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Amyotrophic Lateral Sclerosis Volume 7, 2006 - Issue 4
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ORIGINAL ARTICLE

Multiple transplants of hNT cells into the spinal cord of SOD1 mouse model of familial amyotrophic lateral sclerosis

Svitlana Garbuzova‐Davis Center of Excellence for Aging and Brain Repair; Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of 3Physiology and Biophysics, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Pathology, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USACorrespondence[email protected]
,
Alison E. Willing Center of Excellence for Aging and Brain Repair; Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Anatomy, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Pathology, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA
,
Samuel Saporta Center of Excellence for Aging and Brain Repair; Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Anatomy, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA
,
Eleanor B. Justen Center of Excellence for Aging and Brain Repair
,
Iwona E. Misiuta Center of Excellence for Aging and Brain Repair; Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA
,
James Dellis Center of Excellence for Aging and Brain Repair
&
Paul R. Sanberg Center of Excellence for Aging and Brain Repair; Department of Neurosurgery, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Psychiatry, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA; Department of Pathology, University of South Florida, College of Medicine, Health Sciences Center, Tampa, Florida, USA
 show all
Pages 227-232 | Published online: 10 Jul 2009

References

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  • Hartley R. S., Trojanowski J. Q., Lee V. M. Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTERA2 neurons (NT2N, hNT). J Comp Neurol 1999; 415: 404–18
  • Garbuzova‐Davis S., Willing A. E., Milliken M., et al. Positive effect of transplantation of hNT Neurons (Ntera 2/D1 cell‐line) in a model of familial amyotrophic lateral sclerosis. Exp Neurol 2002; 174: 169–80
  • Willing A. E., Garbuzova‐Davis S., Saporta S., Milliken M., Cahill D. W., Sanberg P. R. hNT neurons delay onset of motor deficit in a model of amyotrophic lateral sclerosis. Brain Res Bull 2001; 56: 525–30
  • Garbuzova‐Davis S., Willing A. E., Milliken M., et al. Intraspinal implantation of hNT neurons into SOD1 mice with apparent motor deficit. Amyotroph Lateral Scler Other Motor Neuron Disord 2001; 2: 175–80
  • Kong J., Xu Z. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J Neurosci. 1998; 18: 3241–50

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