The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis

References

• Stafstrom CE, Carmant L. Seizures and epilepsy: an overview for neuroscientists. Cold Spring Harb Perspect Med. 2015 Jun 1;5(6):a022426-a022426. PubMed PMID: 26033084; PubMed Central PMCID: PMCPMC4448698
   PubMed Web of Science ®Google Scholar
• Camfield P, Camfield C. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord. 2015 Jun;17(2):117–123. PubMed PMID: 25895502.
   PubMed Web of Science ®Google Scholar
• Ge Y, Ding D, Zhang Q, et al. Incidence of sudden unexpected death in epilepsy in community-based cohort in China. Epilepsy Behav. 2017 Nov;76:76–83. PubMed PMID: 28958777.
   PubMed Web of Science ®Google Scholar
• Bitanihirwe BK, Cunningham MG. Zinc: the brain’s dark horse. Synapse. 2009 Nov;63(11):1029–1049. PubMed PMID: 19623531.
   PubMed Web of Science ®Google Scholar
• Mathie A, Sutton GL, Clarke CE, et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther. 2006 Sep;111(3):567–583. PubMed PMID: 16410023.
   PubMed Web of Science ®Google Scholar
• Gaetke LM, Chow CK. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology. 2003 Jul 15;189(1–2):147–163. PubMed PMID: 12821289
   PubMed Web of Science ®Google Scholar
• Yuen AW, Sander JW. Can magnesium supplementation reduce seizures in people with epilepsy? A hypothesis. Epilepsy Res. 2012 Jun;100(1–2):152–156. PubMed PMID: 22406257.
   PubMed Web of Science ®Google Scholar
• Schweizer U, Brauer AU, Kohrle J, et al. Selenium and brain function: a poorly recognized liaison. Brain Res Brain Res Rev. 2004 Jul;45(3):164–178. PubMed PMID: 15210302.
   PubMedGoogle Scholar
• Savaskan NE, Brauer AU, Kuhbacher M, et al. Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. Faseb J. 2003 Jan;17(1):112–114. PubMed PMID: 12424220.
   PubMedGoogle Scholar
• Rayman MP. The importance of selenium to human health. Lancet. 2000 Jul 15;356(9225):233–241. PubMed PMID: 10963212
   PubMed Web of Science ®Google Scholar
• Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients 1. Faseb J. 1987 Dec;1(6):441–445. PubMed PMID: 3315807
   PubMed Web of Science ®Google Scholar
• Marger L, Schubert CR, Bertrand D. Zinc: an underappreciated modulatory factor of brain function. Biochem Pharmacol. 2014 Oct 15;91(4):426–435. PubMed PMID: 25130547
   PubMed Web of Science ®Google Scholar
• Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol. 1989;31:145–238. PubMed PMID: 2689380
   PubMed Web of Science ®Google Scholar
• Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993 Jan;73(1):79–118. PubMed PMID: 8419966.
   PubMed Web of Science ®Google Scholar
• Takeda A. Movement of zinc and its functional significance in the brain. Brain Res Brain Res Rev. 2000 Dec;34(3):137–148. PubMed PMID: 11113504
   PubMedGoogle Scholar
• Du K, Liu MY, Zhong X, et al. Decreased circulating Zinc levels in Parkinson’s disease: a meta-analysis study. Sci Rep. 2017 Jun 20;7(1):3902. PubMed PMID: 28634347; PubMed Central PMCID: PMCPMC5478669.
   PubMedGoogle Scholar
• Hoffmann PR, Berry MJ. The influence of selenium on immune responses. Mol Nutr Food Res. 2008 Nov;52(11):1273–1280. PubMed PMID: 18384097; PubMed Central PMCID: PMCPMC3723386.
   PubMed Web of Science ®Google Scholar
• Hurd R. Zinc binding by valproic acid. Neurosci Abstr. 1981; 7.
   Google Scholar
• Wilder BJ, Karas BJ, Penry JK, et al. Gastrointestinal tolerance of divalproex sodium. Neurology. 1983 Jun;33(6):808–811. PubMed PMID: 6405304
   PubMed Web of Science ®Google Scholar
• McKinney PA, Finkenbine RD, DeVane CL. Alopecia and mood stabilizer therapy. Ann Clin Psychiatry. 1996 Sep;8(3):183–185. PubMed PMID: 8899137
   PubMedGoogle Scholar
• Wallace SJ. A comparative review of the adverse effects of anticonvulsants in children with epilepsy. Drug Saf. 1996 Dec;15(6):378–393. PubMed PMID: 8968693
   PubMed Web of Science ®Google Scholar
• Korkmazer N, Vurucu S, Demirkaya E, et al. Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid. Brain Dev. 2006 Sep;28(8):515–520. PubMed PMID: 16682156.
   PubMed Web of Science ®Google Scholar
• Schulpis KH, Karikas GA, Tjamouranis J, et al. Low serum biotinidase activity in children with valproic acid monotherapy. Epilepsia. 2001 Oct;42(10):1359–1362. PubMed PMID: 11737173
   PubMed Web of Science ®Google Scholar
• Suzuki T, Koizumi J, Moroji T, et al. Effects of long-term anticonvulsant therapy on copper, zinc, and magnesium in hair and serum of epileptics. Biol Psychiatry. 1992 Mar 15;31(6):571–581. PubMed PMID: 1581436
   PubMed Web of Science ®Google Scholar
• Lerman-Sagie T, Statter M, Szabo G, et al. Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy. Clin Neuropharmacol. 1987;10(1):80–86. PubMed PMID: 3102054
   PubMed Web of Science ®Google Scholar
• Ventriglia M, Brewer GJ, Simonelli I, et al. Zinc in Alzheimer’s disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies. J Alzheimers Dis. 2015;46(1):75–87. PubMed PMID: 25697706. .
   PubMed Web of Science ®Google Scholar
• Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 2005 Apr 20;5:13. PubMed PMID: 15840177; PubMed Central PMCID: PMCPMC1097734
   PubMedGoogle Scholar
• Wong CHM, Chan JSK, Sanli D, et al. Aortic valve repair or replacement in patients with aortic regurgitation: A systematic review and meta-analysis. J Card Surg. 2019 Apr 6;34(6):377–384. PubMed PMID: 30953445.
   Web of Science ®Google Scholar
• Liu F, Zhang Q, Zhou D, et al. Effectiveness of (18)F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies. BMC Cancer. 2019 Apr 5;19(1):323. PubMed PMID: 30953476.
   PubMedGoogle Scholar
• Liu Y, Chen Q, Liu X, et al. Genetic association of CHAT rs3810950 and rs2177369 polymorphisms with the risk of Alzheimer’s disease: a meta-analysis. Biomed Res Int. 2016;2016:9418163. PubMed PMID: 27597977; PubMed Central PMCID: PMCPMC5002460. .
   PubMed Web of Science ®Google Scholar
• Du K, Liu M, Pan Y, et al. Association of serum manganese levels with Alzheimer’s Disease and mild cognitive impairment: a systematic review and meta-analysis. Nutrients. 2017 Mar 3;9(3). PubMed PMID: 28273828; PubMed Central PMCID: PMCPMC5372894. DOI:https://doi.org/10.3390/nu9030231.
   Google Scholar
• Karikas GA, Schulpis KH, Bartzeliotou A, et al. Lipids, lipoproteins, apolipoproteins, selected trace elements and minerals in the serum of children on valproic acid monotherapy. Basic Clin Pharmacol Toxicol. 2006 Jun;98(6):599–603. PubMed PMID: 16700824.
   PubMed Web of Science ®Google Scholar
• Verrotti A, Basciani F, Trotta D, et al. Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy. Epilepsy Res. 2002 Jan;48(1–2):71–75. PubMed PMID: 11823111
   PubMed Web of Science ®Google Scholar
• Doneray H, Kara IS, Karakoc A, et al. Serum thyroid hormone profile and trace elements in children receiving valproic acid therapy: a longitudinal and controlled study. J Trace Elem Med Biol. 2012 Oct;26(4):243–247. PubMed PMID: 22683050.
   PubMed Web of Science ®Google Scholar
• Li Q, Cai W, Sun G, et al. Effects of topiramate and sodium valproate on six constant/trace elements in serum of children with epilepsy. Chin J Pract Nerv Dis. 2017;20(11):41–43.
   Google Scholar
• Farahani HN, Ashthiani AR, Masihi MS. Study on serum zinc and selenium levels in epileptic patients. Neurosciences (Riyadh). 2013 Apr;18(2):138–142. PubMed PMID: 23545611
   PubMed Web of Science ®Google Scholar
• Wojciak RW, Mojs E, Stanislawska-Kubiak M, et al. The serum zinc, copper, iron, and chromium concentrations in epileptic children. Epilepsy Res. 2013 Mar;104(1–2):40–44. PubMed PMID: 23103060.
   PubMed Web of Science ®Google Scholar
• Liu CS, Wu HM, Kao SH, et al. Serum trace elements, glutathione, copper/zinc superoxide dismutase, and lipid peroxidation in epileptic patients with phenytoin or carbamazepine monotherapy. Clin Neuropharmacol. 1998 Jan-Feb;21(1):62–64. PubMed PMID: 9579288
   PubMed Web of Science ®Google Scholar
• Davidson DL, Ward NI. Abnormal aluminium, cobalt, manganese, strontium and zinc concentrations in untreated epilepsy. Epilepsy Res. 1988 Sep-Oct;2(5):323–330. PubMed PMID: 3197701
   PubMed Web of Science ®Google Scholar
• Ilhan A, Uz E, Kali S, et al. Serum and hair trace element levels in patients with epilepsy and healthy subjects: does the antiepileptic therapy affect the element concentrations of hair? Eur J Neurol. 1999 Nov 6;6(6):705–709. PubMed PMID: 10529759
   PubMed Web of Science ®Google Scholar
• PY L, LH Y, YZ R, et al. Relationship between antiepileptic drugs and serum copper and zinc. ShangHai YiXue. 1986;3:146–148.
   Google Scholar
• Doretto MC, Simões S, Paiva AMR, et al. Zinc, magnesium and copper profiles in three experimental models of epilepsy. Brain Res. 2002;956(1):166–172. .
   PubMed Web of Science ®Google Scholar
• Prasad DKV, Shaheen U, Satyanarayana U, et al. Association of serum trace elements and minerals with genetic generalized epilepsy and idiopathic intractable epilepsy. Neurochem Res. 2014;39(12):2370–2376. .
   PubMed Web of Science ®Google Scholar
• Ashrafi MR, Shabanian R, Abbaskhanian A, et al. Selenium and intractable epilepsy: is there any correlation? Pediatr Neurol. 2007 Jan;36(1):25–29. PubMed PMID: 17162193.
   PubMed Web of Science ®Google Scholar
• Plonka-Poltorak E, Zagrodzki P, Nicol F, et al. Antioxidant agents and physiological responses in adult epileptic patients treated with lamotrigine. Pharmacol Rep. 2013;65(1):99–106. PubMed PMID: 23563028
   PubMed Web of Science ®Google Scholar
• Sozuer DT, Barutcu UB, Karakoc Y, et al. The effects of antiepileptic drugs on serum zinc and copper levels in children. J Basic Clin Physiol Pharmacol. 1995;6(3–4):265–269. PubMed PMID: 8852271
   PubMedGoogle Scholar
• Gombart AF, Pierre A, Maggini SA. Review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients. 2020 Jan 16;12(1):236. PubMed PMID: 31963293; PubMed Central PMCID: PMCPMC7019735
   Web of Science ®Google Scholar
• Qian F, Misra S, Prabhu KS. Selenium and selenoproteins in prostanoid metabolism and immunity. Crit Rev Biochem Mol Biol. 2019 Dec;54(6):484–516. PubMed PMID: 31996052; PubMed Central PMCID: PMCPMC7122104.
   PubMed Web of Science ®Google Scholar
• Oh C, Keats EC, Bhutta ZA. Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: a systematic review and meta-analysis. Nutrients. 2020 Feb 14;12(2):491. PubMed PMID: 32075071; PubMed Central PMCID: PMCPMC7071347
   Web of Science ®Google Scholar
• Vural Z, Avery A, Kalogiros DI, et al. Trace mineral intake and deficiencies in older adults living in the community and institutions: a systematic review. Nutrients. 2020 Apr 13;12(4):1072. PubMed PMID: 32294896; PubMed Central PMCID: PMCPMC7230219.
   PubMed Web of Science ®Google Scholar
• Ashrafi MR, Shams S, Nouri M, et al. A probable causative factor for an old problem: selenium and glutathione peroxidase appear to play important roles in epilepsy pathogenesis. Epilepsia. 2007 Sep;48(9):1750–1755. PubMed PMID: 17555528.
   PubMed Web of Science ®Google Scholar
• Kendirli MT, Rose DT, Bertram EH. A model of posttraumatic epilepsy after penetrating brain injuries: effect of lesion size and metal fragments. Epilepsia. 2014 Dec;55(12):1969–1977. PubMed PMID: 25470332; PubMed Central PMCID: PMCPMC4285662.
   PubMed Web of Science ®Google Scholar
• Hildebrand MS, Phillips AM, Mullen SA, et al. Loss of synaptic Zn2+ transporter function increases risk of febrile seizures. Sci Rep. 2015 Dec;9(5):17816. PubMed PMID: 26647834; PubMed Central PMCID: PMCPMC4673435
   PubMed Web of Science ®Google Scholar
• Ebadi M, Wilt S, Ramaley R, et al. The role of zinc and zinc-binding proteins in regulation of glutamic acid decarboxylase in brain. Prog Clin Biol Res. 1984;144A:255–275. PubMed PMID: 6328536
   PubMedGoogle Scholar
• Denoyer D, Masaldan S, La Fontaine S, et al. Targeting copper in cancer therapy: copper that cancer. Metallomics. 2015 Nov 7;(11):1459–1476. PubMed PMID: 26313539. DOI:https://doi.org/10.1039/c5mt00149h.
   Google Scholar
• Robinson FR, Johnson MT. Histopathological studies of tissue reactions to various metals implanted in cat brains. ASD Tech Rep. 1961 Oct;61397:13. PubMed PMID: 24546838.
   PubMedGoogle Scholar
• Dymond AM, Kaechele LE, Jurist JM, et al. Brain tissue reaction to some chronically implanted metals. J Neurosurg. 1970 Nov;33(5):574–580. PubMed PMID: 5479495.
   PubMed Web of Science ®Google Scholar
• Babb TL, Kupfer W. Phagocytic and metabolic reactions to chronically implanted metal brain electrodes. Exp Neurol. 1984 Nov;86(2):171–182. PubMed PMID: 6489492
   PubMed Web of Science ®Google Scholar
• Vezzani A, Friedman A, Dingledine RJ. The role of inflammation in epileptogenesis. Neuropharmacology. 2013 Jun;69:16–24. PubMed PMID: 22521336; PubMed Central PMCID: PMCPMC3447120.
   PubMed Web of Science ®Google Scholar
• Bellinger FP, Raman AV, Reeves MA, et al. Regulation and function of selenoproteins in human disease. Biochem J. 2009 Jul 29;422(1):11–22. PubMed PMID: 19627257; PubMed Central PMCID: PMCPMC2912286.
   PubMedGoogle Scholar
• Hatfield DL, Tsuji PA, Carlson BA, et al. Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem Sci. 2014 Mar;39(3):112–120. PubMed PMID: 24485058; PubMed Central PMCID: PMCPMC3943681.
   PubMed Web of Science ®Google Scholar
• Reeves MA, Bellinger FP, Berry MJ. The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. Antioxid Redox Signal. 2010 Apr 1;12(7):809–818. PubMed PMID: 19769485; PubMed Central PMCID: PMCPMC2864655
   PubMed Web of Science ®Google Scholar
• Kieliszek M, Blazejak S. Selenium: significance, and outlook for supplementation. Nutrition. 2013 May;29(5):713–718. PubMed PMID: 23422539.
   PubMed Web of Science ®Google Scholar
• Davis CD, Tsuji PA, Milner JA. Selenoproteins and cancer prevention. Annu Rev Nutr. 2012 Aug 21;32:73–95. PubMed PMID: 22404120. *This study highlights the effects of selenium on the human body from the perspective of nutrition.
   PubMed Web of Science ®Google Scholar
• Saghazadeh A, Mahmoudi M, Meysamie A, et al. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev. 2015 Nov;73(11):760–779. PubMed PMID: 26433016.
   PubMed Web of Science ®Google Scholar
• Das A, Sarwar MS, Hossain MS, et al. Elevated Serum Lipid Peroxidation and Reduced Vitamin C and Trace Element Concentrations Are Correlated With Epilepsy. Clin EEG Neurosci. 2019 Jan;50(1):63–72. PubMed PMID: 29788779.
   PubMed Web of Science ®Google Scholar
• Seven M, Basaran SY, Cengiz M, et al. Deficiency of selenium and zinc as a causative factor for idiopathic intractable epilepsy. Epilepsy Res. 2013 Mar;104(1–2):35–39. PubMed PMID: 23103062.
   PubMed Web of Science ®Google Scholar
• Abdullahi I, Watila MM, Shahi N, et al. Serum magnesium in adult patients with idiopathic and symptomatic epilepsy in Maiduguri, Northeast Nigeria. Niger J Clin Pract. 2019 Feb;22(2):186–193. PubMed PMID: 30729941.
   PubMed Web of Science ®Google Scholar
• Garcia-Penas JJ. [Epilepsy, cognition and ketogenic diet]. Rev Neurol. 2018 Mar 1;66(S01):S71–S75. PubMed PMID: 29516456
   PubMedGoogle Scholar
• Ulamek-Koziol M, Czuczwar SJ, Januszewski S, et al. Ketogenic diet and epilepsy. Nutrients. 2019 Oct 18;11(10):2510. PubMed PMID: 31635247; PubMed Central PMCID: PMCPMC6836058.
   PubMed Web of Science ®Google Scholar
• Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev. 2009 Mar;59(2):293–315. PubMed PMID: 18845187; PubMed Central PMCID: PMCPMC2649682.
   PubMedGoogle Scholar
• Arslan N, Kose E, Guzel O. The effect of ketogenic diet on serum selenium levels in patients with intractable epilepsy. Biol Trace Elem Res. 2017 Jul;178(1):1–6. PubMed PMID: 27873289.
   PubMed Web of Science ®Google Scholar
• Hayashi A, Kumada T, Nozaki F et al., [Changes in serum levels of selenium, zinc and copper in patients on a ketogenic diet using Ketonformula]. No To Hattatsu. 2013 Jul;45(4):288–293. PubMed PMID: 23951940.
   PubMedGoogle Scholar
• Kurekci AE, Alpay F, Tanindi S, et al. Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy. Epilepsia. 1995 Jun;36(6):600–604. PubMed PMID: 7555974. *This study provides a theoretical basis for VPA to increase the clearance rate of Zn.
   PubMed Web of Science ®Google Scholar
• Plonka-Poltorak E, Zagrodzki P, Chlopicka J, et al. Valproic acid modulates superoxide dismutase, uric acid-independent FRAP and zinc in blood of adult epileptic patients. Biol Trace Elem Res. 2011 Dec;143(3):1424–1434. PubMed PMID: 21360059.
   PubMed Web of Science ®Google Scholar
• Yilmaz Y, Tasdemir HA, Paksu MS. The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity. Eur J Paediatr Neurol. 2009 Sep;13(5):439–443. PubMed PMID: 18922714.
   PubMed Web of Science ®Google Scholar
• Armutcu F, Ozerol E, Gurel A, et al. Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. Biol Trace Elem Res. 2004 Winter;102(1–3):1–10. PubMed PMID: 15621922.
   PubMed Web of Science ®Google Scholar
• Graf WD, Oleinik OE, Glauser TA, et al. Altered antioxidant enzyme activities in children with a serious adverse experience related to valproic acid therapy. Neuropediatrics. 1998 Aug;29(4):195–201. PubMed PMID: 9762695.
   PubMed Web of Science ®Google Scholar
• Hamed SA, Abdellah MMN. Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patients. J Pharmacol Sci. 2004;96(4):465.
   PubMed Web of Science ®Google Scholar
• Altunbasak S, Biatmakoui F, Baytok V, et al. Serum and hair zinc levels in epileptic children taking valproic acid. Biol Trace Elem Res. 1997 Jul-Aug;58(1–2):117–125. PubMed PMID: 9363326
   PubMed Web of Science ®Google Scholar
• Taylor A, Ghose K. Diurnal variation of serum copper and zinc in epileptics receiving anti-convulsants. Hum Toxicol. 1986;May5(3)195–200. PubMed PMID: 3710496.
   Google Scholar
• Lifschitz MD, Henkin RI. Circadian variation in copper and zinc in man. J Appl Physiol. 1971 Jul;31(1):88–92. PubMed PMID: 5556968.
   PubMed Web of Science ®Google Scholar
• Liu CS, Wu HM, Kao SH, et al. Phenytoin-mediated oxidative stress in serum of female epileptics: a possible pathogenesis in the fetal hydantoin syndrome. Hum Exp Toxicol. 1997 Mar;16(3):177–181. PubMed PMID: 9088972.
   PubMed Web of Science ®Google Scholar
• Kaji M, Ito M, Okuno T, et al. Serum copper and zinc levels in epileptic children with valproate treatment. Epilepsia. 1992 May-Jun;33(3):555–557. PubMed PMID: 1592036
   PubMed Web of Science ®Google Scholar
• Kuzuya T, Hasegawa T, Shimizu K, et al. Effect of anti-epileptic drugs on serum zinc and copper concentrations in epileptic patients. Int J Clin Pharmacol Ther Toxicol. 1993 Feb;31(2):61–65. PubMed PMID: 8458677
   PubMedGoogle Scholar
• Motta E, Miller K, Ostrowska Z. [Concentration of copper and ceruloplasmin in serum of patients treated for epilepsy]. Wiad Lek. 1998;51(3–4):156–161. PubMed PMID: 9658990
   PubMedGoogle Scholar
• Rotruck JT, Pope AL, Ganther HE, et al. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973 Feb 9;179(4073):588–590. PubMed PMID: 4686466
   PubMed Web of Science ®Google Scholar