189
Views
0
CrossRef citations to date
0
Altmetric
Perspective

Aminoadamantanes: from treatment of Parkinson’s and Alzheimer’s disease to symptom amelioration of long COVID-19 syndrome?

ORCID Icon, &
Pages 101-107 | Received 07 Oct 2022, Accepted 31 Jan 2023, Published online: 08 Feb 2023

References

  • Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends Immunol. 2020;41(12):1100–1115.
  • Agyeman AA, Chin KL, Landersdorfer CB, et al. Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc. 2020;95(8):1621–1631.
  • Saniasiaya J, Narayanan P. Parosmia post COVID-19: an unpleasant manifestation of long COVID syndrome. Postgrad Med J. 2022;98(e2):e96.
  • Managing COVID-19. symptoms (including at the end of life) in the community: summary of NICE guidelines. BMJ. 2020;369:m1461.
  • Lopez-Leon S, Wegman-Ostrosky T, Perelman C, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. Sci Rep. 2021;11(1):16144.
  • Premraj L, Kannapadi NV, Briggs J, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: a meta-analysis. J Neurol Sci. 2022;434:120162.
  • Shivani F, Kumari N, Bai P, et al. Long-term symptoms of COVID-19: one-year follow-up study. Cureus. 2022;14(6):e25937.
  • da Silva CGL, Santana JR, Pinheiro LF, et al. Anatomopathological aspects and clinical correlation of COVID-19: a systematic review. Adv Exp Med Biol. 2021;1353:217–224.
  • Berlit P, Bösel J, Gahn G, et al. Neurological manifestations of COVID-19 - guideline of the German society of neurology. Neurol Res Pract. 2020;2(1):51
  • Davies WL, Grunert RR, Haff RF, et al. Antiviral activity of 1-adamantamine (Amantadine). Science. 1964;144(3620):862–863.
  • Fink K, Nitsche A, Neumann M, et al. Amantadine inhibits SARS-CoV-2 in vitro. Viruses. 2021;13(4):539. epub.
  • Schwab RS. Amantadine in the treatment of Parkinson’s disease. JAMA. 1969;208(7):1168–1170.
  • Müller T, Kuhn W, Möhr JD. Evaluating ADS5102 (amantadine) for the treatment of Parkinson’s disease patients with dyskinesia. Expert Opin Pharmacother. 2019;20(10):1181–1187.
  • Aoki FY, Sitar DS. Clinical pharmacokinetics of amantadine hydrochloride. Clin Pharmacokinet. 1988;14(1):35–51.
  • Danysz W, Dekundy A, Scheschonka A, et al. Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials. J Neural Transm (Vienna). 2021;128(2):127–169. .
  • Kornhuber J, Bormann J, Hübers M, et al. Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. Eur J Pharmacol. 1991;206(4):297–300.
  • Cortes-Borra A, randa-Abreu GE. Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2. Pharmacol Rep. 2021;73(3):962–965.
  • Cortes BA. Does amantadine have a protective effect against COVID-19?. Neurol Neurochir Pol. 2020;54(3):284–285.
  • Smieszek SP, Przychodzen BP, Polymeropoulos MH. Amantadine disrupts lysosomal gene expression: a hypothesis for COVID19 treatment. Int J Antimicrob Agents. 2020;55(6):106004.
  • Jimenez-Jimenez FJ, Alonso-Navarro H, García-Martín E, et al. Anti-inflammatory effects of amantadine and memantine: possible therapeutics for the treatment of covid-19? J Pers Med. 2020;10(4):217. Epub.
  • Tipton PW, Wszolek ZK. What can Parkinson’s disease teach us about COVID-19? Neurol Neurochir Pol. 2020;54(2):204–206.
  • Müller T. GOCOVRI((R)) (amantadine) extended-release capsules in Parkinson’s disease. Neurodegener Dis Manag. 2022;12(1):15–28.
  • Comi G, Leocani L. Assessment, pathophysiology and treatment of fatigue in multiple sclerosis. Expert Rev Neurother. 2002;2(6):867–876.
  • Iaccarino MA, Philpotts LL, Zafonte R, et al. Stimulant use in the management of mild traumatic brain injury: a qualitative literature review. J Atten Disord. 2020;24(2):309–317.
  • Nourbakhsh B, Revirajan N, Morris B, et al. Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial. Lancet Neurol. 2021;20(1):38–48.
  • Perez DQ, Espiritu AI, Jamora RDG. Efficacy and safety of amantadine for the treatment of fatigue in multiple sclerosis: a systematic review and meta-analysis. Neurodegener Dis Manag. 2020;10(6):383–395.
  • Generali JA, Cada DJ. Amantadine: multiple sclerosis-related fatigue. Hosp.Pharm. 2014;49(8):710–712.
  • Nourbakhsh B. Serious side effects of amantadine: rethinking the benefits and risks of medications for MS fatigue. Mult Scler. 2021;27(14):2290.
  • Kraus MF, Smith GS, Butters M, et al. Effects of the dopaminergic agent and NMDA receptor antagonist amantadine on cognitive function, cerebral glucose metabolism and D2 receptor availability in chronic traumatic brain injury: a study using positron emission tomography (PET). Brain Inj. 2005;19(7):471–479.
  • Leclerc AM, Riker RR, Brown CS, et al. Amantadine and modafinil as neurostimulants following acute stroke: a retrospective study of intensive care unit patients. Neurocrit Care. 2021;34(1):102–111.
  • Kamel WA, Kamel MI, Alhasawi A, et al. Effect of pre-exposure use of amantadine on COVID-19 infection: a hospital-based cohort study in patients with Parkinson’s disease or multiple sclerosis. Front Neurol. 2021;12:704186.
  • Rejdak K, Grieb P. Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. Mult Scler Relat Disord. 2020;42:102163.
  • Rejdak K, Fiedor P, Bonek R, et al. The use of amantadine in the prevention of progression and treatment of COVID-19 symptoms in patients infected with the SARS-CoV-2 virus (COV-PREVENT): study rationale and design. Contemp Clin Trials. 2022;116:106755.
  • Rejdak K, Grieb P. Fluvoxamine and amantadine: central nervous system acting drugs repositioned for COVID-19 as early intervention. Curr Neuropharmacol. 2022;20(4):777–781.
  • Folch J, Busquets O, Ettcheto M, et al. Memantine for the treatment of dementia: a review on its current and future applications. J Alzheimers Dis. 2018;62(3):1223–1240.
  • Danysz W, Parsons CG, Kornhuber J, et al. Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents–preclinical studies. Neurosci Biobehav Rev. 1997;21(4):455–468.
  • Danysz W, Parsons CG, Quack G. NMDA channel blockers: memantine and amino-aklylcyclohexanes–in vivo characterization. Amino Acids. 2000;19(1):167–172.
  • Parsons CG, Danysz W, Quack G. Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists–in vitro characterisation. Amino Acids. 2000;19(1):157–166.
  • Honegger UE, Quack G, Wiesmann UN. Evidence for lysosomotropism of memantine in cultured human cells: cellular kinetics and effects of memantine on phospholipid content and composition, membrane fluidity and beta-adrenergic transmission. Pharmacol Toxicol. 1993;73(4):202–208.
  • Riederer P, Ter MV. Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses. J Neural Transm (Vienna). 2020;127(9):1217–1228.
  • Caumont AS, Octave JN, Hermans E. Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells. Neurosci Lett. 2006;394(3):196–201.
  • Li WJ, Chen H-J, Qian L-H, et al. [Effects of glial cell line-derived neurotrophic factor and memantine on long-term prognosis in neonatal rats with periventricular leukomalacia]. Zhongguo Dang Dai Er Ke Za Zhi. 2011;13(9):743–746.
  • Rajasekar N, Nath C, Hanif K, et al. Inhibitory Effect of Memantine on Streptozotocin-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Neurotrophic Factor Decline in Astrocytes. Mol Neurobiol. 2016;53(10):6730–6744.
  • Ranju V, Sathiya S, Kalaivani P, et al. Memantine exerts functional recovery by improving BDNF and GDNF expression in 3-nitropropionic acid intoxicated mice. Neurosci.Lett. 2015;586:1–7.
  • Grossberg GT, Alva G, Hendrix S, et al. Memantine ER maintains patient response in moderate to severe alzheimer’s disease: post hoc analyses from a randomized, controlled, clinical trial of patients treated with cholinesterase inhibitor. Alzheimer Dis Assoc Disord. 2018;32(3):173–178.
  • Müller T. What are the main considerations when prescribing pharmacotherapy for Parkinson’s disease? Expert.Opin.Pharmacother. 2022;23(7):745–750.
  • Gao Y, Ma L, Liang F, et al. The use of amantadine in patients with unresponsive wakefulness syndrome after severe cerebral hemorrhage. Brain Inj. 2020;34(8):1084–1088.
  • Ishida T, Obara Y, Kamei C. Studies on wakefulness-promoting effect of memantine in rats. BehavBrain Res. 2010;206(2):274–278.
  • Reynolds JC, Rittenberger JC, Callaway CW. Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. Resuscitation. 2013;84(6):818–824.
  • Terzano MG, Montanari E, Calzetti S, et al. The effect of amantadine on arousal and EEG patterns in Creutzfeldt-Jakob disease. Arch.Neurol. 1983;40(9):555–559.
  • Falsafi Z, Tafakhori A, Agah E, et al. Safety and efficacy of memantine for multiple sclerosis-related fatigue: a pilot randomized, double-blind placebo-controlled trial. J Neurol Sci. 2020;414:116844.
  • Garssen MP, Schmitz PI, Merkies IS, et al. Amantadine for treatment of fatigue in Guillain-Barre syndrome: a randomised, double blind, placebo controlled, crossover trial. J Neurol Neurosurg Psychiatry. 2006;77(1):61–65.
  • Lovera JF, Frohman E, Brown TR, et al. Memantine for cognitive impairment in multiple sclerosis: a randomized placebo-controlled trial. Mult Scler. 2010;16(6):715–723.
  • Miller P, Soundy A. The pharmacological and non-pharmacological interventions for the management of fatigue related multiple sclerosis. J Neurol Sci. 2017;381:41–54.
  • Sailer M, Heinze H-J, Schoenfeld M, et al. Amantadine influences cognitive processing in patients with multiple sclerosis. Pharmacopsychiatry. 2000;33(1):28–37.
  • Ginde AA, Paredes R, Murray TA, et al. Tixagevimab-cilgavimab for treatment of patients hospitalised with COVID-19: a randomised, double-blind, phase 3 trial. Lancet Respir Med. 2022; Epub.
  • Conte WL, Golzarri-Arroyo L. Tixagevimab and Cilgavimab (Evusheld) boosts antibody levels to SARS-CoV-2 in patients with multiple sclerosis on b-cell depleters. Mult Scler Relat Disord. 2022;63:103905.
  • Keam SJ. Tixagevimab + Cilgavimab: first Approval. Drugs. 2022;82(9):1001–1010.
  • Levin MJ, Ustianowski A, De Wit S, et al. Intramuscular AZD7442 (Tixagevimab-Cilgavimab) for Prevention of Covid-19. N Engl J Med. 2022;386(23):2188–2200.
  • Pringle A, Parsons E, Cowen LG, et al. Using an experimental medicine model to understand the antidepressant potential of the N -Methyl-D-aspartic acid (NMDA) receptor antagonist memantine. J Psychopharmacol. 2012;26(11):1417–1423.
  • Lv X, Li Q, Mao S, et al. The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion. Aging (Albany NY). 2020;12(21):21469–21480.
  • McAllister J, Ghosh S, Berry D, et al. Effects of memantine on mitochondrial function. Biochem Pharmacol. 2008;75(4):956–964.
  • Quarato G, Scrima R, Ripoli M, et al. Protective role of amantadine in mitochondrial dysfunction and oxidative stress mediated by hepatitis C virus protein expression. Biochem Pharmacol. 2014;89(4):545–556.
  • Shevtsova EF, Vinogradova D, Neganova ME, et al. Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and beta-amyloid neurotoxicity. Sci Rep. 2022;12(1):12766.
  • Wang Y, Jiang B, Luo W. Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection. Bioengineered. 2022;13(3):6688–6697.
  • Müller T, Mueller BK, Riederer P. Perspective: treatment for Disease Modification in Chronic Neurodegeneration. Cells. 2021;10(4):873.
  • Takahashi-Ito K, Makino M, Okado K, et al. Memantine inhibits beta-amyloid aggregation and disassembles preformed beta-amyloid aggregates. Biochem Biophys Res Commun. 2017;493(1):158–163.
  • Zhang W, Kandel N, Zhou Y, et al. Drug delivery of memantine with carbon dots for Alzheimer’s disease: blood-brain barrier penetration and inhibition of tau aggregation. J Colloid Interface Sci. 2022;617:20–31.
  • Bodnar W, Aranda-Abreu G, Słaboń-Willand M, et al. The efficacy of amantadine hydrochloride in the treatment of COVID-19 - a single-center observation study. Pol Merkur Lekarski. 2021;49(294):389–393.
  • Butterworth RF. Potential for the repurposing of adamantane antivirals for COVID-19. Drugs R D. 2021;21(3):267–272.
  • Toft-Bertelsen TL, Jeppesen MG, Tzortzini E, et al. Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2. Commun Biol. 2021;4(1):1347.
  • Tronche C, Lestage P, Louis C, et al. Pharmacological modulation of contextual “episodic-like” memory in aged mice. Behav Brain Res. 2010;215(2):255–260.
  • Tur C. Fatigue management in multiple sclerosis. Curr Treat Options Neurol. 2016;18(6):26.
  • Wiwanitkit V. Amantadine, COVID-19 and Parkinsonism. Arch Med Res. 2020;51(7):714.
  • Zhou Y, Gammeltoft KA, Galli A, et al. Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro. Viruses. 2021;13(10):2082.
  • Zoladz PR, Campbell A, PARK C, et al. Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane. Pharmacol Biochem Behav. 2006;85(2):298–06.
  • Klosch G, Zeitlhofer J, Ipsiroglu O. Revisiting the concept of vigilance. Front Psychiatry. 2022;13:874757.
  • Molina JL, Voytek B, Thomas ML, et al. Memantine effects on electroencephalographic measures of putative excitatory/inhibitory balance in schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020;5(6):562–568.
  • Schulz H, Jobert M, Coppola R, et al. The use of diurnal vigilance changes in the EEG to verify vigilance-enhancing effects of memantine in a clinical pharmacological study. Neuropsychobiology. 1996;33(1):32–40.
  • Thrash-Williams B, Ahuja M, Karuppagounder SS, et al. Assessment of therapeutic potential of amantadine in methamphetamine induced neurotoxicity. Neurochem Res. 2013;38(10):2084–2094.
  • Schwab RS, England AC Jr. Amantadine HCL (Symmetrel) and its relation to Levo-Dopa in the treatment of Parkinson’s disease. Trans Am Neurol Assoc. 1969;94:85–90.
  • Rascol O, Tönges L, deVries T, et al. Immediate-release/extended-release amantadine (OS320) to treat Parkinson’s disease with levodopa-induced dyskinesia: analysis of the randomized, controlled ALLAY-LID studies. Parkinsonism Relat Disord. 2022;96:65–73.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.