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Editorial

Human neonatal and infant airway epithelial biology: the new frontier for developmental immunology

, &
Pages 145-147 | Received 27 Sep 2021, Accepted 07 Jan 2022, Published online: 10 Feb 2022

References

  • GBD. 2019 Under-5 mortality collaborators. global, regional, and national progress towards sustainable development goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the global burden of disease study 2019. Lancet. 2021Sep4;398(10303):870–905. Epub 2021 Aug 17. PMID: 34416195; PMCID: PMC8429803.
  • Martinez FD. Early-Life Origins of Chronic Obstructive Pulmonary Disease. N Engl J Med. 2016Sep1;375(9):871–878. PMID: 27579637. ••Comprehensive review of early life determinants of Chronic obstructive Pulmonary Disease (COPD)
  • Tagiyeva N, Devereux G, Fielding S, et al. Outcomes of childhood asthma and wheezy bronchitis. A 50-year cohort study. Am J Respir Crit Care Med. 2016Jan1;193(1):23–30. PMID: 26351837; PMCID: PMC4731615.
  • Olin A, Henckel E, Chen Y, et al. Stereotypic immune system development in newborn children. Cell. 2018;174(5):1277–92.e1214.••Landmark paper demonstranting convergent trajectories in immune development between premature and term infants during teh first montsh of life.
  • Gutierrez MJ, Nino G, Hong X, et al. Epigenomics and early life human humoral immunity: novel paradigms and research opportunities. Front Immunol. 2020;11:1766.
  • Holt P, Strickland D. Innate Immune training for prevention of recurrent wheeze in early childhood. Am J Respir Crit Care Med. 2021;204(4):392–394.
  • Lynch SV, Vercelli D. Microbiota, epigenetics, and trained immunity. convergent drivers and mediators of the asthma trajectory from pregnancy to childhood. Am J Respir Crit Care Med. 2021;203:802–808.
  • Nino G, Rodriguez-Martinez CE, Gutierrez MJ. Early microbial-immune interactions and innate immune training of the respiratory system during health and disease. Children (Basel). 2021May19;8(5):413. PMID: 34069319; PMCID: PMC8158711.
  • Nieto A, Mazón A, Nieto M, et al. Bacterial mucosal immunotherapy with MV130 prevents recurrent wheezing in children: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med. 2021;204(4):462–472.
  • Hewitt RJ, Lloyd CM. Regulation of immune responses by the airway epithelial cell landscape. Nat Rev Immunol. 2021Jan;13:1–16. Epub ahead of print. PMID: 33442032; PMCID: PMC7804588.••Review of recent changes in our understanding of airway epithelial biology with the advent of transcriptomic approaches.
  • Loske J, Röhmel J, Lukassen S, et al. Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children. Nat Biotechnol. 2021. https://doi.org/10.1038/s41587-021-01037-9.
  • Shivaraju M, Chitta UK, Grange RMH, et al. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021Jan1;371(6524):52–57. PMID: 33384370.
  • Wang B, Cardenas M, Bedoya M, et al. Upregulation of neuropeptides and obstructive airway disorder in infancy: a review with focus on post-RSV wheezing and NEHI. Pediatr Pulmonol. 2021Jun;56(6):1297–1306. Epub 2021 Feb 1. PMID: 33524244.
  • Salka K, Arroyo M, Naime S, et al. TSLP production in the human infant airway epithelium and clinical relevance during viral respiratory infections. Am J Respir Cell Mol Biol. 2020Jan;62(1):115–117. PMID: 31891308; PMCID: PMC6938137.••Study demonstrating that TSLP is the predominant innate type 2 cytokine produced by the human infant airway epithelium in response to a viral stimulus (poly I:C) or IL-1b.
  • Salka K, Arroyo M, Chorvinsky E, et al. Innate IFN-lambda responses to dsRNA in the human infant airway epithelium and clinical regulatory factors during viral respiratory infections in early life. Clin Exp Allergy. 2020Sep;50(9):1044–1054. Epub 2020 Jul 26. PMID: 32623773; PMCID: PMC7484417.••Study showing that poly(I:C)-induced production of IFN-lambda in human infant airway epithelial cells is regulated by a p38-MAPK/NF-kB dependent mechanism and exposure to pro-inflammatory sugnals such as IL-1b

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