Pharmacological control of pain during propofol injection: a systematic review and meta-analysis

References

• Tan C, Onsiong M. Pain on injection of propofol. Anaesthesia. 1998;53(5):468–476.
   PubMed Web of Science ®Google Scholar
• Jalota L, Kalira V, George E, et al. Prevention of pain on injection of propofol: systematic review and meta-analysis. Bmj. 2011;342:d1110.
   PubMed Web of Science ®Google Scholar
• Abdusoglu MN, Özkoçak I, Yurtlu BS, et al. A subhypnotic dose of ketamine reduces pain associated with injection of propofol and rocuronium. Eur J Anaesthesiol. 2011;28(3):229–230.
   PubMed Web of Science ®Google Scholar
• Ahmed A, Sengupta S, Das T, et al. Pre-treatment with intravenous granisetron to alleviate pain on propofol injection: a double-blind, randomized, controlled trial. Indian J Anaesth. 2012;56(2):135.
   PubMedGoogle Scholar
• Bashir A, Abbas Z, Farhat S, et al. A prospective randomized open labelled placebo controlled study comparing intravenous lignocaine and tramadol in reducing the incidence and severity of pain on propofol injection. JK Sci. 2011;13(3):119.
   Google Scholar
• Hossain MS, Rashid MM, Rashid MM, et al. Pretreatment with magnesium sulfate to alleviate pain on propofol injection: a prospective randomized double blind study. Mediscope. 2019;6(2):73–77.
   Google Scholar
• Kizilcik N, Menda F, Bilgen S, et al. Effects of a fentanyl-propofol mixture on propofol injection pain: a randomized clinical trial. Korean J Anesthesiol. 2015;68(6):556.
   PubMed Web of Science ®Google Scholar
• Li X, Chen C-J, Tan F, et al. Effect of dexmedetomidine for attenuation of propofol injection pain in electroconvulsive therapy: a randomized controlled study. J Anesth. 2018;32(1):70–76.
   PubMed Web of Science ®Google Scholar
• Khouadja H, Arnous H, Tarmiz K, et al. Pain on injection of propofol: efficacy of paracetamol and lidocaine. Open J Anesthesiol. 2014;4:2014.
   Google Scholar
• Jamuna T, Nicolas Israel Y. Prospective and comparative study of the analgesic effect of intravenous 2% xylocard versus intravenous tramadol in ameliorating propofol injection pain. J Evid Based Med Healthc. 2015;2:3529–3539.
   Google Scholar
• Sarkılar G, Kara İ, Duman A, et al. Effect of dexmedetomidine on pain caused by injection of propofol. Organ. 2012;42:45.
   Google Scholar
• Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomized trials. Br Med J. 2011;343:d5928.
   PubMed Web of Science ®Google Scholar
• Hayat M, Afshan G, Nasir M, et al. Efficacy of intravenous paracetamol in combination with lidocaine pretreatment for reducing pain during injection of propofol. Cureus. 2020;12(2):e6926.
   Web of Science ®Google Scholar
• Uliana GN, Tambara EM, Baretta GAP. Use of remifentanil to reduce propofol injection pain and the required propofol dose in upper digestive tract endoscopy diagnostic tests. Braz J Anesth (English Edition). 2015;65(6):437–444.
   Google Scholar
• Sargın M, Uluer MS, Hyoscine AE. N-butylbromide for preventing propofol injection pain: a randomized, placebo-controlled and double-blind study. Med Princ Pract. 2018;27(1):39–43.
   PubMed Web of Science ®Google Scholar
• Xing J, Liang L, Zhou S, et al. Intravenous lidocaine alleviates the pain of propofol injection by local anesthetic and central analgesic effects. Pain Med. 2018;19(3):598–607.
   PubMed Web of Science ®Google Scholar
• Mohammadi SS, Khosravi M, Shoeibi G. Comparing intravenous lidocaine, ondansetron and their combination on reducing pain of injection of propofol. Arch Anesthesiol Critical Care. 2016;2(1):154–156.
   Google Scholar
• Derakhshan P, Karbasy SH, Bahador R. The effects of nitroglycerine on pain control during the propofol injection; a controlled, double-blinded, randomized clinical trial. Anesth Pain Med. 2015;5(3). DOI:10.5812/aapm.5(3)2015.26141
   PubMedGoogle Scholar
• Nimmaanrat S, Jongjidpranitarn M, Prathep S, et al. Premedication with oral paracetamol for reduction of propofol injection pain: a randomized placebo-controlled trial. BMC Anesthesiol. 2019;19(1):100.
   PubMedGoogle Scholar
• Ayatollahi V, Behdad S, Kargar S, et al. Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. Acta Med Iran. 2012; 50 (9):609–614.
   PubMedGoogle Scholar
• Alipour M, Tabari M, Alipour M. Paracetamol, ondansetron, granisetron, magnesium sulfate and lidocaine and reduced propofol injection pain. Iran Red Crescent Med J. 2014;16:3.
   Web of Science ®Google Scholar
• Galgon RE, Strube P, Heier J, et al. Magnesium sulfate with lidocaine for preventing propofol injection pain: a randomized, double-blind, placebo-controlled trial. J Anesth. 2015;29(2):206–211.
   PubMed Web of Science ®Google Scholar
• He L, Xu J-M, He T, et al. Dexmedetomidine pretreatment alleviates propofol injection pain. Ups J Med Sci. 2014;119(4):338–342.
   PubMed Web of Science ®Google Scholar
• Lee M, Kwon T, Kim S, et al. Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: a double-blind, randomized clinical consort study. Medicine (Baltimore). 2017;96(10):e6288.
   Web of Science ®Google Scholar
• Choi E, Kim D, Jeon Y. Comparative study between 2 different doses of pregabalin and lidocaine on pain following propofol injection: a double-blind, randomized clinical consort study. Medicine (Baltimore). 2016;95(51).
   Web of Science ®Google Scholar
• Salman AE, Salman MA, Saricaoglu F, et al. Pain on injection of propofol: a comparison of methylene blue and lidocaine. J Clin Anesth. 2011;23(4):270–274.
   PubMed Web of Science ®Google Scholar
• Khoshfetrat M, Beirami F, Panah FSA. Comparison of premedication injections of magnesium sulfate, ketamine and lidocaine on the severity of pain induced by intravenous injection of propofol. Arch Anesthesiol Critical Care. 2017;3(4):382–384.
   Google Scholar
• Rahimzadeh P, Faiz SHR, Nikoobakht N, et al. Which one is more efficient on propofol 2% injection pain? Magnesium sulfate or ondansetron: a randomized clinical trial. Adv Biomed Res. 2015;4. DOI:10.4103/2277-9175.151593
   PubMedGoogle Scholar
• Shivanna S, Priye S, Singh D, et al. Efficacy of methylprednisolone and lignocaine on propofol injection pain: a randomised, double-blind, prospective study in adult cardiac surgical patients. Indian J Anaesth. 2016;60(11):848.
   PubMed Web of Science ®Google Scholar
• Singh D, Jagannath S, Priye S. Prevention of propofol injection pain: comparison between lidocaine and ramosetron. J Anaesthesiol Clin Pharmacol. 2014;30(2):213.
   PubMedGoogle Scholar
• Goktug A, Gulec H, Takmaz SA, et al. Lidocaine alleviates propofol related pain much better than metoprolol and nitroglycerin. Rev Bras Anestesiol. 2015;65(5):338–342.
   PubMed Web of Science ®Google Scholar
• Hossain MS, Rahman MA, Islam SA, et al. Effect of low dose ketamine on propofol injection pain: a double-blind clinical trial. KYAMC J. 2020;11(2):96–99.
   Google Scholar
• Ozkan S, Sen H, Sizlan A, et al. Comparison of acetaminophen (with or without tourniquet) and lidocaine in propofol injection pain. Klinik Psikofarmakoloji Bülteni-Bull Clin Psychopharmacol. 2011;21(2):100–104.
   Web of Science ®Google Scholar
• Jeong CW, Lee SH, Ju J, et al. The effect of priming injection of different doses of remifentanil on injection pain of microemulsion propofol premixed with lidocaine. Korean J Anesthesiol. 2011;60(2):78.
   PubMedGoogle Scholar
• Salman EA, Titiz L, Akpek E, et al. Pretreatment with a very low dose of intravenous esmolol reduces propofol injection pain. Agri. 2013;25(1):8–13.
   Google Scholar
• Sapate M, Andurkar U, Markandeya M, et al. To study the effect of injection dexmedetomidine for prevention of pain due to propofol injection and to compare it with injection lignocaine. Rev Bras Anestesiol. 2015;65(6):466–469.
   PubMed Web of Science ®Google Scholar
• Singh A, Sharma G, Gupta R, et al. Efficacy of tramadol and butorphanol pretreatment in reducing pain on propofol injection: a placebo-controlled randomized study. J Anaesthesiol Clin Pharmacol. 2016;32(1):89.
   PubMedGoogle Scholar
• Madan HK, Singh R, Sodhi GS. Comparsion of intravenous lignocaine, tramadol and keterolac for attenuation of propofol injection pain. J Clin Diagn Res. 2016;10(7):UC05.
   PubMed Web of Science ®Google Scholar
• Jeon Y. Reduction of pain on injection of propofol: combination of nitroglycerin and lidocaine. J Anesth. 2012;26(5):728–731.
   PubMed Web of Science ®Google Scholar
• Jeong M, Yoon H. Comparison of the effects of lidocaine pre-administration and local warming of the intravenous access site on propofol injection pain: randomized, double-blind controlled trial. Int J Nurs Stud. 2016;61:209–218.
   PubMed Web of Science ®Google Scholar
• Chaudhary K, Gupta P, Gogia AR. A prospective, randomized, double-blind study to compare the efficacy of lidocaine+ metoclopramide and lidocaine+ ketamine combinations in preventing pain on propofol injection. J Anesth. 2013;27(3):402–406.
   PubMed Web of Science ®Google Scholar
• Sun J, Zhou R, Lin W, et al. Magnesium sulfate plus lidocaine reduces propofol injection pain: a double-blind, randomized study. Clin Ther. 2013;38(1):31–38.
   Google Scholar
• Kim Y-H, Namgung J, Lim C-H. Cisatracurium pretreatment with tourniquet reduces propofol injection pain: a double-blind randomized controlled trial. J Int Med Res. 2014;42(2):360–367.
   PubMed Web of Science ®Google Scholar
• Zahedi H, Maleki A, Rostami G Ondansetron pretreatment reduces pain on injection of propofol. 2012.
   Google Scholar
• Lee H-Y, Kim S-H, So K-Y. Prevention of microemulsion propofol injection pain: a comparison of a combination of lidocaine and ramosetron with lidocaine or ramosetron alone. Korean J Anesthesiol. 2011;61(1):30.
   PubMedGoogle Scholar
• Walker BJ, Neal JM, Mulroy MF, et al. Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: a randomized controlled trial. Reg Anesth Pain Med. 2011;36(1):41–5—5.
   PubMed Web of Science ®Google Scholar
• Çakırgöz M, Demirel I, Duran E, et al. Gabapentin pretreatment for propofol and rocuronium injection pain: a randomized, double-blind, placebo-controlled study. Niger J Clin Pract. 2018;21(1):43–48.
   PubMed Web of Science ®Google Scholar
• Hirmanpour A, Talakoub R, Safavi M, et al. Comparing the injection pain of propofol emulsion 1%(MCT/LCT) and propofol emulsion 2%(Propofol Lipuro) in combination with lidocaine in patients undergoing gynecologic surgery with general anesthesia. Arch Anesthesiol Critical Care. 2017;3(3):342–347.
   Google Scholar
• Sarkar MS, Desai PM, Sageer H, et al. Propofol LCT vs propofol MCT-LCT: randomized controlled trial. Indian J Clin Anaesthesia [Internet] Diva Enterprises Private Limited. 2016;3(2):214.
   Google Scholar
• Singh TH, Devi NA, Arasu T, et al. Effect of palonosetron pretreatment to attenuate the pain caused by propofol injection. J Med Soc. 2017;31(2):90.
   Google Scholar
• Lee JH, Jung SY, Kim M-H, et al. The effect of dexmedetomidine on propofol injection pain. Korean J Anesthesiol. 2014;67(Suppl):S30–S1.
   PubMedGoogle Scholar
• Ryu H-B, Kim S-J. Analgesic effects of palonosetron in the intravenous propofol injection. Korean J Anesthesiol. 2014;66(2):99.
   PubMedGoogle Scholar
• Wang J, Duan J, Xie C, et al. Comparison between intravenous nalbuphine and lidocaine in reducing propofol-induced injection pain during gastroscopy: a randomized controlled trial. Pain Ther. 2020;9(2):563–571.
   PubMed Web of Science ®Google Scholar
• Swati Pandey SSSK, Kiran SSS. A comparison of pain on intravenous injection to two formulations of Propofol, one containing medium chain and long chain triglycerides and the other without medium chain and long chain triglycerides. Int J Res Med Sci. 2019;7(12):4511–4518.
   Google Scholar
• Singh DK, Jindal P, Singh G. Comparative study of attenuation of the pain caused by propofol intravenous injection, by granisetron, magnesium sulfate and nitroglycerine. Saudi J Anaesth. 2011;5(1):50.
   PubMedGoogle Scholar
• Nishimoto R, Kashio M, Tominaga M. Propofol-induced pain sensation involves multiple mechanisms in sensory neurons. Pflügers Archiv - European Journal of Physiology. 2015;467(9):2011–2020.
   PubMed Web of Science ®Google Scholar
• Ohmizo H, Obara S, Iwama H. Mechanism of injection pain with long and longmedium chain triglyceride emulsive propofol. Can J Anaesthesia. 2005;52(6):595.
   PubMed Web of Science ®Google Scholar
• Sim JY, Lee SH, Park DY, et al. Pain on injection with microemulsion propofol. Br J Clin Pharmacol. 2009;67(3):316–325.
   PubMed Web of Science ®Google Scholar
• Sinharoy P, Zhang H, Sinha S, et al. Propofol restores TRPV1 sensitivity via a TRPA1‐, nitric oxide synthase‐dependent activation of PKCε. Pharmacol Res Perspect. 2015;3:4.
   Web of Science ®Google Scholar
• Euasobhon P, Dej‐arkom S, Siriussawakul A, et al. Lidocaine for reducing propofol‐induced pain on induction of anaesthesia in adults. Cochrane Database Syst Rev. 2016;2. Article number CD007874.
   PubMedGoogle Scholar
• Pei S, Zhou C, Zhu Y, et al. Efficacy of ondansetron for the prevention of propofol injection pain: a meta-analysis. J Pain Res. 2017;10:445.
   PubMed Web of Science ®Google Scholar