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ORIGINAL ARTICLE

Time course and determinants of leptin decline during weight loss in obese boys and girls

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Pages 2-10 | Received 13 Mar 2006, Published online: 12 Jul 2009

References

  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372(6505)425–32
  • Faooqi I, Matarese G, Lord G, Keogh J, Lawrence E, Agwu C, et al. Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest. 2002; 110: 1093–103
  • Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest. 2005; 115: 3579–86
  • Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med. 1996; 334(5)292–5
  • Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, et al. Human leptin levels are pulsatile and inversely related to pituitary- adrenal function. Nat Med. 1997; 3(5)575–9
  • Hassink SG, Sheslow DV, de Lancey E, Opentanova I, Considine RV, Caro JF. Serum leptin in children with obesity: relationship to gender and development. Pediatrics. 1996; 98: 201–3
  • Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997; 82(9)2904–10
  • Lonnqvist F, Nordfors L, Jansson M, Thorne A, Schalling M, Arner P. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest. 1997; 99(10)2398–404
  • Montague CT, Prins JB, Sanders L, Digby JE, O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes. 1997; 46(3)342–7
  • Hardie L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol. 1997; 47(1)101–6
  • Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, et al. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes. 1996; 45(5)699–701
  • Berneis K, Vosmeer S, Keller U. Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. Eur J Endocrinol. 1996; 135(6)663–5
  • Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, et al. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest. 1997; 100(4)808–13
  • Kolaczynski JW, Ohannesian JP, Considine RV, Marco CC, Caro JF. Response of leptin to short-term and prolonged overfeeding in humans. J Clin Endocrinol Metab. 1996; 81(11)4162–5
  • Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, et al. Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes. 1996; 45(11)1511–5
  • van Aggel-Leijssen DP, van Baak MA, Tenenbaum R, Campfield LA, Saris WH. Regulation of average 24 h human plasma leptin level; the influence of exercise and physiological changes in energy balance. Int J Obes Relat Metab Disord. 1999; 3(2)151–8
  • Lahlou N, Landais P, De Boissieu D, Bougneres PF. Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes. 1997; 46(6)989–93
  • Nagy TR, Gower BA, Trowbridge CA, Dezenberg C, Shewchuk RM, Goran MI. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab. 1997; 82(7)2148–52
  • Argente J, Barrios V, Chowen JA, Sinha MK, Considine RV. Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr. 1997; 131(6)833–8
  • Falorni A, Bini V, Molinari D, Papi F, Celi F, Di Stefano G, et al. Leptin serum levels in normal weight and obese children and adolescents: relationship with age, sex, pubertal development, body mass index and insulin. Int J Obes Relat Metab Disord. 1997; 21(10)881–90
  • Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab. 1997; 82(9)2849–55
  • Ahmed ML, Ong KK, Morrell DJ, Cox L, Drayer N, Perry L, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab. 1999; 84(3)899–905
  • Reiterer EE, Sudi KM, Mayer A, Limbert-Zinterl C, Stalzer-Brunner C, Fuger G, et al. Changes in leptin, insulin and body composition in obese children during a weight reduction program. J Pediatr Endocrinol Metab. 1999; 12(6)853–62
  • Gutin B, Ramsey L, Barbeau P, Cannady W, Ferguson M, Litaker M, et al. Plasma leptin concentrations in obese children: changes during 4-mo periods with and without physical training. Am J Clin Nutr. 1999; 69(3)388–94
  • Di Stefano G, Bini V, Papi F, Celi F, Contessa G, Berioli MG, et al. Leptin serum concentrations predict the responsiveness of obese children and adolescents to weight excess reduction program. Int J Obes Relat Metab Disord. 2000; 24(12)1586–91
  • Pilcova R, Sulcova J, Hill M, Blaha P, Lisa L. Leptin levels in obese children: Effects of gender, weight reduction and androgens. Physiol Res. 2003; 52: 53–60
  • Reinehr T, Kratzch J, Kiess W, Andler W. Circulating soluble leptin receptor, leptin, and insulin before and after weight loss in obese children. Int J Obes. 2005; 29: 1230–5
  • Nysom K, Molgaard C, Hutchings B, Michaelsen KF. Body mass index of 0 to 45-y-old Danes: reference values and comparison with published European reference values. Int J Obes Relat Metab Disord. 2001; 25: 177–84
  • Schaefer F, Georgi M, Zieger A, Scharer K. Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children. Pediatr Res. 1994; 35(5)617–24
  • Wabitsch M, Braun U, Heinze E, Muche R, Mayer H, Teller W, et al. Body composition in 5–18-y-old obese children and adolescents before and after weight reduction as assessed by deuterium dilution and bioelectrical impedance analysis. Am J Clin Nutr. 1996; 64: 1–6
  • Diggle, P, Heagerty, P, Liang, K-Y, Zeger, S. Analysis of longitudinal data. Second ed. Oxford: Oxford University Press; 2002.
  • Wing RR, Sinha MK, Considine RV, Lang W, Caro JF. Relationship between weight loss maintenance and changes in serum leptin levels. Horm Metab Res. 1996; 28(12)698–703
  • Wadden TA, Considine RV, Foster GD, Anderson DA, Sarwer DB, Caro JS. Short- and long-term changes in serum leptin dieting obese women: effects of caloric restriction and weight loss. J Clin Endocrinol Metab. 1998; 83(1)214–8
  • Zimmet P, Hodge A, Nicolson M, Staten M, de Courten M, Moore J, et al. Serum leptin concentration, obesity, and insulin resistance in Western Samoans: cross sectional study. BMJ. 1996; 313(7063)965–9
  • Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996; 81(12)4406–13
  • Ravussin E, Gautier JF. Metabolic predictors of weight gain. Int J Obes Relat Metab Disord. 1999; 23: 37–41
  • Bagdade J, Bierman E, Porte DJ. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest. 1967; 46: 1549–57
  • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995; 269(5223)546–9
  • Woods S, Lotter E, McKay L, Porte D. Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. Nature. 1979; 282: 503–5
  • Butte NF, Hopkinson JM, Nicolson MA. Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab. 1997; 82(2)585–9
  • Schubring C, Englaro P, Siebler T, Blum WF, Demirakca T, Kratzsch J, et al. Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm Res. 1998; 50(5)276–83
  • Schwartz MW, Woods SC, Seeley RJ, Barsh GS, Baskin DG, Leibel RL. Is the energy homeostasis system inherently biased toward weight gain?. Diabetes. 2003; 52: 232–8
  • Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, et al. Role of leptin in the neuroendocrine response to fasting. Nature. 1996; 382(6588)250–2
  • Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab. 1998; 83(5)1407–13

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