Omega 3 fatty acids, inflammation and DNA methylation: an overview

References

• Simopoulos AP. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999;70:560S–569S.
   PubMed Web of Science ®Google Scholar
• Verlengia R, Gorjao R, Kanunfre C, et al. Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells. J Nutr Biochem. 2004;15:657–665.10.1016/j.jnutbio.2004.04.008
   PubMed Web of Science ®Google Scholar
• Trebble T, Arden NK, Stroud MA, et al. Inhibition of tumour necrosis factor-α and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. Br J Nutr. 2003;90:405–412.10.1079/BJN2003892
   PubMed Web of Science ®Google Scholar
• Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med. 1989;320:265–271.10.1056/NEJM198902023200501
   PubMed Web of Science ®Google Scholar
• Yaqoob P, Calder P. Effects of dietary lipid manipulation upon inflammatory mediator production by murine macrophages. Cell Immunol. 1995;163:120–128.10.1006/cimm.1995.1106
   PubMed Web of Science ®Google Scholar
• Richard C, Lewis ED, Goruk S, et al. A dietary supply of docosahexaenoic acid early in life is essential for immune development and the establishment of oral tolerance in female rat offspring. J Nutr. 2016;146:2398–2406.10.3945/jn.116.237149
   Web of Science ®Google Scholar
• Olson MV, Liu Y-C, Dangi B, et al. Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. Inflamm Res. 2013;62:1003–1013.10.1007/s00011-013-0658-4
   Web of Science ®Google Scholar
• Al-Khalifa H, Givens DI, Rymer C, et al. Effect of n-3 fatty acids on immune function in broiler chickens. Poult Sci. 2012;91:74–88.10.3382/ps.2011-01693
   PubMed Web of Science ®Google Scholar
• Itariu BK, Zeyda M, Hochbrugger EE, et al. Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial. Am J Clin Nutr. 2012;96:1137–1149.10.3945/ajcn.112.037432
   PubMed Web of Science ®Google Scholar
• Tartibian B, Maleki BH, Abbasi A. Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men. Clin J Sport Med. 2011;21:131–137.10.1097/JSM.0b013e31820f8c2f
   PubMed Web of Science ®Google Scholar
• Calder PC. Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance. Biochem Biophys Acta – Mol Cell Biol Lipids. 2015;1851:469–484.
   PubMed Web of Science ®Google Scholar
• Rudkowska I, Paradis A-M, Thifault E, et al. Transcriptomic and metabolomic signatures of an n-3 polyunsaturated fatty acids supplementation in a normolipidemic/normocholesterolemic Caucasian population. J Nutr Biochem. 2013;24:54–61.10.1016/j.jnutbio.2012.01.016
   Web of Science ®Google Scholar
• Bouwens M, van de Rest O, Dellschaft N, et al. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am J Clin Nutr. 2009;90:415–424.10.3945/ajcn.2009.27680
   PubMed Web of Science ®Google Scholar
• Holliday R. Epigenetics: a historical overview. Epigenetics. 2006;1:76–80.
   PubMed Web of Science ®Google Scholar
• Huang B, Jiang C, Zhang R. Epigenetics: the language of the cell? Epigenomics. 2014;6:73–88.10.2217/epi.13.72
   PubMed Web of Science ®Google Scholar
• Bernstein BE, Meissner A, Lander ES. The mammalian epigenome. Cell. 2007;128:669–681.10.1016/j.cell.2007.01.033
   PubMed Web of Science ®Google Scholar
• Barski A, Cuddapah S, Cui K, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007;129:823–837.10.1016/j.cell.2007.05.009
   PubMed Web of Science ®Google Scholar
• Kouzarides T. Chromatin modifications and their function. Cell. 2007;128:693–705.10.1016/j.cell.2007.02.005
   PubMed Web of Science ®Google Scholar
• Berger SL. The complex language of chromatin regulation during transcription. Nature. 2007;447:407–412.10.1038/nature05915
   PubMed Web of Science ®Google Scholar
• Jenuwein T. Translating the histone code. Science (80-.). 2001;293:1074–1080.
   PubMed Web of Science ®Google Scholar
• Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002;16:6–21.10.1101/gad.947102
   PubMed Web of Science ®Google Scholar
• Goll MG, Bestor TH. Eukaryotic cytosine methyltransferases. Ann Rev Biochem. 2005;74:481–514.10.1146/annurev.biochem.74.010904.153721
   PubMed Web of Science ®Google Scholar
• Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet. 2006;15:R17–R29.10.1093/hmg/ddl046
   PubMed Web of Science ®Google Scholar
• Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128:683–692.10.1016/j.cell.2007.01.029
   PubMed Web of Science ®Google Scholar
• Park LK, Friso S, Choi S-W. Nutritional influences on epigenetics and age-related disease. Proc Nutr Soc. 2012;71:75–83.10.1017/S0029665111003302
   PubMed Web of Science ®Google Scholar
• Brunet A, Berger SL. Epigenetics of aging and aging-related disease. J Gerontol Ser A Biol SciMed Sci. 2014;69:S17–S20.
   PubMed Web of Science ®Google Scholar
• Benayoun BA, Pollina EA, Brunet A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol. 2015;16:593–610.10.1038/nrm4048
   PubMed Web of Science ®Google Scholar
• Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol. 2010;28:1057–1068.10.1038/nbt.1685
   PubMed Web of Science ®Google Scholar
• Kelly TK, De Carvalho DD, Jones PA. Epigenetic modifications as therapeutic targets. Nat Biotechnol. 2010;28:1069–1078.10.1038/nbt.1678
   PubMed Web of Science ®Google Scholar
• Jones PA, Takai D. The role of DNA methylation in mammalian epigenetics. Science. 2001;293:1068–1070.10.1126/science.1063852
   PubMed Web of Science ®Google Scholar
• Gilbert SF. Ageing and cancer as diseases of epigenesis. J Biosci. 2009;34:601–604.10.1007/s12038-009-0077-4
   PubMed Web of Science ®Google Scholar
• Wilson VL, Smith RA, Ma S, et al. Genomic 5-methyldeoxycytidine decreases with age. J Biol Chem. 1987;262:9948–9951.
   PubMed Web of Science ®Google Scholar
• Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell. 2015;14:924–932.10.1111/acel.12349
   PubMed Web of Science ®Google Scholar
• Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene. 2002;21:5400–5413.10.1038/sj.onc.1205651
   PubMed Web of Science ®Google Scholar
• Muka T, Koromani F, Portilla E, et al. The role of epigenetic modifications in cardiovascular disease: a systematic review. Int J Cardiol. 2016;212:174–183.10.1016/j.ijcard.2016.03.062
   PubMed Web of Science ®Google Scholar
• Lam LL, Emberly E, Fraser HB, et al. Factors underlying variable DNA methylation in a human community cohort. Proc Nat Acad Sci. 2012;109:17253–17260.10.1073/pnas.1121249109
   PubMed Web of Science ®Google Scholar
• Gomes MVM, Toffoli LV, Arruda DW, et al. Age-related changes in the global DNA methylation profile of leukocytes are linked to nutrition but are not associated with the MTHFR C677T genotype or to Functional capacities. Suzuki H, editor. PLoS ONE. 2012;7:e52570.10.1371/journal.pone.0052570
   PubMed Web of Science ®Google Scholar
• Choi S-W, Friso S. Epigenetics: a new bridge between nutrition and health. Adv Nutr. 2010;1:8–16.10.3945/an.110.1004
   PubMed Web of Science ®Google Scholar
• Bacalini MG, Friso S, Olivieri F, et al. Present and future of anti-ageing epigenetic diets. Mech Ageing Dev. 2014;136–137:101–115.10.1016/j.mad.2013.12.006
   Web of Science ®Google Scholar
• Aslibekyan S, Wiener HW, Havel PJ, et al. DNA methylation patterns are associated with n-3 fatty acid intake in Yup’ik people. J Nutr. 2014;144:425–430.10.3945/jn.113.187203
   Web of Science ®Google Scholar
• Bersamin A, Luick BR, King IB, et al. Westernizing diets influence fat intake, red blood cell fatty acid composition, and health in remote alaskan native communities in the center for alaska native health study. J Am Diet Assoc. 2008;108:266–273.10.1016/j.jada.2007.10.046
   PubMed Web of Science ®Google Scholar
• O’Brien DM, Kristal AR, Jeannet MA, et al. Red blood cell 15 N: a novel biomarker of dietary eicosapentaenoic acid and docosahexaenoic acid intake. Am J Clin Nutr. 2009;89:913–919.10.3945/ajcn.2008.27054
   Web of Science ®Google Scholar
• Chen RZ, Pettersson U, Beard C, et al. DNA hypomethylation leads to elevated mutation rates. Nature. 1998;395:89–93.
   PubMed Web of Science ®Google Scholar
• Voisin S, Almén MS, Moschonis G, et al. Dietary fat quality impacts genome-wide DNA methylation patterns in a cross-sectional study of Greek preadolescents. Eur J Hum Genet. 2015;23:654–662.10.1038/ejhg.2014.139
   Web of Science ®Google Scholar
• Harris WS. n-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr. 1997;65:1645S–1654S.
   PubMed Web of Science ®Google Scholar
• Das UN. Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how? Prostaglandins. Leukot Essent Fat Acids. 2000;63:351–362.10.1054/plef.2000.0226
   PubMed Web of Science ®Google Scholar
• Raatz SK, Johnson LK, Rosenberger TA, et al. Twice weekly intake of farmed Atlantic salmon (Salmo salar) positively influences lipoprotein concentration and particle size in overweight men and women. Nutr Res. 2016;36:899–906.10.1016/j.nutres.2016.06.011
   Web of Science ®Google Scholar
• Dekkers KF, van Iterson M, Slieker RC, et al. Blood lipids influence DNA methylation in circulating cells. Genome Biol. 2016;17:138–150.10.1186/s13059-016-1000-6
   Web of Science ®Google Scholar
• Gluckman PD, Hanson MA, Cooper C, et al. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359:61–73.10.1056/NEJMra0708473
   PubMed Web of Science ®Google Scholar
• Gluckman PD, Hanson MA. Living with the past: evolution, development, and patterns of disease. Science. 2004;305:1733–1736.10.1126/science.1095292
   PubMed Web of Science ®Google Scholar
• Amarasekera M, Noakes P, Strickland D, et al. Epigenome-wide analysis of neonatal CD4 + T-cell DNA methylation sites potentially affected by maternal fish oil supplementation. Epigenetics. 2014;9:1570–1576.10.4161/15592294.2014.983366
   PubMed Web of Science ®Google Scholar
• Lind MV, Martino D, Harsløf LBS, et al. Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: a pilot study. Prostaglandins Leukot Essent Fat Acids. 2015;101:1–7.10.1016/j.plefa.2015.07.003
   Web of Science ®Google Scholar
• van Dijk SJ, Zhou J, Peters TJ, et al. Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial. Clin Epigenetics. 2016;8:114–127.10.1186/s13148-016-0281-7
   PubMed Web of Science ®Google Scholar
• Burdge GC, Wootton SA. Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88:411–422.10.1079/BJN2002689
   PubMed Web of Science ®Google Scholar
• Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men. Br J Nutr. 2002;88:355–363.10.1079/BJN2002662
   PubMed Web of Science ®Google Scholar
• Lohner S, Fekete K, Marosvölgyi T, et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. Ann Nutr Metab. 2013;62:98–112.10.1159/000345599
   PubMed Web of Science ®Google Scholar
• Zhang FF, Cardarelli R, Carroll J, et al. Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics. 2011;6:623–629.10.4161/epi.6.5.15335
   PubMed Web of Science ®Google Scholar
• Dedeurwaerder S, Defrance M, Bizet M, et al. A comprehensive overview of infinium human methylation 450 data processing. Brief Bioinform. 2014;15:929–941.10.1093/bib/bbt054
   PubMed Web of Science ®Google Scholar
• Zhu Z-Z, Hou L, Bollati V, et al. Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis. Int J Epidemiol. 2012;41:126–139.10.1093/ije/dyq154
   PubMed Web of Science ®Google Scholar
• Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860–921.10.1038/35057062
   PubMed Web of Science ®Google Scholar
• Schmid CW. Does SINE evolution preclude Alu function? Nucleic Acids Res. 1998;26:4541–4550.10.1093/nar/26.20.4541
   PubMed Web of Science ®Google Scholar
• Kochanek S, Renz D, Doerfler W. DNA methylation in the Alu sequences of diploid and haploid primary human cells. EMBO J. 1993;12:1141–1151.
   PubMed Web of Science ®Google Scholar
• Kemp JR, Longworth MS. Crossing the LINE toward genomic instability: LINE-1 retrotransposition in cancer. Front Chem. 2015;3:68.
   PubMed Web of Science ®Google Scholar
• Agodi A, Barchitta M, Quattrocchi A, et al. Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population. Genes Nutr. 2015;10:30.10.1007/s12263-015-0480-4
   Web of Science ®Google Scholar
• Garcia-Lacarte M, Milagro FI, Zulet MA, et al. LINE-1 methylation levels, a biomarker of weight loss in obese subjects, are influenced by dietary antioxidant capacity. Redox Rep. 2016;21:67–74.10.1179/1351000215Y.0000000029
   PubMed Web of Science ®Google Scholar
• Marques-Rocha JL, Milagro FI, Mansego ML, et al. LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals. Epigenetics. 2016;11:49–60.10.1080/15592294.2015.1135286
   PubMed Web of Science ®Google Scholar
• Zhang FF, Morabia A, Carroll J, et al. Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population. J Nutr. 2011;141:1165–1171.10.3945/jn.110.134536
   PubMed Web of Science ®Google Scholar
• Schulz WA, Steinhoff C, Florl AR. Methylation of endogenous human retroelements in health and disease.In: Doerfler W, Böhm P, editors. DNA methylation Development Genetic Disease, and Cancer. Berlin, Heidelberg: Springer; 2006. p. 211–250.10.1007/3-540-31181-5
   Google Scholar
• Joyce BT, Gao T, Zheng Y, et al. Prospective changes in global DNA methylation and cancer incidence and mortality. Br J Cancer. 2016;115:465–472.10.1038/bjc.2016.205
   Web of Science ®Google Scholar
• Baccarelli A, Wright R, Bollati V, et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology. 2010;21:819–828.10.1097/EDE.0b013e3181f20457
   PubMed Web of Science ®Google Scholar
• Bollati V, Schwartz J, Wright R, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev. 2009;130:234–239.10.1016/j.mad.2008.12.003
   PubMed Web of Science ®Google Scholar
• Jintaridth P, Mutirangura A. Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol Genomics. 2010;41:194–200.10.1152/physiolgenomics.00146.2009
   PubMed Web of Science ®Google Scholar
• Lee H-S, Barraza-Villarreal A, Hernandez-Vargas H, et al. Modulation of DNA methylation states and infant immune system by dietary supplementation with -3 PUFA during pregnancy in an intervention study. Am J Clin Nutr. 2013;98:480–487.10.3945/ajcn.112.052241
   PubMed Web of Science ®Google Scholar
• Mickleborough TD, Tecklenburg SL, Montgomery GS, et al. Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting proinflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. Clin Nutr. 2009;28:71–77.10.1016/j.clnu.2008.10.012
   PubMed Web of Science ®Google Scholar
• Gorjão R, Azevedo-Martins AK, Rodrigues HG, et al. Comparative effects of DHA and EPA on cell function. Pharmacol Ther. 2009;122:56–64.10.1016/j.pharmthera.2009.01.004
   PubMed Web of Science ®Google Scholar
• Turk HF, Chapkin RS. Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Prostaglandins Leukot Essent Fat Acids. 2013;88:43–47.10.1016/j.plefa.2012.03.008
   PubMed Web of Science ®Google Scholar
• Kim W, Fan Y-Y, Barhoumi R, et al. n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation. J Immunol. 2008;181:6236–6243.10.4049/jimmunol.181.9.6236
   PubMed Web of Science ®Google Scholar
• Chapkin RS, Wang N, Fan Y-Y, et al. Docosahexaenoic acid alters the size and distribution of cell surface microdomains. Biochim Biophys Acta Biomembr. 2008;1778:466–471.10.1016/j.bbamem.2007.11.003
   PubMed Web of Science ®Google Scholar
• Reseland JE, Haugen F, Hollung K, et al. Reduction of leptin gene expression by dietary polyunsaturated fatty acids. J Lipid Res. 2001;42:743–750.
   PubMed Web of Science ®Google Scholar
• Shen W, Wang C, Xia L, et al. Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated fatty acids. Sci Rep. 2014;4:5282.
   PubMed Web of Science ®Google Scholar
• Fan C, Liu X, Shen W, et al. The regulation of leptin, leptin receptor and pro-opiomelanocortin expression by N-3 Pufas in diet-induced obese mice is not related to the methylation of their promoters. Nutr Metab (Lond). 2011;8:31.10.1186/1743-7075-8-31
   Web of Science ®Google Scholar
• Vallvé J-C, Uliaque K, Girona J, et al. Unsaturated fatty acids and their oxidation products stimulate CD36 gene expression in human macrophages. Atherosclerosis. 2002;164:45–56.10.1016/S0021-9150(02)00046-1
   PubMed Web of Science ®Google Scholar
• Alexander Aguilera A, Hernández Díaz G, Lara Barcelata M, et al. Induction of Cd36 expression elicited by fish oil PUFA in spontaneously hypertensive rats. J Nutr Biochem. 2006;17:760–765.10.1016/j.jnutbio.2005.12.007
   Web of Science ®Google Scholar
• Do Amaral CL, Milagro FI, Curi R, et al. DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil. Biomed Res Int. 2014;2014:1–10.
   Google Scholar
• Varela-Moreiras G, Ruiz E, Valero T, et al. The Spanish diet: an update. Nutr Hosp. 2013;28:13–20.
   PubMed Web of Science ®Google Scholar
• Parra D, Ramel A, Bandarra N, et al. A diet rich in long chain omega-3 fatty acids modulates satiety in overweight and obese volunteers during weight loss. Appetite. 2008;51:676–680.10.1016/j.appet.2008.06.003
   PubMed Web of Science ®Google Scholar
• Benatti P, Peluso G, Nicolai R, et al. Polyunsaturated fatty acids: biochemical, nutritional and epigenetic properties. J Am Coll Nutr. 2004;23:281–302.10.1080/07315724.2004.10719371
   PubMed Web of Science ®Google Scholar
• Nakamura MT, Nara TY. Structure, function, and dietary regulation oF Δ6, Δ5, and Δ9 desaturases. Ann Rev Nutr. 2004;24:345–376.10.1146/annurev.nutr.24.121803.063211
   PubMed Web of Science ®Google Scholar
• Marquardt A, Stöhr H, White K, et al. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66:175–183.10.1006/geno.2000.6196
   PubMed Web of Science ®Google Scholar
• Glaser C, Heinrich J, Koletzko B. Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism. Metabolism. 2010;59:993–999.10.1016/j.metabol.2009.10.022
   PubMed Web of Science ®Google Scholar
• Hoile SP, Clarke-Harris R, Huang R-C, et al. Supplementation with N-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells. Schunck W-H, editor. PLoS ONE. 2014;9:e109896.10.1371/journal.pone.0109896
   PubMed Web of Science ®Google Scholar
• Jaudszus A, Gruen M, Watzl B, et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. J Lipid Res. 2013;54:923–935.10.1194/jlr.P031260
   PubMed Web of Science ®Google Scholar
• Rovito D, Giordano C, Vizza D, et al. Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. J Cell Physiol. 2013;228:1314–1322.10.1002/jcp.v228.6
   PubMed Web of Science ®Google Scholar
• Fujiki K, Kano F, Shiota K, et al. Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes. BMC Biol. 2009;7:38.10.1186/1741-7007-7-38
   PubMed Web of Science ®Google Scholar
• Nilsson E, Jansson PA, Perfilyev A, et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes. 2014;63:2962–2976.10.2337/db13-1459
   PubMed Web of Science ®Google Scholar
• Ling C, Del Guerra S, Lupi R, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia. 2008;51:615–622.10.1007/s00125-007-0916-5
   PubMed Web of Science ®Google Scholar
• Brøns C, Jacobsen S, Nilsson E, et al. Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner. J Clin Endocrinol Metab. 2010;95:3048–3056.10.1210/jc.2009-2413
   PubMed Web of Science ®Google Scholar
• Kirchner H, Nylen C, Laber S, et al. Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass. Surg Obes Relat Dis. 2014;10:671–678.10.1016/j.soard.2013.12.019
   PubMed Web of Science ®Google Scholar
• Epstein FH, Barnes PJ, Karin M. Nuclear factor-κB – a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066–1071.10.1056/NEJM199704103361506
   PubMed Web of Science ®Google Scholar
• Zhao Y, Joshi-Barve S, Barve S, et al. Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation. J Am Coll Nutr. 2004;23:71–78.10.1080/07315724.2004.10719345
   PubMed Web of Science ®Google Scholar
• Sullivan KE, Reddy ABM, Dietzmann K, et al. Epigenetic regulation of tumor necrosis factor alpha. Mol Cell Biol. 2007;27:5147–5160.10.1128/MCB.02429-06
   PubMed Web of Science ®Google Scholar
• Kochanek S, Radbruch A, Tesch H, et al. DNA methylation profiles in the human genes for tumor necrosis factors alpha and beta in subpopulations of leukocytes and in leukemias. Proc Nat Acad Sci USA. 1991;88:5759–5763.10.1073/pnas.88.13.5759
   Web of Science ®Google Scholar
• Takei S, Fernandez D, Redford A, et al. Methylation status of 5’-regulatory region of tumor necrosis factor α gene correlates with differentiation stages of monocytes. Biochem Biophys Res Commun. 1996;220:606–612.10.1006/bbrc.1996.0450
   Web of Science ®Google Scholar
• Nimmo ER, Prendergast JG, Aldhous MC, et al. Genome-wide methylation profiling in Crohnʼs disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis. 2012;18:889–899.10.1002/ibd.21912
   PubMed Web of Science ®Google Scholar
• Zhu J, Xia L, Ji C, et al. Differential DNA methylation status between human preadipocytes and mature adipocytes. Cell Biochem Biophys. 2012;63:1–15.10.1007/s12013-012-9336-3
   Web of Science ®Google Scholar
• Gazzar ME, Yoza BK, Chen X, et al. G9a and HP1 couple histone and DNA methylation to TNF transcription silencing during endotoxin tolerance. J Biol Chem. 2008;283:32198–32208.10.1074/jbc.M803446200
   PubMed Web of Science ®Google Scholar
• Bollati V, Favero C, Albetti B, et al. Nutrients intake is associated with DNA methylation of candidate inflammatory genes in a population of obese subjects. Nutrients. 2014;6:4625–4639.10.3390/nu6104625
   PubMed Web of Science ®Google Scholar
• Hermsdorff HH, Mansego ML, Campión J, et al. TNF-alpha promoter methylation in peripheral white blood cells: relationship with circulating TNFα, truncal fat and n-6 PUFA intake in young women. Cytokine. 2013;64:265–271.10.1016/j.cyto.2013.05.028
   PubMed Web of Science ®Google Scholar
• Kochanek S, Toth M, Dehmel A, et al. Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta. Proc Nat Acad Sci USA. 1990;87:8830–8834.10.1073/pnas.87.22.8830
   Web of Science ®Google Scholar
• Lou S, Lee H-M, Qin H, et al. Whole-genome bisulfite sequencing of multiple individuals reveals complementary roles of promoter and gene body methylation in transcriptional regulation. Genome Biol. 2014;15:408.10.1186/s13059-014-0408-0
   PubMed Web of Science ®Google Scholar
• Gross TJ, Kremens K, Powers LS, et al. Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses. J Immunol. 2014;192:2326–2338.10.4049/jimmunol.1301758
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Otero M, Imagawa K, et al. Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1 (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem. 2013;288:10061–10072.10.1074/jbc.M112.421156
   PubMed Web of Science ®Google Scholar
• Berkley AM, Hendricks DW, Simmons KB, et al. Recent thymic emigrants and mature naive T Cells exhibit differential DNA methylation at key cytokine loci. J Immunol. 2013;190:6180–6186.10.4049/jimmunol.1300181
   Web of Science ®Google Scholar
• Northrop JK, Thomas RM, Wells AD, et al. Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol. 2006;177:1062–1069.10.4049/jimmunol.177.2.1062
   PubMed Web of Science ®Google Scholar
• Williams CL, Schilling MM, Cho SH, et al. STAT4 and T-bet are required for the plasticity of IFN- expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation. J Immunol. 2013;191:678–687.10.4049/jimmunol.1203360
   Web of Science ®Google Scholar
• Caughey GE, Mantzioris E, Gibson RA, et al. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 1996;63:116–122.
   PubMed Web of Science ®Google Scholar