730
Views
20
CrossRef citations to date
0
Altmetric
Review

Clinical pharmacology of old age

, , &
Pages 749-755 | Received 06 Dec 2018, Accepted 12 Jun 2019, Published online: 24 Jun 2019

References

  • Chen CH, Nakayama M, Nevo E, et al. Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol. 1998 Nov;32(5):1221–1227.
  • Rodeheffer RJ, Gerstenblith G, Becker LC, et al. rcise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation. 1984 Feb;69(2):203–213.
  • Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985 Apr;33(4):278–285.
  • Sotaniemi EA, Arranto AJ, Pelkonen O, et al. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther. 1997 Mar;61(3):331–339.
  • Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother. 2004 Dec;2(4):274–302.
  • Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003 Aug;38(8):843–853.
  • Sultana J, Leal I, de Wilde M, et al. Identifying data elements to measure frailty in a Dutch Nationwide electronic medical record database for use in postmarketing safety evaluation: an exploratory study. Drug Saf. 2019 January 08;42:713–719. First Online.
  • Mangoni AA, Jackson SHD. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol. 2004 Jan;57(1):6–14.
  • Carroll C, Hassanin A. Polypharmacy in the elderly-when good drugs lead to bad outcomes: a teachable moment. JAMA Intern Med. 2017 Jun 1;177(6):871. .
  • Kight A. Polypharmacy in the elderly. The 2010 AAFP Scientific Assembly. [cited 2018 Dec 2]. Available from: https://www.mdmag.com/conference-coverage/aafp_2010/how-many-pills-do-your-elderly-patients-take-each-day
  • Beers MH, Ouslander JG, Rollingher I, et al. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA division of geriatric Medicine. Arch Intern Med. 1991 Sep;151(9):1825–1832.
  • American Geriatrics Society Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults.By the American Geriatrics Society. Beers criteria update expert panel. J Am Geriatr Soc. 2015;1–20.
  • Jano E, Aparasu RR. Healthcare outcomes associated with beers’ criteria: a systematic review. Ann Pharmacother. 2007 Mar;41(3):438–447.
  • Winit-Watjana W, Sakulrat P, Kespichayawattana J. Criteria for high-risk medication use in Thai older patients. Arch Gerontol Geriatr. 2008 Jul-Aug;47(1):35–51. Epub 2007 Aug 6.
  • Chang CB, Chan DC. Comparison of published explicit criteria for potentially inappropriate medications in older adults. Drugs Aging. 2010 Dec 1;27(12):947–957.
  • Mahony D, Gallager P, Ryan C, et al. STOPP and START criteria: A new approach to detecting potentially inappropriate prescribing in old age. Eur Geriatr Med. 2010;1:45–51.
  • Morin L, Laroche ML, Texier G, et al. Prevalence of potentially inappropriate medication use in older adults living in nursing homes: a systematic review. J Am Med Dir Assoc. 2016;17:862e1–862e9.
  • 76000 elderly people were dispensed at least 15 medicines during 2017. [cited 2019 May 1]. https://www.fhi.no/en/news/2018/76000-elderly-dispensed-15-medicines-in-2017/
  • Qato DM, Wilder J, Schumm LP. Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs 2011. AMA Intern Med. 2016 Apr;176(4):473–482.
  • Saraf AA, Petersen AW, Simmons SF. Medications associated with geriatric syndromes and their prevalence in older hospitalized adults discharged to skilled nursing facilities. J Hosp Med. 2016 Oct;11(10):694–700.
  • Wimmer BC, Cross AJ, Jokanovic N. Clinical outcomes associated with medication regimen complexity in older people: a systematic review. J Am Geriatr Soc. 2017 Apr;65(4):747–753.
  • Sacarny A, Barnett ML, Le J. Effect of peer comparison letters for high-volume primary care prescribers of quetiapine in older and disabled adults: a randomized clinical trial. JAMA Psychiatry. 2018 Oct 1;75(10):1003–1011.
  • Boyd CM, Darer J, Boult C. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005 Aug 10;294(6):716–724.
  • Rochon PA. Drug prescribing to older adults. [cited 2019 May 1]. https://www.uptodate.com/contents/drug-prescribing-for-older-adults
  • Federman AD, Adams AS, Ross-Degnan D. Supplemental insurance and use of effective cardiovascular drugs among elderly medicare beneficiaries with coronary heart disease. JAMA. 2001 Oct 10;286(14):1732–1739.
  • Keijsers CJ, van Hensbergen L, Jacobs L . Geriatric pharmacology and pharmacotherapy education for health professionals and students: a systematic review. Br J Clin Pharmacol. 2012 Nov;74(5):762–773.
  • Kolberg ES. Adherence as a language game. Int J Clin Pharm. 2017 Apr;39(2):487–490.
  • Chodick G, Weitzman D, Shalev V. Adherence to statins and the risk of psoriasis: a population-based cohort study. Br J Dermatol. 2015 Aug;173(2):480–487.
  • Shalev V, Goldshtein I, Halpern Y, et al. Association between persistence with statin therapy and reduction in low-density lipoprotein cholesterol level: analysis of real-life data from community settings. Pharmacotherapy. 2014 Jan;34(1):1–8.
  • Rabinowich L, Steinvil A, Leshem-Rubinow E, et al. Adherence to statins is associated with reduced incidence of idiopathic venous thromboembolism: real-life data from a large healthcare maintenance organisation. Heart. 2012 Dec;98(24):1817–1821.
  • Zucker I, Chodick G, Grunhaus L. Adherence to treatment with selective serotonin reuptake inhibitors and the risk for fractures and bone loss: a population-based cohort study. CNS Drugs. 2012 Jun 1;26(6):537–547.
  • Weitzman D, Koren G. Quantifying patients’ drug adherence by electronic records fo drug purchasing. Harefuah. 2018 Oct;157(10):627–630.
  • Murru A, Pacchiarotti I, Amann BL, et al. Treatment adherence in bipolar I and schizoaffective disorder, bipolar type. J Affect Disord. 2013 Dec;151(3):1003–1008.
  • Farrer M, Kachergus J, Forno L, et al. Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications. Ann Neurol. 2004 Feb;55(2):174–179.
  • Shuchi Mittal S, Kjetil Bjørnevik K, Im DS, et al. beta2-adrenoreceptor is a regulator of the alpha-synuclein gene driving risk of parkinsons disease. Science. 2017;357(6354):891–898.
  • Koren G, Nordon G, Radinsky K, et al. Chronic use of β-blockers and the risk of parkinson’s disease. Clin Drug Investig. 2019 May;39(5):463–468.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.