologic study. Chest. 2013;143(1):30–36.
   PubMed Web of Science ®Google Scholar
• Cammarota G, Longhini F, Perucca R, et al. New setting of neurally adjusted ventilatory assist during noninvasive ventilation through a helmet. Anesthesiology. 2016;125(6):1181–1189.
   PubMed Web of Science ®Google Scholar
• Longhini F, Pan C, Xie J, et al. New setting of neurally adjusted ventilatory assist for noninvasive ventilation by facial mask: a physiologic study. Crit Care. 2017;21(1):170.
   PubMedGoogle Scholar
• Costa R, Navalesi P, Spinazzola G, et al. Influence of ventilator settings on patient-ventilator synchrony during pressure support ventilation with different interfaces. Intensive Care Med. 2010;36(8):1363–1370.
   PubMed Web of Science ®Google Scholar
• Fraticelli AT, Lellouche F, L’Her E, et al. Physiological effects of different interfaces during noninvasive ventilation for acute respiratory failure. Crit Care Med. 2009;37(3):939–945.
   PubMed Web of Science ®Google Scholar
• Navalesi P, Costa R, Ceriana P, et al. Non-invasive ventilation in chronic obstructive pulmonary disease patients: helmet versus facial mask. Intensive Care Med. 2007;33(1):74–81.
   PubMed Web of Science ®Google Scholar
• Olivieri C, Costa R, Spinazzola G, et al. Bench comparative evaluation of a new generation and standard helmet for delivering non-invasive ventilation. Intensive Care Med. 2013;39(4):734–738.
   PubMed Web of Science ®Google Scholar
• Vaschetto R, De Jong A, Conseil M, et al. Comparative evaluation of three interfaces for non-invasive ventilation: a randomized cross-over design physiologic study on healthy volunteers. Crit Care. 2014;18(1):R2.
   PubMed Web of Science ®Google Scholar
• Olivieri C, Longhini F, Cena T, et al. New versus conventional helmet for delivering noninvasive ventilation: a physiologic, crossover randomized study in critically Ill patients. Anesthesiology. 2016;124(1):101–108.
   PubMed Web of Science ®Google Scholar
• Longhini F, Scarlino S, Gallina MR, et al. Comparison of neurally adjusted ventilator assist in infants before and after extubation. Minerva Pediatr. 2018 Apr;70(2):133-140.
   Web of Science ®Google Scholar
• Zhu K, Rabec C, Gonzalez-Bermejo J, et al. Combined effects of leaks, respiratory system properties and upper airway patency on the performance of home ventilators: a bench study. BMC Pulm Med. 2017;17(1):145.
   PubMedGoogle Scholar
• Adler D, Perrig S, Takahashi H, et al. Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessness. Sleep Breath. 2012;16(4):1081–1090.
   PubMed Web of Science ®Google Scholar
• Duiverman ML, Huberts AS, van Eykern LA, et al. Respiratory muscle activity and patient-ventilator asynchrony during different settings of noninvasive ventilation in stable hypercapnic COPD: does high inspiratory pressure lead to respiratory muscle unloading? Int J Chron Obstruct Pulmon Dis. 2017;12:243–257.
   PubMed Web of Science ®Google Scholar