Advanced search
Publication Cover
Expert Review of Clinical Pharmacology Volume 14, 2021 - Issue 3
Submit an article Journal homepage
7,892
Views
1
CrossRef citations to date
0
Altmetric
Letter to the Editor

Serious flaws in targeting LDL-C reduction in the management of cardiovascular disease in familial hypercholesterolemia

Uffe Ravnskova Lund, SwedenCorrespondence[email protected]
View further author information
,
Michel de Lorgerilb Faculté de Médecine, Laboratoire Coeur et Nutrition, TIMC-CNRS, Université Grenoble-Alpes, La Tronche, FranceView further author information
,
Malcolm Kendrickc East Cheshire Trust, Macclesfield District General Hospital, Cheshire, UKView further author information
&
David M. Diamondd Department of Psychology and Department of Molecular Pharmacology and Physiology, Center for Preclinical and Clinical Research on PTSD, University of South Florida, Tampa, FL, USAView further author information
Pages 405-406 | Received 28 Jan 2021, Accepted 09 Feb 2021, Published online: 22 Feb 2021

References

  • Polychronopoulos G, Tziomalos K. Treatment of heterozygous familial hypercholesterolemia: what does the future hold? Expert Rev Clin Pharmacol. 2020;13:1229–1234.
  • Ravnskov U, de Lorgeril M, Diamond DM, et al. LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature. Exp Rev Clin Pharmacol. 2018;11:959–970.
  • Ravnskov U, de Lorgeril M, Kendrick M, et al. Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia. Med Hypotheses. 2018;121:60–63.
  • Ravnskov U. Is atherosclerosis caused by high cholesterol? QJM. 2002;95:397–403.
  • Ravnskov U, McCully KS. Vulnerable plaque formation from obstruction of vasa vasorum by homocysteinylated and oxidized lipoprotein aggregates complexed with microbial remnants and LDL autoantibodies. Ann Clin Lab Sci. 2009;39:3–16.
  • Ravnskov U, McCully KS. Infections may be causal in the pathogenesis of atherosclerosis. Am J Med Sci. 2012;344:391–394.
  • Ravnskov U, Diamond DM, Hama R, et al. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open. 2016;6:e010401.
  • Ravnskov U, de Lorgeril M, Diamond DM, et al. The LDL paradox: higher LDL-cholesterol is associated with greater longevity. Epidemiol Public Health 2020;3:1040–1046.
  • Diamond DM, Alabdulgader AA, de Lorgeril M, et al. Dietary recommendations for familial hypercholesterolaemia: an evidence-free zone. BMJ Evid Based Med. 2020;bmjebm-2020-111412. DOI:10.1136/bmjebm-2020-111412
  • Jansen AC, van Aalst-cohen ES, Tanck MW, et al. Genetic determinants of cardio- vascular disease risk in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2005;25:1475–1481.
  • Boos CJ, Lip GY. Assessment of mean platelet volume in coronary artery disease—what does it mean? Thromb Res. 2007;120:11–13.
  • Mori Y, Wada H, Nagano, et al. Hypercoagulable state in the Watanabe heritable hyperlipidemic rabbit, an animal model for the progression of atherosclerosis. Effect of probucol on coagulation. Thromb Haemost. 1989;61:140–143.
  • Boffa MB, Koschinsky ML. Thematic Review Series: lipoprotein (a): coming of Age at Last Lipoprotein (a): truly a direct prothrombotic factor in cardiovascular disease? J Lipid Res. 2016;57:745–757.
  • Seed M, Hoppichler F, Reaveley D, et al. Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med. 1990;322:1494–1499.
  • DuBroff R, Malhotra A, de Lorgeril M. Hit or miss: the new cholesterol targets. BMJ Evid Based Med. 2020;bmjebm-2020-111413. DOI:10.1136/bmjebm-2020-111413

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.