Prognostic value of cryoglobulins, protein electrophoresis, and serum immunoglobulins for lymphoma development in patients with Sjögren’s syndrome. A retrospective cohort study

References

• Talal N, Bunim JJ. The development of malignant lymphoma in the course of Sjögren’s syndrome. Am J Med. 1964;36:529–540.10.1016/0002-9343(64)90101-9
   PubMed Web of Science ®Google Scholar
• Zintzaras E, Voulgarelis M, Moutsopoulos H. The risk of lymphoma development in autoimmune disease: a meta-analysis. Arch Intern Med. 2005;165:2337–2344.10.1001/archinte.165.20.2337
   PubMed Web of Science ®Google Scholar
• Kassan SS, Thomas TL, Moutsopoulos HM, et al. Increased risk of lymphoma in Sicca syndrome. Ann Intern Med. 1978;89:888–892.10.7326/0003-4819-89-6-888
   PubMed Web of Science ®Google Scholar
• Theander E, Henriksson G, Ljunberg O, et al. Lymphoma and other malignancies in primary Sjögren’s syndrome: a cohort study on cancer incidence and lymphoma predictors. Ann Rheum Dis. 2006;65:796–803.10.1136/ard.2005.041186
   PubMed Web of Science ®Google Scholar
• Tzioufas AG, Kapsogeorgou EK, Moutsopoulos HM. Pathogenesis of Sjögren’s syndrome: what we know and what we should learn. J Autoimmun. 2012;39:4–8.10.1016/j.jaut.2012.01.002
   PubMed Web of Science ®Google Scholar
• Fox RI. Sjögren’s syndrome. Lancet. 2005;366:321–331.10.1016/S0140-6736(05)66990-5
   PubMed Web of Science ®Google Scholar
• Shiboski SC, Shiboski CH, Criswell LA, et al. American College of Rheumatology classification criteria for Sjögren’s syndrome: a data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance Cohort. Arthritis Care Res. 2012;64:475–487.10.1002/acr.21591
   PubMed Web of Science ®Google Scholar
• Baimpa E, Dahabreh IJ, Voulgarelis M, et al. Hematologic manifestations and predictors of lymphoma in primary Sjögren syndrome: clinical and pathophysiologic aspects. Medicine (Baltimore). 2009;88:284–293.10.1097/MD.0b013e3181b76ab5
   PubMed Web of Science ®Google Scholar
• Voulgarelis M, Dafni UG, Isenberg DA, et al. Malignant lymphoma in primary Sjögren’s syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren’s syndrome. Arthritis Rheum. 1999;42:1765–1772.10.1002/(ISSN)1529-0131
   PubMed Web of Science ®Google Scholar
• Theander E, Manthorpe LT, Jacobsson LT. Mortality and cause of death in primary Sjögren’s syndrome: a prospective cohort study. Arthritis Rheum. 2004;50:1262–1269.10.1002/art.20176
   PubMed Web of Science ®Google Scholar
• Ramos-Casals M, Tzioufas AG, Font J. Primary Sjögren’s syndrome: new clinical and therapeutic concepts. Ann Rheum Dis. 2005;64:347–354.
   PubMed Web of Science ®Google Scholar
• Voulgarelis M, Skopouli FN. Clinical, immunologic, and molecular factors predicting lymphoma development in Sjögren’s syndrome patients. Clin Rev Allergy Immunol. 2007;32:265–274.10.1007/s12016-007-8001-x
   PubMed Web of Science ®Google Scholar
• Tzioufas AG, Boumba DS, Skopouli FN, et al. Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjögren’s syndrome. Arthritis Rheum. 1996;39:767–772.10.1002/(ISSN)1529-0131
   PubMed Web of Science ®Google Scholar
• Moutsopoulos HM, Tzioufas AG, Bai MK, et al. Papadimitriou. Association of serum IgM kappa monoclonality in patients with Sjögren’s syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary glands. Ann Rheum Dis. 1990;49:929–931.10.1136/ard.49.11.929
   PubMed Web of Science ®Google Scholar
• Skopouli FN, Dafni U, Ioannidis JP, et al. Clinical evolution, and morbidity and mortality of primary Sjögren’s syndrome: an aid to the diagnosis of malignant lymphoma. Ann Rheum Dis. 2000;45:210–219.
   Google Scholar
• Quartuccio L, Isola M, Baldini C, et al. Biomarkers of lymphoma in Sjögren’s syndrome and evaluation of the lymphoma risk in prelymphomatous conditions: Results of a multicenter study. J Autoimmun. 2014;51:75–80.10.1016/j.jaut.2013.10.002
   PubMed Web of Science ®Google Scholar
• Bijlsma JW, Burmester G, da Silva JA, et al, editors. EULAR compendium on rheumatic diseases. London: BMJ Publishing Group; 2009. p. 322, §biological predictive factors.
   Google Scholar
• Brito-Zeron P, Ramos-Casals M, Bove A, et al. Predicting adverse outcomes in primary Sjögren’s syndrome: identification of prognostic factors. Rheumatology (Oxford). 2007;46:1359–1362.10.1093/rheumatology/kem079
   PubMed Web of Science ®Google Scholar
• Ioannidis JP, Vassiliou VA, Moutsopoulos HM. Long term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren’s syndrome. Arthritis Rheum. 2002;46:741–747.10.1002/art.10221
   PubMed Web of Science ®Google Scholar
• Ramos-Casals M, Brito-Zerón P, Yagüe J, et al. Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjögren’s syndrome. Rheumatology (Oxford). 2005;44:89–94.10.1093/rheumatology/keh407
   PubMed Web of Science ®Google Scholar
• Walters MT, Stevenson FK, Herbert A, et al. Urinary monoclonal free light chains in primary Sjögren’s syndrome: an aid to the diagnosis of malignant lymphoma. Ann Rheum Dis. 1986;45:210–219.10.1136/ard.45.3.210
   PubMed Web of Science ®Google Scholar
• De Vita S, Boiocchi M, Sorrentino D, et al. Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren’s syndrome. Arthritis Rheum. 1997;40:318–331.10.1002/(ISSN)1529-0131
   PubMed Web of Science ®Google Scholar
• Brito-Zerón P, Ramos-Casals M, Nardi N, et al. Circulating monoclonal immunoglobulins in Sjögren syndrome: prevalence and clinical significance in 237 patients. Medicine (Baltimore). 2005;84:90–97.10.1097/01.md.0000157398.37679.47
   PubMed Web of Science ®Google Scholar
• Theander E, Vasaitis L, Baecklund E, et al. Lymphoid organization in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren’s syndrome. Ann Rheum Dis. 2011;70:1363–1368.10.1136/ard.2010.144782
   PubMed Web of Science ®Google Scholar
• Fox RI. The importance of minor salivary gland biopsy in prediction of lymphoma in Sjögren’s syndrome: should we be obtaining more information about prognosis from minor salivary gland samples? Ann Rheum Dis. 2011;70:1351–1353.10.1136/ard.2011.152751
   PubMed Web of Science ®Google Scholar
• Zulman J, Jaffe R, Talal N. Evidence that the malignant lymphoma of Sjögren's syndrome is a monoclonal B-cell neoplasm. N engl J Med. 1978;299:1215–1220.10.1056/NEJM197811302992204
   PubMed Web of Science ®Google Scholar
• Vitali C, Bombardieri S, Jonsson R, et al. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554–558.10.1136/ard.61.6.554
   PubMed Web of Science ®Google Scholar
• Daniels TE, Cox D, Shiboski CH, et al. Lanfranchi H, et al, for the Sjögren’s International Collaborative Clinical Alliance Research Groups. Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjögren’s syndrome among 1,726 registry participants. Arthritis Rheum. 2011;63:2021–2030.10.1002/art.v63.7
   PubMed Web of Science ®Google Scholar
• Vermeersch P, Gijbels K, Knockaert D, et al. Establishment of reference values for immunoglobulins in the cryoprecipitate. Clin Immunol. 2008 Nov;129(2):360–364.10.1016/j.clim.2008.07.012
   PubMed Web of Science ®Google Scholar
• Bossuyt X, Schiettekatte G, Bogaerts A, et al. Serum protein electrophoresis by CZE 2000 clinical capillary electrophoresis system. Clin Chem. 1998 Apr;44(4):749–759.
   PubMed Web of Science ®Google Scholar
• Bossuyt X, Lissoir B, Mariën G, et al. Automated serum protein electrophoresis by Capillarys. Clin Chem Lab Med. 2003 May;41(5):704–710.
   PubMed Web of Science ®Google Scholar
• Bahler DW, Miklos JA, Swerdlow SH. Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomas. Blood. 1997;89:3335–3344.
   PubMed Web of Science ®Google Scholar
• Royer B, Cazals-Hatem D, Sibilia J, et al. Lymphomas in patients with Sjögren’s syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood. 1997;90:766–775.
   PubMed Web of Science ®Google Scholar