282
Views
2
CrossRef citations to date
0
Altmetric
Perspective

The reality of LAMAs for adult asthmatic patients

, &
Pages 1087-1094 | Received 16 Apr 2020, Accepted 09 Jul 2020, Published online: 20 Jul 2020

References

  • Global Initiative for Asthma. Global strategy for asthma management and prevention. 2020. [cited 2019 Oct 10]. Available from: www.ginasthma.com
  • Dharmage S, Perret J, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7. DOI:10.3389/fped.2019.00246
  • Selroos O, Kupczyk M, Kuna P, et al. National and regional asthma programmes in Europe. Eur Respir Rev. 2015;24:474–483.
  • Sá-Sousa A, Fonseca J, Pereira A, et al. The Portuguese severe asthma registry: development, features, and data sharing policies. Biomed Res Int. 2018;2018:1–12.
  • Price D, Fletcher M, van der Molen T. Asthma control and management in 8,000 European patients: the REcognise Asthma and Link to Symptoms and Experience (REALISE) survey. NPJ Prim Care Respir Med. 2014;24. DOI:10.1038/npjpcrm.2014.9
  • Boehringer ingelheim pharmaceuticals I summary of product characteristics labelling and package leaflet. 208. [cited 2020 Jan 9]. Available from: http://mri.cts-mrp.eu/download/NL_H_0299_001_FinalPI.pdf
  • National Institute for Health and Care Excellence. ESNM55: asthma: tiotropium (Spiriva Respimat) [online]. 2015 [cited 2020 Jan 10]. Available from: http://www.nice.org.uk/advice/esnm
  • Sobieraj D, Baker W, Nguyen E, et al. Association of inhaled corticosteroids and long-acting muscarinic antagonists with asthma control in patients with uncontrolled, persistent asthma. JAMA. 2018;319(14):1473.
  • Lewis M, Short A, Lewis K. Autonomic nervous system control of the cardiovascular and respiratory systems in asthma. Respir Med. 2006;100:1688–1705.
  • Ferrando M, Bagnasco D, Braido F, et al. Umeclidinium for the treatment of uncontrolled asthma. Expert Opin Investig Drugs. 2017;26:761–766.
  • Cazzola M, Ora J, Rogliani P, et al. Role of muscarinic antagonists in asthma therapy. Expert Rev Respir Med. 2017;11:239–253. .
  • Scott G, Fryer A. Role of parasympathetic nerves and muscarinic receptors in allergy and asthma. Chem Immunol Allergy. 2012;48–69. DOI:10.1159/000336498
  • Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol. 2001;125:129–144.
  • Rogers L, Hanania N. Role of anticholinergics in asthma management. Curr Opin Pulm Med. 2015;21:103–108.
  • Mansfield L, Bernstein J. Tiotropium in asthma: from bench to bedside. Respir Med. 2019;154:47–55.
  • Gosens R, Gross N. The mode of action of anticholinergics in asthma. Eur Respir J. 2018;52:1701247.
  • Chari V, McIvor R. Tiotropium for the treatment of asthma: patient selection and perspectives. Can Respir J. 2018;2018:1–10. .
  • Lipworth B. Emerging role of long acting muscarinic antagonists for asthma. Br J Clin Pharmacol. 2013;77:55–62.
  • Boehringer Ingelheim Limited. Spiriva Respimat 2.5 microgram inhalation solution. [cited 2020 Jan 9]. Available from: http://www.medicines.org.uk/emc/medicine/20134/SPC
  • U.S. Food and Drug Administration. Prescribing information for Spiriva® Respimat® (tiotropium bromide) inhalation spray, for oral inhalation. 2017 [cited 2020 Mar 22]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021936s007lbl.pdf
  • Quirce S, Dominguez-Ortega J, Barranco P. Anticholinergics for treatment of asthma. J Investig Allergol Clin Immunol. 2015;25:84–93.
  • Haney S, Hancox RJ. Recovery from bronchoconstriction and bronchodilator tolerance. Clin Rev Allergy Immunol. 2006;31:181–196.
  • Calzetta L, Matera MG, Cazzola M. Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy. Eur J Pharmacol. 2015 Aug 15;761:168–173. Epub 2015 May 14. .
  • Halpin DM, Kaplan AG, Russell RK. Why choose tiotropium for my patient? A comprehensive review of actions and outcomes versus other bronchodilators. Respir Med. 2017;128:28–41.
  • Peters SP, Kunselman SJ, Icitovic N, et al. Tiotropium bromide stepup therapy for adults with uncontrolled asthma. N Engl J Med. 2010;363:1715–1726.
  • Kerstjens HAM, Casale TB, Bleecker ER, et al. Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, doubleblind, placebo-controlled, parallel-group, active-comparator, randomized trials. Lancet Respir Med. 2015;3:367–376.
  • Paggiaro P, Halpin DM, Buhl R, et al. The effect of tiotropium in symptomatic asthma despite low- to medium-dose inhaled corticosteroids: a randomized controlled trial. J Allergy Clin Immunol Pract. 2016;4:104–113.e2.
  • Fardon T, Haggart K, Lee D, et al. A proof of concept study to evaluate stepping down the dose of fluticasone in the combination with salmeterol and tiotropium in severe persistent asthma. Respir Med. 2007;101:1218–1228.
  • Kerstjens HA, Disse B, Schröder-Babo W, et al. Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial. J Allergy Clin Immunol. 2007;128:308–314.
  • Kerstjens HA, Engel M, Dahl R, et al. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367:1198–1207.
  • Abadoglu O, Berk S. Tiotropium may improve asthma symptoms and lung function in asthmatic patients with irreversible airway obstruction: the reallife data. Clin Respir J. 2016;10(4):421–427.
  • Slater M, Pavord I, Step SD. 4: stick or twist? A review of asthma therapy. BMJ Open Respir Res. 2016;3:e000143.
  • Chung K, Wenzel S, Brozek J, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2013;43:343–373.
  • Rhee C, Yoshisue H, Lad R. Fixed-dose combinations of long-acting bronchodilators for the management of COPD: global and Asian perspectives. Adv Ther. 2019;36:495–519.
  • Lee L, Yang S, Kerwin E, et al. The effect of fluticasone furoate/umeclidinium in adult patients with asthma: a randomized, dose-ranging study. Respir Med. 2015;54–62. DOI:10.1016/j.rmed.2014.09.012
  • Lazarus S, Krishnan J, King T, et al. Mometasone or tiotropium in mild asthma with a low sputum eosinophil level. N Engl J Med. 2015;380(21):2009–2019.
  • Ciprandi G, Tosca M, Silvestri M, et al. Inflammatory biomarkers for asthma endotyping and consequent personalized therapy. Expert Rev Clin Immunol. 2017;13(7):715–721.
  • Robinson D, Humbert M, Buhl R, et al. Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications. Clin Exp Allergy. 2017;47(2):161–175. .
  • Casale TB, Bateman ED, Aalbers R, et al. Once-daily tiotropium Respimat add-on therapy improves lung function and asthma control in moderate symptomatic asthma, independent of baseline characteristics. Eur Respir J. 2017;50:PA647.
  • Kerstjens HAM, Moroni-Zentgraf P, Tashkin DP, et al. Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status. Respir Med. 2016;117:198–206.
  • Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. 2002;19:217–224.
  • United States national institute of health, clinical trials database. [cited 2019 Oct 20]. Available from: https://clinicaltrials.gov/ct2/show/NCT02571777
  • United States national institute of health, clinical trials database. [cited 2019 Oct 20]. Available from: https://clinicaltrials.gov/ct2/show/record/NCT02924688
  • Paggiaro P, Kuna P, Kots M, et al. Efficacy and safety of a fixed combination extrafine beclomethasone dipropionate, formoterol fumarate, and glycopyrronium bromide (BDP/FF/GB) pMDI treatment compared to fixed combination BDP/FF in patients with uncontrolled asthma on medium dose ICS/LABA: the TRIMARAN study. Am J Respir Crit Care Med. 2019;199:A7080.
  • Canonica GWW, Virchow JC, Kotz M, et al. Efficacy and safety of high ICS dose fixed combination ICS/LABA/LAMA pMDI compared with ICS/LABA and ICS/LABA + LAMA in patients with uncontrolled asthma: the TRIGGER study. Am J Respir Crit Care Med. 2019;199:7362.
  • Virchow JC, Canonica WG, Paggiaro P, et al. Reducing the rate of severe asthma exacerbations using single-inhaler extrafine BDP/FF/GB combination compared to BDP/FF in patients with uncontrolled asthma: pooled results from the TRIMARAN and TRIGGER studies. Am J Respir Crit Care Med. 2019;394(10210):1737–1749.
  • Chapman D, Irvin C. Mechanisms of airway hyper-responsiveness in asthma: the past, present and yet to come. Clin Exp Allergy. 2015;45:706–719.
  • Bateman E, Rennard S, Barnes P, et al. Alternative mechanisms for tiotropium. Pulm Pharmacol Ther. 2009;22:533–542.
  • Cazzola M, Calzetta L, Puxeddu E, et al. Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells. Respir Res. 2016;17(1):70. .
  • Morrison J, Pearson S. The parasympathetic nervous system and the diurnal variation of lung mechanics in asthma. Respir Med. 1991;85:285–289.
  • Casarosa P, Pieper MP, Gantner F. Cross-talk between the human muscarinic M3 and b2 receptors: evidence for heterologous desensitization. Am J Respir Crit Care Med. 2010;181 (abs A6373).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.