229
Views
2
CrossRef citations to date
0
Altmetric
Original Research

The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study

ORCID Icon, ORCID Icon, , , , , , , , & ORCID Icon show all
Pages 89-97 | Received 23 Jul 2021, Accepted 03 Feb 2022, Published online: 22 Feb 2022

References

  • Lee CMY, Colagiuri S, Woodward M, et al. Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. BMJ Open Diabetes Res Care. 2019;7(1):e000794. Papers of special note have been highlighted as: • of interest or •• of considerable interest
  • Brannick B, Dagogo-Jack S. Prediabetes and cardiovascular disease: pathophysiology and interventions for prevention and risk reduction. Endocrinol Metab Clin North Am. 2018;47(1):33–50.
  • Forouhi NG, Luan J, Hennings S, et al. Incidence of type 2 diabetes in England and its association with baseline impaired fasting glucose: the Ely study 1990-2000. Diabet Med. 2007;24(2):200–207.
  • Cai X, Zhang Y, Li M, et al. Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis. BMJ. 2020;370:m2297.
  • Gujral UP, Jagannathan R, He S, et al. Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis. BMJ Open Diabetes Res Care. 2021;9(1):e001776.
  • Diabetes Prevention Program (DPP) Research Group. The Diabetes Prevention Program (DPP): description of lifestyle intervention. Diabetes Care. 2002;25(12):2165–2171.
  • Galaviz KI, Narayan KMV, Lobelo F, et al. Lifestyle and the prevention of type 2 diabetes: a status report. Am J Lifestyle Med. 2015;12(1):4–20.
  • American Diabetes Association. 3. prevention or delay of type 2 diabetes: standards of medical care in diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S34–39.
  • Bansal N. Prediabetes diagnosis and treatment: a review. World J Diabetes. 2015;6(2):296–303.
  • Koufakis T, Grammatiki M, Kotsa K. Type 2 diabetes management in people aged over seventy-five years: targets and treatment strategies. Maturitas. 2021;143:118–126.
  • Norman AW, Frankel JB, Heldt AM, et al. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209(4458):823–825.
  • Kadowaki S, Norman AW. Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. J Clin Invest. 1984;73(3):759–766.
  • Cheng S, So WY, Zhang D, et al. Calcitriol reduces hepatic triglyceride accumulation and glucose output through Ca2+/CaMKKβ/AMPK activation under insulin-resistant conditions in type 2 diabetes mellitus. Curr Mol Med. 2016;16(8):747–758.
  • Leung PS. The modulatory action of vitamin d on the renin-angiotensin system and the determination of hepatic insulin resistance. Molecules. 2019;24(13):2479.
  • Dong B, Zhou Y, Wang W, et al. Vitamin D receptor activation in liver macrophages ameliorates hepatic inflammation, steatosis, and insulin resistance in mice. Hepatology. 2020;71(5):1559–1574.
  • Szymczak-Pajor I, Drzewoski J, Śliwińska A. The molecular mechanisms by which vitamin d prevents insulin resistance and associated disorders. Int J Mol Sci. 2020;21(18):6644.
  • von Hurst Pr, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr. 2010;103(4):549–555. **An important RCT showing that supplementation should target plasma 25(OH)D concentrations > 32 ng/ml for an improvement in IR to be evident.
  • American Diabetes Association. 2. classification and diagnosis of diabetes: standards of medical care in diabetes-2021. Diabetes Care. 2021;44(Suppl 1):S15–33.
  • Karras SN, Grant WB, Naughton DP, et al. Defining optimal vitamin D cut-off levels: Τhe role of parathyroid hormone concentrations. Hormones (Athens). 2016;15(4):565–567.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930.
  • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–419.
  • Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85(7):2402–2410.
  • Urbaniak GC, Plous S. Research Randomizer (Version 4.0) [Computer software]. Retrieved on 2013 Jun 22, from http://www.randomizer.org/
  • Faul F, Erdfelder E, Lang AG, et al. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191.
  • Kuchay MS, Laway BA, Bashir MI, et al. Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: a 1-year, open-label randomized study. Indian J Endocrinol Metab. 2015;19(3):387–392.
  • Grübler MR, Gängler S, Egli A, et al. Effects of vitamin D3 on glucose metabolism in patients with severe osteoarthritis: a randomized double-blind trial comparing daily 2000 with 800 IU vitamin D3. Diabetes Obes Metab. 2021;23(4):1011–1019.
  • Fuleihan G E-H, Baddoura R, Habib RH, et al. Effect of vitamin D replacement on indexes of insulin resistance in overweight elderly individuals: a randomized controlled trial. Am J Clin Nutr. 2016;104(2):315–323.
  • Meehan M, Penckofer S. The role of Vitamin D in the aging adult. J Aging Gerontol. 2014;2(2):60–71.
  • Karras SN, Koufakis T, Antonopoulou V, et al. Characterizing neonatal vitamin D deficiency in the modern era: a maternal-neonatal birth cohort from Southern Europe. J Steroid Biochem Mol Biol. 2020;198:105555.
  • Samefors M, Östgren CJ, Mölstad S, et al. Vitamin D deficiency in elderly people in Swedish nursing homes is associated with increased mortality. Eur J Endocrinol. 2014;170(5):667–675.
  • Lu Q, Wan Z, Guo J, et al. Association between serum 25-hydroxyvitamin D concentrations and mortality among adults with prediabetes. J Clin Endocrinol Metab. 2021;106(10):e4039–4048.
  • Zheng YT, Cui QQ, Hong YM, et al. A meta-analysis of high dose, intermittent vitamin D supplementation among older adults. PLoS One. 2015;10(1):e0115850.
  • Ish-Shalom S, Segal E, Salganik T, et al. Comparison of daily, weekly, and monthly vitamin D3 in ethanol dosing protocols for two months in elderly hip fracture patients. J Clin Endocrinol Metab. 2008;93(9):3430–3435.
  • Rafiq S, Jeppesen PB. Is hypovitaminosis D related to incidence of type 2 diabetes and high fasting glucose level in healthy subjects: a systematic review and meta-analysis of observational studies. Nutrients. 2018;10(1):59.
  • Lucato P, Solmi M, Maggi S, et al. Low vitamin D levels increase the risk of type 2 diabetes in older adults: a systematic review and meta-analysis. Maturitas. 2017;100:8–15.
  • Karras SN, Anagnostis P, Antonopoulou V, et al. The combined effect of vitamin D and parathyroid hormone concentrations on glucose homeostasis in older patients with prediabetes: a cross-sectional study. Diab Vasc Dis Res. 2018;15(2):150–153.
  • Grammatiki M, Karras S, Kotsa K. The role of vitamin D in the pathogenesis and treatment of diabetes mellitus: a narrative review. Hormones (Athens). 2019;18(1):37–48.
  • Koufakis T, Dimitriadis G, Metallidis S, et al. The role of autoimmunity in the pathophysiology of type 2 diabetes: looking at the other side of the moon. Obes Rev. 2021;22(8):e13231.
  • DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214–223.
  • Zhang Y, Tan H, Tang J, et al., Effects of Vitamin D supplementation on prevention of type 2 diabetes in patients with prediabetes: a systematic review and meta-analysis. Diabetes Care. 43(7): 1650–1658. 2020.
  • Barbarawi M, Zayed Y, Barbarawi O, et al. effect of vitamin d supplementation on the incidence of diabetes mellitus. J Clin Endocrinol Metab. 2020;105(8):dgaa335.
  • Sollid ST, Hutchinson MY, Fuskevåg OM, et al. No effect of high-dose vitamin D supplementation on glycemic status or cardiovascular risk factors in subjects with prediabetes. Diabetes Care. 2014;37(8):2123–2131.
  • Niroomand M, Fotouhi A, Irannejad N, et al. Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized clinical trial. Diabetes Res Clin Pract. 2019;148:1–9.
  • Karras SN, Koufakis T, Dimakopoulos G, et al. Vitamin D equilibrium affects sex-specific changes in lipid concentrations during Christian Orthodox fasting. J Steroid Biochem Mol Biol. 2021;211:105903.
  • Pittas AG, Dawson-Hughes B, Sheehan P, et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019;381(6):520–530.
  • Dawson-Hughes B, Staten MA, Knowler WC, et al. Intratrial exposure to Vitamin D and new-onset diabetes among adults with prediabetes: a secondary analysis from the Vitamin D and type 2 diabetes (D2d) study. Diabetes Care. 2020;43(12):2916–2922.
  • Kresevic DM, Denton JE, Burant CJ, et al. Racial difference in response to Vitamin D supplementation. J Natl Med Assoc. 2015;107(2):18–24.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.