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Review

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies

Pages 61-90 | Received 08 Nov 2018, Accepted 30 Nov 2018, Published online: 11 Jan 2019

References

  • Meyer TW, Hostetter TH. Uremia. N Engl J Med. 2007;357(13):1316–1325.
  • Coresh J, Selvin E, Stevens LA, et al. Prevalence of chronic kidney disease in the United States. JAMA. 2007;298(17):2038–2047.
  • Barsoum RS. Chronic kidney disease in the developing world. N Engl J Med. 2006;354(10):997–999.
  • Kurella Tamura M, Unruh ML, Nissenson AR, et al. Frequent Hemodialysis Network (FHN) Trial group. Effect of more frequent hemodialysis on cognitive function in the frequent hemodialysis network trials. Am J Kidney Dis. 2013;61(2):228–237.
  • Murray AM, Bell EJ, Tupper DE, et al. The Brain in Kidney Disease (BRINK) cohort study: design and baseline cognitive function. Am J Kidney Dis. 2016;67(4):593–600.
  • Seliger SL, Siscovick DS, Stehman-Breen CO, et al. Moderate renal impairment and risk of dementia among older adults: the cardiovascular health cognition study. J Am Soc Nephrol. 2004;15(7):1904–1911.
  • Raskin NH, Fishman RA. Neurologic disorders in renal failure (second of two parts). N Engl J Med. 1976;294(4):204–210.
  • Seifter JL, Samuels MA. Uremic encephalopathy and other brain disorders associated with renal failure. Semin Neurol. 2011;31(2):139–143.
  • Fraser CL. Neurological manifestations of the uremic state. In: Arieff AI, Griggs RC, editors. Metabolic brain dysfunction in systemic disorders. Boston: Little Brown; 1992. p. 139–166.
  • Barkovich AJ. Toxic and metabolic brain disorders. Pediatric neuroimaging. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005.
  • Young RR, Shahani BT. Asterixis: one type of negative myoclonus. Adv Neurol. 1986;43:137–156.
  • Chadwick D, French AT. Uraemic myoclonus: an example of reticular reflex myoclonus? J Neurol Neurosurg Psychiatry. 1979;42(1):52–55.
  • Chadwick D, Hallett M, Harris R, et al. Clinical, biochemical and physiological factors distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan plus a monoamine oxidase inhibitor, and clonazepam. Brain. 1977;100(3):455–487.
  • Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12(1):61–65.
  • Enomoto M, Inoue Y, Namba K, et al. Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients. Mov Disord. 2008;23(6):811–816.
  • Trenkwalder C, Allen R, Högl B, et al. Restless legs syndrome associated with major diseases: A systematic review and new concept. Neurology. 2016;86(14):1336–1343.
  • Tarhan NC, Agildere AM, Benli US, et al. Osmotic demyelination syndrome in end-stage renal disease after recent hemodialysis: MRI of the brain. AJR Am J Roentgenol. 2004;182(3):809–816.
  • Triger DR, Joekes AM. Severe muscle cramp due to acute hypomagnesaemia in haemodialysis. Br Med J. 1969;2(5660):804–805.
  • Toyoda K, Ninomiya T. Stroke and cerebrovascular diseases in patients with chronic kidney disease. Lancet Neurol. 2014;13(8):823–833.
  • Drechsler C, Kalim S, Wenger JB, et al. Protein carbamylation is associated with heart failure and mortality in diabetic patients with end-stage renal disease. Kidney Int. 2015;87(6):1201–1208.
  • Sandsmark DK, Messé SR, Zhang X, et al. CRIC study investigators. Proteinuria, but not eGFR, predicts stroke risk in chronic kidney disease: chronic renal insufficiency cohort study. Stroke. 2015;46(8):2075–2080.
  • Masson P, Webster AC, Hong M, et al. Chronic kidney disease and the risk of stroke: A systematic review and meta-analysis. Nephrol Dial Transplant. 2015;30(7):1162–1169.
  • Cohen SN, Syndulko K, Rever B, et al. Visual evoked potentials and long latency event-related potentials in chronic renal failure. Neurology. 1983;33(9):1219–1222.
  • Antonelli AR, Bonfioli F, Garrubba V, et al. Audiological findings in elderly patients with chronic renal failure. Acta Otolaryngol Suppl. 1990;476:54–68.
  • Frasnelli JA, Temmel AF, Quint C, et al. Olfactory function in chronic renal failure. Am J Rhinol. 2002;16(5):275–279.
  • Wang HC, Brown P, Lees AJ. Acute movement disorders with bilateral basal ganglia lesions in uremia. Mov Disord. 1998;13(6):952–957.
  • Wang HC, Hsu JL, Shen YY. Acute bilateral basal ganglia lesions in patients with diabetic uremia: an FDG-PET study. Clin Nucl Med. 2004;29(8):475–478.
  • Cupidi C, Piccoli F, La Bella V. Acute reversible parkinsonism in a diabetic-uremic patient. Clin Neurol Neurosurg. 2006;108(6):601–603.
  • Park JH, Kim HJ, Kim SM. Acute chorea with bilateral basal ganglia lesions in diabetic uremia. Can J Neurol Sci. 2007;34(2):248–250.
  • Kiryluk K, Khan F, Valeri A. Acute chorea and bilateral basal ganglia lesions in a haemodialysis patient. Kidney Int. 2008;73(9):1087–1091.
  • Dicuonzo F, Di Fede R, Salvati A, et al. Acute extrapyramidal disorder with bilateral reversible basal ganglia lesions in a diabetic uremic patient: diffusion-weighted imaging and spectroscopy findings. J Neurol Sci. 2010;293(1–2):119–121.
  • Lin JJ. Generalized chorea in the syndrome of acute bilateral basal ganglia lesions in patients with diabetic uremia. J Clin Neurosci. 2011;18(9):1266–1268.
  • Wali GM, Khanpet MS, Mali RV. Acute movement disorder with bilateral basal ganglia lesions in diabetic uremia. Ann Indian Acad Neurol. 2011;14(3):211–213.
  • Renard D, Castelnovo G, Taieb G, et al. Bilateral basal ganglia lesions in a diabetic-uremic patient with dystonia. Acta Neurol Belg. 2011;111(2):166–167.
  • Vaziri D, Pratt H, Saiki JK, et al. Evaluation of somatosensory pathway by short latency evoked potentials in patients with end-stage renal disease maintained on hemodialysis. Int J Artif Organs. 1981;4(1):17–22.
  • Kiernan MC, Walters RJ, Andersen KV, et al. Nerve excitability changes in chronic renal failure indicate membrane depolarization due to hyperkalaemia. Brain. 2002;125(Pt 6):1366–1378.
  • Krishnan AV, Phoon RK, Pussell BA, et al. Ischaemia induces paradoxical changes in axonal excitability in end-stage kidney disease. Brain. 2006;129(Pt 6):1585–1592.
  • Heidbreder E, Schafferhans K, Heidland A. Disturbances of peripheral and autonomic nervous system in chronic renal failure: effects of hemodialysis and transplantation. Clin Nephrol. 1985;23(5):222–228.
  • Vita G, Bellinghieri G, Trusso A, et al. Uremic autonomic neuropathy studied by spectral analysis of heart rate. Kidney Int. 1999;56(1):232–237.
  • Ando Y, Asahara K, Obayashi K, et al. Autonomic dysfunction and anemia in neurologic disorders. J Auton Nerv Syst. 1996;61(2):145–148.
  • Biaggioni I, Robertson D, Krantz S, et al. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med. 1994;121(3):181–186.
  • Winkler AS, Marsden J, Chaudhurit KR, et al. Erythropoietin depletion and anaemia in diabetes mellitus. Diabet Med. 1999;16(10):813–819.
  • Ricerca BM, Todaro L, Caputo S, et al. Blunted erythropoietin response to aneamia in type 1 diabetic patients. Diabetes Care. 1999;22(4):647.
  • Spertini F, Wauters JP, Poulenas I. Carpal tunnel syndrome: a frequent, invalidating, longterm complication of chronic hemodialysis. Clin Nephrol. 1984;21(2):98–101.
  • Wilbourn AJ, Furlan AJ, Hulley W, et al. Ischemic monomelic neuropathy. Neurology. 1983;33(4):447–451.
  • Berman SS, Gentile AT, Glickman MH, et al. Distal revascularization interval ligation for limb salvage and maintenance of dialysis access in ischemic steal syndrome. J Vasc Surg. 1997;26(3):393–402.
  • Miles AM. Vascular steal syndrome and ischaemic monomelic neuropathy: two variants of upper limb ischaemia after haemodialysis vascular access surgery. Nephrol Dial Transplant. 1999;14(2):297–300.
  • Campistol JM. Uremic myopathy. Kidney Int. 2002;62(5):1901–1913.
  • De Deyn PP, Vanholder R, Eloot S, et al. Guanidino compounds as uremic (neuro) toxins. Semin Dial. 2009;22(4):340–345.
  • Hughes JR. Correlation between EEG and chemical changes in uremia. Electroencephalogr Clin Neurophysiol. 1980;48(5):583–694.
  • Smogorzewski M, Ni Z, Massry SG. Function and metabolism of brain synaptosomes in chronic renal failure. Artif Organs. 1995;19(8):795–800.
  • Nomoto K, Scurlock C, Bronster D. Dexmedetomidine controls twitch-convulsive syndrome in the course of uremic encephalopathy. J Clin Anesth. 2011;23(8):646–648.
  • Ho VB, Fitz CR, Chuang SH, et al. Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics. 1993;13(2):269–292.
  • Chang MH, Li JY, Lee SR, et al. Non-ketotic hyperglycaemic chorea: a SPECT study. J Neurol Neurosurg Psychiatry. 1996;60(4):428–430.
  • Finelli PF, DiMario FJ Jr. Diagnostic approach in patients with symmetric imaging lesions of the deep gray nuclei. Neurologist. 2003;9(5):250–261.
  • Adachi N, Lei B, Deshpande G, et al. Uraemia suppresses central dopaminergic metabolism and impairs motor activity in rats. Intensive Care Med. 2001;27(10):1655–1660.
  • Depner TA. Uremic Toxicity: urea and Beyond. Semin Dial. 2001;14(4):246–251.
  • Deguchi T, Isozaki K, Yousuke K, et al. Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier. J Neurochem. 2006;96(4):1051–1059.
  • Baumgaertel MW, Kraemer M, Berlit P. Neurologic complications of acute and chronic renal disease. Handb Clin Neurol. 2014;119:383–393.
  • Savica V, Bellinghieri G, Di Stefano C, et al. Plasma and muscle carnitine levels in haemodialysis patients with morphological–ultrastructural examination of muscle samples. Nephron. 1983;35(4):232–236.
  • Thompson CH, Kemp GJ, Taylor DJ, et al. Effect of chronic uraemia on skeletal muscle metabolism in man. Nephrol Dial Transplant. 1993;8(3):218–222.
  • Yazdi PG, Moradi H, Yang JY, et al. Skeletal muscle mitochondrial depletion and dysfunction in chronic kidney disease. Int J Clin Exp Med. 2013;6(7):532–539.
  • Martinez AW, Recht NS, Hostetter TH, et al. Removal of p-cresol sulfate by hemodialysis. J Am Soc Nephrol. 2005;16(11):3430–3436.
  • Ritz E, Stefanski A, Rambausek M. The role of the parathyroid glands in the uremic syndrome. Am J Kidney Dis. 1995;26(5):808–813.
  • Sutters M, Gaboury CL, Bennett WM. Severe hyperphosphatemia and hypocalcemia: a dilemma in patient management. J Am Soc Nephrol. 1996;7(10):2056–2061.
  • Kielstein JT, Zoccali C. Asymmetric dimethylarginine: A cardiovascular risk factor and a uremic toxin coming of age. Am J Kidney Dis. 2005;46(2):186–202.
  • Shin YK, Hong SC, Ihn YK, et al. A case of a patient with both chorea and restless legs syndrome. J Korean Med Sci. 2008;23(3):533–536.
  • Yoon JW, Pahl MV, Vaziri ND. Spontaneous leukocyte activation and oxygen-free radical generation in end-stage renal disease. Kidney Int. 2007;71(2):167–172.
  • Nishimura Y, Shibata K, Funaki T, et al. A case of subacute parkinsonism presenting as bilateral basal ganglia legions by MRI in diabetic uremic syndrome. Rinsho Shinkeigaku. 2013;53(3):217–223.
  • Marsh JT, Brown WS, Wolcott D, et al. rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int. 1991;39(1):155–163.
  • Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis. 2010;55(4):726–741.
  • Brodeur C, Montplaisir J, Godbout R, et al. Treatment of restless legs syndrome and periodic movements during sleep with Ldopa: a double-blind, controlled study. Neurology. 1988;38(12):1845–1848.
  • Winkelmann J, Stautner A, Samtleben W, et al. Long-term course of restless legs syndrome in dialysis patients after kidney transplantation. Mov Disord. 2002;17(5):1072–1076.
  • Cairo G, Recalcati S, Pietrangelo A, et al. The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic Biol Med. 2002;32(12):1237–1243.
  • Kim MK, Baek KH, Lim DJ, et al. Erythropoietin response to anemia and its association with autonomic neuropathyin type 2 diabetic patients without advanced renal failure. J Diabetes Complications. 2010;24(2):90–95.
  • Friedland J, Paterson D. Potassium and fatigue. Lancet. 1988;2(8617):961–962.
  • Vaziri ND. Anemia and anemia correction: surrogate markers or causes of morbidity in chronic kidney disease? Nat Clin Pract Nephrol. 2008;4(8):436–445.
  • Berrone E, Beltramo E, Solimine C, et al. Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem. 2006;281(14):9307–9313.
  • Jagadha V, Deck JH, Halliday WC, et al. Wernicke’s encephalopathy in patients on peritoneal dialysis or hemodialysis. Ann Neurol. 1987;21(1):78–84.
  • Hung SC, Hung SH, Tarng DC, et al. Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis. 2001;38(5):941–947.
  • Slatopolsky E, Martin K, Hruska K. Parathyroid hormone metabolism and its potential as a uremic toxin. Am J Physiol. 1980;239(1):F1–12.
  • Cogan MG, Covey CM, Arieff AI, et al. Central nervous system manifestations of hyperparathyroidism. Am J Med. 1978;65(6):963–970.
  • Engel AG. Metabolic and endocrine myopathies. In: Walton J, editor. Disorders of voluntary muscle, 5th ed. Vol. 25, 811–868. Edinburgh: Churchill Livingstone; 1988.
  • Craver L, Marco MP, Martínez I, et al. Mineral metabolism parameters throughout chronic kidney disease stages 1–5–achievement of K/DOQI target ranges. Nephrol Dial Transplant. 2007;22(4):1171–1176.
  • Von Kaulla KN, Von Kaulla E, Wasantapruck S, et al. Blood coagulation in uremic patients before and after hemodialysis and transplantation of the kidney. Arch Surg. 1966;92(2):184–191.
  • Lipton SA, Kim WK, Choi YB, et al. Neurotoxicity with dual actions of homocysteine at the N-methyl-D spartate receptor. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5923–5928.
  • Fassbender K, Mielke O, Bertsch T, et al. Homocysteine in cerebral macroangiography and microangiopathy. Lancet. 1999;353(9164):1586–1587.
  • Ohtake T, Negishi K, Okamoto K, et al. Manganese-induced parkinsonism in a patient undergoing maintenance hemodialysis. Am J Kidney Dis. 2005;46(4):749–753.
  • Da Silva CJ, Da Rocha AJ, Jeronymo S, et al. A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: manganism symptoms and T1 hyperintense changes in the basal ganglia. AJNR Am J Neuroradiol. 2007;28(8):1474–1479.
  • Alfrey AC, LeGendre GR, Kaehny WD. The dialysis encephalopathy syndrome. Possible aluminum intoxication. N Engl J Med. 1976;294(4):184–188.
  • Drew DA, Bhadelia R, Tighiouart H, et al. Anatomic brain disease in hemodialysis patients: a cross-sectional study. Am J Kidney Dis. 2013;61(6):271–278.
  • Griva K, Thompson D, Jayasena D, et al. Cognitive functioning pre- to post-kidney transplantation — a prospective study. Nephrol Dial Transplant. 2006;21(11):3275–3282.
  • Radić J, Ljutić D, Radić M, et al. transplantation improves cognitive and psychomotor functions in adult haemodialysis patients. Am J Nephrol. 2011;34(5):399–406.
  • Schmidt R, Schmidt H, Curb JD, et al. Early inflammation and dementia: a 25-year follow-up of the honolulu-asia aging study. Ann Neurol. 2002;52(2):168–174.
  • Fujisaki K, Tsuruya K, Yamato M, et al. Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol. Nephrol Dial Transplant. 2014;29(3):529–538.
  • Deng G, Vaziri ND, Jabbari B, et al. Increased tyrosine nitration of the brain in chronic renal insufficiency: reversal by antioxidant therapy and angiotensin converting enzyme inhibition. J Am Soc Nephrol. 2001;12(9):1892–1899.
  • Martinez-Vea A, Salvadó E, Bardají A, et al. Silent cerebral white matter lesions and their relationship with vascular risk factors in middle-aged predialysis patients with CKD. Am J Kidney Dis. 2006;47(2):241–250.
  • Descombes E, Boulat O, Perriard F, et al. Water-soluble vitamin levels in patients undergoing high-flux hemodialysis and receiving long-term oral postdialysis vitamin supplementation. Artif Organs. 2000;24(10):773–778.
  • Bukhari FJ, Moradi H, Gollapudi P, et al. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Nephrol Dial Transplant. 2011;26(7):2137–2144.
  • Calingasan NY, Chun WJ, Park LC, et al. Oxidative stress is associated with region-specific neuronal death during thiamine deficiency. J Neuropathol Exp Neurol. 1999;58(9):946–958.
  • Atkinson MA, White CT. Hepcidin in anemia of chronic kidney disease: review for the pediatric nephrologist. Pediatr Nephrol. 2012;27(1):33–40.
  • Schuster S, Wilson J, Erslev AJ, et al. Physiologic regulation and tissue localization of renal erythropoietin mRNA. Blood. 1987;70(1):316–318.
  • Besarab A, Ayyoub F. Anemia in renal disease. In: Schrier RW, editor. Diseases of the kidney and urinary tract. 8th ed. Philadelphia: Lippincott Williams and Wilkins; 2007. p. 2406–2430.
  • Larson LM, Phiri KS, Pasricha SR. Iron and cognitive development: what is the evidence? Ann Nutr Metab. 2017;71(Suppl 3):25–38.
  • Lewis EG, O’neill WM, Dustman RE, et al. Temporal effects of hemodialysis on measures of neural efficiency. Kidney Int. 1980;17(3):357–363.
  • Day E, Bentham PW, Callaghan R, et al. Thiamine for prevention and treatment of wernicke- korsakoff syndrome in people who abuse alcohol (Cochrane Review). Cochrane Database Syst Rev. 2013;7:CD004033.
  • Isenberg-Grzeda E, Hsu AJ, Hatzoglou V, et al. Palliative treatment of thiamine-related encephalopathy (Wernicke’s encephalopathy) in cancer: A case series and review of the literature. Palliat Support Care. 2015;13(5):1241–1249.
  • Thomson AD, Cook CC, Touquet R, et al. The Royal College of Physicians report on alcohol: guidelines for managing Wernicke’s encephalopathy in the accident and emergency department. Alcohol. 2002;37(6):513–521.
  • Goodman WG, Hladik GA, Turner SA, et al. The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J Am Soc Nephrol. 2002;13(4):1017–1024.
  • Moe SM, Chertow GM, Coburn JW, et al. Achieving NKF-K/DOQI bone metabolism and disease treatment goals with cinacalcet HCl. Kidney Int. 2005;67(2):760–771.
  • Biasioli S, D’Andrea G, Feriani M, et al. Uremic encephalopathy: an updating. Clin Nephrol. 1986;25(2):57–63.
  • Okada J, Yoshikawa K, Matsuo H, et al. Reversible MRI and CT findings in uremic encephalopathy. Neuroradiology. 1991;33(6):524–526.
  • Fugate JE, Claassen DO, Cloft HJ, et al. Posterior reversible encephalopathy syndrome: associated clinical and radiologic findings. Mayo Clin Proc. 2010;85(5):427–432.
  • Iwafuchi Y, Okamoto K, Oyama Y, et al. Posterior reversible encephalopathy syndrome in a patient with severe uremia without hypertension. Intern Med. 2016;55(1):63–68.
  • Lee YH. Diabetic nephropathy with acute symmetrical changes in the basal ganglia regions. Clin Radiol. 2005 Jul;60(7):815–820.
  • Yavuz A, Tetta C, Ersoy FF, et al. Uremic toxins: a new focus on an old subject. Semin Dial. 2005;18(3):203–211.
  • Forrest MD, Wall MJ, Press DA, et al. The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS One. 2012;7(12):e51169.
  • Van Den Noort S, Eckel RE, Brine K, et al. Brain metabolism in uremic and adenosine-infused rats. J Clin Invest. 1968;47(9):2133–2142.
  • Zhan M, Brooks C, Liu F, et al. Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int. 2013;83(4):568–581.
  • Lonergan ET, Semar M, Sterzel RB, et al. Erythrocyte transketolase activity in dialyzed patients. A reversible metabolic lesion of uremia. N Engl J Med. 1971;284(25):1399–1403.
  • Bettendorff L. Thiamine in excitable tissues: reflections on a non-cofactor role. Metab Brain Dis. 1994. 9. Sep(3):183–209.
  • Bartynski W. Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol. 2008;29(6):1043–1049.
  • de Oliveira RA, Fechine LM, Neto FC, et al. Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis. Int Urol Nephrol. 2008;40(4):1095–1098.
  • Kennedy AC, Linton AL, Eaton JC. Urea levels in cerebrospinal fluid after haemodialysis. Lancet. 1962;1(7226):410–411.
  • Benna P, Lacquaniti F, Triolo G, et al. Acute neurologic complications of hemodialysis. Study of 14,000 hemodialyses in 103 patients with chronic renal failure. Ital J Neurol Sci. 1981;2(1):53–57.
  • Trinh-Trang-Tan MM, Cartron JP, Bankir L. Molecular basis for the dialysis disequilibrium syndrome: altered aquaporin and urea transporter expression in the brain. Nephrol Dial Transplant. 2005;20(9):1984–1988.
  • Arieff AI, Guisado R, Massry SG, et al. Central nervous system pH in uremia and the effects of hemodialysis. J Clin Invest. 1976;58(2):306–311.
  • Pauli HG, Vorburger C, Reubi F. Chronic derangements of cerebrospinal fluid acid-base components in man. J Appl Physiol. 1962;17:993–998.
  • Cowie J, Lambie AT, Robson JS. The influence of extracorporeal dialysis on the acid-base composition of blood and cerebrospinal fluid. Clin Sci. 1962;23:397–404.
  • Rodrigo F, Shideman J, Mchugh R, et al. Osmolality changes during haemodialysis. Natural history, clinical correlations, and influence of dialysate glucose and intravenous mannitol. Ann Intern Med. 1977;86(5):554–561.
  • Jack R, Rabin PL, McKinney TD. Dialysis encephalopathy: a review. Int J Psychiatry Med. 1983–1984;13(4):309–326.
  • Kurella M, Mapes DL, Port FK, et al. Correlates and outcomes of dementia among dialysis patients: the dialysis outcomes and practice patterns study. Nephrol Dial Transplant. 2006;21(9):2543–2548.
  • Exley C. Aluminium and medicine. In: Merce ALR, Felcman J, Recio MAL, editors. Molecular and supramolecular bioinorganic chemistry: applications in medical sciences. New York (NY): Nova Science Pub Inc; 2009. p. 45.
  • Niu PY, Niu Q, Zhang QL, et al. Aluminum impairs rat neural cell mitochondria in vitro. Int J Immunopathol Pharmacol. 2005;18(4):683–699.
  • McCarthy JT, Milliner DS, Johnson WJ. Clinical experience with desferrioxamine in dialysis patients with aluminium toxicity. Q J Med. 1990;74(275):257–276.
  • Chua GC, Sitoh YY, Lim CCT, et al. MRI findings in osmotic myelinolysis. Clin Radiol. 2002;57(9):800–806.
  • Adams RD, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto underscribed disease occurring in alcoholic and malnourished patients. AMA Arch Neurol Psychiatry. 1959;81(2):154–172.
  • Spasovski G, Vanholder R, Allolio B, et al. practice guideline on diagnosis and treatment of hyponatraemia. Intensive Care Med. 2014;40(3):320–331.
  • Vega D, Maalouf NM, Sakhaee K. Increased propensity for calcium phosphate kidney stones with topiramate use. Expert Opin Drug Saf. 2007;6(5):547–557.
  • Israni RK, Kasbekar N, Haynes K, et al. Use of antiepileptic drugs in patients with kidney disease. Semin Dial. 2006;19(5):408–416.
  • Gabardi S, Abramson S. Drug dosing in chronic kidney disease. Med Clin North Am. 2005;89(3):649–687.
  • Frenchie D, Bastani B. Significant removal of phenytoin during high flux dialysis with cellulose triacetate dialyzer. Nephrol Dial Transplant. 1998;13(3):817–818.
  • Vulliemoz S, Iwanowski P, Landis T, et al. Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves. Seizure. 2000;18(5):June):376–378.
  • Armstrong CM, Cota G. Calcium block of Na+ channels and its effect on closing rate. Proc Natl Acad Sci U S A. 1999;96(7):4154–4157.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930.
  • Turjanski N, Lees AJ, Brooks DJ. Striatal dopaminergic function inrestless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology. 1999;52(5):932–937.
  • Mizuno S, Mihara T, Miyaoka T, et al. CSF iron, ferritin and transferrin levels in restless legs syndrome. J Sleep Res. 2005;14(1):43–47.
  • Brismar J, Ozand PT. CT and MR of the brain in the diagnosis of organic acidemias. Experiences from 107 patients. Brain Dev. 1994;16 Suppl:104–124.
  • Oh SH, Lee KY, Im JH, et al. Chorea associated with non-ketotic hyperglycemia and hyperintensity basal ganglia lesion on T1-weighted brain MRI study: a meta-analysis of 53 cases including four present cases. J Neurol Sci. 2002;200(1–2):57–62.
  • Lai SL, Tseng YL, Hsu MC, et al. Magnetic resonance imaging and single-photon emission computed tomography changes in hypoglycemia-induced chorea. Mov Disord. 2004;19(4):475–478.
  • Hattan E, Chalk C, Postuma RB. Is there a higher risk of restless legs syndrome in peripheral neuropathy? Neurology. 2009;72(11):955–960.
  • Takaki J, Nishi T, Nangaku M, et al. Clinical and psychological aspects of restless legs syndrome in uremic patients on hemodialysis. Am J Kidney Dis. 2003;41(4):833–839.
  • Sloand JA, Shelly MA, Feigin A, et al. A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome. Am J Kidney Dis. 2004;43(4):663–670.
  • Lauerma H, Markkula J. Treatment of restless legs syndrome with tramadol: an open study. J Clin Psychiatry. 1999;60(4):241–244.
  • Novak M, Mendelssohn D, Shapiro CM, et al. Diagnosis and management of sleep apnea syndrome and restless legs syndrome in dialysis patients. Semin Dial. 2006;19(3):210–216.
  • Adams RD, Foley JM. The neurological disorder associated with liver disease. Res Publ Assoc Res Nerv Ment Dis. 1953;32:198–237.
  • Tyler HR. Neurological disorders in renal failure. Am J Med. 1968;44(5):734–748.
  • Stark RJ. Reversible myoclonus with uraemia. Br Med J (Clin Res Ed). 1981;282(6270):1119–1120.
  • Tedeschi F, Trabattoni G, Tagliavini F, et al. Encephalopathy with myoclonus in an uremic non dialysed patient. A Case Report Acta Neurol (Napoli). 1982;4(2):129–134.
  • Zuckermann EG, Glaser GH. Urea-induced myoclonic seizures. An experimental study of site of action and mechanism. Arch Neurol. 1972;27(1):14–28.
  • Muscatt S, Rothwell J, Obeso J, et al. Urea-induced stimulus-sensitive myoclonus in the rat. Adv Neurol. 1986;43:553–563.
  • Wang HC, Cheng SJ. The syndrome of acute bilateral basal ganglia lesions in diabetic uremic patients. J Neurol. 2003;250(8):948–955.
  • Kim TK, Seo SI, Kim JH, et al. Diffusion-weighted magnetic resonance imaging in the syndrome of acute bilateral basal ganglia lesions in diabetic uremia. Mov Disord. 2006;21(8):1267–1270.
  • Lee PH, Shin DH, Kim JW, et al. Parkinsonism with basal ganglia lesions in a patient with uremia: evidence of vasogenic edema. Parkinsonism Relat Disord. 2006;12(2):93–96.
  • Li JY, Yong TY, Sebben R, et al. Bilateral basal ganglia lesions in patients with end-stage diabetic nephropathy. Nephrology (Carlton). 2008;13(1):68–72.
  • Hung SC, Hung SH, Tarng DC, et al. Chorea induced by thiamine deficiency in hemodialysis patients. Am J Kidney Dis. 2001;37(2):427–430.
  • Lee EJ, Park JH, Ihn Y, et al. Acute bilateral basal ganglia lesions in diabetic uraemia: diffusion-weighted MRI. Neuroradiology. 2007;49(12):1009–1013.
  • Tajima Y, Mito Y, Yanai M, et al. Unusual basal ganglia lesions in a diabetic uraemic patient proven to be demyelination: first pathological observation. BMJ Case Rep. 2012;2012:bcr2012006522.
  • Dell LA, Brown MS, Orrison WW. Physiologic intracranial calcifications with hyperintensity on MR imaging. AJNR Am J Neuroradiol. 1988;9(6):1145–1148.
  • Middleton FA, Strick PL. Basal ganglia output and cognition: evidence from anatomical, behavioral and clinical studies. Brain Cogn. 2000 Mar;42(2):183–200.
  • Sperlágh B, Vizi ES. The role of extracellular adenosine in chemical neurotransmission in the hippocampus and basal ganglia: pharmacological and clinical aspects. Curr Top Med Chem. 2011;11(8):1034–1046.
  • New DI, Chesser AM, Thuraisingham RC, et al. Cerebral artery responses to pressure and flow in uremic hypertensive and spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 2003;284(4):H1212–H1216.
  • Port JD, Beauchamp JNJ. Reversible intracerebral pathologic entities mediated by vascular autoregulatory dysfunction. Radiographics. 1998;18(2):353–367.
  • Cheng SJ, Hsuch JH, Po HL, et al. Neuroimaging characteristics of basal ganglia lesions in diabetic patients: correlation with clinical features. Acta Neurol Taiwan. 2001;10:14–20.
  • Mooradian AD. Central nervous system complications of diabetes mellitus—a perspective from the blood–brain barrier. Brain Res Brain Res Rev. 1997;23(3):210–218.
  • Kwok RP, Juorio AV. Concentration of striatal tyramine and dopamine metabolism in diabetic rats and effect of insulin administration. Neuroendocrinology. 1986;43(5):590–596.
  • Janavs JL, Aminoff MJ. Dystonia and chorea in acquired systemic disorders. J Neurol Neurosurg Psychiatry. 1998;65(4):436–445.
  • Scheuhammer A, Cherian M. The distribution and excretion of manganese: the effects of manganese dose, L-dopa & pretreatment with zinc. Toxicol Appl Pharmacol. 1982;65(2):203–213.
  • Herrero Hernandez E, Valentini MC, Discalzi G. T1-weighted hyperintensity in basal ganglia at brain magnetic resonance imaging: are different pathologies sharing a common mechanism? Neurotoxicology. 2002;23(6):669–674.
  • Seo YA, Li Y, Wessling-Resnick M. Iron depletion increases manganese uptake and potentiates apoptosis through ER stress. Neurotoxicology. 2013;38:67–73.
  • Prevett MC, Rossor MN. Central pontine and extrapontine myelinolysis presenting with parkinsonism in a patient with cystic fibrosis. Mov Disord. 1999;14(3):523–525.
  • Avrahami E, Cohn DF, Feibel M, et al. MRI demonstration and CT correlation of the brain in patients with idiopathic intracerebral calcification. J Neurol. 1994;241(6):381–384.
  • Govaert P, Lequin M, Swarte R, et al. Changes in globus pallidus with (pre) term kernicterus. Pediatrics. 2003;112(6 Pt 1):1256–1263.
  • Casanova MF, Araque JM. Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging. Psychiatry Res. 2003;121(1):59–87.
  • Cummings JL, Gosenfeld LF, Houlihan JP, et al. Neuropsychiatric disturbances associated with idiopathic calcification of th basal ganglia. Biol Psychiatry. 1983;18(5):591–601.
  • Kerr DN, Ward MK, Ellis HA, et al. Aluminium intoxication in renal disease. Ciba Found Symp. 1992;169:123–135.
  • Schabowski J, Ksiazek A, Paprzycki P, et al. Ferrum, copper, zinc and manganese in tissues of patients treated with long-standing hemodialysis programme. Ann Univ Mariae Curie Sklodowska Med. 1994;49:61–66.
  • Keen CL, Lo¨Nnerdal B, Hurley LS. Manganese. In: Frieden E, editor. Biochemistry of the essential ultra-trace elements. New York (NY): Plenum; 1984. p. 89–132.
  • Chen H, Li X, Epstein PN. MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes. 2005;54(5):1437–1446.
  • Wedler FC, Ley BW, Grippo AA. Manganese (II) dynamics and distribution in glial cells cultured from chick cerebral cortex. Neurochem Res. 1989;14(11):1129–1135.
  • Wang C, Gordon PB, Hustvedt SO, et al. MR imaging properties and pharmacokinetics of MnDPDP in healthy volunteers. Acta Radiol. 1997;38(4 pt 2):665–676.
  • Davidsson L, Cederblad A, Lönnerdal B, et al. Manganese retention in man: a method for estimating manganese absorption in man. Am J Clin Nutr. 1989;49(1):170–179.
  • Hosokawa S, Oyamaguchi A, Yoshida O. Trace elements and complications in patients undergoing chronic hemodialysis. Nephron. 1990;55(4):375–379.
  • Bast-Pettersen R, Ellingsen DG, Hetland SM, et al. Neuropsychological function in manganese alloy plant workers. Int Arch Occup Environ Health. 2004;77(4):277–287.
  • Shinotoh H, Snow BJ, Hewitt KA, et al. MRI and PET studies of manganese-intoxicated monkeys. Neurology. 1995;45(6):1199–1204.
  • Aschner M, Gannon M, Kimelberg HK. Manganese uptake and efflux in cultured astrocytes. J Neurochem. 1992;58(2):730–735.
  • Ellingsen DG, Haug E, Gaarder PI, et al. Endocrine and immunologic markers in manganese alloy production workers. Scand J Work Environ Health. 2003;29(3):230–238.
  • Marinho CR, Manso CF. O2 generation during neuromelanin synthesis. The action of manganese. Acta Med Port. 1993;6(11):547–554.
  • Takeda A. Manganese action in brain function. Brain Res Brain Res Rev. 2003;41(1):79–87.
  • Brouillet EP, Shinobu L, McGarvey U, et al. Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp Neurol. 1993;120(1):89–94.
  • Ono K, Komai K, Yamada M. Myoclonic involuntary movement associated with chronic manganese poisoning. J Neurol Sci. 2002;199(1–2):93–96.
  • Beuter A, Lambert G, MacGIbbon B. Quantifying postural tremor in workers exposed to low levels of manganese. J Neurosci Methods. 2004;139(2):247–255.
  • Kenney C, Hunter C, Davidson A, et al. Metoclopramide, an increasingly recognized cause of tardive dyskinesia. J Clin Pharmacol. 2008;48(3):379–384.
  • United States Renal Data System. 2006 annual report. Morbidity and mortality, Neuroepidemiology: Incident and prevalent stroke [online], 2006. Available from: http://www.usrds.org/2006/pdf/06_morb_morte_06.pdf
  • Sozio SM, Armstrong PA, Coresh J, et al. Cerebrovascular disease incidence, characteristics, and outcomes in patients initiating dialysis: the choices for healthy outcomes in caring for ESRD (CHOICE) study. Am J Kidney Dis. 2009;54(3):468–477.
  • Dad T, Weiner DE. Stroke and chronic kidney disease: epidemiology, pathogenesis, and management across kidney disease stages. Semin Nephrol. 2015;35(4):311–422.
  • Naganuma T, Uchida J, Tsuchida K, et al. Silent cerebral infarction in hemodialysis patients. Kidney Int. 2005;67(6):2434–2439.
  • Kobayashi M, Hirawa N, Yatsu K, et al. Relationship between silent brain infarction and chronic kidney disease. Nephrol Dial Transplant. 2009;24(1):201–207.
  • Leonard A, Shapiro FL. Subdural hematoma in regularly hemodialyzed patients. Ann Intern Med. 1975;82(5):650–658.
  • Major RW, Cheung CK, Gray LJ, et al. Statins and cardiovascular primary prevention in CKD: A meta-analysis. Clin J Am Soc Nephrol. 2015;10(5):732–739.
  • Kotanko P, Garg AX, Depner T. FHN trial group. Effects of frequent hemodialysis on blood pressure: results from the randomized frequent hemodialysis network trials. Hemodial Int. 2015 Jul;19(3):386–401.
  • Jung JM, Kim HJ, Ahn H, et al. Chronic kidney disease and intravenous thrombolysis in acute stroke: A systematic review and meta-analysis. J Neurol Sci. 2015;358(1–2):345–350.
  • Kohli A, Tandon P, Kher V. Chronic inflammatory demyelinating polyradiculoneuropathy with membranous glomerulonephritis: report of one case. Clin Neurol Neurosurg. 1992;94(1):31–33.
  • Panjwani M, Truong LD, Eknoyan G. Membranous glomerulonephritis associated with inflammatory demyelinating peripheral neuropathies. Am J Kidney Dis. 1996;27(2):279–283.
  • Oh SJ, Clements RS Jr, Lee YW, et al. Rapid improvement in nerve conduction velocity following renal transplantation. Ann Neurol. 1978;4(4):369–373.
  • Pietrzak I, Baczyk K. Erythrocyte transketolase activity and guanidino compounds in hemodialysis patients. Kidney Int Suppl. 2001;78:S97–101.
  • Jennekens FGI. Peripheral neuropathy in renal and hepatic insufficiency. In: Matthews WB, editor. Handbook of clinical neurology. Vol. 51. Neuropathies. Amsterdam: Elsevier; 1987. p. 355–364.
  • Bolton CF. Electrophysiologic changes in uremic neuropathy after successful renal transplantation. Neurology. 1976;26(2):152–161.
  • Orbach H, Tishler M, Shoenfeld Y. Intravenous immunoglobulin and the kidney–a two-edged sword. Semin Arthritis Rheum. 2004;34(3):593–601.
  • Kuwabara S, Nakazawa R, Azuma N, et al. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med. 1999;38(6):472–475.
  • Okada H, Moriwaki K, Kanno Y, et al. Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin. Nephrol Dial Transplant. 2000;15(9):1410–1413.
  • Albertazzi A, Cappelli P, Di Marco T, et al. The natural history of uremic neuropathy. Contrib Nephrol. 1988;65:130–137.
  • Jassal SV, Coulshed SJ, Douglas JF, et al. Autonomic neuropathy predisposing to arrhythmias in hemodialysis patients. Am J Kidney Dis. 1997;30(2):219–223.
  • Zochodne DW. The autonomic nervous system in peripheral neuropathies. Handb Clin Neurol. 2000;75(31):681–712.
  • Jelkmann W, Bauer C. Beta 2-adrenergic stimulation of erythropoiesis in busulfan treated mice. Exp Hematol. 1980;8(6):742–748.
  • López-Barneo J, González-Rodríguez P, Gao L, et al. Oxygen sensing by the carotid body: mechanisms and role in adaptation tohypoxia. Am J Physiol Cell Physiol. 2016;310(8):C629–642.
  • Chesterton LJ, Sigrist MK, Bennett T, et al. Reduced baroreflex sensitivity is associated with increased vascular calcification and arterial stiffness. Nephrol Dial Transplant. 2005;20(6):1140–1147.
  • Sato M, Horigome I, Chiba S, et al. Autonomic insufficiency as a factor contributing to dialysis-induced hypotension. Nephrol Dial Transplant. 2001;16(8):1657–1862.
  • Mallamaci F, Zoccali C, Ciccarelli M, et al. Autonomic function in uremic patients treated by hemodialysis or CAPD and in transplant patients. Clin Nephrol. 1986;25(4):175–180.
  • Freeman R. Current pharmacologic treatment for orthostatic hypotension. Clin Auton Res. 2008;Suppl 1:14–18.
  • Low PA, Vernino S, Suarez G. Autonomic dysfunction in peripheral nerve disease. Muscle Nerve. 2003;27(6):646–661.
  • Rosas SE, Wasserstein A, Kobrin S, et al. Preliminary observations of sildenafil treatment for erectile dysfunction in dialysis patients. Am J Kidney Dis. 2001;37(1):134–137.
  • Prakash S, Garg AX, Heidenheim AP, et al. Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review. Nephrol Dial Transplant. 2004;19(10):2553–2558.
  • Gousheh J, Iranpour A. Association between carpel tunnel syndrome and arteriovenous fistula in hemodialysis patients. Plast Reconstr Surg. 2005;116(2):508–513.
  • Campistol JM, Solé M, Muñoz-Gomez J, et al. Amyloid and nonamyloid carpal tunnel syndrome in patients receiving chronic renal dialysis. Am J Nephrol. 1990;10(5):389–396.
  • Wilson SW, Pollard RE, Lees VC. Management of carpal tunnel syndrome in renal dialysis patients using an extended carpal tunnel release procedure. J Plast Reconstr Aesthet Surg. 2008;61(9):1090–1094.
  • Eknoyan G, Beck GJ, Cheung AK, et al. Hemodialysis (HEMO) study group. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med. 2002;347(25):2010–2019.
  • Komsuoglu SS, Mehta R, Jones LA, et al. Brainstem auditory evoked potentials in chronic renal failure and maintenance hemodialysis. BAEP in dialysis: I and III-V prolonged and reversed by dialysis. Neurology. 1985;35(3):419–423.
  • Shvili Y, Gafter U, Zohar Y, et al. Brainstem auditory evoked responses in rats with experimental chronic renal failure. Clin Sci (Lond). 1989;76(4):415–417.
  • Saini JS, Jain IS, Dhar S, et al. Uremic optic neuropathy. J Clin Neuroophthalmol. 1989;9(2):131–133.
  • Mirahmadi MK, Vaziri ND. Hearing loss in end-stage renal disease effect of dialysis. J Dial. 1980;4(4):159–165.
  • Brown JJ, Sufit RL, Sollinger HW. Visual evoked potential changes following renal transplantation. Visual evoked potential changes following renal transplantation. Electroencephalogr Clin Neurophysiol. 1987;66(2):101–107.
  • Diesel W, Emms M, Knight BK, et al. Morphologic features of the myopathy associated with chronic renal failure. Am J Kidney Dis. 1993;22(5):677–684.
  • Rasheed K, Sethi P, Bixby E. Severe vitamin D deficiency induced myopathy associated with rhabydomyolysis. N Am J Med Sci. 2013;5(5):334–336.
  • Sharma V, Borah P, Basumatary LJ, et al. Myopathies of endocrine disorders: A prospective clinical and biochemical study. Ann Indian Acad Neurol. 2014;17(3):298–302.
  • Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged < or =60 y. Am J Clin Nutr. 2004;80(3):752–758.
  • Sangkabutra T, Crankshaw DP, Schneider C, et al. Impaired K+ regulation contributes to exercise limitation in end-stage renal failure. Kidney Int. 2003;63(1):283–290.
  • Mutsaers HA, Wilmer MJ, Reijnders D, et al. Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochim Biophys Acta. 2013;1832(1):142–150.
  • Wang X, Hu Z, Hu J, et al. Insulin resistance accelerates muscle protein degradation: activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling. Endocrinology. 2006;147(9):4160–4168.
  • Carrero JJ, Stenvinkel P, Cuppari L, et al. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr. 2013;23(2):77–90.
  • Thomas SS, Mitch WE. Mechanisms stimulating muscle wasting in chronic kidney disease: the roles of the ubiquitin-proteasome system and myostatin. Clin Exp Nephrol. 2013 Apr;17(2):174–182.
  • Olvera-Soto MG, Melquiades-Castillo D, Castillo-Martínez L, et al. 25 hydroxyvitamin D and nutritional parameters correlation in adults with stage 4 chronic kidney disease. Clin Nutr ESPEN. 2018;28: 80–87.
  • Semeniuk J, Shalansky KF, Taylor N, et al. Evaluation of the effect of intravenous l-carnitine on quality of life in chronic hemodialysis patients. Clin Nephrol. 2000;54(6):470–477.
  • Wang XH, Du J, Klein JD, et al. Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function. Kidney Int. 2009;76(7):751–759.

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