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Articles

Is the self a higher-order or fundamental function of the brain? The “basis model of self-specificity” and its encoding by the brain’s spontaneous activity

Pages 203-222 | Received 18 Nov 2014, Accepted 20 Oct 2015, Published online: 01 Feb 2016

REFERENCES

  • Andreasen, N. C., O’Leary, D. S., Cizadlo, T., Arndt, S., Rezai, K., Watkins, G. L., … Hichwa, R. D. (1995). Remembering the past: Two facets of episodic memory explored with positron emission tomography. The American Journal of Psychiatry, 152, 1576–1585.
  • Andrews-Hanna, J. R. (2012). The brain’s default network and its adaptive role in internal mentation. The Neuroscientist, 18(3), 251–270. doi:10.1177/1073858411403316
  • Andrews-Hanna, J. R., Reidler, J. S., Huang, C., & Buckner, R. L. (2010). Evidence for the default network’s role in spontaneous cognition. Journal of Neurophysiology, 104(1), 322–335. doi:10.1152/jn.00830.2009
  • Andrews-Hanna, J. R., Reidler, J. S., Sepulcre, J., Poulin, R., & Buckner, R. L. (2010). Functional-anatomic fractionation of the brain’s default network. Neuron, 65(4), 550–562. doi:10.1016/j.neuron.2010.02.005
  • Bai, Y., Nakao, T., Xu, J., Qin, P., Chaves, P., Heinzel, A., … Northoff, G. (2015). Resting state glutamate predicts elevated pre-stimulus alpha during self-relatedness: A combined EEG-MRS study on “rest-self overlap”. Social Neuroscience, 1–15. Advance online publication.
  • Buckner, R. L., Andrews-Hanna, J. R., & Schacter, D. L. (2008). The brain’s default network: Anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences, 1124, 1–38. doi:10.1196/annals.1440.011
  • Cabral, J., Kringelbach, M. L., & Deco, G. (2013). Exploring the network dynamics underlying brain activity during rest. Progress in Neurobiology, 114, 102–131.
  • Carhart-Harris, R. L., Leech, R., Erritzoe, D., Williams, T. M., Stone, J. M., Evans, J., … Nutt, D. J. (2013). Functional connectivity measures after psilocybin inform a novel hypothesis of early psychosis. Schizophrenia Bulletin, 39(6), 1343–1351. doi:10.1093/schbul/sbs117
  • Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., … Nutt, D. (2014). The entropic brain: A theory of conscious states informed by neuroimaging research with psychedelic drugs. Frontiers in Human Neuroscience, 8, 20. doi:10.3389/fnhum.2014.00020
  • Christoff, K., Cosmelli, D., Legrand, D., & Thompson, E. (2011). Specifying the self for cognitive neuroscience. Trends in Cognitive Sciences, 15(3), 104–112. doi:10.1016/j.tics.2011.01.001
  • Christoff, K., Gordon, A. M., Smallwood, J., Smith, R., & Schooler, J. W. (2009). Experience sampling during fMRI reveals default network and executive system contributions to mind wandering. Proceedings of the National Academy of Sciences, 106(21), 8719–8724. doi:10.1073/pnas.0900234106
  • Churchland, P. S. (2002). Self-representation in nervous systems. Science, 296(5566), 308–310. doi:10.1126/science.1070564
  • Cunningham, S. J., Brady-Van den Bos, M., & Turk, D. J. (2011). Exploring the effects of ownership and choice on self-memory biases. Memory, 19(5), 449–461. doi:10.1080/09658211.2011.584388
  • Cunningham, S. J., Turk, D. J., Macdonald, L. M., & Neil Macrae, C. (2008). Yours or mine? Ownership and memory. Consciousness and Cognition, 17(1), 312–318. doi:10.1016/j.concog.2007.04.003
  • D’Argembeau, A. (2013). On the role of the ventromedial prefrontal cortex in self-processing: The valuation hypothesis. Frontiers in Human Neuroscience, 7. doi:10.3389/fnhum.2013.00372
  • D’Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., … Salmon, E. (2005). Self-referential reflective activity and its relationship with rest: A PET study. Neuroimage, 25(2), 616–624. doi:10.1016/j.neuroimage.2004.11.048
  • Damasio, A. (1999a). The feeling of what happens: Body and emotion in the making of consciousness. New York, NY: Harcourt Brace.
  • Damasio, A. R. (1999b). How the brain creates the mind. Scientific American, 281(6), 112–117. doi:10.1038/scientificamerican1299-112
  • Damasio, A. (2010). Self comes to mind: Constructing the conscious mind. New York, NY: Pantheon.
  • de Greck, M., Enzi, B., Prösch, U., Gantman, A., Tempelmann, C., Northoff, G. (2010). Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli. Human Brain Mapping, 31(11), 1802–1812.
  • de Greck, M., Rotte, M., Paus, R., Moritz, D., Thiemann, R., Proesch, U., … Northoff, G. (2008). Is our self based on reward? Self-relatedness recruits neural activity in the reward system. Neuroimage, 39(4), 2066–2075. doi:10.1016/j.neuroimage.2007.11.006
  • de Greck, M., Supady, A., Thiemann, R., Tempelmann, C., Bogerts, B., Forschner, L., … Northoff, G. (2009). Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics–A fMRI study. Human Brain Mapping, 30(5), 1691–1704. doi:10.1002/hbm.v30:5
  • de Pasquale, F., Della Penna, S., Snyder, A., Marzetti, L., Pizzella, V., Romani, G., & Corbetta, M. (2012). A cortical core for dynamic integration of functional networks in the resting human brain. Neuron, 74(4), 753–764. doi:10.1016/j.neuron.2012.03.031
  • Enzi, B., de Greck, M., Prösch, U., Tempelmann, C., Northoff, G., & Reif, A. (2009). Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality. PLoS One, 4(12), e8429. doi:10.1371/journal.pone.0008429
  • Ersner-Hershfield, H., Wimmer, G. E., & Knutson, B. (2008). Saving for the future self: Neural measures of future self-continuity predict temporal discounting. Social Cognitive and Affective Neuroscience, 4(1), 85–92. doi:10.1093/scan/nsn042
  • Frings, C., & Wentura, D. (2014). Self-priorization processes in action and perception. Journal of Experimental Psychology. Human Perception & Performance, 40(5), 1737–1740. doi:10.1037/a0037376
  • Gallagher, S. (2000). Philosophical conceptions of the self: Implications for cognitive science. Trends in Cognitive Sciences, 4(1), 14–21. doi:10.1016/S1364-6613(99)01417-5
  • Glimcher, P. W., & Fehr, E. (2013). Neuroeconomics: Decision making and the brain. New York, NY: Academic Press.
  • Goel, V., & Dolan, R. J. (2003a). Reciprocal neural response within lateral and ventral medial prefrontal cortex during hot and cold reasoning. Neuroimage, 20(4), 2314–2321. doi:10.1016/j.neuroimage.2003.07.027
  • Goel, V., & Dolan, R. J. (2003b). Explaining modulation of reasoning by belief. Cognition, 87(1), B11–22. doi:10.1016/S0010-0277(02)00185-3
  • Humphreys, G. W., & Sui, J. (2015). Attentional control and the self: The Self-Attention Network (SAN). Cognitive Neuroscience, 1–13. Advance online publication. PMID:25945926.
  • James, W. (1890a). The principles of psychology (Vol. 1). New York, NY: Holt.
  • James, W. (1890b). The principles of psychology (Vol. 2). New York, NY: Holt.
  • Kim, K., & Johnson, M. K. (2012). Extended self: Medial prefrontal activity during transient association of self and objects. Social Cognitive and Affective Neuroscience, 7(2), 199–207. doi:10.1093/scan/nsq096
  • Klein, S. B. (2012). Self, memory, and the self-reference effect: An examination of conceptual and methodological issues. Personality and Social Psychology Review, 16(3), 283–300. doi:10.1177/1088868311434214
  • Knyazev, G. G. (2013). EEG correlates of self-referential processing. Frontiers in Human Neuroscience, 7. doi:10.3389/fnhum.2013.00264
  • Lee, T.-W., Northoff, G., & Wu, Y.-T. (2014). Resting network is composed of more than one neural pattern: An fMRI study. Neuroscience, 274, 198–208. doi:10.1016/j.neuroscience.2014.05.035
  • Lipsman, N., Nakao, T., Kanayama, N., Krauss, J. K., Anderson, A., Giacobbe, P., … Northoff, G. (2014). Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex – Single unit recording in an intracranial study. Cortex, 60, 139–144. doi:10.1016/j.cortex.2014.09.008
  • Lou, H. C., Gross, J., Biermann-Ruben, K., Kjaer, T. W., & Schnitzler, A. (2010). Coherence in consciousness: Paralimbic gamma synchrony of self-reference links conscious experiences. Human Brain Mapping, 31(2), 185–192. doi:10.1002/hbm.20855
  • Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007). Wandering minds: The default network and stimulus-independent thought. Science, 315(5810), 393–395. doi:10.1126/science.1131295
  • McKiernan, K. A., D’Angelo, B. R., Kaufman, J. N., & Binder, J. R. (2006). Interrupting the “stream of consciousness”: An fMRI investigation. Neuroimage, 29(4), 1185–1191. doi:10.1016/j.neuroimage.2005.09.030
  • Mitchell, J. P., Schirmer, J., Ames, D. L., & Gilbert, D. T. (2011). Medial prefrontal cortex predicts intertemporal choice. Journal of Cognitive Neuroscience, 23(4), 857–866. doi:10.1162/jocn.2010.21479
  • Modinos, G., Ormel, J., Aleman, A., & García, A. V. (2009). Activation of anterior insula during self-reflection. PLoS One, 4(2), e4618. doi:10.1371/journal.pone.0004618
  • Moran, J. M., Macrae, C. N., Heatherton, T. F., Wyland, C. L., & Kelley, W. M. (2006). Neuroanatomical evidence for distinct cognitive and affective components of self. Journal of Cognitive Neuroscience, 18(9), 1586–1594. doi:10.1162/jocn.2006.18.9.1586
  • Nakao, T., Bai, Y., Nashiwa, H., & Northoff, G. (2013). Resting-state EEG power predicts conflict-related brain activity in internally guided but not in externally guided decision-making. Neuroimage, 66, 9–21. doi:10.1016/j.neuroimage.2012.10.034
  • Nakao, T., Ohira, H., & Northoff, G. (2012). Distinction between externally vs. internally guided decision-making: Operational differences, meta-analytical comparisons and their theoretical implications. Frontiers in Neuroscience, 6, 31. doi:10.3389/fnins.2012.00031
  • Northoff, G. (2007). Psychopathology and pathophysiology of the self in depression - Neuropsychiatric hypothesis. Journal of Affective Disorders, 104(1–3), 1–14. doi:10.1016/j.jad.2007.02.012
  • Northoff, G. (2012). Immanuel Kant’s mind and the brain’s resting state. Trends in Cognitive Sciences, 16(7), 356–359. doi:10.1016/j.tics.2012.06.001
  • Northoff, G. (2013). Brain and self-A neurophilosophical account. Child Adolesc Psychiatry Ment Health, 7, 28. doi:10.1186/1753-2000-7-28
  • Northoff, G. (2014a). Unlocking the brain: Volume 1: Coding (Vol. 1). New York, NY: Oxford University Press.
  • Northoff, G. (2014b). Unlocking the brain. Volume II: Consciousness. Oxford: Oxford University Press.
  • Northoff, G. (2014c). Minding the brain: A guide to philosophy & neuroscience. London: Palgrave Macmillan.
  • Northoff, G., & Hayes, D. J. (2011). Is our self nothing but reward? Biological Psychiatry, 69(11), 1019–1025. doi:10.1016/j.biopsych.2010.12.014
  • Northoff, G., Heinzel, A., Bermpohl, F., Niese, R., Pfennig, A., Pascual-Leone, A., & Schlaug, G. (2004). Reciprocal modulation and attenuation in the prefrontal cortex: An fMRI study on emotional-cognitive interaction. Human Brain Mapping, 21(3), 202–212. doi:10.1002/(ISSN)1097-0193
  • Northoff, G., & Panksepp, J. (2008). The trans-species concept of self and the subcortical-cortical midline system. Trends in Cognitive Sciences, 12(7), 259–264. doi:10.1016/j.tics.2008.04.007
  • Northoff, G., Qin, P., & Feinberg, T. E. (2011). Brain imaging of the self–conceptual, anatomical and methodological issues. Consciousness and Cognition, 20(1), 52–63. doi:10.1016/j.concog.2010.09.011
  • Northoff, G., Qin, P., & Nakao, T. (2010). Rest-stimulus interaction in the brain: A review. Trends in Neurosciences, 33(6), 277–284. doi:10.1016/j.tins.2010.02.006
  • Northoff, G., Schneider, F., Rotte, M., Matthiae, C., Tempelmann, C., Wiebking, C., … Panksepp, J. (2009). Differential parametric modulation of self-relatedness and emotions in different brain regions. Human Brain Mapping, 30(2), 369–382. doi:10.1002/hbm.20510
  • Northoff, G., & Sibille, E. (2014). Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings. Molecular Psychiatry, 19(9), 966–977. doi:10.1038/mp.2014.68
  • Panksepp, J. (1998a). Affective neuroscience: The foundations of human and animal emotions. New York, NY: Oxford University Press.
  • Panksepp, J. (1998b). The preconscious substrates of consciousness: Affective states and the evolutionary origins of the SELF. Journal of Consciousness Studies, 5, 566–582.
  • Panksepp, J. (2011). Cross-species affective neuroscience decoding of the primal affective experiences of humans and related animals. PLoS One, 6(9), e21236. doi:10.1371/journal.pone.0021236
  • Phan, K. L., Taylor, S. F., Welsh, R. C., Ho, S.-H., Britton, J. C., & Liberzon, I. (2004). Neural correlates of individual ratings of emotional salience: A trial-related fMRI study. Neuroimage, 21(2), 768–780. doi:10.1016/j.neuroimage.2003.09.072
  • Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002). Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI. Neuroimage, 16(2), 331–348. doi:10.1006/nimg.2002.1087
  • Prebble, S. C., Addis, D. R., & Tippett, L. J. (2013). Autobiographical memory and sense of self. Psychological Bulletin, 139(4), 815–840. doi:10.1037/a0030146
  • Qin, P., & Northoff, G. (2011). How is our self related to midline regions and the default-mode network? Neuroimage, 57(3), 1221–1233. doi:10.1016/j.neuroimage.2011.05.028
  • Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001). A default mode of brain function. Proceedings of the National Academy of Sciences, 98(2), 676–682. doi:10.1073/pnas.98.2.676
  • Roy, M., Shohamy, D., & Wager, T. D. (2012). Ventromedial prefrontal-subcortical systems and the generation of affective meaning. Trends in Cognitive Sciences, 16(3), 147–156. doi:10.1016/j.tics.2012.01.005
  • Sadaghiani, S., Hesselmann, G., Friston, K. J., & Kleinschmidt, A. (2010). The relation of ongoing brain activity, evoked neural responses, and cognition. Frontiers in Systems Neuroscience, 4, 20. doi:10.3389/fnsys.2010.00020
  • Schilbach, L., Bzdok, D., Timmermans, B., Fox, P. T., Laird, A. R., Vogeley, K., … Soriano-Mas, C. (2012). Introspective minds: Using ALE meta-analyses to study commonalities in the neural correlates of emotional processing, social & unconstrained cognition. PLoS One, 7(2), e30920. doi:10.1371/journal.pone.0030920
  • Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., … Northoff, G. (2008). The resting brain and our self: Self-relatedness modulates resting state neural activity in cortical midline structures. Neuroscience, 157(1), 120–131. doi:10.1016/j.neuroscience.2008.08.014
  • Seth, A. K. (2013). Interoceptive inference, emotion, and the embodied self. Trends in Cognitive Sciences, 17(11), 565–573. doi:10.1016/j.tics.2013.09.007
  • Seth, A. K., Suzuki, K., & Critchley, H. D. (2011). An interoceptive predictive coding model of conscious presence. Frontiers in Psychology, 2. doi:10.3389/fpsyg.2011.00395
  • Stawarczyk, D., Majerus, S., Maquet, P., D’Argembeau, A., & Gilbert, S. (2011). Neural correlates of ongoing conscious experience: Both task-unrelatedness and stimulus-independence are related to default network activity. PLoS One, 6(2), e16997. doi:10.1371/journal.pone.0016997
  • Sui, J., Chechlacz, M., Rotshtein, P., & Humphreys, G. W. (2015). Lesion-symptom mapping of self-prioritization in explicit face categorization: Distinguishing hypo-and hyper-self-biases. Cerebral Cortex, 25(2), 374–383. doi:10.1093/cercor/bht233.
  • Sui, J., Liu, M., Mevorach, C., & Humphreys, G. W. (2015). The salient self: The left intraparietal sulcus responds to social as well as perceptual-salience after self-association. Cerebral Cortex, 25(4), 1060–1068. doi:10.1093/cercor/bht302
  • Sui, J., Chechlacz, M., & Humphreys, G. W. (2012). Dividing the self: Distinct neural substrates of task-based and automatic self-prioritization after brain damage. Cognition, 122(2), 150–162. doi:10.1016/j.cognition.2011.10.008
  • Sui, J., Chechlacz, M., Rotshtein, P., & Humphreys, G. W. (2015). Lesion-symptom mapping of self-prioritization in explicit face categorization: Distinguishing hypo- and hyper-self-biases. Cerebral Cortex, 25(2), 374–383. doi:10.1093/cercor/bht233
  • Sui, J., He, X., & Humphreys, G. W. (2012). Perceptual effects of social salience: Evidence from self-prioritization effects on perceptual matching. Journal of Experimental Psychology: Human Perception and Performance, 38(5), 1105.
  • Sui, J., & Humphreys, G. W. (2015). Super-size me: Self biases increase to larger stimuli. Psychonomic Bulletin & Review, 22(2), 550–558. doi:10.3758/s13423-014-0690-6
  • Sui, J., Rotshtein, P., & Humphreys, G. W. (2013). Coupling social attention to the self forms a network for personal significance. Proceedings of the National Academy of Sciences, 110(19), 7607–7612. doi:10.1073/pnas.1221862110
  • Tagliazucchi, E., Von Wegner, F., Morzelewski, A., Brodbeck, V., Jahnke, K., & Laufs, H. (2013). Breakdown of long-range temporal dependence in default mode and attention networks during deep sleep. Proceedings of the National Academy of Sciences, 110(38), 15419–15424. doi:10.1073/pnas.1312848110
  • Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., … Laureys, S. (2011). Two distinct neuronal networks mediate the awareness of environment and of self. Journal of Cognitive Neuroscience, 23(3), 570–578. doi:10.1162/jocn.2010.21488
  • Wang, C., Oyserman, D., Liu, Q., Li, H., & Han, S. (2013). Accessible cultural mind-set modulates default mode activity: Evidence for the culturally situated brain. Social Neuroscience, 8(3), 203–216. doi:10.1080/17470919.2013.775966
  • Whitfield-Gabrieli, S., Moran, J. M., Nieto-Castañón, A., Triantafyllou, C., Saxe, R., & Gabrieli, J. D. E. (2011). Associations and dissociations between default and self-reference networks in the human brain. Neuroimage, 55(1), 225–232. doi:10.1016/j.neuroimage.2010.11.048

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