References
- Wong A, Isbister G, McNulty R, et al. Efficacy of a two bag acetylcysteine regimen to treat paracetamol overdose (2NAC study). EClinicalMedicine. 2020;20(100288). DOI:https://doi.org/10.1016/j.eclinm.2020.100288.
- Pettie JM, Caparrotta TM, Hunter RW, et al. Safety and efficacy of the SNAP 12-hour acetylcysteine regimen for the treatment of paracetamol overdose. EClinicalMedicine. 2019;11:11–17.
- Mullins ME, Yu M, O’Grady L, et al. Adverse reactions in patients treated with the one-bag method of N-acetylcysteine for acetaminophen ingestion. Toxicol Commun. 2020;4(1):49–54.
- Daoud A, Dalhoff KP, Christensen MB, et al. Two-bag intravenous N-acetylcysteine, antihistamine pretreatment and high plasma paracetamol levels are associated with a lower incidence of anaphylactoid reactions to N-acetylcysteine. Clin Toxicol. 2020;58(7):698–704.
- Acetylcysteine. Lexi-drugs. Hudson, OH: Lexicomp; 2015 [cited 2021 Apr 1]. Available from: https://online-lexicom/lco/action/doc/retrieve/docid/patch_f/6281?cesid=aJGRYIydhv7&searchUrl=%2Flco%2Faction%2Fsearch%3Fq%3Dacetylcysteine%26t%3Dname%26va%3Dacetylcysteine#doa
- Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology. 2005;42(6):1364–1372. .
- Dahlin DC, Miwa GT, Lu AY, et al. N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci USA. 1984;81(5):1327–1331.
- Lauterburg BH, Corcoran GB, Mitchell JR. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest. 1983;71(4):980–991.
- Smilkstein MJ, Knapp GL, Kulig KW, et al. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985). N Engl J Med. 1988;319(24):1557–1562.
- Prescott LF. Treatment of severe acetaminophen poisoning with intravenous acetylcysteine. Arch Intern Med. 1981;141(3 Spec No):386–389.
- Yarema M, Chopra P, Sivilotti MLA, et al. Anaphylactoid reactions to intravenous N-acetylcysteine during treatment for acetaminophen poisoning. J Med Toxicol. 2018;14(2):120–127. .
- Bailey GP, Najafi J, Elamin MEMO, et al. Delays during the administration of acetylcysteine for the treatment of paracetamol overdose. Br J Clin Pharmacol. 2016;82(5):1358–1363. .
- Hayes BD, Klein-Schwartz W, Doyon S. Frequency of medication errors with intravenous acetylcysteine for acetaminophen overdose. Ann Pharmacother. 2008;42(6):766–770.
- *Chiew AL, Reith D, Pomerleau A, et al., Updated guidelines for the management of paracetamol poisoning in Australia and New Zealand. Med J Aust. 212(4): 175–183. 2020. .
- GGC Medicines: SNAP: a shorter regimen for the management of paracetamol overdose in adults Jan 21 [Internet]. Available from: https://ggcmedicines.org.uk/blog/medicines-update/snap-a-shorter-regimen-for-the-management-of-paracetamol-overdose-in-adults-jan-21/. Accessed April 1, 2021.
- *Hodgman MJ, Garrard AR. A review of acetaminophen poisoning. Crit Care Clin. 2012;28(4): 499–516. .
- Guidelines for the management of acetaminophen overdose. [cited 2021 Apr 1]. Available from: https://www.tylenolprofessional.com/sites/tylenol_hcp_us/files/acetaminphen_overdose_treatment_info.pdf
- Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002;40(1):3–20.
- Prescott LF, Illingworth RN, Critchley JA, et al. Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J. 1979;2(6198):1097–1100.
- DailyMed - ACETADOTE- acetylcysteine injection, solution [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=472f158a-5ab9-4308-8e49-1116e6ea3d39. Accessed April 1, 2021.
- Rumack BH, Peterson RC, Koch GG, et al. Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141(3 Spec No):380–385.
- Statistical review and evaluation. Available from: www.accessdata.fda.gov/drugsatfda_docs/nda/2004/21-539_Acetadote_Statr.pdf. Accessed April 1, 2021.
- Kerr F, Dawson A, Whyte IM, et al. The Australasian clinical toxicology investigators collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45(4):402–408. .
- Furmaga J, Wax P, Kleinschmidt K. N-acetylcysteine (NAC)-induced hyponatremia caused by an electronic medical record (EMR) order error. J Med Toxicol. 2015;11(3):355–358.
- Mullins ME, Vitkovitsky IV. Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. Clin Toxicol. 2011;49(8):755–759.
- Heard K, Schaeffer TH. Massive acetylcysteine overdose associated with cerebral edema and seizures. Clin Toxicol. 2011;49(5):423–425.
- Mahmoudi GA, Astaraki P, Mohtashami AZ, et al. N-acetylcysteine overdose after acetaminophen poisoning. Int Med Case Rep J. 2015;8:65–69.
- Srinivasan V, Corwin D, Verceles AC. An accidental overdose of N-acetylcysteine during treatment for acetaminophen toxicity. Clin Toxicol. 2015;53(5):500.
- Personne M. A 10-fold bolus dose of N-acetylcysteine with fatal consequences. Clin Toxicol. 2018;56(6):446.
- Bailey B, Blais R, Letarte A. Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Annals of Emergency Medicine. 2004;44(4):401–406.
- Au V, Zakaria M. A study on the medication errors in the administration of n-acetylcysteine for paracetamol overdose patients in Malaysia. Hong Kong J Emerg Med. 2014;21(6):361–367.
- Mullins ME, Yarema MC, Sivilotti MLA, et al. Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489. Toxicol Res (Camb). 2019;8(6):1057–1058. .
- Baumgartner K, Filip A, Liss D, et al. N-acetylcysteine for acetaminophen toxicity: the one-bag regimen. Br J Clin Pharm. 2020.
- Kao LW, Kirk MA, Furbee RB, et al. What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med. 2003;42(6):741–750.
- Johnson MT, McCammon CA, Mullins ME, et al. Evaluation of a simplified N-acetylcysteine dosing regimen for the treatment of acetaminophen toxicity. Ann Pharmacother. 2011;45(6):713–720.
- Mullins ME, Yarema MC, Sivilotti MLA. Comment on “Transition to two-bag intravenous acetylcysteine for acetaminophen overdose. Clin Toxicol. 2020;58(5):433–435.
- Bateman DN, Dear JW. Reply to the ‘comment on “acetylcysteine in paracetamol poisoning: a perspective of 45 years of use”’ by M. E. Mullins, M. C. Yarema, M. L. A. Sivilotti, M. Thompson, D. A. Algren, M. C. Beuhler and C. P. Holstege, Toxicol. Res., 2019, 8. Toxicol Res (Camb). 2019;8(6):1059.
- Thanacoody HKR, Gray A, Dear JW, et al. Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). BMC Pharmacol Toxicol. 2013;14(20). DOI:https://doi.org/10.1186/2050-6511-14-20.
- *Bateman DN, Dear JW, Thanacoody HKR, et al., Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet. 383(9918): 697–704. 2014. .
- Isbister GK, Downes MA, Mcnamara K, et al. A prospective observational study of a novel 2-phase infusion protocol for the administration of acetylcysteine in paracetamol poisoning. Clin Toxicol. 2016;54(2):120–126.
- Wong A, Graudins A. Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions. Clin Toxicol. 2016;54(2):115–119.
- McNulty R, Lim JME, Chandru P, et al. Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose. Clin Toxicol. 2018;56(7):618–621.
- Schmidt LE, Rasmussen DN, Petersen TS, et al. Fewer adverse effects associated with a modified two-bag intravenous acetylcysteine protocol compared to traditional three-bag regimen in paracetamol overdose. Clin Toxicol. 2018;56(11):1128–1134. .
- Chiew AL, Isbister GK, Kirby KA, et al. Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clin Toxicol. 2017;55(10):1–11.
- Wong A, McNulty R, Taylor D, et al. The NACSTOP trial: a multicenter, cluster-controlled trial of early cessation of acetylcysteine in acetaminophen overdose. Hepatology. 2019;69(2):774–784. .
- Heard K, Rumack BH, Green JL, et al. A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning. Clin Toxicol. 2014;52(5):512–518. .
- Pauley KA, Sandritter TL, Lowry JA, et al. Evaluation of an alternative intravenous N-acetylcysteine regimen in pediatric patients. J Pediatr Pharmacol Ther. 2015;20(3):178–185.
- Oakley E, Robinson J, Deasy C. Using 0.45% saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning. Emerg Med Australas. 2011;23(1):63–67.
- Chiew AL, Isbister GK, Duffull SB, et al. Evidence for the changing regimens of acetylcysteine. Br J Clin Pharm. 2016;81(3):471–481.