273
Views
0
CrossRef citations to date
0
Altmetric
Perspective

Perspectives on deprescribing in palliative care

, , &
Pages 411-421 | Received 07 Oct 2022, Accepted 28 Mar 2023, Published online: 19 Apr 2023

References

  • Kelley AS, Morrison RS. Palliative care for the seriously ill. N Engl J Med. 2015;373(8):747–755.
  • Kelley AS, Bollens-Lund E. Identifying the population with serious illness: the “denominator” challenge. J Palliat Med. 2018;21(S2):S7–16.
  • Center to Advance Palliative Care and the National Palliative Care Research Center. America’s care of serious illness: a state-by-state report card on access to palliative care in our nation’s hospitals. NY: Center to Advance Palliative Care, National Palliative Care Research Center; Sep, 2019. Availabile at: https://reportcard.capc.org/wp-content/uploads/2020/05/CAPC_State-by-State-Report-Card_051120.pdf. Accessed on: Oct 6, 2022.
  • World Health Organization. Palliative Care. 2022. https://www.who.int/news-room/fact-sheets/detail/palliative-care. Accessed Oct 5, 2022.
  • Morrison RS, Dietrich J, Ladwig S, et al. Palliative care consultation teams cut hospital costs for Medicaid beneficiaries. Health Aff. 2011;30(3):454–463.
  • Morrison RS, Penrod JD, Cassel JB, et al. Cost savings associated with US hospital palliative care consultation programs. Arch Intern Med. 2008;168(16):1783–1790.
  • Kavalieratos D, Corbelli J, Zhang D, et al. Association between palliative care and patient and caregiver outcomes: a systematic review and meta-analysis. JAMA. 2016;316(20):2104–2114.
  • Cadogan CA, Murphy M, Boland M, et al. Prescribing practices, patterns, and potential harms in patients receiving palliative care: a systematic scoping review. Exp Research Clin Soc Pharm. 2021;3:100050.
  • Stevenson J, Abernethy AP, Miller C, et al. Managing comorbidities in patients at the end of life. BMJ. 2004;329(7471):909–912.
  • Currow DC, Stevenson JP, Abernethy AP, et al. Prescribing in palliative care as death approaches. J Am Geriatr Soc. 2007;55(4):590–595.
  • Reeve E, Gnjidic D, Long J, et al. A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice. Br J Clin Pharmacol. 2015;80(6):1254–1268.
  • van Merendonk Ln, Crul M. Deprescribing in palliative patients with cancer: a concise review of tools and guidelines. Support Care Cancer. 2022;30(4):2933–2943.
  • Hedman C, Frisk G, Bjorkhem-Bergman L. Deprescribing in palliative cancer care. Life (Basel). 2022;12(5).
  • McNeill R, Hanger HC, Chieng J, et al. Polypharmacy in palliative care: two deprescribing tools compared with a clinical review. J Palliat Med. 2021;24(5):661–667.
  • Low CE, Sanchez Pellecer DE, Santivasi WL, et al. Deprescribing in hospice patients: discontinuing aspirin, multivitamins, and statins. Mayo Clin Proc Innov Qual Outcomes. 2021;5(4):721–726.
  • Oliveira R, Teodoro T. Palliative care in patients living with dementia: the role of deprescribing. Acta Med Port. 2019;32(11):735.
  • Gardner E. Deprescribing in end-of-life care. Br J Community Nurs. 2019;24(10):474–477.
  • Buxbaum JD, Chernew ME, Fendrick AM, et al. Contributions of public health, pharmaceuticals, and other medical care to US life expectancy changes, 1990-2015. Health Aff. 2020;39(9):1546–1556.
  • Strand V, Singh JA. Improved health-related quality of life with effective disease-modifying antirheumatic drugs: evidence from randomized controlled trials. Am J Manag Care. 2007;13(9):S237–251.
  • Stuchiner T, Lucas L, Baraban E, et al. Quality of life among injectable and oral disease-modifying therapy users in the Pacific Northwest Multiple Sclerosis Registry. BMC Neurol. 2020;20(1):439.
  • Boyd CM, Darer J, Boult C, et al. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance. JAMA. 2005;294(6):716–724.
  • Blinderman CD. Integrating palliative care with disease-modifying therapy. Virtual Mentor. 2013;15(12):1017–1021.
  • Thienprayoon R, LeBlanc T. Early integration of palliative care into the care of patients with cancer. Hematology Am Soc Hematol Educ Program. 2015;2015:479–483.
  • Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010;363(8):733–742.
  • O’Mahony D, O’Connor MN. Pharmacotherapy at the end-of-life. Age Ageing. 2011;40(4):419–422.
  • Pasina L, Rizzi B, Nobili A, et al. Anticholinergic load and delirium in end-of-life patients. Eur J Clin Pharmacol. 2021;77(9):1419–1424.
  • de Jong Mr, Van der Elst M, Hartholt KA. Drug-related falls in older patients: implicated drugs, consequences, and possible prevention strategies. Ther Adv Drug Saf. 2013;4(4):147–154.
  • Rochon PA, Gurwitz JH. The prescribing cascade revisited. Lancet. 2017;389(10081):1778–1780.
  • Scott IA, Hilmer SN, Reeve E, et al. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern Med. 2015;175(5):827–834.
  • Tjia J, Kutner JS, Ritchie CS, et al. Perceptions of statin discontinuation among patients with life-limiting illness. J Palliat Med. 2017;20(10):1098–1103.
  • Reigada C, Arantzamendi M, Centeno C. Palliative care in its own discourse: a focused ethnography of professional messaging in palliative care. BMC Palliat Care. 2020;19(1):88.
  • Grant M, Back A, Dettmar N. Public perceptions of advance care planning, palliative care, and hospice: a scoping review. J Palliat Med. 2021;24(1):46–52.
  • Cambia Palliative Care Center of Excellence. Our work. University of Washington. https://cpcce.uw.edu/our-work. Published 2022. Accessed Sep 25, 2022.
  • Tjia J, Clayton MF, Fromme EK, et al. Shared medication PLanning in (SIMPLIfy) home hospice: an educational program to enable goal-concordant prescribing in home hospice. J Pain Symptom Manage. 2021;62(5):1092–1099.
  • Pengo MF, Czaban M, Berry MP, et al. The effect of positive and negative message framing on short term continuous positive airway pressure compliance in patients with obstructive sleep apnea. J Thorac Dis. 2018;10(Suppl 1):S160–169.
  • Carfora V, Pastore M, Catellani P. A cognitive-emotional model to explain message framing effects: reducing meat consumption. Front Psychol. 2021 Mar 29;12:583209.
  • Bayliss EA, Shetterly SM, Drace ML, et al. Deprescribing education vs usual care for patients with cognitive impairment and primary care clinicians: the OPTIMIZE pragmatic cluster randomized trial. JAMA Intern Med. 2022;182(5):534–542.
  • Sanders JJ, Curtis JR, Tulsky JA. Achieving goal-concordant care: a conceptual model and approach to measuring serious illness communication and its impact. J Palliat Med. 2018;21(S2):S17–27.
  • Stevens EM, Kim S, Leshner G, et al. The attitudinal and motivational effects of anti-waterpipe messages. Am J Health Behav. 2019;43(3):478–489.
  • Tjia J, Lund JL, Mack DS, et al. Methodological challenges for epidemiologic studies of deprescribing at the end of life. Curr Epidemiol Rep. 2021;8(3):116–129.
  • By the American Geriatrics Society Beers Criteria Update Expert P. American Geriatrics Society. 2019 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–694.
  • O’Mahony D, O’Sullivan D, Byrne S, et al. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015 Mar;44(2):213–218.
  • Lindsay J, Dooley M, Martin J, et al. The development and evaluation of an oncological palliative care deprescribing guideline: the ‘OncPal deprescribing guideline’. Support Care Cancer. 2015;23(1):71–78.
  • Lavan AH, Gallagher P, Parsons C , et al. STOPPFrail (Screening Tool of Older Persons Prescriptions in Frail adults with limited life expectancy): consensus validation. Age Ageing. 2017 Jul 1;46(4):600–607.
  • Curtin D, Gallagher P, O’Mahony D. Deprescribing in older people approaching end-of-life: development and validation of STOPPFrail version 2. Age Ageing. 2021 Feb 26;50(2):465–471.
  • Curtin D, Jennings E, Daunt R, et al. Deprescribing in older people approaching end of life: a randomized controlled trial using STOPPFrail criteria. J Am Geriatr Soc. 2020 Apr;68(4):762–769.
  • Lavan AH, Gallagher P, O’Mahony D. Inter-rater reliability of STOPPFrail [Screening tool of older persons prescriptions in frail adults with limited life expectancy] criteria amongst 12 physicians. Eur J Clin Pharmacol. 2018;74(3):331–338.
  • Hanlon JT, Tjia J. Avoiding adverse drug withdrawal events when stopping unnecessary medications according to the STOPPFrail criteria. Sr Care Pharm. 2021 Mar 1;36(3):136–141.
  • Bahat G, Ilhan B, Bay I, et al. Explicit versus implicit evaluation to detect inappropriate medication use in geriatric outpatients. Aging Male. 2020;23(3):179–184.
  • Curtin D, Gallagher PF. O’Mahony D. Explicit criteria as clinical tools to minimize inappropriate medication use and its consequences. Ther Adv Drug Saf. 2019;10:2042098619829431.
  • Hanlon JT, Schmader KE, Samsa GP, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992;45(10):1045–1051.
  • Hanlon JT, Schmader KE. The medication appropriateness index at 20: where it started, where it has been, and where it may be going. Drugs Aging. 2013 Nov;30(11):893–900.
  • Suhrie EM, Hanlon JT, Jaffe EJ, et al. Impact of a geriatric nursing home palliative care service on unnecessary medication prescribing. Am J Geriatr Pharmacother. 2009;7(1):20–25.
  • Schuling J, Gebben H, Veehof LJ, et al. Deprescribing medication in very elderly patients with multimorbidity: the view of Dutch GPs. A qualitative study. BMC Fam Pract. 2012;13:56.
  • Ailabouni NJ, Nishtala PS, Mangin D, et al. Challenges and enablers of deprescribing: a general practitioner perspective. PLoS ONE. 2016;11(4):e0151066.
  • Ailabouni NJ, Weir KR, Reeve E, et al. Barriers and enablers of older adults initiating a deprescribing conversation. Patient Educ Couns. 2022;105(3):615–624.
  • Kamal AH, Bull JH, Swetz KM, et al. Future of the palliative care workforce: preview to an impending crisis. Am J Med. 2017;130(2):113–114.
  • Quill TE, Abernethy AP. Generalist plus specialist palliative care–creating a more sustainable model. N Engl J Med. 2013;368(13):1173–1175.
  • Furuno JP, Noble BN, McPherson ML, et al. Variation in hospice patient and admission characteristics by referral location. Med Care. 2020;58(12):1069–1074.
  • Kelley AS, Covinsky KE, Gorges RJ, et al. Identifying older adults with serious illness: a critical step toward improving the value of health care. Health Serv Res. 2017;52(1):113–131.
  • Kelley AS, Ferreira KB, Bollens-Lund E, et al. Identifying older adults with serious illness: transitioning from ICD-9 to ICD-10. J Pain Symptom Manage. 2019;57(6):1137–1142.
  • Ariadne Labs. Serious Illness Care. https://www.ariadnelabs.org/serious-illness-care/. Published 2022. Accessed Sep 16, 2022.
  • Bernacki RE, Block SD. for the American College of Physicians high value care task force. communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014;174(12):1994–2003.
  • Weir KR, Bonner C, McCaffery K, et al. Pharmacists and patients sharing decisions about medicines: development and feasibility of a conversation guide. Res Social Adm Pharm. 2019;15(6):682–690.
  • National Consensus Project for Quality Palliative Care. Clinical Practice Guidelines for Quality Palliative Care, 4th edition. Richmond VA: National Coalition for Hospice and Palliative Care; 2018. Available at: https://www.nationalcoalitionhpc.org/ncp. Accessed on Oct 6, 2022.
  • Shrestha S, Poudel A, Steadman K, et al. Outcomes of deprescribing interventions in older patients with life-limiting illness and limited life expectancy: a systematic review. Br J Clin Pharmacol. 2020 Oct;86(10):1931–1945. Epub 2019 Dec 12. PMID: 31483057; PMCID: PMC7495295. DOI:10.1111/bcp.14113.
  • Schenker Y, Park SY, Jeong K, et al. Associations between polypharmacy, symptom burden, and quality of life in patients with advanced, life-limiting illness. J Gen Intern Med. 2019;34(4):559–566.
  • Stinson MJ, Gurevitz S, Carrigan A. Deprescribing at the end of life in older patients. JAAPA. 2019;32(7):20–24.
  • Kutner JS, Blatchford PJ, Taylor DH Jr, et al. Safety and benefit of discontinuing statin therapy in the setting of advanced, life-limiting illness: a randomized clinical trial. JAMA Intern Med. 2015 May;175(5):691–700.
  • Clark CM, Hejna M, Shao E, et al. Knowledge and attitudes of student pharmacists regarding polypharmacy and deprescribing: a cross-sectional study. Pharmacy (Basel). 2020;8(4):220.
  • Garfinkel D, Ilhan B, Bahat G. Routine deprescribing of chronic medications to combat polypharmacy. Ther Adv Drug Saf. 2015;6(6):212–233.
  • Loganathan M, Singh S, Franklin BD, et al. Interventions to optimise prescribing in care homes: systematic review. Age Ageing. 2011;40(2):150–162.
  • Steinman M, Reeve E. Deprescribing. UpToDate, Inc. https://www.uptodate.com/contents/deprescribing#references. Published 2022. Updated April 22, 2022. Accessed September 15, 2022.
  • Paque K, Vander Stichele R, Elseviers M, et al. Barriers and enablers to deprescribing in people with a life-limiting disease: a systematic review. Palliat Med. 2019;33(1):37–48.
  • Steinman MA, Handler SM, Gurwitz JH, et al. Beyond the prescription: medication monitoring and adverse drug events in older adults. J Am Geriatr Soc. 2011;59(8):1513–1520.
  • Hazen ACM, Zwart DLM, Poldervaart JM, et al. Non-dispensing pharmacists’ actions and solutions of drug therapy problems among elderly polypharmacy patients in primary care. Fam Pract. 2019;36(5):544–551.
  • Bregnhoj L, Thirstrup S, Kristensen MB, et al. Combined intervention programme reduces inappropriate prescribing in elderly patients exposed to polypharmacy in primary care. Eur J Clin Pharmacol. 2009;65(2):199–207.
  • Korenvain C, MacKeigan LD, Dainty KN, et al. Exploring deprescribing opportunities for community pharmacists using the behaviour change wheel. Res Social Adm Pharm. 2020;16(12):1746–1753.
  • McPherson ML, Walker K How to include a pharmacist in the palliative care mix. Center to Advance Palliative Care. https://www.capc.org/blog/how-include-pharmacist-palliative-care-mix/. Updated October 18, 2021 Accessed September 16, 2022.
  • Mantelli S, Jungo KT, Rozsnyai Z, et al. How general practitioners would deprescribe in frail oldest-old with polypharmacy - the LESS study. BMC Fam Pract. 2018;19(1):169.
  • Ibrahim K, Cox NJ, Stevenson JM, et al. A systematic review of the evidence for deprescribing interventions among older people living with frailty. BMC Geriatr. 2021;21(1):258.
  • Tremblay Z, Mumbere D, Laurin D, et al. Health impacts and characteristics of deprescribing interventions in older adults: protocol for a systematic review and meta-analysis. JMIR Res Protoc. 2021;10(12):e25200.
  • Thio SL, Nam J, van Driel ML, et al. Effects of discontinuation of chronic medication in primary care: a systematic review of deprescribing trials. Br J Gen Pract. 2018;68(675):e663–672.
  • Page A, Khalil H, Etherton-Beer C, et al. The efficacy of deprescribing interventions on health outcomes in people aged over 65 years: a systematic review protocol. JBI Database System Rev Implement Rep. 2014;12(4):124–134.
  • Page AT, Clifford RM, Potter K, et al. The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta-analysis. Br J Clin Pharmacol. 2016;82(3):583–623.
  • Ulley J, Harrop D, Ali A, et al. Deprescribing interventions and their impact on medication adherence in community-dwelling older adults with polypharmacy: a systematic review. BMC Geriatr. 2019;19(1):15.
  • Tjia J, Velten SJ, Parsons C, et al. Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging. 2013;30(5):285–307.
  • Berard A. Pharmacoepidemiology research-real-world evidence for decision making. Front Pharmacol. 2021;12:723427.
  • Brown B, Gude WT, Blakeman T, et al. Clinical performance feedback intervention theory (CP-FIT): a new theory for designing, implementing, and evaluating feedback in health care based on a systematic review and meta-synthesis of qualitative research. Implement Sci. 2019;14(1):40.
  • Berger ML, Sox H, Willke RJ, et al. Good practices for real-world data studies of treatment and/or comparative effectiveness: recommendations from the joint ISPOR-ISPE special task force on real-world evidence in health care decision making. Pharmacoepidemiol Drug Saf. 2017;26(9):1033–1039.
  • Rahme E, Choquette D, Beaulieu M, et al. Impact of a general practitioner educational intervention on osteoarthritis treatment in an elderly population. Am J Med. 2005;118(11):1262–1270.
  • Li Y, Whelan CM, Husain AF. Deprescribing in the home palliative setting. J Pall Med. 2021;24(7):1030–1035.
  • American Society of Health System Pharmacists. ASHP Residency Directory. https://accreditation.ashp.org/directory/#/program/residency. Accessed on Feb 16, 2023.
  • American Society of Health System Pharmacists. Required and elective educational outcomes, goals, objectives, and instructional objectives for postgraduate year two (PGY2) pharmacy residencies in pain management and palliative care. Available at: https://www.ashp.org/-/media/assets/professional-development/residencies/docs/pgy2-pain-management-palliative-care.ashx. Accessed on Feb 16, 2023.
  • Brandt NJ, Cooke CE. Centers for Medicare and Medicaid Services support for medication therapy management (enhanced medication therapy management): testing strategies for improving medication use among beneficiaries enrolled in Medicare Part D. Clin Geriatr Med. 2017;33(2):153–164.
  • Jokanovic N, Tan EC, van den Bosch D, et al. Clinical medication review in Australia: a systematic review. Res Social Adm Pharm. 2016;12(3):384–418.
  • Agarwal SD, Barnett ML, Souza J, et al. Adoption of Medicare’s transitional care management and chronic care management codes in primary care. JAMA. 2018;320(24):2596–2597.
  • Marcotte LM, Reddy A, Zhou L, et al. Trends in utilization of transitional care management in the United States. JAMA Netw Open. 2020;3(1):e1919571.
  • Weissman JS, Gazarian P, Reich A, et al. Recent trends in the use of medicare advance care planning codes. J Palliat Med. 2020;23(12):1568–1570.
  • Ladin K, Bronzi OC, Gazarian PK, et al. Understanding the use of Medicare procedure codes for advance care planning: a national qualitative study. Health Aff. 2022;41(1):112–119.
  • Krishnaswami A, Steinman MA, Goyal P, et al. Deprescribing in older adults with cardiovascular disease. J Am Coll Cardiol. 2019;73(20):2584–2595.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.