Pediatric bronchoscopy: recent advances and clinical challenges

References

• Wood RE, Fink RJ. Applications of flexible fiberoptic bronchoscopes in infants and children. Chest. 1978;73:737–740.
   PubMed Web of Science ®Google Scholar
• Midulla F, de Blic J, Barbato A, et al. Flexible endoscopy of paediatric airways. Eur Respir J. 2003;22:698–708.
   PubMed Web of Science ®Google Scholar
• Faro A, Wood RE, Schechter MS, Leong AB, Wittkugel E, Abode K, Chmiel JF, Daines C, Davis S, Eber E, Huddleston C, Kilbaugh T, Kurland G, Midulla F, Molter D, Montgomery GS, Retsch-Bogart G, Rutter MJ, Visner G, Walczak SA, Ferkol TW, Michelson PH; American Thoracic Society Ad Hoc Committee on Flexible Airway Endoscopy in Children. Official American Thoracic Society technical standards: flexible airway endoscopy in children. Am J Respir Crit Care Med. 2015 May 1;191(9):1066–80. doi: 10.1164/rccm.201503-0474ST. PMID: 25932763
   Google Scholar
• Eber E, Antón-Pacheco JL, de Blic J, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J.2017 Dec 14; 50(6):1700901. PMID: 29242258.
   PubMed Web of Science ®Google Scholar
• Teague WG. Blood eosinophilia may not adequately estimate lung fluid eosinophilia in childhood asthma. J Allergy Clin Immunol Pract. 2019 September-October;7(7):2497–2498. PMID: 31495436
   PubMed Web of Science ®Google Scholar
• Kirst ME, Baker D, Li E, et al. Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation. PLoS One.2019 Sept 19; 14(9):e0222323. PMID: 31536536; PMCID: PMC6752789.
   PubMed Web of Science ®Google Scholar
• Ren CL, Esther CR Jr, Debley JS, et al. ATS Ad hoc committee on infants with recurrent or Persistent wheezing. Official American thoracic society clinical practice guidelines: diagnostic evaluation of infants with recurrent or persistent wheezing. Am J Respir Crit Care Med. 2016 August 1;194(3):356–373. PMID: 27479061.
   PubMed Web of Science ®Google Scholar
• Januska MN, Goldman DL, Webley W, et al. Bronchoscopy in severe childhood asthma: irresponsible or irreplaceable? Pediatr Pulmonol. 2020 March;553:795–802. Epub 2019 Nov 15. PMID: 31730298; PMCID: PMC7385726
   PubMed Web of Science ®Google Scholar
• Hysinger E, Friedman N, Jensen E, et al. Bronchoscopy in neonates with severe bronchopulmonary dysplasia in the NICU. J Perinatol. 2019 February;392:263–268. Epub 2018 Dec 5. PMID: 30518799.
   PubMed Web of Science ®Google Scholar
• Faro A, Wood RE, Schechter MS, et al. American thoracic society Ad hoc committee on flexible airway endoscopy in children. Official American thoracic society technical standards: flexible airway endoscopy in children. Am J Respir Crit Care Med.2015 May 1; 191(9):1066–1080. PMID: 25932763.
   PubMed Web of Science ®Google Scholar
• Barron SP, Kennedy MP. Single-use (disposable) flexible bronchoscopes: the future of bronchoscopy? Adv Ther. 2020 November;3711:4538–4548. . Epub 2020 Sept 17. PMID: 32944885; PMCID: PMC7497855
   PubMed Web of Science ®Google Scholar
• Chan JK, Ng I, Ang JP, et al. Randomised controlled trial comparing the Ambu aScopeTM2 with a conventional fibreoptic bronchoscope in orotrachealintubation of anaesthetised adult patients. Anaesth Intensive Care. 2015;43(4):479–484. .
   PubMed Web of Science ®Google Scholar
• Kristensen MS, Fredensborg BB. The disposable Ambu aScope vs. a conventional flexible videoscope for awake intubation—a randomised study. Acta Anaesthesiol Scand. 2013;57(7):888–895.
   PubMed Web of Science ®Google Scholar
• Zaidi SR, Collins AM, Mitsi E, et al. Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591). BMC Pulm Med. 2017 May 5;17(1):83.
   PubMedGoogle Scholar
• Wahidi MM, Lamb C, Murgu S, et al. American association for bronchology and interventional pulmonology (AABIP) statement on the use of bronchoscopy and respiratory specimen collection in patients with suspected or confirmed COVID-19 infection. J Bronchology Interv Pulmonol. 2020 Oct;27(4):e52–e54. .
   PubMed Web of Science ®Google Scholar
• McCahon RA, Whynes DK. Cost comparison of reusable and single-use fibrescopes in a large English teaching hospital. Anaesthesia. 2015;70(6):699–706.
   PubMed Web of Science ®Google Scholar
• Perbet S, Blanquet M, Mourgues C, et al. Cost analysis of (Ambu_aScopeTM) and reusable bronchoscopes in the ICU. Ann Intensive Care. 2017;7(3):1–6. .
   PubMedGoogle Scholar
• Edenharter GM, Gartner D, Pfo¨rringer D. Decision support for the capacity management of bronchoscopy devices: optimizing the cost-efficient mix of reusable and single-use devices through mathematical modeling. Anesth Analg. 2017;124(6):1963–1967.
   PubMed Web of Science ®Google Scholar
• Wood RE. The diagnostic effectiveness of the flexible bronchoscope in children. Pediatr Pulmonol. 1985 July-August;1(4):188–192. PMID: 4069807
   PubMedGoogle Scholar
• Wood RE. Spelunking in the pediatric airways: explorations with the flexible fiberoptic bronchoscope. Pediatr Clin North Am. 1984 August;31(4):785–799. . PMID: 6462800
   PubMed Web of Science ®Google Scholar
• Raine J, Warner JO. Fibreoptic bronchoscopy without general anaesthetic. Arch Dis Child. 1991 April;66(4):481–484. . PMID: 2031604; PMCID: PMC1793008
   PubMedGoogle Scholar
• Chai J, Wu XY, Han N, et al. A retrospective study of anesthesia during rigid bronchoscopy for airway foreign body removal in children: propofol and sevoflurane with spontaneous ventilation. Paediatr Anaesth. 2014 October;2410:1031–1036. Epub 2014 August 22. PMID: 25145573.
   PubMed Web of Science ®Google Scholar
• Chen L, Yu L, Fan Y, et al. A comparison between total intravenous anaesthesia using propofol plus remifentanil and volatile induction/maintenance of anaesthesia using sevoflurane in children undergoing flexible fibreoptic bronchoscopy. Anaesth Intensive Care. 2013 November;41(6):742–749. PMID: 24180715.
   PubMed Web of Science ®Google Scholar
• Londino AV 3rd, Jagannathan N. Anesthesia in diagnostic and therapeutic pediatric bronchoscopy. Otolaryngol Clin North Am. 2019 December;526:1037–1048. Epub 2019 Sept 11. PMID: 31521368.
   PubMed Web of Science ®Google Scholar
• de Blic J. Flexible bronchoscopy. In: Midulla F, Eber E, editors. ERS handbook: paediatric respiratory medicine. Sheffield: The European Respiratory Society; 2013. p. 132–139.
   Google Scholar
• Soyer T. The role bronchoscopy in the diagnosis of airway disease in children. J Thorac Dis. 2016;8:3420–3426.
   PubMed Web of Science ®Google Scholar
• Nicolai T. The role of rigid and flexible bronchoscopy in children. Paediatr Respir Rev. 2011;12:190–195.
   PubMed Web of Science ®Google Scholar
• Eber E, Antón-Pacheco JL, de Blic J, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J. 2017;50:1700901.
   PubMed Web of Science ®Google Scholar
• Yan C, Hu Y, Qiu G, et al. The clinical safety and efficacy of flexible bronchoscopy in a neonatal intensive care unit. Exp Ther Med. 2020;20:95.
   PubMed Web of Science ®Google Scholar
• Midulla F, Nenna R, Eber E. Bronchoalveolar lavage. In: Midulla F, Eber E, editors. ERS handbook: paediatric respiratory medicine. Sheffield: The European Respiratory Society; 2013. p. 140–145.
   Google Scholar
• Ratjen F, Bruch J. Adjustment of bronchoalveolar lavage volume to body weight in children. Pediatr Pulmonol. 1996;21:184–188.
   PubMed Web of Science ®Google Scholar
• Midulla F, Villani A, Merolla R, et al. Bronchoalveolar lavage studies in children without parenchymal lung disease: cellular constituents and protein levels. Pediatr Pulmonol. 1995;20:112–118.
   PubMed Web of Science ®Google Scholar
• de Blic J, McKelvie P, Le Bourgeois M, et al. Value of bronchoalveolar lavage in the management of severe acute pneumonia and interstitial pneumonitis in the immunocompromised child. Thorax. 1987;42:759–765.
   PubMed Web of Science ®Google Scholar
• Gilchrist FJ, Salamat S, Clayton S, et al. Bronchoalveolar lavage in children with cystic fibrosis: how many lobes should be sampled? Arch Dis Child. 2011;96:215–217.
   PubMed Web of Science ®Google Scholar
• Pohunek P, Pokorná H, Stríz I. Comparison of cell profiles in separately evaluated fractions of bronchoalveolar lavage (BAL) fluid in children. Thorax. 1996;51:615–618.
   PubMed Web of Science ®Google Scholar
• Gonsky K, Cohn R, Widger J, et al. Utility of bronchoscopy in immunocompromised paediatric patients: systematic review. Pediatr Resp Rev. 2020;34:24–34.
   PubMed Web of Science ®Google Scholar
• Tschiedel E, Goralski A, Steinmann J, et al. Multiplex PCR of bronchoalveolar lavage fluid in children enhances the rate of pathogen detection. BMC Pulm Med. 2019;19:132.
   PubMed Web of Science ®Google Scholar
• Radhakrishnan D, Yamashita C, Gillio-Meina C, et al. Translational research in pediatrics III: bronchoalveolar lavage. Pediatrics. 2014;134:135–154.
   PubMed Web of Science ®Google Scholar
• Sacco O, Santoro F, Ribera E, et al. Short-length ligamentum arteriosum as a cause of congenital narrowing of the left main stem bronchus. Pediatr Pulmonol. 2016;51(12):1356–1361.
   PubMed Web of Science ®Google Scholar
• Cakir E, Ersu RH, Uyan ZS, et al. Flexible bronchoscopy as a valuable tool in the evaluation of persistent wheezing in children. Int J Pediatr Otorhinolaryngol. 2009;73:1666–1668.
   PubMed Web of Science ®Google Scholar
• Gu W, Jiang W, Zhang X, et al. Refractory wheezing in Chinese children under 3 years of age: bronchial inflammation and airway malformation. BMC Pediatr. 2016;16:145.
   PubMed Web of Science ®Google Scholar
• Boesch RP, Baughn JM, Cofer SA, et al. Trans-nasal flexible bronchoscopy in wheezing children: diagnostic yield, impact on therapy, and prevalence of laryngeal cleft. Pediatr Pulmonol. 2018;53(3):310–315.
   PubMed Web of Science ®Google Scholar
• Marguet C, Jouen-Boedes F, Dean TP, et al. Bronchoalveolar cell profiles in children with asthma, infantile wheeze, chronic cough, or cystic fibrosis. Am J Respir Crit Care Med. 1999;159:1533–1540.
   PubMed Web of Science ®Google Scholar
• Le Bourgeois M, Goncalves M, Le Clainche L, et al. Bronchoalveolar cells in children<3 years old with severe recurrent wheezing. Chest. 2002;122:791–797.
   PubMed Web of Science ®Google Scholar
• Saglani S, Nicholson AG, Scallan M, et al. Investigation of young children with severe recurrent wheeze: any clinical benefit? Eur Resp J. 2006;27:29–35.
   PubMed Web of Science ®Google Scholar
• Boyer D, Barsky E, Papantonakis CM, et al. Diagnostic evaluation of infants with recurrent wheezing. Ann Am Thorac Soc. 2016;13:2057–2059.
   PubMed Web of Science ®Google Scholar
• Goussard P, Gie RP, Kling S, et al. Bronchoscopic assessment of airway involvement in children presenting with clinically significant airway obstruction due to tuberculosis. Pediatr Pulmonol. 2013;48:1000–1007.
   PubMed Web of Science ®Google Scholar
• Walters E, Goussard P, Bosch C, et al. GeneXpert MTB/RIF on bronchoalveolar lavage samples in children with suspected complicated intrathoracic tuberculosis: A pilot study. Pediatr Pulmonol. 2014;49:1133–1137.
   PubMed Web of Science ®Google Scholar
• Kitz R, Boehles HJ, Rosewich M, et al. Lipid-laden alveolar macrophages and pH monitoring in gastroesophageal reflux-related respiratory symptoms. Pulm Med. 2012;2012:673637.
   PubMedGoogle Scholar
• Abdallah AF, El-Desoky T, Fathi K, et al. Clinical utility of bronchoalveolar lavage pepsin in diagnosis of gastroesophageal reflux among wheezy infants. Can Respir J. 2016;51:9480843.
   Google Scholar
• Ribeiro V, Andrade J, Rose S, et al. Children with severe persistent asthma have disparate peripheral blood and lower airway eosinophil levels. J Allergy Clin Immunol Pract. 2019 September-October;77:2494–2496. . Epub 2019 Mar 21. PMID: 30904479; PMCID: PMC6733616
   PubMed Web of Science ®Google Scholar
• Teague WG, Lawrence MG, Shirley DT, et al. Lung lavage granulocyte patterns and clinical phenotypes in children with severe, therapy-resistant asthma. J Allergy Clin Immunol Pract. 2019 July-August;76:1803–1812.e10. Epub 2019 January 14. PMID: 30654199; PMCID: PMC6612461
   PubMed Web of Science ®Google Scholar
• Patel KK, Vicencio AG, Du Z, et al. Infectious Chlamydia pneumoniae is associated with elevated interleukin-8 and airway neutrophilia in children with refractory asthma. Pediatr Infect Dis J. 2010 December;29(12):1093–1098. . PMID: 21155094.
   PubMed Web of Science ®Google Scholar
• Patel KK, Webley WC. Respiratory chlamydiainfection induce release of hepoxilin A3 and histamine production by airway neutrophils. Front Immunol. 2018 October 15;9:2357. PMID: 30374355; PMCID: PMC6196283.
   PubMed Web of Science ®Google Scholar
• Xu X, Zhang D, Zhang H, et al. Neutrophil histamine contributes to inflammation in mycoplasma pneumonia. J Exp Med. 2006 December 25;20313:2907–2917. Epub 2006 December 11. PMID: 17158962; PMCID: PMC2118183.
   PubMed Web of Science ®Google Scholar
• Vicencio AG, Santiago MT, Tsirilakis K, et al. Fungal sensitization in childhood persistent asthma is associated with disease severity. Pediatr Pulmonol. 2014 January;491:8–14. Epub 2013 February 8. PMID: 23401301
   PubMed Web of Science ®Google Scholar
• Goldman DL, Chen Z, Shankar V, et al. Lower airway microbiota and mycobiota in children with severe asthma. J Allergy Clin Immunol. 2018 February;1412:808–811. e7. Epub . 2017 October 13. PMID: 29031597.
   PubMed Web of Science ®Google Scholar
• Spencer CY, Millman J, Veiga K, et al. Airway autoimmune inflammatory response (AAIR) syndrome: an asthma-autoimmune overlap disorder? Pediatrics. 2018 March;1413:e20170138. . Epub 2018 February 15. PMID: 29449341
   PubMed Web of Science ®Google Scholar
• Maggi JC, Nussbaum E, Babbitt C, et al. Pediatric fiberoptic bronchoscopy as adjunctive therapy in acute asthma with respiratory failure. Pediatr Pulmonol. 2012 December;4712:1180–1184. Epub 2012 May 15. PMID: 22588986
   PubMed Web of Science ®Google Scholar
• Cramer JD, Meraj T, Lavin JM, et al. Object-related aspiration deaths in children and adolescents in the United States, 1968 to 2017. JAMA. 2019 November 26;322(20):2020–2022. PMID: 31769817; PMCID: PMC6902204.
   PubMed Web of Science ®Google Scholar
• Schramm D, Ling K, Schuster A, et al. Foreign body removal in children: recommendations versus real life – a survey of current clinical management in Germany. Pediatr Pulmonol. 2017;52:656–661.
   PubMed Web of Science ®Google Scholar
• Righini CA, Morel N, Karkas A, et al. What is the diagnostic value of flexible bronchoscopy in the initial investigation of children with suspected foreign body aspiration? Int J Pediatr Otorhinolaryngol. 2007;71:1383–1390.
   PubMed Web of Science ®Google Scholar
• Martinot A, Closset M, Marquette CH, et al. Indications for flexible versus rigid bronchoscopy in children with suspected foreign-body aspiration. Am J Respir Crit Care Med. 1997;155:1676–1679.
   PubMed Web of Science ®Google Scholar
• Qiu W, Wu L, Chen Z. Foreign body aspiration in children with negative multi-detector computed tomography results: own experience during 2011–2018. Int J Pediatr Otorhinolaryngol. 2019;124(2019):90–93.
   PubMedGoogle Scholar
• Tenenbaum T, Kähler G, Janke C, et al. Management of foreign body removal in children by flexible bronchoscopy. J Bronchology Interv Pulmonol. 2017;24:21–28.
   PubMed Web of Science ®Google Scholar
• Tang LF, Xu YC, Wang YS, et al. Airway foreign body removal by flexible bronchoscopy: experience with 1027 children during 2000–2008. World J Pediatr. 2009;38:191–195.
   Google Scholar
• Moslehi MA. Foreign body retrieval by using flexible cryoprobe in children. J Bronchology Interv Pulmonol. 2020 July 7;Online ahead of print. doi: 10.1097/LBR.0000000000000698. PMID: 32649328.
   Google Scholar
• Hammer J, Trachsel D, Nicolai T, et al. Caution to use bronchoscopic CO2 cryotherapy for foreign body removal in children. Pediatr Pulmonol. 2016;51:889–891.
   PubMed Web of Science ®Google Scholar
• Swanson KL, Prakash UBS, Midthun DE, et al. Flexible bronchoscopic management of airway foreign bodies in children. Chest. 2002;121:1695–1700.
   PubMed Web of Science ®Google Scholar
• Schramm D, Yu Y, Wiemers A, Vossen C, Snijders D, Krivec U, Priftis K, Eber E, Pohunek P. Pediatric flexible and rigid bronchoscopy in European centers-Availability and current practice. Pediatr Pulmonol. 2017 Nov;52(11):1502–1508. doi: 10.1002/ppul.23823. Epub 2017 Sep 14. PMID: 28910517
   Google Scholar
• Brkic F, Umihanic S, Altumbabic H, et al. Death as a consequence of foreign body aspiration in children. Medical Archives. 2018;72:220. PMID: 30061771 PMCID: PMC6021165
   PubMedGoogle Scholar
• Shlizerman L, Mazzawi S, Rakover Y, et al. Foreign body aspiration in children: the effects of delayed diagnosis. Am J Otolaryngol. 2010;31:320–324.
   PubMed Web of Science ®Google Scholar
• Gaillard D, Jouet JB, Egreteau L, et al. Airway epithelial damage and inflammation in children with recurrent bronchitis. Am J Respir Crit Care Med. 1994 September;150(3):810–817. PMID: 8087356
   PubMed Web of Science ®Google Scholar
• Looi K, Sutanto EN, Banerjee B, et al. Bronchial brushings for investigating airway inflammation and remodelling. Respirology. 2011 July;16(5):725–737. PMID: 21624002
   PubMed Web of Science ®Google Scholar
• Bush A, Pohunek P. Brush biopsy and mucosal biopsy. Am J Respir Crit Care Med. 2000 August;162(2 Pt 2):S18–22. . PMID: 10934126
   PubMed Web of Science ®Google Scholar
• Barbato A, Turato G, Baraldo S, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med. 2006;174:975–981.
   PubMed Web of Science ®Google Scholar
• Pohunek P, Warner JO, Turzíková J, Kudrmann J, Roche WR. Markers of eosinophilic inflammation and tissue re-modelling in children before clinically diagnosed bronchial asthma. Pediatr Allergy Immunol. 2005 Feb;16(1):43–51. doi: 10.1111/j.1399-3038.2005.00239.x. PMID: 15693911
   Google Scholar
• Malmström K, Lohi J, Malmberg LP, et al. Airway hyperresponsiveness, remodeling and inflammation in infants with wheeze. Clin Exp Allergy. 2020 May;50(5):558–566. Epub 2020 Mar 23. PMID: 32159879
   PubMed Web of Science ®Google Scholar
• Gaillard D, Jouet JB, Egreteau L, et al. Airway epithelial damage and inflammation in children with recurrent bronchitis. Am J Respir Crit Care Med. 1994 September;150(3):810–817.
   PubMed Web of Science ®Google Scholar
• Koucký V, Uhlík J, Hoňková L, et al. Ventilation inhomogeneity and bronchial basement membrane changes in chronic neutrophilic airway inflammation. Chest. 2020 April;1574:779–789. Epub 2019 November 9.
   PubMed Web of Science ®Google Scholar
• de Blic J, Marchac V, Scheinmann P. Complications of flexible bronchoscopy in children: prospective study of 1,328 procedures. Eur Respir J. 2002 November;20(5):1271–1276. . PMID: 12449184
   PubMed Web of Science ®Google Scholar
• Salva PS, Theroux C, Schwartz D. Safety of endobronchial biopsy in 170 children with chronic respiratory symptoms. Thorax. 2003 December;58(12):1058–1060.
   PubMed Web of Science ®Google Scholar
• Regamey N, Balfour-Lynn I, Rosenthal M, et al. Time required to obtain endobronchial biopsies in children during fiberoptic bronchoscopy. Pediatr Pulmonol. 2009 January;44(1):76–79. PMID: 19085925
   PubMed Web of Science ®Google Scholar
• Greene CL, Reemtsen B, Polimenakos A, et al. Role of clinically indicated transbronchial lung biopsies in the management of pediatric post-lung transplant patients. Ann Thorac Surg. 2008 July;86(1):198–203. PMID: 18573423
   PubMed Web of Science ®Google Scholar
• Fan LL, Kozinetz CA, Wojtczak HA, et al. Diagnostic value of transbronchial, thoracoscopic, and open lung biopsy in immunocompetent children with chronic interstitial lung disease. J Pediatr. 1997 October;131(4):565–569. PMID: 9386660
   PubMed Web of Science ®Google Scholar
• Fruchter O, Kramer MR. Retrieval of various aspirated foreign bodies by flexible cryoprobe: in vitro feasibility study. Clin Respir J. 2015 April;92:176–179. Epub 2014 Mar 6. PMID: 24521482
   PubMed Web of Science ®Google Scholar
• Lentz RJ, Taylor TM, Kropski JA, et al. Utility of flexible bronchoscopic cryobiopsy for diagnosis of diffuse parenchymal lung diseases. J Bronchology Interv Pulmonol. 2018 April;25(2):88–96. .
   PubMed Web of Science ®Google Scholar
• Sharp C, McCabe M, Adamali H, et al. Use of transbronchial cryobiopsy in the diagnosis of interstitial lung disease-a systematic review and cost analysis. QJM. 2017 April 1;110(4):207–214. PMID: 27521581.
   PubMed Web of Science ®Google Scholar
• Rodgers BM, Moazam F, Talbert JL. Endotracheal cryotherapy in the treatment of refractory airway strictures. Ann Thorac Surg. 1983 January;35(1):52–57. . PMID: 6849581
   PubMed Web of Science ®Google Scholar
• Wang H, Zhang J, Li D, et al. Efficacy of bronchoscopic therapies for bronchial mucoepidermoid carcinoma in children: results from six patients. Tumori. 2015 January-February;1011:52–56. . Epub 2015 Feb 6. PMID: 25702664
   PubMed Web of Science ®Google Scholar
• Srikanta JT, Swarna S, Shylendra DS, et al. Transbronchial lung cryobiopsy for diagnosis of pediatric interstitial lung disease. Indian Pediatr. 2018 June 15;55(6):519–520. PMID: 29978822
   PubMed Web of Science ®Google Scholar
• Hammer J, Trachsel D, Nicolai T, et al. Caution to use bronchoscopic CO2 cryotherapy for foreign body removal in children. Pediatr Pulmonol. 2016 September;519:889–891. . Epub 2016 April 29. PMID: 27128205
   PubMed Web of Science ®Google Scholar
• Wang KP. Staging of bronchogenic carcinoma by bronchoscopy. Chest. 1994;106:588–593.
   PubMed Web of Science ®Google Scholar
• Holty JE, Kuschner WG, Gould MK. Accuracy of transbronchial needle aspiration for mediastinal staging of non-small cell lung cancer: a meta-analysis. Thorax. 2005;60:949–955.
   PubMed Web of Science ®Google Scholar
• Hermens FH, Van Engelenburg TC, Visser FJ, et al. Diagnostic yield of transbronchial histology needle aspiration in patients with mediastinal lymph node enlargement. Respiration. 2003;70:631–635.
   PubMed Web of Science ®Google Scholar
• Ferna´ndez-Villar A, Leiro V, Blanco M, et al. Efficacy and safety of the eXcelon transbronchial aspiration needle in mediastinal lymph node enlargement: a case-control study. Respiration. 2007;74:208–213.
   PubMed Web of Science ®Google Scholar
• Diacon AH, Schuurmans MM, Theron J, et al. Utility of rapid on-site evaluation of transbronchial needle aspirates. Respiration. 2005;72:182–188.
   PubMed Web of Science ®Google Scholar
• Wang KP, Terry PB. Transbronchial needle aspiration in the diagnosis and staging of bronchogenic carcinoma. Am Rev Respir Dis. 1983;127:344–347.
   PubMed Web of Science ®Google Scholar
• Goussard P, Gie RP, Kling S, et al. The diagnostic value and safety of transbronchial needle aspiration biopsy in children with mediastinal lymphadenopathy. Pediatr Pulmonol. 2010;45:1173–1179.
   PubMed Web of Science ®Google Scholar
• Bilaçeroğlu S, Günel O, Eriş N, et al. Transbronchial needle aspiration in diagnosing intrathoracic tuberculous lymphadenitis. Chest. 2004;126:259–267.
   PubMed Web of Science ®Google Scholar
• NICE. Lung cancer guidelines. 2019. http://guidance.nice.org.uk/ng122 ( accessed 2019 Oct 14).
   Google Scholar
• Navani N, Lawrence DR, Kolvekar S, et al. Endobronchial ultrasound-guided transbronchial needle aspiration prevents mediastinoscopies in the diagnosis of isolated mediastinal lymphadenopathy: a prospective trial. Am J Respir Crit Care Med. 2012;186:255–260.
   PubMed Web of Science ®Google Scholar
• Annema JT, van Meerbeeck JP, Rintoul RC, et al. Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA. 2010;304:2245–2252.
   PubMed Web of Science ®Google Scholar
• Masters IB, Ware RS, Zimmerman PV, et al. Airway sizes and proportions in children quantified by a video-bronchoscopic technique. BMC Pulm Med. 2006;6:5.
   PubMedGoogle Scholar
• Steinfort DP, Wurzel D, Irving LB, et al. Endobronchial ultrasound in pediatric pulmonology. Pediatr Pulmonol. 2009;44:303–308.
   PubMed Web of Science ®Google Scholar
• Gilbert CR, Feller-Kopman D, Akulian J, et al. Interventional pulmonology procedures in the pediatric population. Pediatr Pulmonol. 2014;49:597–604.
   PubMed Web of Science ®Google Scholar
• Wurzel DF, Steinfort DP, Massie J, et al. Paralysis and a perihilar protuberance: an unusual presentation of sarcoidosis in a child. Pediatr Pulmonol. 2009;44:410–414.
   PubMed Web of Science ®Google Scholar
• Madan K, Ayub II, Mohan A, et al. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in mediastinal lymphadenopathy. Indian J Pediatr. 2015;82:378–380.
   PubMed Web of Science ®Google Scholar
• Gilbert CR, Chen A, Akulian JA, et al. The use of convex probe endobronchial ultrasound-guided transbronchial needle aspiration in a pediatric population: a multicenter study. Pediatr Pulmonol. 2014;49:807–815.
   PubMed Web of Science ®Google Scholar
• Dhooria S, Madan K, Pattabhiraman V, et al. A multicenter study on the utility and safety of EBUS-TBNA and EUS-B-FNA in children. Pediatr Pulmonol. 2016;51:1031–1039.
   PubMed Web of Science ®Google Scholar
• Gulla KM, Gunathilaka G, Jat KR, et al. Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration in children with mediastinal pathology. Pediatr Pulmonol. 2019 June;546:881–885. Epub 2019 Mar 19. PMID: 30891940
   PubMed Web of Science ®Google Scholar
• Al-Najjar H, Breen R, Santis G, et al. The utility and safety of linear endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the paediatric population. Eur Respir J.2020 April 30; 55(4):1902277. PMID: 31980494.
   PubMed Web of Science ®Google Scholar
• Madan K, Garg P, Kabra SK, et al. Transesophageal bronchoscopic ultrasound-guided fine-needle aspiration (EUS-B-FNA) in a 3-year-old child. J Bronchology Interv Pulmonol. 2015 October;22(4):347–350. PMID: 26492608
   PubMed Web of Science ®Google Scholar
• Wang Memoli JS, Nietert PJ, Silvestri GA. Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule. Chest. 2012;142:385–393.
   PubMed Web of Science ®Google Scholar
• Mittal S, Bharati SJ, Kabra SK, et al. Paediatric endobronchial ultrasound-guided transbronchial needle aspiration: anaesthetic and procedural considerations. Indian J Anaesth. 2018 February;62(2):150–151. PMID: 29491526; PMCID: PMC5827487
   PubMed Web of Science ®Google Scholar
• Herth FJ, Ernst A, Becker HD. Endobronchial ultrasound-guided transbronchial lung biopsy in solitary pulmonary nodules and peripheral lesions. Eur Respir J. 2002;20:972–974.
   PubMed Web of Science ®Google Scholar
• Madan K, Iyer H, Madan NK, et al. Efficacy and safety of EBUS-TBNA and EUS-B-FNA in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2020 October 19;56:23–33. Epub ahead of print. PMID: 33073498.
   PubMed Web of Science ®Google Scholar
• Cohen MD, Weber TR, Rao CC. Balloon dilatation of tracheal and bronchial stenosis. AJR Am J Roentgenol. 1984;142:477–478.
   PubMed Web of Science ®Google Scholar
• Goussard P, Morrison J, Bekker A, et al. Acquired neonatal bronchial stenosis after selective intubation: successful managed with balloon dilatation. Clin Case Rep. 2019 March 29;7(5):917–919. PMID: 31110714; PMCID: PMC6509923.
   PubMed Web of Science ®Google Scholar
• Xin Y, Wang G, Gao X, et al. Interventional bronchoscopy via laryngeal mask airway (LMA) under general anesthesia in children using adult flexible bronchoscope. Kuwait Med J. 2016;48:317–322.
   Web of Science ®Google Scholar
• Jaffe RB. Balloon dilation of congenital and acquired stenosis of the trachea and bronchi. Radiology. 1997;203:405–409.
   PubMed Web of Science ®Google Scholar
• McLaren CA, Elliott MJ, Roebuck DJ. Tracheobronchial intervention in children. Eur J Radiol. 2005;53:22–34.
   PubMed Web of Science ®Google Scholar
• Eber E, Antón-Pacheco JL, de Blic J, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J. 2017 December 14;50(6):1700901. PMID:.
   PubMed Web of Science ®Google Scholar
• Ortiz R, Dominguez E, De La Torre C, et al. Early endoscopic dilation and mitomycin application in the treatment of acquired tracheal stenosis. Eur J Pediatr Surg. 2014;24:39–45.
   PubMed Web of Science ®Google Scholar
• Guarisco JL, Yang CJ. Balloon dilation in the management of severe airway stenosis in children and adolescents. J Pediatr Surg. 2013;48:1676–1681.
   PubMed Web of Science ®Google Scholar
• Hautefort C, Teissier N, Viala P, et al. Balloon dilation laryngoplasty for subglottic stenosis in children: eight years’ experience. Arch Otolaryngol Head Neck Surg. View In ArticleCross Ref 2012;138: 235–240.
   PubMedGoogle Scholar
• Bent JP, Shah MB, Nord R, et al. Balloon dilation for recurrent stenosis after pediatric laryngotracheoplasty. Ann Otol Rhinol Laryngol. View In ArticleCross Ref 2010;119: 619–627.
   PubMed Web of Science ®Google Scholar
• Durden F, Sobol SE. Balloon laryngoplasty as a primary treatment for subglottic stenosis. Arch Otolaryngol Head Neck Surg. 2007;133:772–775. [ View In ArticleCross Ref].
   PubMedGoogle Scholar
• Whigham AS, Howell R, Choi S, Peña M, Zalzal G, Preciado D. Outcomes of balloon dilation in pediatric subglottic stenosis. Ann Otol Rhinol Laryngol. 2012 Jul;121(7):442–8. doi:10.1177/000348941212100704. PMID: 22844863
   Google Scholar
• Antón-Pacheco JL, Comas JV, Luna C, et al. Treatment strategies in the management of severe complications following slide tracheoplasty in children. Eur J Cardiothorac Surg. 2014;46:280–285.
   PubMed Web of Science ®Google Scholar
• Wood JW, Thornton B, Brown CS, et al. Traumatic tracheal injury in children: a case series supporting conservative management. Int J Pediatr Otorhinolaryngol. 2015;79:716–720.
   PubMed Web of Science ®Google Scholar
• Choong CK, Sweet SC, Zoole JB, et al. Bronchial airway anastomotic complications after pediatric lung transplantation: incidence, cause, management, and outcome. J Thorac Cardiovasc Surg. 2006;131:198–203.
   PubMed Web of Science ®Google Scholar
• Hoff SR, Chang KW. The proximal bronchoplasty retrieval technique for removal of embedded distal airway foreign bodies. Int J Pediatr Otorhinolaryngol. 2014;78:148–151.
   PubMed Web of Science ®Google Scholar
• Thornton CS, Yunker WK. Rigid bronchoscopy and balloon dilation for removal of aspirated thumbtacks: case series and literature review. Int J Pediatr Otorhinolaryngol. 2015;79:1541–1543.
   PubMed Web of Science ®Google Scholar
• Sirbu H, Busch T, Aleksic I, et al. Bronchopleural fistula in the surgery of non-small cell lung cancer: incidence, risk factors and management. Ann Thorac Cardiovasc Surg. 2001;7:330–336.
   PubMedGoogle Scholar
• Turk AE, Karanas YL, Cannon W, et al. Staged closure of complicated bronchopleural fistulas. Ann Plastic Surg. 2000;45:560–564.
   PubMed Web of Science ®Google Scholar
• Saleemi MS, McLaren C, Sharma BK, et al. Bronchopleural fistula in a newborn undergoing ECMO-transbronchial closure. J Perinatol. 2013;33:659–660.
   PubMed Web of Science ®Google Scholar
• Goussard P, Gie RP, Kling S, et al. Fibrin glue closure of persistent bronchopleural fistula following pneumonectomy for post-tuberculosis bronchiectasis. Pediatr Pulmonol. 2008 July;43(7):721–725. PMID: 18500738
   PubMed Web of Science ®Google Scholar
• York EL, Lewall DB, Hirji M, Gelfand ET, Modry DL. Endoscopic diagnosis and treatment of postoperative bronchopleural fistula. Chest. 1990 Jun;97(6):1390–2. doi: 10.1378/chest.97.6.1390. PMID: 2347224
   Google Scholar
• Sarkar P, Chandak T, Shah R, et al. Diagnosis and management bronchopleural fistula. Indian J Chest Dis Allied Sci. 2010;52:97–104.
   PubMedGoogle Scholar
• Donato LL, Mai Hong Tran T, Ammouche C, et al. Pediatric interventional bronchoscopy. Clin Chest Med. 2013;34:569–582.
   PubMed Web of Science ®Google Scholar
• Hathorn C, Armitage N, Wensley D, et al. Bronchial balloon occlusion in children with complex pulmonary air leaks. Arch Dis Child. 2013;98:136–140.
   PubMed Web of Science ®Google Scholar
• Toth JW, Podany AB, Reed MF, et al. Endobronchial occlusion with one-way endobronchial valves: a novel technique for persistent air leaks in children. J Pediatr Surg. 2015;50(1):82‐85. .
   PubMed Web of Science ®Google Scholar
• Jaspers GJ, Willemse BWM, Kneyber MCJ. Endobronchial valve placement for a severe pneumothorax in a child on ECLS. Pediatr Pulmonol. 2019;54:18751877.
   Web of Science ®Google Scholar
• Tzifa KT, Maxwell EL, Chait P, et al. Endoscopic treatment of congenital H-Type and recurrent tracheoesophageal fistula with electrocautery and histoacryl glue. Int J Pediatr Otorhinolaryngol. 2006;70:925–930.
   PubMed Web of Science ®Google Scholar
• Daniel SJ, Smith MM. Tracheoesophageal fistula: open versus endoscopic repair. Curr Opin Otolaryngol Head Neck Surg. 2016;24:510–515.
   PubMed Web of Science ®Google Scholar
• Meier JD, Sulman CG, Almond PS, et al. Endoscopic management of recurrent congenital tracheoesophageal fistula: a review of techniques and results. Int J Pediatr Otorhinolaryngol. 2007;71:691–697.
   PubMed Web of Science ®Google Scholar
• Nardo GD, Oliva S, Barbato M, et al. Video: argon plasma coagulator in a 2-month-old child with tracheoesophageal fistula. Surg Endosc. 2012;26:2678–2680.
   PubMed Web of Science ®Google Scholar
• Aworanti O, Awadalla S. Management of recurrent tracheoesophageal fistulas: a systematic review. Eur J Pediatr Surg. 2014;24:365–375.
   PubMed Web of Science ®Google Scholar
• Lelonge Y, Varlet F, Varela P, et al. Chemocauterization with trichloroacetic acid in congenital and recurrent tracheoesophageal fistula: a minimally invasive treatment. Surg Endosc. 2016;30:1662–1666.
   PubMed Web of Science ®Google Scholar
• Martin LD, Mhyre JM, Shanks A, et al. 3,423 emergency intubations at a university hospital: airway outcomes and complications. Anesthesiology. 2011;114:42–48.
   PubMed Web of Science ®Google Scholar
• Balaban O, Tobias JD. Videolaryngoscopy in neonates, infants, and children. Pediatr Crit Care Med. 2017 May;18(5):477–485. . PMID: 28319487
   PubMed Web of Science ®Google Scholar
• Choudhry DK, Brenn BR, Lutwin-Kawalec M, et al. Effect of 90° counterclockwise rotation of the endotracheal tube on its advancement through the larynx during nasal fiberoptic intubation in children: a randomized and blinded study. Paediatr Anaesth. 2016;26:378–383.
   PubMed Web of Science ®Google Scholar
• Donato L, Tran TMH, Ghori UK, et al. Pediatric interventional pulmonology. Clin Chest Med. 2018 March;39(1):229–238. PMID: 29433718
   PubMed Web of Science ®Google Scholar
• Olutoye OO, Olutoye OA. EXIT procedure for fetal neck masses. Curr Opin Pediatr. 2012 June;24(3):386–393. PMID: 22498672
   PubMed Web of Science ®Google Scholar
• Dighe MK, Peterson SE, Dubinsky TJ, et al. EXIT procedure: technique and indications with prenatal imaging parameters for assessment of airway patency. Radiographics. 2011;31:511–526.
   PubMed Web of Science ®Google Scholar
• Santos XM, Papanna R, Johnson A, et al. The use of combined ultrasound and magnetic resonance imaging in the detection of fetal anomalies. Prenat Diagn. 2010;30:402–407.
   PubMed Web of Science ®Google Scholar
• Holzki J, Kellner M. Life threatening unilateral pulmonary overinflation might be more successfully treated by contralateral selective intubation than by emergency pneumonectomy. Paediatr Anaesth. 2003;13:432–437.
   PubMedGoogle Scholar
• Chalak LF, Kaiser JR, Arrington RW. Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. Paediatr Anaesth. 2007;17:183186.
   Web of Science ®Google Scholar
• Hammer GB, Harrison TK, Vricella LA, et al. Single lung ventilation in children using a new pediatric bronchial blocker. Paediatr Anaesth. 2002;12:69–72.
   PubMedGoogle Scholar
• Serio P, Fainardi V, Leone R, et al. Tracheobronchial obstruction: follow-up study of 100 children treated with airway stenting. Eur J Cardiothorac Surg. 2014;45:e100–e109.
   PubMed Web of Science ®Google Scholar
• Fayon M, Donato L, de Blic J, et al. French experience of silicone tracheobronchial stenting in children. Pediatr Pulmonol. 2005;39:21–27.
   PubMed Web of Science ®Google Scholar
• Nicolai T. Airway stents in children. Pediatr Pulmonol. 2008;43:330–344.
   PubMed Web of Science ®Google Scholar
• Lund ME, Force S. Airway stenting for patients with benign airway disease and the Food and Drug Administration advisory: a call for restraint. Chest. 2007;132:1107–1108.
   PubMed Web of Science ®Google Scholar
• Antón-Pacheco JL, Luna C, García E, et al. Initial experience with a new biodegradable airway stent in children: is this the stent we were waiting for? Pediatr Pulmonol. 2016;51:607–612.
   PubMed Web of Science ®Google Scholar
• Sztanó B, Kiss G, Márai K, et al. Biodegradable airway stents in infants - potential life-threatening pitfalls. Int J Pediatr Otorhinolaryngol. 2016;91:86–89.
   PubMed Web of Science ®Google Scholar
• Butler CR, Speggiorin S, Rijnberg FM, et al. Outcomes of slide tracheoplasty in 101 children: a 17-year single-center experience. J Thorac Cardiovasc Surg. 2014;147:1783–1789.
   PubMed Web of Science ®Google Scholar
• Stramiello JA, Mohammadzadeh A, Ryan J, Brigger MT. The role of bioresorbable intraluminal airway stents in pediatric tracheobronchial obstruction: A systematic review. Int J Pediatr Otorhinolaryngol. 2020 Dec;139:110405. doi: 10.1016/j.ijporl.2020.110405. Epub 2020 Sep 30. PMID: 33017664
   Google Scholar
• Griffiths BT, James P, Morgan G, Diamantopoulos A, Durward A, Nyman A. Biodegradable Stents for the Relief of Vascular Bronchial Compression in Children With Left Atrial Enlargement. J Bronchology Interv Pulmonol. 2020 Jul;27(3):200–204. doi: 10.1097/LBR.0000000000000654. PMID: 32101914
   Google Scholar
• Ha J, Mondal A, Zhao Z, et al. Pediatric airway stent designed to facilitate mucus transport and atraumatic removal. IEEE Trans Biomed Eng. 2020;67:177–184.
   PubMed Web of Science ®Google Scholar
• Mondal A, Ha J, Jo VY, et al. Preclinical evaluation of a pediatric airway stent for tracheobronchomalacia. J Thorac Cardiovasc Surg. 2020 March 15. doi: 10.1016/j.jtcvs.2020.07.099. S0022–5223(20)30572–9
   Web of Science ®Google Scholar
• Awab A, Khan MS, Youness HA. Whole lung lavage – technical details, challenges and management of complications. J Thorac Dis. 2017;9:1697–1706.
   PubMed Web of Science ®Google Scholar
• Wood RE. Whole lung lavage. In: Priftis KN, Anthracopoulos MB, Eber E, et al., editors. Paediatric bronchoscopy. Progress in respiratory research. Basel, Karger; 2010. p. 75–82.Wood RE. Whole lung lavage. In: Priftis KN, Anthracopoulos MB, Eber E, et al., editors. Paediatric bronchoscopy. Progress in respiratory research. Basel, Karger; 2010. p. 75–82.
   Google Scholar
• Wilson CA, Wilmshurst SL, Black AE. Anesthetic techniques to facilitate lung lavage for pulmonary alveolar proteinosis in children-new airway techniques and a review of the literature. Paediatr Anaesth. 2015;25:546–553.
   PubMed Web of Science ®Google Scholar
• de Blic J. Pulmonary alveolar proteinosis in children. Paediatr Respir Rev. 2004;5:316–322.
   PubMedGoogle Scholar
• Mahut B, de Blic J, Le Bourgeois M, et al. Partial and massive lung lavages in an infant with severe pulmonary alveolar proteinosis. Pediatr Pulmonol. 1992;13:50–53.
   PubMed Web of Science ®Google Scholar
• Tsai WC, Lewis D, Nasr SZ, et al. Liquid ventilation in an infant with pulmonary alveolar proteinosis. Pediatr Pulmonol. 1998;26:283–286.
   PubMed Web of Science ®Google Scholar
• Reiter K, Schoen C, Griese M, et al. Whole-lung lavage in infants and children with pulmonary alveolar proteinosis. Paediatr Anaesth. 2010;20:1118–1123.
   PubMed Web of Science ®Google Scholar
• Campo I, Luisetti M, Griese M, et al. Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. Orphanet J Rare Dis. 2016;11:115.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Sakagami T, Young LR, et al. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. Am J Respir Crit Care Med. 2010;182:1292–1304.
   PubMed Web of Science ®Google Scholar
• Valimahamed-Mitha S, Berteloot L, Ducoin H, et al. Lung involvement in children with lysinuric protein intolerance. J Inherit Metab Dis. 2015;38:257–263.
   PubMed Web of Science ®Google Scholar
• Gulhan B, Ozcelik U, Gurakan F, et al. Different features of lung involvement in Niemann-Pick disease and Gaucher disease. Respir Med. 2012;106:1278–1285.
   PubMed Web of Science ®Google Scholar
• Sias SM, Daltro PA, Marchiori E, et al. Clinic and radiological improvement of lipoid pneumonia with multiple bronchoalveolar lavages. Pediatr Pulmonol. 2009;44:309–315.
   PubMed Web of Science ®Google Scholar
• Tempe DK, Sharma A. Insights into anesthetic challenges of whole lung lavage. J Cardiothorac Vasc Anesth. 2019;33:2462–2464.
   PubMed Web of Science ®Google Scholar
• Karamzadeh AM, Wong BJF, Crumley RJ, et al. Lasers in pediatric airway surgery: current and future clinical applications. Lasers Surg Med. 2004;35:128–134.
   PubMed Web of Science ®Google Scholar
• Lee GS, Irace A, Rahbar R. The efficacy of the flexible fiber CO2 laser delivery system in the endoscopic management of pediatric airway problems: our long-term experience. Int J Pediatr Otorhinolaryngol. 2017;97:218–222.
   PubMed Web of Science ®Google Scholar
• Eber E, Anton-Pacheco JL, de Blic J, et al. ERS statement: interventional bronchoscopy in children. Eur Respir J. 2017;50:1700901.
   PubMed Web of Science ®Google Scholar
• Donato L, Tran TMH, Ghori UK, et al. Pediatric interventional pulmonology. Clin Chest Med. 2018;39:229–238.
   PubMed Web of Science ®Google Scholar
• Myer CM, Willging PJ, McMurray S, et al. Use of the laryngeal microresector system. Laryngoscope. 1999;109:1165–1166.
   PubMed Web of Science ®Google Scholar
• Rees CJ, Tridico TI, Kirse DJ. Expanding applications for the microdebrider in pediatric endoscopic airway surgery. Otolaryngo Head Neck Surg. 2005;133(4):509–513.
   PubMed Web of Science ®Google Scholar
• Pasquale K, Wiatrak B, Woolley A, et al. Microdebrider versus CO2 laser removal of recurrent respiratory papillomas: a prospective analysis. Laryngoscope. 2003;113:139–143.
   PubMed Web of Science ®Google Scholar
• Carifi M, Napolitano D, Morandi M, et al. Recurrent respiratory papillomatosis: current and future perspectives. Clin Risk Manage. 2015;11: 731–738.
   PubMed Web of Science ®Google Scholar
• Hller T, Allegro J, Chadha NK, et al. Voice outcomes following repeated surgical resection of laryngeal papillomata in children. Otolaryngol Head Neck Surg. 2009;141(4):522–526. .
   PubMed Web of Science ®Google Scholar
• Turbulent Gas BL. Clouds and respiratory pathogen emissions: potential implications for reducing transmission of COVID-19. JAMA. 2020;323(18):1837–1838.
   PubMed Web of Science ®Google Scholar
• Asadi S, Bouvier N, Wexler AS, et al. The coronavirus pandemic and aerosols: does COVID-19 transmit via expiratory particles? Aerosol Sci Technol. 2020;54:635–638.
   PubMed Web of Science ®Google Scholar
• Stadnytskyi V, Bax CE, Bax A, et al. The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proc Nat Acad Sci. 2020;117:202006874.
   Web of Science ®Google Scholar
• Somsen GA, van Rijn C, Kooij S, et al. Small droplet aerosols in poorly ventilated spaces and SARS-CoV-2 transmission. Lancet Respir Med. 2020;8(7):658–659.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). Transmission of SARS-CoV-2: implications for infection prevention precautions. 2020 Jul 9. file:///C:/Users/AEC1/AppData/Local/Temp/WHO-2019-nCoV-Sci_Brief-Transmission_modes-2020.3-eng.pdf
   Google Scholar
• Harding H, Broom A, Broom J. Aerosol generating procedures and infective risk to healthcare workers: SARS-CoV-2 - the limits of the evidence. J Hosp Infect. 2020;105(4):717–725.
   PubMed Web of Science ®Google Scholar
• Schünemann HJ, Khabsa J, Solo K, et al. Ventilation techniques and risk for transmission of coronavirus disease, including COVID-19: a living systematic review of multiple streams of evidence. Ann Intern Med. 2020 May 22. [Epub ahead of print] 173:204–216.
   Web of Science ®Google Scholar
• Mick P, Murphy R. Aerosol-generating otolaryngology procedures and the need for enhanced PPE during the COVID-19 pandemic: a literature review. J Otolaryngol Head Neck Surg. 2020;49(1):29.
   PubMed Web of Science ®Google Scholar
• Francom CR, Javia LR, Wolter NE, et al. Pediatric laryngoscopy and bronchoscopy during the COVID-19 pandemic: a four-center collaborative protocol to improve safety with perioperative management strategies and creation of a surgical tent with disposable drapes. Int J Pediatr Otorhinolaryngol. 2020 Jul;134:110059.
   PubMed Web of Science ®Google Scholar
• Goussard P, Van Wyk L, Burke J, et al. Bronchoscopy in children with COVID-19: a case series. Pediatr Pulmonol. 2020 Aug 7. 10.1002/ppul.25015. Epub ahead of print.
   Web of Science ®Google Scholar
• Pollaers K, Herbert H, Vijayasekaran S. Pediatric microlaryngoscopy and bronchoscopy in the COVID-19 era. JAMA Otolaryngol Head Neck Surg. 2020;146(7):608–612.
   PubMed Web of Science ®Google Scholar