Radon exposure: a major cause of lung cancer

References

• United Nations Environment Programme (UNEP). Radiation: effects and sources. Vienna: United Nations: United Nations Environment Programme; 2016.
   Google Scholar
• Appleton JD. Radon in air and water essentials of medical geology. Dordrecht: Springer; 2013. p. 239–277.
   Google Scholar
• International Agency for Research on Cancer. Internalized alpha particle emitting radionuclides vol 100D. Lyon:IARC Monographs; Radiation. 2012.
   Google Scholar
• Iglesias C, Taboada J. Radon in Galicia. Procedia Earth Planet Sci. 2014;8:70–74.
   Google Scholar
• Quindos LS, Fernández PL, Sainz C, et al. Indoor radon in a Spanish region with different gamma exposure levels. J Environ Radioact. 2008;99:1544–1547.
   PubMed Web of Science ®Google Scholar
• National Research Council. Committee on health risks of exposure to radon (BEIR VI). Health effects of exposure to radon. Washington, DC: National Academy Press; 1999.
   Google Scholar
• Radon. IARC Monogr Eval Carcinog Risks Hum. 1988;43:173–259.
   PubMedGoogle Scholar
• Yngvenson A, Williams C, Hjerpe A, et al. p53 mutations in lung cancer associated with residential radon exposure. Cancer Epidemiol Biomarkers Prev. 1999;8:433–438.
   PubMed Web of Science ®Google Scholar
• U.S. Environmental Protection Agency. A citizen’s guide to radon: the guide to protecting yourself and your family from radon. U.S: Environmental Protection Agency; 2012.
   Google Scholar
• World Health Organization. Handbook on indoor radon: a public health perspective 2009. Geneva: WHO; 2009.
   Google Scholar
• Hauri DD, Huss A, Zimmermann F, et al. Prediction model for assessing residential radon concentration in Switzerland. J Environ Radioact. 2012;112:83–89.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Barros-Dios JM. Radon and lung cancerImplications for health workers, citizens and public administrators. Med Clínica. 2007;128:545–549.
   PubMed Web of Science ®Google Scholar
• Barros-Dios JM, Ruano-Ravina A, Gastelu-Iturri J, et al. Factors underlying residential radon concentration: results from Galicia, Spain. Environ Res. 2007;103:185–190.
   PubMed Web of Science ®Google Scholar
• Shaw SB, Eckhardt DAV. An assessment of radon in groundwater in New York state. Health Phys. 2012;103:311–316.
   PubMed Web of Science ®Google Scholar
• Richter M, Jann O, Kemski J, et al. Determination of radon exhalation from construction materials using VOC emission test chambers. Indoor Air. 2013;23:397–405.
   PubMed Web of Science ®Google Scholar
• Sundal AV, Henriksen H, Soldal O, et al. The influence of geological factors on indoor radon concentrations in Norway. Sci Total Environ. 2004;328:41–53.
   PubMed Web of Science ®Google Scholar
• Quindos LS, Fernández PL, Soto J. National survey on indoor radon in Spain. Environ Int. 1991;17:449–453.
   Web of Science ®Google Scholar
• Quindós LS, Fernández PL, Soto J. Study of areas of Spain with high indoor radon. Rad Meas. 1995;24:207–210.
   Web of Science ®Google Scholar
• Lorenzo-González M, Ruano-Ravina A, Peón J, et al. Residential radon in Galicia: a cross-sectional study in a radon-prone area. J Radiol Prot. 2017;37:728–741.
   PubMed Web of Science ®Google Scholar
• Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.
   PubMed Web of Science ®Google Scholar
• Bray F, Ferlay J, Soerjomataram I. Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
   PubMed Web of Science ®Google Scholar
• De Angelis R, Sant M, Coleman MP, et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE–5-a population-based study. Lancet Oncol. 2014;15:23–34.
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7–30.
   PubMed Web of Science ®Google Scholar
• SEER Cancer Statistic Review, 1975–2014. National Cancer Institute 2017. Available from: https://seer.cancer.gov/csr/1975_2014/
   Google Scholar
• Torre LA, Siegel RL, Jemal A. Lung cancer statistics. Adv Exp Med Biol. 2016;893:1–19.
   PubMed Web of Science ®Google Scholar
• Allemani C, Matsuda T, Di Carlo V, et al. Global surveillance of trends in cancer survival: analysis of individual records for 37,513,025 patients diagnosed with one of 18 cancers during 2000–2014 from 322 population-based registries in 71 countries (CONCORD-3). Lancet. 2018;391:1023–1075.
   Google Scholar
• De la Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clin Chest Med. 2011;32:605–644.
   PubMed Web of Science ®Google Scholar
• Lopez AD, Mathers CD, Ezzati M, et al. Measuring the global burden of disease and risk factors, 1990–2001. In: Lopez AD, Mathers CD, Ezzati M, et al., editors. Global burden of disease and risk factors. Internet. Washington (DC): World Bank; 2006. Chapter 1: 1-13.
   Google Scholar
• IARC. Tobacco smoking. IARC Monogr Eval Carcinog Risk Chem Hum. 1986;38:1–421.
   Google Scholar
• Hoffmann D, Hoffmann I. The changing cigarette, 1950–1995. J Toxicol Environ Health. 1997;50:307–364.
   PubMed Web of Science ®Google Scholar
• Rudin CM, Avila-Tang E, Harris CC, et al. Lung cancer in never smokers molecular profiles and therapeutic implications. Clin Cancer Res. 2009;15:5646–5661.
   PubMed Web of Science ®Google Scholar
• Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers – a different disease. Nat Rev Cancer. 2007;7:778–790.
   PubMed Web of Science ®Google Scholar
• Schüz J, Espina C, Villain P, et al. Her working groups of scientific experts, 2015. European code against cancer 4th edition: 12 ways to reduce your cancer risk. Cancer Epidemiol. 2015;39(Suppl. 1):S1–10.
   PubMedGoogle Scholar
• Darby S, Hill D, Auvinen A, et al. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005;330:223.
   PubMed Web of Science ®Google Scholar
• Krewski D, Lubin JH, Zielinski, et al. Residential radon and risk of lung cancer: a combined analysis of 7 North American case-control studies. Epidemiology. 2005;16:137–145.
   PubMed Web of Science ®Google Scholar
• U.S. Department of Health and Human Services. The health consequences of involuntary exposure to tobacco smoke: a report of the surgeon general external. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2006.
   Google Scholar
• U.S. Department of Health and Human Services. A report of the surgeon general: how tobacco smoke causes disease: what it means to you. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2010.
   Google Scholar
• Vallières E, Pintos J, Parent M-E, et al. Occupational exposure to wood dust and risk of lung cancer in two population-based case-control studies in Montreal, Canada. Environ Health Glob Access Sci Source. 2015;14:1.
   PubMed Web of Science ®Google Scholar
• Villeneuve PJ, Parent M-É, Harris SA, et al. Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces. BMC Cancer. 2012;12:595.
   PubMed Web of Science ®Google Scholar
• Boniol M, Koechlin A, Boyle P. Meta-analysis of occupational exposures in the rubber manufacturing industry and risk of cancer. Int J Epidemiol. 2017;46:1940–1947.
   PubMed Web of Science ®Google Scholar
• Guha N, Merletti F, Steenland NK, et al. Lung cancer risk in painters: a meta-analysis. Environ Health Perspect. 2010;118:303–312.
   PubMed Web of Science ®Google Scholar
• Boffetta P, Autier P, Boniol M, et al. An estimate of cancers attributable to occupational exposures in France. J Occup Environ Med. 2010;52:399–406.
   PubMed Web of Science ®Google Scholar
• Steenland K, Burnett ÃC, Lalich N, et al. Dying for work: the magnitude of US mortality from selected causes of death associated with occupation. Am J Ind Med. 2003;482:461–482.
   Google Scholar
• Ruano-Ravina A, Figueiras A, Barreiro-Carracedo MA, et al. Occupation and smoking as risk factors for lung cancer: a population-based case-control study. Am J Ind Med. 2003;43:149–155.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Figueiras A, Barros-Dios JM. Noxious exposures in leisure time and risk of lung cancer: a neglected exposure? Epidemiology. 2002;13:235–236.
   PubMed Web of Science ®Google Scholar
• Prini-Guadalupe L, Pérez-Ríos M, Ruano-Ravina A, et al. Leisure time activities and lung cancer. Epidemiology. 2012;23:352–353.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, García-Lavandeira JA, Torres-Durán M, et al. Leisure time activities related to carcinogen exposure and lung cancer risk in never smokers. A case-control study. Environ Res. 2014;132:33–37.
   PubMed Web of Science ®Google Scholar
• Tarrazo-Antelo AM, Ruano-Ravina A, Abal Arca J, et al. Fruit and vegetable consumption and lung cancer risk: a case-control study in Galicia, Spain. Nutr Cancer. 2014;66:1030–1037.
   PubMed Web of Science ®Google Scholar
• Dosil-Díaz O, Ruano-Ravina A, Gestal-Otero JJ, et al. Consumption of fruit and vegetables and risk of lung cancer: a case-control study in Galicia, Spain. Nutrition. 2008;24:407–413.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Figueiras A, Dosil-Diaz O, et al. A population based case-control study on fruit and vegetable intake and lung cancer: a paradox effect? Nutr Cancer. 2002;43:47–51.
   PubMed Web of Science ®Google Scholar
• Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150–1155.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Figueiras A, Barros-Dios JM. Type of wine and risk of lung cancer: a case control study in Spain. Thorax. 2004;9:981-985.
   Google Scholar
• García Lavandeira JA, Ruano-Ravina A, Kelsey KT, et al. Alcohol consumption and lung cancer risk in never smokers: a pooled analysis of case-control studies. Eur J Public Health. 2018;28:521–527.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, García-Basteiro AL, Pérez-Ríos M, et al. Lung cancer survival and deletion of GSTM1 and GSTT1 genes A case-series from Spain. Tumori. 2013;99:445–451.
   PubMed Web of Science ®Google Scholar
• Ramos Hernández C, Mouronte-Roibás C, Barros-Dios JM, et al. Deletion of GSTM1 and GSTT1 genes and lung cancer survival: a systematic review. Tumori. 2017;103:338–344.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Pereyra MF, Castro MT, et al. Genetic susceptibility, residential radon, and lung cancer in a radon prone area. J Thorac Oncol. 2014;9:1073–1080.
   PubMed Web of Science ®Google Scholar
• López-Cima MF, González-Arriaga P, García-Castro L, et al. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of Northern Spain. BMC Cancer. 2007;7:1–12.
   PubMed Web of Science ®Google Scholar
• Kiyohara C, Horiuchi T, Takayama K, et al. Genetic polymorphisms involved in carcinogen metabolism and DNA repair and lung cancer risk in a Japanese population. J Thorac Oncol. 2012;7:954–962.
   PubMed Web of Science ®Google Scholar
• Bei L, Xiao-Dong T, Yu-Fang G, et al. DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: a meta-analysis. Bull Cancer. 2015;102:332–339.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Torres-Durán M, Kelsey KT, et al. Residential radon, EGFR mutations and ALK alterations in never-smoking lung cancer cases. Eur Respir J. 2016;48:1462–1470.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Perez-Becerra R, Fraga M, et al. Analysis of the relationship between p53 immunohistochemical expression and risk factors for lung cancer, with special emphasis on residential radon exposure. Ann Oncol. 2007;19:109–114.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Faraldo-Valles MJ, Barros-Dios JM. Is there a specific mutation of p53 gene due to radon exposure? A systematic review. Int J Radiat Biol. 2009;85:614–621.
   PubMed Web of Science ®Google Scholar
• Van Dillen T, Dekkers F, Bijwaard H, et al. Lung cancer from radon: a two-stage model analysis of the WISMUT Cohort, 1955–1998. Radiat Res. 2011;175:119–130.
   PubMed Web of Science ®Google Scholar
• Keil AP, Richardson DB, Troester MA. Healthy worker survivor bias in the Colorado Plateau uranium miners cohort. Am J Epidemiol. 2015;181:762–770.
   PubMed Web of Science ®Google Scholar
• Rage E, Caër-Lorho S, Drubay D, et al. Mortality analyses in the updated French cohort of uranium miners (1946–2007). Int Arch Occup Environ Health. 2015;88:717–730.
   PubMed Web of Science ®Google Scholar
• Tomasek L. Lung cancer in a Czech cohort exposed to radon in dwellings 50 years of follow-up. Neoplasma. 2012;59:559–565.
   PubMed Web of Science ®Google Scholar
• Kreuzer M, Grosche B, Schnelzer M, et al. Radon and risk of death from cancer and cardiovascular diseases in the German uranium miner cohort study: follow-up 1946–2003. Radiat Environ Biophys. 2010;49:177–185.
   PubMed Web of Science ®Google Scholar
• Lubin JH, Wang ZY, Boice JD, et al. Risk of lung cancer and residential radon in China: pooled results of two studies. Int J Cancer J Int Cancer. 2004;109:132–137.
   PubMed Web of Science ®Google Scholar
• Barros-Dios JM, Barreiro MA, Ruano-Ravina A, et al. Exposure to residential radon and lung cancer in Spain: a population-based case-control study. Am J Epidemiol. 2002;156:548–555.
   PubMed Web of Science ®Google Scholar
• Barros-Dios JM, Ruano-Ravina A, Pérez-Ríos M, et al. Residential radon exposure, histologic types, and lung cancer risk. A case-control study in Galicia, Spain. Cancer Epidemiol Biomarkers Prev. 2012;21:951–958.
   PubMed Web of Science ®Google Scholar
• Pershagen G, Akerblom G, Axelson O, et al. Residential radon exposure and lung cancer in Sweden. N Engl J Med. 1994;330:159–164.
   PubMed Web of Science ®Google Scholar
• Kreienbrock L, Kreuzer M, Gerken M, et al. Case control study on lung cancer and residential radon in western Germany. Am J Epidemiol. 2001;153:42–52.
   PubMed Web of Science ®Google Scholar
• Pavia M, Bianco A, Pileggi C, et al. Meta-analysis of residential exposure to radon gas and lung cancer. Bull World Health Organ. 2003;81:732–738.
   PubMed Web of Science ®Google Scholar
• Zhang Z-L, Sun J, Dong J-Y, et al. Residential radon and lung cancer risk: an updated metaanalysis of case-control studies. Asian Pac J Cancer. 2012;13:2459–2465.
   PubMedGoogle Scholar
• Schoenberg JB, Klotz JB, Wilcox HB, et al. Case-control study of residential radon and lung cancer among New Jersey women. Cancer Res. 1990;50:6520–6524.
   PubMed Web of Science ®Google Scholar
• Létourneau EG, Krewski D, Choi NW, et al. Case-control study of residential radon and lung cancer in Winnipeg, Manitoba, Canada. Am J Epidemiol. 1994;140:310–322.
   PubMed Web of Science ®Google Scholar
• Auvinen A, Mäkeläinen I, Hakama M, et al. Indoor radon exposure and risk of lung cancer: a nested case-control study in Finland. J Natl Cancer Inst. 1996;88:966–972.
   PubMedGoogle Scholar
• Field RW, Steck DJ, Smith BJ, et al. Residential radon gas exposure and lung cancer: the IOWA radon lung cancer study. Am J Epidemiol. 2000;151:1091–1102.
   PubMed Web of Science ®Google Scholar
• Baysson H, Tirmarche M, Tymen G, et al. Indoor radon and lung cancer in France. Epidemiology. 2004;15:709–716.
   PubMed Web of Science ®Google Scholar
• Bochicchio F, Forastiere F, Farchi S, et al. Residential radon exposure, diet and lung cancer: a case-control study in a Mediterranean region. Int J Cancer. 2005;114:983–991.
   PubMed Web of Science ®Google Scholar
• Wichmann HE, Rosario AS, Heid IM, et al. Increased lung cancer risk due to residential radon in a pooled and extended analysis of studies in Germany. Health Phys. 2005;88:71–79.
   PubMed Web of Science ®Google Scholar
• Wilcox HB, Al-Zoughool M, Garner MJ, et al. Case-control study of radon and lung cancer in New Jersey. Radiat Prot Dosimetry. 2008;128:169–179.
   PubMed Web of Science ®Google Scholar
• Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–2917.
   PubMed Web of Science ®Google Scholar
• Alavanja MC, Brownson RC, Lubin JH, et al. Residential radon exposure and lung cancer among nonsmoking women. J Natl Cancer Inst. 1994;86:1829–1837.
   PubMedGoogle Scholar
• Lagarde F, Axelson G, Damber L, et al. Residential radon and lung cancer among never-smokers in Sweden. Epidemiology. 2001;12:396–404.
   PubMed Web of Science ®Google Scholar
• Torres-Duran M, Ruano-Ravina A, Parente-Lamelas I, et al. Lung cancer in never smokers: a case-control study in a radon-prone area (Galicia, Spain). Eur Respir J. 2014;44:994–1001.
   PubMed Web of Science ®Google Scholar
• Torres-Durán M, Barros-Dios JM, Fernández-Villar A, et al. Residential radon and lung cancer in never smokers A systematic review. Cancer Lett. 2014;345:21–26.
   PubMed Web of Science ®Google Scholar
• Lorenzo-Gonzalez M, Ruano-Ravina A, Torres-Durán M, et al. Lung cancer and residential radon in never smokers: a pooling study in the Northwest of Spain. Environ Res. 2019;172:713–718.
   PubMed Web of Science ®Google Scholar
• Wang Z, Lubin JH, Wang L, et al. Residential radon and lung cancer risk in a high-exposure area of Gansu Province, China. Am J Epidemiol. 2002;155:554–564.
   PubMed Web of Science ®Google Scholar
• Kreuzer M, Heinrich J, Kreienbrock L, et al. Risk factors for lung cancer among nonsmoking women. Int J Cancer. 2002;100:706–713.
   PubMed Web of Science ®Google Scholar
• Burns PA. UNSCEAR 54th session and 2006 report. J Radiol Prot. 2006;26:442–444.
   PubMed Web of Science ®Google Scholar
• Robertson A, Allen J, Laney R, et al. The cellular and molecular carcnogenic effects of radon exposure: a review. Int J Mol Sci. 2013;14:14024–14063.
   PubMed Web of Science ®Google Scholar
• Taylor JA, Watson MA, Deveraux TR, et al. P53 mutation hotspot in radon-associated lung cancer. Lancet. 1994;334:86–87.
   Google Scholar
• Choi JR, Koh SB, Park SY, et al. Novel genetic associations between lung cancer and indoor radon exposure. J Cancer Prev. 2017;22:234–240.
   PubMed Web of Science ®Google Scholar
• Loiselle JJ, Kee JM, Sutherland LC. Human lung epitelial cells cultued in the presence of radon-emitting rock experience gene expression changes similar to those associated with tobacco smoke exposure. J Environ Radioact. 2019;196:64–81.
   PubMed Web of Science ®Google Scholar
• Xu Q, Fang L, Chen B, et al. Radon induced mitochondrial dysfunction in human bronchial epithelial cells and epithelial-mesenchymal transition with long-term exposure. Toxic Res. 2018;8:90–100.
   Web of Science ®Google Scholar
• Autsavampromporn N, Klunkin P, Threeratana C, et al. Short telomere length as a biomarker risk of lung cancer development induced by high radon levels: a pilot study. Int J Environ Res Public Health. 2018;15:2152.
   Web of Science ®Google Scholar
• Schubauer-Berigan MK, Daniels RD, Pinkerton LE. Radon exposure and mortality among white and American Indian uranium miners: an update of the Colorado Plateau cohort. Am J Epidemiol. 2009;169:718–730.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Narocki C, López-Jacob MJ, et al. Indoor radon in Spanish workplaces. A pilot study before the introduction of the European Directive 2013/59/Euratom. Gac Sanit. 2018; S0213–9111(18):30142–0.
   Google Scholar
• Bolus NE. NCRP report 160 and what it means for medical imaging and nuclear medicine. J Nucl Med Technol. 2013;41:255–260.
   PubMedGoogle Scholar
• Ruano-Ravina A, Wakeford R The increasing exposure of the global population to ionizing radiation. Submitted.
   Google Scholar
• Torres-Durán M, Ruano-Ravina A, Parente-Lamelas I, et al. Alpha-1 antitrypsin deficiency and lung cancer risk. J Thorac Oncol. 2015;10:1279–1284.
   PubMed Web of Science ®Google Scholar
• Bonner MR, Bennett WP, Xiong W, et al. Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women. Int J Cancer. 2006;119:1462–1467.
   PubMed Web of Science ®Google Scholar
• Torres-Durán M, Ruano-Ravina A, Kelsey KT, et al. Environmental tobacco smoke exposure and EGFR and ALK alterations in never smokers’ lung cancer Results from the LCRINS study. Cancer Lett. 2017;411:130–135.
   PubMed Web of Science ®Google Scholar
• Salgado-Espinosa T, Barros-Dios JM, Ruano-Ravina A. Radon exposure and oropharyngeal cancer risk. Cancer Lett. 2015;369:45–49.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Dacosta-Urbieta A, Barros-Dios JM, et al. Radon exposure and tumors of the central nervous system. Gac Sanit. 2018;32:567–575.
   PubMed Web of Science ®Google Scholar
• Chen B, Yuan TW, Wang AQ, et al. Exposure to radon and kidney cancer: a systematic review and meta-analysis of observational epidemiological studies. Biomed Environ Sci. 2018;31:805–815.
   PubMed Web of Science ®Google Scholar
• Barbosa-Lorenzo R, Barros-Dios JM, Raíces Aldrey M, et al. Residential radon and cancers other than lung cancer: a cohort study in Galicia, a Spanish radon-prone area. Eur J Epidemiol. 2016;31:437–441.
   PubMed Web of Science ®Google Scholar
• Barbosa-Lorenzo R, Barros-Dios JM, Ruano-Ravina A. Radon and stomach cancer. Int J Epidemiol. 2017;46:767–768.
   PubMed Web of Science ®Google Scholar
• Messier KP, Serre ML. Lung and stomach cancer associations with groundwater radon in North Carolina, USA. Int J Epidemiol. 2017;46:676–685.
   PubMed Web of Science ®Google Scholar
• Kendall GM, Smith TJ. Doses to organs and tissues from radon and its decay products. J Radiol Prot. 2002;22:389–406.
   PubMedGoogle Scholar
• Global Strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (COPD). GOLD Report. 2019. Available from: https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf
   Google Scholar
• Turner MC, Krewski D, Chen Y, et al. Radon and COPD mortality in the American Cancer Society Cohort. Eur Respir J. 2012;39:1113–1119.
   PubMed Web of Science ®Google Scholar
• Barbosa-Lorenzo R, Ruano-Ravina A, Ramis R, et al. Residential radon and COPD An ecological study in Galicia, Spain. Int J Radiat Biol. 2017;93:222–230.
   PubMed Web of Science ®Google Scholar
• Ruano-Ravina A, Castro-Bernárdez M, Sande-Meijide M, et al. Short- versus long-term radon detectors: a comparative study in Galicia, NW Spain. J Environ Radioact. 2008;99:1121–1126.
   PubMed Web of Science ®Google Scholar
• Demoury C, Ielsch G, Hemon D, et al. A statistical evaluation of the influence of housing characteristics and geogenic radon potential on indoor radon concentrations in France. J Environ Radioact. 2013;126:216–225.
   PubMed Web of Science ®Google Scholar
• Rauch SA, Henderson SB. A comparison of two methods for ecologic classification of radon exposure in British Columbia: residential observations and the radon potential map of Canada. Can J Public Health. 2013;104(3):e240–5.
   PubMed Web of Science ®Google Scholar
• Appleton JD, Miles JCH, Young M. Comparison of Northern Ireland radon maps based on indoor radon measurements and geology with maps derived by predictive modelling of airborne radiometric and ground permeability data. Sci Total Environ. 2011;409:1572–1583.
   PubMed Web of Science ®Google Scholar
• Elío J, Crowley Q, Scanlon R, et al. Logistic regression model for detecting radon prone areas in Ireland. Sci Total Environ. 2017;599–600:1317–1329.
   PubMed Web of Science ®Google Scholar
• Elío J, Crowley Q, Scanlon R, et al. Estimation of residential radon exposure and definition of radon priority areas based on expected lung cancer incidence. Environ Int. 2018;114:69–76.
   PubMed Web of Science ®Google Scholar
• Directiva 2013/59/Euratom del Consejo de 5 de diciembre de 2013. [Internet].[citado abril 2019] Avaliable from: http://www.boe.es/doue/2014/013/L00001-00073.pdf
   Google Scholar
• Barbosa-Lorenzo R, Ruano-Ravina A, Cerdeira Caramés S, et al. Residential radon and lung cancer. An ecologic study in Galicia, Spain. Med Clínica. 2015;144:304–308.
   PubMed Web of Science ®Google Scholar
• United States Environmental Protection Agency. Radon. [Internet]. [cited 2019 Apr] Avaliable from https://www.epa.gov/radon/find-information-about-local-radon-zones-and-state-contact-information#radonmap
   Google Scholar
• Public Health England. UKradon. [Internet]. [cited 2019 Apr] Disponible desde: http://www.ukradon.org/information/ukmaps
   Google Scholar
• Environmental Protection Agency. Radon map [Internet]. [cited 2019 Apr] Avaliable from: http://www.epa.ie/radiation/radonmap/
   Google Scholar
• Dubois G, Bossew P, Tollefsen T, et al. First steps towards a European atlas of natural radiation: status of the European indoor radon map. J Environ Radioact. 2010;101:786–798.
   PubMed Web of Science ®Google Scholar
• Bossew P, Tollefsen T, Cinelli G, et al. Status of the European atlas of natural radiation. Radiat Prot Dosimetry. 2015;167:29–36.
   PubMed Web of Science ®Google Scholar
• Tollefsen T, Gruber V, Bossew P, et al. Status of the European indoor radon map. Radiat Prot Dosimetry. 2011;145:110–116.
   PubMed Web of Science ®Google Scholar
• Gruber V, Bossew P, De Cort M, et al. The European map of the geogenic radon potential. J Radiol Prot. 2013;33:51–60.
   PubMed Web of Science ®Google Scholar
• Laboratorio de Radón de Galicia (Radongal) [Internet] 2013. [cited 2019 Apr]. Available from: http://www.usc.es/radongal/mapa_med.html
   Google Scholar