144
Views
8
CrossRef citations to date
0
Altmetric
Clinical Trial

Alternative trial design in amyotrophic lateral sclerosis saves time and patients

, , , &
Pages 266-269 | Received 26 Sep 2006, Accepted 25 Apr 2007, Published online: 10 Jul 2009

References

  • Traynor B. J., Codd M. B., Corr B., Forde C., Frost E., Hardiman O. Incidence and prevalence of ALS in Ireland, 1995–1997: a population‐based study. Neurology 1999; 52: 504–9
  • Levy G., Kaufmann P., Buchsbaum R., Montes J., Barsdorf A., Arbing R., et al. A two‐stage design for a phase II clinical trial of coenzyme Q10 in ALS. Neurology 2006; 66: 660–3
  • Whitehead J. The Design and Analysis of Sequential Clinical Trials. J.Wiley and Sons Ltd., Chichester 1997, Rev. 2nd edn
  • Whitehead J. Monotherapy trials: sequential design. Epilepsy Res 2001; 45: 81–7
  • Graf M., Ecker D., Horowski R., Kramer B., Riederer P., Gerlach M., et al. High dose vitamin E therapy in amyotrophic lateral sclerosis as add‐on therapy to riluzole: results of a placebo‐controlled double‐blind study. J Neural Transm 2005; 112: 649–60
  • Skovlund E., Walloe L. Sequential or fixed sample trial design? A case study by stochastic simulation. J Clin Epidemiol 1991; 44: 265–72
  • Bolland K., Weeks A., Whitehead J., Lees KR; GAIN International Steering Committee and the Investigators. How a sequential design would have affected the GAIN International Study of gavestinel in stroke. Cerebrovasc Dis 2004; 17: 111–7
  • Groeneveld G. J., van der Tweel I., Wokke J. H. J., Van den Berg L. H. Sequential designs for clinical trials in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2004; 5: 1–6

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.