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Expert Review of Respiratory Medicine Volume 13, 2019 - Issue 6
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Editorial

Advances in synthetic lung surfactant protein technology

Frans J. WaltherDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1931-159XView further author information
ORCID Icon,
Larry M. GordonDepartments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAView further author information
&
Alan J. WaringDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USAView further author information
Pages 499-501 | Received 17 Dec 2018, Accepted 27 Feb 2019, Published online: 06 Mar 2019

References

  • Avery ME, Mead J. Surface properties in relation to atelectasis and hyaline membrane disease. AMA J Dis Child. 1959;97(5,Part 1):517–523.
  • Nogee LM, Wert SE, Proffit SA, et al. Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency. Am J Respir Crit Care Med. 2000;161:973–981.
  • Griese M, Lorenz E, Hengst M, et al. Surfactant proteins in pediatric interstitial lung disease. Pediatr Res. 2016;79(1–1):34–41.
  • Waring A, Taeusch W, Bruni R, et al. Synthetic amphipathic sequences of surfactant protein-B mimic several physicochemical and in vivo properties of native pulmonary surfactant proteins. Pept Res. 1989;2(5):308–313.
  • Walther FJ, Gordon LM, Waring AJ. Design of surfactant protein B peptide mimics based on the saposin fold for synthetic lung surfactants. Biomed Hub. 2016;1(3).
  • Waring AJ, Walther FJ, Gordon LM, et al. The role of charged amphipathic helices in the structure and function of surfactant protein B. J Pept Res. 2005;66(6):364–374.
  • Walther FJ, Waring AJ, Hernandez-Juviel JM, et al. Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. PLoS One. 2010;5(1):e8672.
  • Waring AJ, Gupta M, Gordon LM, et al. Stability of an amphipathic helix-hairpin surfactant peptide in liposomes. Biochim Biophys Acta. 2016;1858(12):3113–3119.
  • Revak SD, Merritt TA, Hallman M, et al. The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants. Pediatr Res. 1991;29(5):460–465.
  • Davis AJ, Jobe AH, Häfner D, et al. Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant. Am J Respir Crit Care Med. 1998;157(2):553–559.
  • Johansson J, Some M, Linderholm BM, et al. A synthetic surfactant based on a poly-Leu SP-C analog and phospholipids: effects on tidal volumes and lung gas volumes in ventilated immature newborn rabbits. J Appl Physiol (1985). 2003;95(5):2055–2063.
  • Ricci F, Murgia X, Razzetti R, et al. In vitro and in vivo comparison between poractant alfa and the new generation synthetic surfactant CHF5633. Pediatr Res. 2017;81(2):369–375.
  • Walther FJ, Waring AJ, Hernández-Juviel JM, et al. Surfactant protein C peptides with salt-bridges (“ion-locks”) promote high surfactant activities by mimicking the α-helix and membrane topography of the native protein. PeerJ. 2014;2:e485.
  • Czyzewski AM, McCaig LM, Dohm MT, et al. Effective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins. Sci Rep. 2018;8(1):6795.
  • Sweet DG, Turner MA, Straňák Z, et al. A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. Arch Dis Child Fetal Neonatal Ed. 2017;102(6):F497–F503.
  • Härtel C, Paul P, Hanke K, et al. Less invasive surfactant administration and complications of preterm birth. Sci Rep. 2018 May 29;8(1):8333.
  • Mulder EE, Lopriore E, Rijken M, et al. Changes in respiratory support of preterm infants in the last decade: are we improving? Neonatology. 2012;101(4):247–253.
  • Walther FJ, Hernández-Juviel JM, Waring AJ. Aerosol delivery of synthetic lung surfactant. PeerJ. 2014;2:e403.
  • Walther FJ, Gupta M, Lipp MM, et al. Aerosol delivery of dry powder synthetic lung surfactant to surfactant-deficient rabbits and preterm lambs on non-invasive respiratory support. Gates Open Res. 2019;3:6.

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