Emerging concepts on the use of ketamine for chronic pain

References

• Domino EF. Taming the ketamine tiger. 1965. Anesthesiology. 2010;113:678–684.
   PubMed Web of Science ®Google Scholar
• Kronenberg RH. Ketamine as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. J Pain Palliative Care Pharmacother. 2002;16:27–35.
   PubMedGoogle Scholar
• Niesters M, Martini C, Dahan A. Ketamine for chronic pain: risks and benefits. Br J Clin Pharmacol. 2014;77:357–367.
   PubMed Web of Science ®Google Scholar
• Maher DP, Chen L, Mao J. Intravenous ketamine infusions for neuropathic pain management: a promising therapy in need of optimization. Anesth Analg. 2017;124:661–674.
   PubMed Web of Science ®Google Scholar
• Sanacora G, Frye MA, McDonald W, et al. A consensus statement on the use of ketamine in the treatment of mood disorders. JAMA Psychiatry. 2017;74:399–405.
   PubMed Web of Science ®Google Scholar
• Caddy C, Amit BH, McCloud TL, et al. Ketamine and other glutamate receptor modulators for depression in adults. Cochrane Database Syst Rev. 2015;(9). Art. No.: CD011612.
   Web of Science ®Google Scholar
• Mion G, Le Masson J, Granier C, et al. A retrospective study of ketamine administration and the development of acute or post-traumatic stress disorder in 274 war-wounded soldiers. Anaesthesia. 2017;72:1476–1483.
   PubMed Web of Science ®Google Scholar
• Feder A, Parides MK, Murrough JW, et al. Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry. 2014;71:681–688.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Bhatia A, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for chronic pain from the american society of regional anesthesia and pain medicine, the american academy of pain medicine, and the american society of anesthesiologists. Reg Anesth Pain Med. 2018;43:521–546.
   PubMed Web of Science ®Google Scholar
• Schwenk ES, Viscusi ER, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for acute pain management from the american society of regional anesthesia and pain medicine, the american academy of pain medicine, and the american society of anesthesiologists. Reg Anesth Pain Med. 2018;43:456–466.
   PubMed Web of Science ®Google Scholar
• Thielking M Is the ketamine boom getting out of hand? Scientific American, 2018 Sep 26. 2019, https://www.scientificamerican.com/article/is-the-ketamine-boom-getting-out-of-hand/.
   Google Scholar
• Orhurhu V, Orhurhu MS, Bhatia A, et al. Ketamine infusions for chronic pain: a systematic review and meta-analysis of randomized controlled trials. Anesth Analg. 2019 Jul;129(1):241-254.
   PubMedGoogle Scholar
• Newport DJ, Carpenter LL, McDonald WM, et al. Ketamine and other NMDA antagonists: early clinical trials and possible mechanisms in depression. Am J Psychiatry. 2015;172:950–966.
   PubMed Web of Science ®Google Scholar
• Schoevers RA, Chaves TV, Balukova SM, et al. Oral ketamine for the treatment of pain and treatment-resistant depression. Br J Psychiatry. 2016;208:108–113.
   PubMed Web of Science ®Google Scholar
• Popova V, Daly EJ, Trivedi M, et al. Efficacy and safety of flexibly dosed esketamine nasal spray combined with a newly initiated oral antidepressant in treatment-resistant depression: a randomized double-blind active-controlled study. Am J Psychiatry. 2019;176(6):428–438.
   PubMed Web of Science ®Google Scholar
• Brutcher RE, Kurihara C, Bicket MC, et al. Compounded topical pain creams to treat localized chronic pain: a randomized controlled trial. Ann Intern Med. 2019;170(5):309–318.
   PubMed Web of Science ®Google Scholar
• Finnerup NB, Haroutounian S, Kamerman P, et al. Neuropathic pain: an updated grading system for research and clinical practice. Pain. 2016;157(8):1599–1606.
   PubMed Web of Science ®Google Scholar
• Johnson MI. The Landscape of Chronic Pain: broader Perspectives. Medicina (Kaunas). 2019;55(5):1-19.
   Web of Science ®Google Scholar
• Sluka KA, Clauw DJ. Neurobiology of fibromyalgia and chronic widespread pain. Neuroscience. 2016;338:114–129.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Mao J. Neuropathic pain: mechanisms and their clinical implications. Br Med J. 2014;348:f7656.
   PubMed Web of Science ®Google Scholar
• Orhurhu V, Orhurhu MS, Bhatia A, et al. Ketamine infusions for chronic pain: A systematic review and meta-analysis of randomized controlled trials. Anesth Analg. 2019;129(1):241–254.
   PubMed Web of Science ®Google Scholar
• Melzack RCKSensory, motivational, and central control determinants of pain: a new conceptual modelThe skin senses: proceedings of the first international symposium of the skin sensesKenshalo DeditorCharles C. ThomasFlorida1968Florida State University in Tallahassee,423–443.
   Google Scholar
• Melzack R. The short-form mcgill pain questionnaire. Pain. 1987;30:191–197.
   PubMed Web of Science ®Google Scholar
• Cleeland CS, Ryan KM. Pain assessment: global use of the brief pain inventory. Ann Acad Med Singapore. 1994;23:129–138.
   PubMedGoogle Scholar
• Ware JE Jr., Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Conceptual framework and item selection. Med Care. 1992;30:473–483.
   PubMed Web of Science ®Google Scholar
• Uddin Z, MacDermid JC. Quantitative sensory testing in chronic musculoskeletal pain. Pain Med. 2016;17:1694–1703.
   PubMed Web of Science ®Google Scholar
• Hocking G, MJ C. Ketamine in chronic pain management: an evidence-based review. Anesth Analg. 2003;97:1730–1739.
   PubMed Web of Science ®Google Scholar
• Himmelseher S, Durieux ME. Ketamine for perioperative pain management. Anesthesiology. 2005;102:211–220.
   PubMed Web of Science ®Google Scholar
• Bell RF, Dahl JB, Moore RA, et al. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand. 2005;49:1405–1428.
   PubMed Web of Science ®Google Scholar
• Dahan A, Olofsen E, Sigtermans M, et al. Population pharmacokinetic-pharmacodynamic modeling of ketamine-induced pain relief of chronic pain. Eur J Pain. 2011;15:258–267.
   PubMed Web of Science ®Google Scholar
• Peltoniemi MA, Hagelberg NM, Olkkola KT, et al. Ketamine: A review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin Pharmacokinet. 2016;55:1059–1077.
   PubMed Web of Science ®Google Scholar
• Leung LY, Baillie TA. Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)-6-hydroxynorketamine. J Med Chem. 1986;29:2396–2399.
   PubMed Web of Science ®Google Scholar
• Sigtermans MJ, van Hilten JJ, Bauer MC, et al. Ketamine produces effective and long-term pain relief in patients with complex regional pain syndrome type 1. Pain. 2009;145:304–311.
   PubMed Web of Science ®Google Scholar
• Sigtermans M, Dahan A, Mooren R, et al. S(+)-ketamine effect on experimental pain and cardiac output: a population pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. Anesthesiology. 2009;111:892–903.
   PubMed Web of Science ®Google Scholar
• Goldberg ME, Torjman MC, Schwartzman RJ, et al. Pharmacodynamic profiles of ketamine (R)- and (S)- with 5-day inpatient infusion for the treatment of complex regional pain syndrome. Pain Physician. 2010;13:379–387.
   PubMed Web of Science ®Google Scholar
• Herd DW, Anderson BJ, Holford NH. Modeling the norketamine metabolite in children and the implications for analgesia. Paediatr Anaesth. 2007;17:831–840.
   PubMed Web of Science ®Google Scholar
• J HM S, Voss L, Ketamine DB. More mechanisms of action than just NMDA blockade. Trends Anesthesia Crit Care. 2014;4:76–81.
   Google Scholar
• Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain. 1991;44:293–299.
   PubMed Web of Science ®Google Scholar
• Davies SN, Lodge D. Evidence for involvement of N-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat. Brain Res. 1987;424:402–406.
   PubMed Web of Science ®Google Scholar
• Dickenson AH, Sullivan AF. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology. 1987;26:1235–1238.
   PubMed Web of Science ®Google Scholar
• Eide PK, Jorum E, Stubhaug A, et al. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain. 1994;58:347–354.
   PubMed Web of Science ®Google Scholar
• Eichenberger U, Neff F, Sveticic G, et al. Chronic phantom limb pain: the effects of calcitonin, ketamine, and their combination on pain and sensory thresholds. Anesth Analg. 2008;106:1265–1273.
   PubMed Web of Science ®Google Scholar
• Noppers I, Niesters M, Swartjes M, et al. Absence of long-term analgesic effect from a short-term S-ketamine infusion on fibromyalgia pain: a randomized, prospective, double blind, active placebo-controlled trial. Eur J Pain. 2011;15:942–949.
   PubMed Web of Science ®Google Scholar
• Lodge D, Watkins JC, Bortolotto ZA, et al. The 1980s: D-AP5, LTP and a decade of NMDA receptor discoveries. Neurochem Res. 2019;44:516–530.
   PubMed Web of Science ®Google Scholar
• Okon T. Ketamine: an introduction for the pain and palliative medicine physician. Pain Physician. 2007;10:493–500.
   PubMedGoogle Scholar
• Collingridge GL, Kehl SJ, McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J Physiol. 1983;334:33–46.
   PubMed Web of Science ®Google Scholar
• Cahusac PM, Evans RH, Hill RG, et al. The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats. Neuropharmacology. 1984;23:719–724.
   PubMed Web of Science ®Google Scholar
• Aanonsen LM, Wilcox GL. Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists. J Pharmacol Exp Ther. 1987;243:9–19.
   PubMed Web of Science ®Google Scholar
• Yang C, Yang J, Luo A, et al. Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites. Transl Psychiatry. 2019;9(1):280.
   PubMedGoogle Scholar
• Zanos P, Gould TD. Mechanisms of ketamine action as an antidepressant. Mol Psychiatry. 2018;23(4):801–811.
   PubMed Web of Science ®Google Scholar
• Garcia LS, Comim CM, Valvassori SS, et al. Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(1):140–144.
   PubMed Web of Science ®Google Scholar
• Lumsden EW, Troppoli TA, Myers SJ, et al. Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function. Proc Nat Acad Sci. 2019;116(11):5160–5169.
   PubMed Web of Science ®Google Scholar
• Kavalali ET, Monteggia LM, Metabolite TK. 2R,6R-hydroxynorketamine blocks nmda receptors and impacts downstream signaling linked to antidepressant effects. Neuropsychopharmacology. 2018;43(1):221–222.
   PubMed Web of Science ®Google Scholar
• Rabben T, Oye I. Interindividual differences in the analgesic response to ketamine in chronic orofacial pain. Eur J Pain. 2001;5(3):233–240.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhu ZR, Ou BC, et al. Dopamine D2/D3 but not dopamine D1 receptors are involved in the rapid antidepressant-like effects of ketamine in the forced swim test. Behav Brain Res. 2015;279:100–105.
   PubMed Web of Science ®Google Scholar
• Pacheco Dda F, Romero TR, Duarte ID. Central antinociception induced by ketamine is mediated by endogenous opioids and mu- and delta-opioid receptors. Brain Res. 2014;1562:69–75.
   PubMed Web of Science ®Google Scholar
• Fidecka S. Interactions of ketamine, naloxone and morphine in the rat. Pol J Pharmacol. 1987;39(1):33–40.
   Google Scholar
• Campos AR, Santos FA, Rao VS. Ketamine-induced potentiation of morphine analgesia in rat tail-flick test: role of opioid-, alpha2-adrenoceptors and ATP-sensitive potassium channels. Biol Pharm Bull. 2006;29(1):86–89.
   PubMed Web of Science ®Google Scholar
• Mikkelsen S, Ilkjaer S, Brennum J, et al. The effect of naloxone on ketamine-induced effects on hyperalgesia and ketamine-induced side effects in humans. Anesthesiology. 1999;90(6):1539–1545.
   PubMed Web of Science ®Google Scholar
• Yanagihara Y, Ohtani M, Kariya S, et al. Plasma concentration profiles of ketamine and norketamine after administration of various ketamine preparations to healthy Japanese volunteers. Biopharm Drug Dispos. 2003;24(1):37–43.
   PubMed Web of Science ®Google Scholar
• Grant IS, Nimmo WS, Clements JA. Pharmacokinetics and analgesic effects of i.m. and oral ketamine. Br J Anaesth. 1981;53(8):805–810.
   PubMed Web of Science ®Google Scholar
• Chong C, Schug SA, Page-Sharp M, et al. Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: preliminary findings from a three-way randomized, crossover study. Clin Drug Investig. 2009;29(5):317–324.
   PubMed Web of Science ®Google Scholar
• Fanta S, Kinnunen M, Backman JT, et al. Population pharmacokinetics of S-ketamine and norketamine in healthy volunteers after intravenous and oral dosing. Eur J Clin Pharmacol. 2015;71(4):441–447.
   PubMed Web of Science ®Google Scholar
• Carr DB, Goudas LC, Denman WT, et al. Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. Pain. 2004;108(1–2):17–27.
   PubMed Web of Science ®Google Scholar
• Giorgetti R, Marcotulli D, Tagliabracci A, et al. Effects of ketamine on psychomotor, sensory and cognitive functions relevant for driving ability. Forensic Sci Int. 2015;252:127–142.
   PubMed Web of Science ®Google Scholar
• Chaparro LE, Smith SA, Moore RA, et al. Pharmacotherapy for the prevention of chronic pain after surgery in adults. Cochrane Database Syst Rev. 2013;7:CD008307.
   PubMed Web of Science ®Google Scholar
• McNicol ED, Schumann R, Haroutounian S. A systematic review and meta-analysis of ketamine for the prevention of persistent post-surgical pain. Acta Anaesthesiol Scand. 2014;58:1199–1213.
   PubMed Web of Science ®Google Scholar
• Klatt E, Zumbrunn T, Bandschapp O, et al. Intra- and postoperative intravenous ketamine does not prevent chronic pain: A systematic review and meta-analysis. Scand J Pain. 2015;7:42–54.
   PubMed Web of Science ®Google Scholar
• Schwartzman RJ, Alexander GM, Grothusen JR, et al. Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: a double-blind placebo controlled study. Pain. 2009;147:107–115.
   PubMed Web of Science ®Google Scholar
• Orhurhu VJ, Roberts JS, Cohen SP. Ketamine in acute and chronic pain management. StatPearls. Tampa/St. Petersburg, FL: Treasure Island StatPearls Publishing; 2019.
   Google Scholar
• Bell RF, Dahl JB, Moore RA, et al. Peri-operative ketamine for acute post-operative pain: a quantitative and qualitative systematic review (Cochrane review). Acta Anaesthesiol Scand. 2005;49(10):1405–1428.
   PubMed Web of Science ®Google Scholar
• Anwar S, Cooper J, Rahman J, et al. Prolonged perioperative use of pregabalin and ketamine to prevent persistent pain after cardiac surgery. Anesthesiology. 2019;131:119–131.
   PubMed Web of Science ®Google Scholar
• Schwenk ES, Goldberg SF, Patel RD, et al. Adverse drug effects and preoperative medication factors related to perioperative low-dose ketamine infusions. Reg Anesth Pain Med. 2016;41:482–487.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Wang S, Chen L, et al. An intravenous ketamine test as a predictive response tool in opioid-exposed patients with persistent pain. J Pain Symptom Manage. 2009;37:698–708.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Verdolin MH, Chang AS, et al. The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients. J Pain. 2006;7:391–398.
   PubMed Web of Science ®Google Scholar
• Cohen SP, Chang AS, Larkin T, et al. The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain. Anesth Analg. 2004;99:1753–1759.
   PubMed Web of Science ®Google Scholar
• Elia N, Tramer MR. Ketamine and postoperative pain–a quantitative systematic review of randomised trials. Pain. 2005;113:61–70.
   PubMed Web of Science ®Google Scholar
• Noppers IM, Niesters M, Aarts LP, et al. Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases. Pain. 2011;152:2173–2178.
   PubMed Web of Science ®Google Scholar
• Wong GL, Tam YH, Ng CF, et al. Liver injury is common among chronic abusers of ketamine. Clin Gastroenterol Hepatol. 2014;12:1759–62.e1.
   PubMed Web of Science ®Google Scholar
• Morgan CJ, Curran HV. Ketamine use: a review. Addiction. 2012;107:27–38.
   PubMed Web of Science ®Google Scholar
• Gregoire MC, MacLellan DL, Finley GA. A pediatric case of ketamine-associated cystitis. Urology. 2008;71:1232–1233.
   PubMed Web of Science ®Google Scholar
• Pagel PS, Kampine JP, Schmeling WT, et al. Ketamine depresses myocardial contractility as evaluated by the preload recruitable stroke work relationship in chronically instrumented dogs with autonomic nervous system blockade. Anesthesiology. 1992;76:564–572.
   PubMed Web of Science ®Google Scholar
• Ward J, Standage C. Angina pain precipitated by a continuous subcutaneous infusion of ketamine. J Pain Symptom Manage. 2003;25:6–7.
   PubMed Web of Science ®Google Scholar
• Tajerian M, Leu D, Yang P, et al. Differential efficacy of ketamine in the acute versus chronic stages of complex regional pain syndrome in mice. Anesthesiology. 2015;123(6):1435–1447.
   PubMed Web of Science ®Google Scholar
• Liman S, Cheung CW, Wong KL, et al. Preventive treatment with ketamine attenuates the ischaemia-reperfusion response in a chronic postischaemia pain model. Oxid Med Cell Longev. 2015;2015:380403.
   PubMedGoogle Scholar
• Sasaki A, Serizawa K, Andoh T, et al. Pharmacological differences between static and dynamic allodynia in mice with herpetic or postherpetic pain. J Pharmacol Sci. 2008;108(3):266–273.
   PubMed Web of Science ®Google Scholar
• Zhou H, Zhang Q, Martinez E, et al. Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex. Nat Commun. 2018;9(1):3751.
   PubMedGoogle Scholar