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Perspective

How close are we to definitively identifying the respiratory health effects of e-cigarettes?

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Pages 549-556 | Received 20 Mar 2018, Accepted 30 May 2018, Published online: 08 Jun 2018

References

  • Glasser AM, Katz L, Pearson JL, et al. Overview of electronic nicotine delivery systems: a systematic review. Am J Prev Med. 2017;52(2):e33–e66.
  • Yoong SL, Stockings E, Chai LK, et al. Prevalence of electronic nicotine delivery systems (ENDS) use among youth globally: a systematic review and meta-analysis of country level data. Aust N Z J Public Health; 2018;42(3):303–308.
  • Kasza KA, Ambrose BK, Conway KP, et al. Tobacco-product use by adults and youths in the United States in 2013 and 2014. N Engl J Med. 2017;376(4):342–353.
  • Coleman BN, Rostron B, Johnson SE, et al. Electronic cigarette use among US adults in the population assessment of tobacco and health (PATH) study, 2013–2014. Tob Control. 2017;26(e2):e117–e126.
  • Dockrell M, Morison R, Bauld L, et al. E-cigarettes: prevalence and attitudes in Great Britain. Nicotine Tob Res. 2013;15:1737–1744.
  • Hajek P. Electronic cigarettes have a potential for huge public health benefit. BMC Med. 2014;12:225.
  • Levy DT, Borland R, Lindblom EN, et al. Potential deaths averted in USA by replacing cigarettes with e-cigarettes. Tob Control. 2018;27(1):18–25.
  • Pisinger C, Dossing M. A systematic review of health effects of electronic cigarettes. Prev Med. 2014;69:248–260.
  • National Academies of Sciences, Engineering and Medicine. Public health consequences of e-cigarettes. Washington, DC: The National Academies Press; 2018. [cited 2018 Jan 30]. Available from: www.nationalacademies.org/eCigHealthEffects.
  • US Food and Drug Administration. Harmful and potentially harmful constituents in tobacco products and tobacco smoke: established List. Silver Spring, MD, USA: US Food and Drug Administration. 2012. [cited 2018 Jan 28]. Available from https://www.fda.gov/TobaccoProducts/Labeling/RulesRegulationsGuidance/ucm297786.htm
  • Laugesen M Safety report on the Ruyan® e-cigarette cartridge and inhaled aerosol. 2008. [cited 2017 Nov 18]. Available from: http://www.healthnz.co.nz/RuyanCartridgeReport30-Oct-08.pdf
  • Laugesen M Ruyan® e-cigarette bench-top tests. Poster session presented at: 15th annual meeting of the Society for Research on Nicotine and Tobacco (SRNT). Apr 27–30, 2009. Saggart, Dublin, Ireland. Poster 5–11. [cited 2018 Nov 20]. Available from: http://www.healthnz.co.nz/DublinEcigBenchtopHandout.pdf
  • Westenberger B. Evaluation of e-cigarettes. St. Louis, MO: Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis. 2009. [cited 2017 Nov 10]. Available from: http://www.fda.gov/downloads/drugs/Scienceresearch/UCM173250.pdf
  • Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23(2):133–139.
  • Williams M, Villarreal A, Bozhilov K, et al. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013;8(3):e57987.
  • Farsalinos KE, Voudris V, Poulas K. Are metals emitted from electronic cigarettes a reason for health concern? A risk-assessment analysis of currently available literature. Int J Environ Res Public Health. 2015;12(5):5215–5232.
  • Lerner CA, Sundar IK, Watson RM, et al. Environmental health hazards of e-cigarettes and their components: oxidants and copper in e-cigarette aerosols. Environ Pollut. 2015;198:100–107.
  • Saffari A, Daher N, Ruprecht A, et al. Particulate metals and organic compounds from electronic and tobacco-containing cigarettes: comparison of emission rates and secondhand exposure. Environ Sci Process Impacts. 2014;16:2259–2267.
  • Dunbar ZR, Das A, O’Connor RJ, et al. Lead levels in selected electronic cigarettes from Canada and the United States. Int J Environ Res Public Health. 2018 Jan 19;15(1):154.
  • Wei B, Goniewicz ML, O’Connor RJ, et al. Urinary metabolite levels of flame retardants in electronic cigarette users: a study using the data from NHANES 2013–2014. Int J Environ Res Public Health. 2018;15(2):pii:E201.
  • Pellegrino RM, Tinghino B, Mangiaracina G, et al. Electronic cigarettes: an evaluation of exposure to chemicals and fine particulate matter (PM). Ann Ig. 2012;24(4):279–288.
  • World Health Organization. WHO air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide: global update 2005, summary of risk assessment. Geneva, Switzerland: World Health Organization; 2006.
  • Farsalinos KE, Polosa R. Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review. Ther Adv Drug Saf. 2014;5(2):67–86.
  • Lerner CA, Sundar IK, Yao H, et al. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One. 2015;10(2):e0116732.
  • Leigh NJ, Lawton RI, Hershberger PA, et al. Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS). Tob Control. 2016;25(Suppl 2):ii81–ii87.
  • Garcia-Arcos I, Geraghty P, Baumlin N, et al. Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner. Thorax. 2016;71(12):1119–1129.
  • Welz C, Canis M, Schwenk-Zieger S, et al. Cytotoxic and genotoxic effects of electronic cigarette liquids on human mucosal tissue cultures of the oropharynx. J Environ Pathol Toxicol Oncol. 2016;35(4):343–354.
  • Yu V, Rahimy M, Korrapati A, et al. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016;52:58–65.
  • Ganapathy V, Manyanga J, Brame L, et al. Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage. PLoS ONE. 2017;12(5):e0177780.
  • Holliday R, Kist R, Bauld L. E-cigarette vapour is not inert and exposure can lead to cell damage. Evid Based Dent. 2016;17(1):2–3.
  • Larcombe AN, Janka MA, Mullins BJ, et al. The effects of electronic cigarette aerosol exposure on inflammation and lung function in mice. Am J Physiol Lung Cell Mol Physiol. 2017;313(1):L67–L79.
  • Lee HW, Park SH, Weng MW, et al. E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells. Proc Natl Acad Sci U S A. 2018;115(7):E1560–E1569.
  • Glantz SA, Bareham DW. E-cigarettes: use, effects on smoking, risks, and policy implications. Annu Rev Public Health. 2018;39:215–255.
  • Pechacek TF, Nayak P, Gregory KR, et al. The potential that electronic nicotine delivery systems can be a disruptive technology: results from a national survey. Nicotine Tob Res. 2016;18(10):1989–1997.
  • Polosa R, Morjaria JB, Caponnetto P, et al. Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study. Intern Emerg Med. 2014;9(5):537–546.
  • Marini S, Buonanno G, Stabile L, et al. Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide. Toxicol Appl Pharmacol. 2014;278:9–15.
  • Vardavas CI, Anagnostopoulos N, Kougias M, et al. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide. Chest. 2012;141(6):1400–1406.
  • Kumral TL, Saltürk Z, Yildirim G, et al. How does electronic cigarette smoking affect sinonasal symptoms and nasal mucociliary clearance? B-ENT. 2016;12(1):17–21.
  • Dicpinigaitis PV, Lee Chang A, Dicpinigaitis AJ, et al. Effect of electronic cigarette use on the urge-to-cough sensation. Nicotine Tob Res. 2016;18(8):1763–1765.
  • Dicpinigaitis PV, Lee Chang A, Dicpinigaitis AJ, et al. Effect of e-cigarette use on cough reflex sensitivity. Chest. 2016;149(1):161–165.
  • Choi K, Bernat D. E-cigarette use among Florida youth with and without asthma. Am J Prev Med. 2016;51(4):446–453.
  • McConnell R, Barrington-Trimis JL, Wang K, et al. Electronic cigarette use and respiratory symptoms in adolescents. Am J Respir Crit Care Med. 2017;195(8):1043–1049.
  • Wang MP, Ho SY, Leung LT, et al. Electronic cigarette use and respiratory symptoms in Chinese adolescents in Hong Kong. JAMA Pediatrics. 2016;170(1):89–91.
  • Kim SY, Sim S, Choi HG. Active, passive, and electronic cigarette smoking is associated with asthma in adolescents. Sci Rep. 2017;7(1):17789.
  • Schweitzer RJ, Wills TA, Tam E, et al. E-cigarette use and asthma in a multiethnic sample of adolescents. Prev Med. 2017;105:226–231.
  • Cho JH, Paik SY. Association between electronic cigarette use and asthma among high school students in South Korea. PLoS One. 2016;11(3):e0151022.
  • Tagiyeva N, Devereux G, Fielding S, et al. Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study. Am J Respir Crit Care Med. 2016;193(1):23–30.
  • Lange P, Çolak Y, Ingebrigtsen TS, et al. Long-term prognosis of asthma, chronic obstructive pulmonary disease, and asthma-chronic obstructive pulmonary disease overlap in the Copenhagen City Heart study: a prospective population-based analysis. Lancet Respir Med. 2016;4(6):454–462.
  • Farsalinos KE, Spyrou A, Tsimopoulou K, et al. Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Nat Scientific Rep. 2014;4:4133.
  • Hajek P, Przulj D, Phillips A, et al. Nicotine delivery to users from cigarettes and from different types of e-cigarettes. Psychopharmacology. 2017;234(5):773–779.
  • Brandon TH, Goniewicz ML, Hanna NH, et al. Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. J Clin Oncol. 2015;33(8):952–963.
  • Drope J, Cahn Z, Kennedy R, et al. Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine. CA Cancer J Clin. 2017;67(6):449–471.
  • Shahab L, Goniewicz M, Blount B, et al. nicotine, carcinogen, and toxin exposure in long-term e-cigarette and nicotine replacement therapy users: a cross-sectional study. Ann Intern Med. 2017;166(6):390–400.
  • Goniewicz ML, Gawron M, Smith DM, et al. Exposure to nicotine and selected toxicants in cigarette smokers who switched to electronic cigarettes: a longitudinal within-subjects observational study. Nicotine Tob Res. 2017;19(2):160–167.
  • Carpenter MJ, Heckman BW, Wahlquist AE, et al. A naturalistic, randomized pilot trial of e-cigarettes: uptake, exposure, and behavioral effects. Cancer Epidemiol Biomarkers Prev. 2017;26(12):1795–1803.
  • McRobbie H, Phillips A, Goniewicz ML, et al. Effects of switching to electronic cigarettes with and without concurrent smoking on exposure to nicotine, carbon monoxide, and acrolein. Cancer Prev Res (Phila). 2015;8(9):873–878.
  • Sherwood CL, Boitano S. Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine. Respir Res. 2016;17(1):57.
  • Saint-Criq V, Gray MA. Role of CFTR in epithelial physiology. Cell Mol Life Sci. 2017;74(1):93–115.
  • Ghosh A, Coakley RC, Mascenik T, et al. Chronic e-cigarette exposure alters the human bronchial epithelial proteome. Am J Respir Crit Care Med. 2018. Epub ahead of print.
  • Kaur G, Pinkston R, Mclemore B, et al. Immunological and toxicological risk assessment of e-cigarettes. Eur Respir Rev. 2018;27(147):170119.
  • Polosa R, Morjaria JB, Caponnetto P, et al. Evidence for harm reduction in COPD smokers who switch to electronic cigarettes. Respir Res. 2016;17:166.
  • Schober W, Szendrei K, Matzen W, et al. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J Hyg Environ Health. 2014;217(6):628–637.
  • Czogala J, Goniewicz ML, Fidelus B, et al. Secondhand exposure to vapors from electronic cigarettes. Nicotine Tob Res. 2014;16(6):655–662.
  • Logue JM, Sleiman M, Montesinos VN, et al. Emissions from electronic cigarettes: assessing vapers’ intake of toxic compounds, secondhand exposures, and the associated health impacts. Environ Sci Technol. 2017;51(16):9271–9279.
  • Poulianiti K, Karatzaferi C, Flouris AD, et al. Antioxidant responses following active and passive smoking of tobacco and electronic cigarettes. Toxicol Mech Methods. 2016;26(6):455–461.
  • Wilson N, Hoek J, Thomson G, et al. Should e-cigarette use be included in indoor smoking bans? Bull World Health Organ. 2017;95:540–541.
  • Rubinstein ML, Delucchi K, Benowitz NL, et al. Adolescent exposure to toxic volatile organic chemicals from e-cigarettes. Pediatrics. 2018;14(4):e20173557.
  • U.S. Preventing tobacco use among youth and young adults: a report of the surgeon general. Atlanta (GA): Department of Health and Human Services; 2010.
  • Willett JG, Bennett M, Hair EC, et al. Recognition, use and perceptions of JUUL among youth and young adults. Tob Control. 2018. DOI:10.1136/tobaccocontrol-2018-054273.
  • Kavuluru R, Han S, Hahn EJ. On the popularity of the USB flash drive-shaped electronic cigarette Juul. Tob Control. 2018. DOI:10.1136/tobaccocontrol-2018-054259

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