289
Views
2
CrossRef citations to date
0
Altmetric
Review

Contemporary management and treatment strategies for asthma during pregnancy

& ORCID Icon
Pages 1149-1157 | Received 27 Apr 2020, Accepted 24 May 2021, Published online: 08 Jul 2021

References

  • Kwon HL, Belanger K, Bracken MB. Asthma prevalence among pregnant and childbearing-aged women in the United States: estimates from national health surveys. Ann Epidemiol. 2003;13(5):317–324.
  • Hansen C, et al. Medication exposure in pregnancy risk evaluation program: the prevalence of asthma medication use during pregnancy. Maternal Child Health. 2013;17(9):1611–1621.
  • Schatz M, Dombrowski MP, Wise R, et al. The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity. J Asthma. 2010;47(1):46–50. .
  • Schatz M, Dombrowski MP, Wise R, et al. Asthma morbidity during pregnancy can be predicted by severity classification. J Allergy Clin Immunol. 2003;112(2):283–288. .
  • Stenius-Aarniala B, Piirila P, Teramo K. Asthma and pregnancy: a prospective study of 198 pregnancies. Thorax. 1988;43(1):12–18.
  • White RJ, Coutts II, Gibbs CJ, et al. A prospective study of asthma during pregnancy and the puerperium. Respir Med. 1989;83(2):103–106.
  • Cohen J,M, Bateman BT, Huybrechts KF, et al. Poorly controlled asthma during pregnancy remains common in the united states. J Allergy Clin Immunol Pract. 2019;7(8):2672–2680.
  • Ali Z, Nilas L, Ulrik CS. Postpartum airway responsiveness and exacerbation of asthma during pregnancy-a pilot study. J Asthma Allergy. 2017;10:261–267.
  • Murphy V, Namazy J, Powell H, et al. A meta-analysis of adverse perinatal outcomes in women with asthma. Br J Obstet Gynaecol. 2011;118(11):1314–1323.
  • Kemppainen M, Lahesmaa-Korpinen AM, Kauppi P, et al. Maternal asthma is associated with increased risk of perinatal mortality. PLoS One. 2018;13:5.
  • Triche EW, Saftlas AF, Belanger K, et al. Association of asthma diagnosis, severity, symptoms, and treatment with risk of preeclampsia. Obstet Gynecol. 2004;104(3):585–593.
  • Jana N, Vasishta K, Saha SC, et al. Effect of bronchial asthma on the course of pregnancy, labour and perinatal outcome. J Obstet Gynaecol( Tokyo 1995. 1995;21(3):227–232. .
  • Stenius-Aarniala BS, Hedman J, Teramo KA. Acute asthma during pregnancy. Thorax. 1996;51(4):411–414.
  • Minerbi-Codish I, Fraser D, Avnun L, et al. Influence of asthma in pregnancy on labor and the newborn. Respiration. 1998;65(2):130–135.
  • Mihrshahi S, Belousova E, Marks GB, et al. Childhood Asthma Prevention T. Pregnancy and birth outcomes in families with asthma. J Asthma. 2003;40(2):181–187.
  • Dombrowski MP, Schatz M, Wise R, et al. Asthma during pregnancy. Obstet Gynecol. 2004;103(1):5–12. .
  • Bracken MB, Triche EW, Belanger K, et al. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstet Gynecol. 2003;102(4):739–752.
  • Schatz M, Zeiger RS, Hoffman CP, et al. Perinatal outcomes in the pregnancies of asthmatic women: a prospective controlled analysis. Am J Respir Crit Care Med. 1995;151(4):1170–1174. .
  • Murphy VE, Jensen ME, Robijn AL, et al. How maternal BMI modifies the impact of personalized asthma management in pregnancy. J Allergy Clin Immunol Pract. 2020;8(1):219–228.
  • Murphy VE, Clifton VL, Gibson PG. The effect of cigarette smoking on asthma control during exacerbations in pregnant women. Thorax. 2010;65(8):739–744.
  • Kallen B, Rydhstroem H, Aberg A. Asthma during pregnancy–a population based study. Eur J Epidemiol. 2000;16(2):167–171.
  • Grzeskowia LE, Smith B, Roy A, et al. Patterns, predictors and outcomes of asthma control and exacerbations during pregnancy: a prospective cohort study. Eur Respir J. 2016;18:2.
  • Powell H, et al. Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trial. Lancet. 2011;378(9795):p 983–90. .
  • Morten M, et al. Managing Asthma in Pregnancy (MAP) trial: FENO levels and childhood asthma. J Allergy Clin Immunol. 2018;142(6):1765–1772.e4. .
  • Amaral L, Martins C, Coimbra A. Use of the control of allergic rhinitis and asthma test and pulmonary function tests to assess asthma control in pregnancy. Aust N Z J Obstet Gynaecol. 2017;58:1–5.
  • Koo YH, Kim Y, Park GW, et al. Effect of pregnancy on quantitative medication use and relation to exacerbations in asthma. Biomed Res Int. 2017;2017:1–15.
  • Sawicki E, Stewart K, Wong S, et al. Management of asthma by pregnant women attending an Australian maternity hospital. Aust N Z J Obstet Gynaecol. 2012;52(2):183–188.
  • Beau AB, Didier A, Hurault-Delarue C, et al. Prescriptions of astham medications before and during pregnancy in France: an observational study. J Asthma. 2017;54:258–264.
  • Lim AS, Stewart K, Abramson MJ, et al. Asthma during pregnancy: the experiences, concerns and views of pregnant women with asthma. J Asthma. 2012;49(5):474–479.
  • Robijn AL, Jensen ME, Gibson PG, et al. Trends in asthma self-management skills and inhaled corticosteroid use during pregnancy and postpartum from 2004-2017. J Asthma. 2018;56(6):594–602. .
  • Lim A, Stewart K, Abramson M, et al. Management of pregnant women with asthma by Australian general practitioners. BMC Fam Pract. 2011;12:121.
  • Cimbollek S, Plaza V, Quirce S, et al. Knowledge, attitude and adherence of Spanish healthcare professionals to asthma management recommendations during pregnancy. Allergol. Immunopathol. Mar-Apr 2013;41(2):114-20.
  • Cydulka R, Emerman C, Schreiber D, et al. Acute asthma among pregnant women presenting to the emergency department. Am J Respir Crit Care Med. 1999;160:887–892.
  • McCallister J, Benninger C, Frey H, et al. Pregnancy related treatment disparities of acute asthma exacerbations in the emergency department. Respir Med. 2011;105(10):1434–1440.
  • Murphy VE, Gibson P, Talbot PI, et al. Severe asthma exacerbations during pregnancy. Obstet Gynecol. 2005;106(5 Pt 1):1046–1054.
  • Sorri M, Hartikainen A, Karja I. Rhinitis during pregnancy. Rhinology. 1980;18(2):83–86.
  • Munn M, Groome L, Atterbury J. Pneumonia as a complication of pregnancy. J Matern Fetal Med. 1999;8: 151–154.
  • Murphy VE, Powell H, Wark PAB, et al. A prospective study of respiratory viral infection in pregnant women with and without asthma. Chest. 2013;144(2):420–427.
  • Namazy J, Schatz M, Yang SJ, et al. Antibiotics for respiratory infections during pregnancy: prevalence and risk factors. J Allergy Clin Immunol Pract. 2016;4(6):1256–1257.
  • Ali Z, Ulrik CS. Incidence and risk factors for exacerbations of asthma during pregnancy. J Asthma Allergy. 2013;6:53–60.
  • Murphy VE, Jensen ME, Powell H. Influence of maternal body mass index and macrophage activation on asthma exacerbations in pregnancy. J Allergy Clin Immunol Pract. 2017;5(4):981–987.
  • Skuladottir H, Wilcox AJ, Ma C, et al. Corticosteroid use and risk of orofacial clefts. Birth Defects Res A Clin Mol Teratol. 2014;100(6):499–506. .
  • Namazy J, Cabana M, Scheuerle A, et al. The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy. J Allergy Clin Immunol. 2015 Feb;135(2):407-12.
  • Bandoli G, Palmsten K, Forbess Smith CJ, et al. Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes. Rheum Dis Clin North Am. 2017;43(3):489–502.
  • Namazy J, Schatz M, Long L, et al. Use of inhaled steroids by pregnant asthmatic women does not reduce intrauterine growth. J Allergy Clin Immunol. 2004;113(3):427–432. .
  • Rahimi R, Nikfar S, Abdollahi M. Meta-analysis finds use of inhaled corticosteroids during pregnancy safe: a systematic meta-analysis review. Hum Exp Toxicol. 2006;25(8):447–452.
  • Charlton RA, Snowball JM, Nightingale AL, et al. Safety of Fluticasone Propionate Prescribed for Asthma During Pregnancy: a UK Population-Based Cohort Study. J Allergy Clin Immunol Pract. 2015;3(5):772–779 e773.
  • Wilson J. Use of sodium cromoglycate during pregnancy: results on 296 asthmatic women. 1982;8(Suppl):45–51. Acta Therap.
  • Tata LJ, Lewis SA, McKeever TM, et al. A comprehensive analysis of adverse obstetric and pediatric complications in women with asthma. Am J Respir Crit Care Med. 2007;175(10):991–997. .
  • Cavero-Carbonell C, Vinkel-Hansen A, Rabanque-Hernandez MJ, et al. Fetal Exposure to Montelukast and Congenital Anomalies: a Population Based Study in Denmark. Birth Defects Res. 2017;109(6):452–459.
  • Namazy J, Cabana MD, Scheuerle AE, et al. The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy. J Allergy Clin Immunol. 2015;135(2):407–412. .
  • Briggs GG, Freeman RK, Towers CV, et al. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. Philadelphia : Wolters Kluwer/Lippincott Williams & Wilkins Health. 2015.
  • Munsie JW, Lin S, Browne ML, et al. Maternal bronchodilator use and the risk of orofacial clefts. Hum Reprod. 2011;26(11):3147–3154. .
  • Garne E, Hansen AV, Morris J, et al. Use of asthma medication during pregnancy and risk of specific congenital anomalies: a European case-malformed control study. J Allergy Clin Immunol. 2015;136(6):1496–1502 e1497. .
  • Lin S, Munsie JPW, Herdt-Losavio ML, et al. Maternal asthma medication use and the risk of selected birth defects. Pediatrics. 2012;129:e317–e324.
  • Heinonen OP, Slone D, Shapiro S. Birth defects and drugs in pregnancy. Littleton, Mass: Publishing Sciences Group; 1977.
  • Wilton LV, Pearce GL, Martin RM, et al. The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England. Br J Obstet Gynaecol. 1998;105(8):882–889.
  • Eltonsy S, Forget A, Beta BL. 2-agonists use during pregnancy and the risk of congenital malformations. Birth Defects Res A Clin Mol Teratol. 2011;91(11):937–947.
  • Eltonsy S, Forget A, Beauchesne MF, et al. Risk of congenital malformations for asthmatic pregnant women using a long-acting beta(2)-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy. J Allergy Clin Immunol. 2015;135(1):123–130.
  • Rodger MA, Makropoulos D, Walker M, et al. Participation of pregnant women in clinical trials: will they participate and why? Am J Perinatol. 2003;20(2):69–75.
  • Schatz M, Krishnan JA, Chambers CC. Implications of changes in FDA prescribing information regarding the safety and use of asthma biologics during pregnancy. Ann Am Thorac Soc. 2018;15(10):1131–1136.
  • Firoozi F, Lemiere C, Ducharme FM, et al. Effect of maternal moderate to severe asthma on perinatal outcomes. Respir Med. 2010.
  • Blais L, Forget A. Asthma exacerbations during the first trimester of pregnancy and the risk of congenital malformations among asthmatic women. J Allergy Clin Immunol. 2008;121(6):1379–1384, 1384 e1371.
  • Expert Panel Report 3EPR-3): guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007;120(5 Suppl):S94–138.
  • Schatz M, Zeiger RS, Harden K, et al. The safety of asthma and allergy medications during pregnancy. J Allergy Clin Immunol. 1997;100(3):301–306.
  • Norjavaara E, De Verdier MG. Normal pregnancy outcomes in a population-based study including 2,968 pregnant women exposed to budesonide. J Allergy Clin Immunol. 2003;111(4):736–742.
  • Martel MJ, Rey E, Beauchesne MF, et al. Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study. BMJ. 2005;330(7485):230. .
  • Kallen B, Rydhstroem H, Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol. 1999;93(3):392–395.
  • Bakhireva LN, Jones KL, Schatz M, et al., Organization Of Teratology Information Services Research G. Asthma medication use in pregnancy and fetal growth. J Allergy Clin Immunol. 2005;116(3):503–509. .
  • Breton M, Beauchesne MF, Lemiere C, et al. Risk of perinatal mortality associated with asthma during pregnancy: 2-stage sampling cohort study. Ann Allergy Asthma Immunol. 2010;105(3):211–217.
  • Kallen B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications. Eur J Clin Pharmacol. 2007;63(4):363–373.
  • Blais L, Beauchesne MF, Rey E, et al. Use of inhaled corticosteroids during the first trimester of pregnancy and the risk of congenital malformations among women with asthma. Thorax. 2007;62(4):320–328.
  • Blais L, Beauchesne MF, Lemiere C, et al. High doses of inhaled corticosteroids during the first trimester of pregnancy and congenital malformations. J Allergy Clin Immunol. 2009;124(6):1229–1234 e1224.
  • Lin S, Herdt-Losavio M, Gensburg L, et al. Maternal, asthma medication use, and the risk of congenital heart defects. Birth Defects Res A Clin Mol Teratol. 2009;85(2):161–168.
  • Lin S, Munsie J, Herdt-Losavio M, et al. Maternal asthma medication use and the risk of gastroschisis. Am J Epidemiol. 2008;168:73–79.
  • Robijn AL, Murphy VE, Gibson PG. Recent developments in asthma in pregnancy. Curr Opin Pulm Med. 2018;25:11–17.
  • Cossette B, Beauchesne MF, Forget A, et al. Relative perinatal safety of salmeterol vs formoterol and fluticasone vs budesonide use during pregnancy. Ann Allergy Asthma Immunol. 2014;112(5):459–464. .
  • NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol. 2005;115(1):34–46. .
  • Bakhireva LN, Jones KL, Schatz M, et al. Safety of leukotriene receptor antagonists in pregnancy. J Allergy Clin Immunol. 2007;119(3):618–625. .
  • Sarkar M, Koren G, Kalra S, et al. Montelukast use during pregnancy; a multicentre, prospective,comparative study of infant outcomes. Eur J Clin Pharmacol. 2009;65(12):1259–1264. .
  • Nelsen LM, Shields KE, Cunningham ML, et al. Congenital malformations among infants born to women receiving montelukast, inhaled corticosteroids, and other asthma medications. J Allergy Clin Immunol. 2012;129(1):251–254.e256. .
  • Schatz M, Dombrowski MP, Wise R, et al. The relationship of asthma medication use to perinatal outcomes. J Allergy Clin Immunol. 2004;113(6):1040–1045. .
  • Namazy J, Murphy V, Powell H, et al. Effects of asthma severity, exacerbations and oral corticosteroids on perinatal outcomes. Eur Respir J. 2012;41(5):1082–1090.
  • Park-Wyllie LMP, Pastuszak A, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiologic studies. Teratology. 2000;62:385–392.
  • Hyiid A, Molgaard-Nielesen D. Corticosteroid use during pregnancy and the risk of orofacial clefts. CMAJ. 2011;183:796–804.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.