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Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets

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Pages 634-641 | Received 07 Apr 2016, Accepted 05 Aug 2016, Published online: 09 Sep 2016

References

  • Apel K, Hirt H. 2004. Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol. 55:373–399.
  • Baeverle P, Henkel T. 1994. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 12:141–179.
  • Bowie A, O’Neill LAJ. 2000. Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol. 59:13–23.
  • Brzozowski T, Ptak A, Kwiecien S, Pajdo R, Drozdowicz D, Pawlik M, Konturek SJ, Pawlik WW. 2003. Importance of nitric oxide (NO) and adenosine in the mechanism of gastric preconditioning induced by short ischemia. Rocz Akad Med Bialymst. 48:42–47.
  • Chen ZW, Chien MS, Chang NY, Chen TH, Wu CM, Huang C, Lee WC, Hsuan SL. 2011. Mechanisms underlying Actinobacillus pleuropneumoniae exotoxin apxi induced expression of IL-1β, IL-8 and TNF-α in porcine alveolar macrophages. Vet Res. 81:2–4.
  • De Groot J, Kruijt L, Scholten JW, Boersma WJ, Buist WG, Engel B, Van Reenen CG. 2005. Age, gender and litter-related variation in T-lymphocyte cytokine production in young pigs. Immunology. 115:495–505.
  • Dröge W. 2002. Free radicals in the physiological control of cell function. Physiol Rev. 82:47–95.
  • Guzik T, Korbut R, Adamek-Guzik T. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol. 54:469–487.
  • Halliwell B. 2007. Oxidative stress and cancer: have we moved forward? Biochem J. 401:1–11.
  • Halliwell B, Gutteridge JM. 1990. The antioxidants of human extracellular fluids. Arch Biochem Biophys. 280:1–8.
  • Henkel T, Machleidt T, Alkalay I, Krönke M, Ben-Neriah Y, Baeuerle PA. 1993. Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B. Nature. 365:182–185.
  • Higashi N, Bang K, Gesser B, Lund M, Thestrup-Pedersen K. 2001. Cytokine expression of skin T-lymphocytes from patients with atopic dermatitis. Acta Derm Venereol. 81:3–7.
  • Hou Y, Wang L, Yi D, Ding B, Yang Z, Li J, Chen X, Qiu Y, Wu G. 2013. N-acetylcysteine reduces inflammation in the small intestine by regulating redox, egf and TLR4 signalling. Amino Acids. 45:513–522.
  • Johnson IR, Ball RO, Baracos VE, Field CJ. 2006. Glutamine supplementation influences immune development in the newly weaned piglet. Dev Comp Immunol. 30:1191–1202.
  • Kenworthy R. 1976. Observations on the effects of weaning in the young pig. Clinical and histopathological studies of intestinal function and morphology. Res Vet Sci. 21:69–75.
  • Kyriakis SC, Tzika ED, Lyras DN, Tsinas AC, Saoulidis K, Sarris K. 1998. Effect of an inactivated parapoxvirus based immunomodulator (baypamun) on post weaning diarrhoea syndrome and wasting pig syndrome of piglets. Res Vet Sci. 64:187–190.
  • Lv Q, Zhang S, Zhao R. 2011. Transportation stress alters the expression of immunoregulatory cytokines in the porcine thymus. Vet J. 187:229–233.
  • Murtaugh MP, Baarsch MJ, Zhou Y, Scamurra RW, Lin G. 1996. Inflammatory cytokines in animal health and disease. Vet Immunol Immunopathol. 54:45–55.
  • McCracken BA, Spurlock ME, Roos MA, Zuckermann FA, Gaskins HR. 1999. Weaning anorexia may contribute to local inflammation in the piglet small intestine. J Nutr. 129:613–619.
  • Niekamp S, Sutherland M, Dahl G, Salak-Johnson J. 2007. Immune responses of piglets to weaning stress: impacts of photoperiod. J Anim Sci. 85:93–100.
  • O’Connell MA, Bennett BL, Mercurio F, Manning AM, Mackman N. 1998. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J Bio Chem. 273:30410–30414.
  • Palacio J, Markert U, Martínez P. 2011. Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages. Inflamm Res. 60:695–704.
  • Pié S, Awati A, Vida S, Falluel I, Williams B, Oswald I. 2007. Effects of added fermentable carbohydrates in the diet on intestinal proinflammatory cytokine-specific mRNA content in weaning piglets. J Anim Sci. 85:673–683.
  • Pie S, Lalles JP, Blazy F, Laffitte J, Seve B, Oswald IP. 2004. Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr. 134:641–647.
  • Qiu Y, Zhang J, Liu Y, Ma H, Cao F, Xu J, Hou Y, Xu L. 2013. The combination effects of acetaminophen and N-acetylcysteine on cytokines production and NF-κB activation of lipopolysaccharide-challenged piglet mononuclear phagocytes in vitro and in vivo. Vet Immunol Immunop. 152:381–388.
  • Schmittgen TD, Livak KJ. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108.
  • Schreck R, Rieber P, Baeuerle PA. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa b transcription factor and hiv-1. Embo J. 10:2247.
  • Schuerwegh A, Dombrecht E, Stevens W, Van Offel J, Bridts C, De Clerck L. 2003. Influence of pro-inflammatory (IL-1 alpha, IL-6, TNF-alpha, IFN-gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthr Cartilage. 11:681–687.
  • Schulze-Osthoff K, Los M, Baeuerle PA. 1995. Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes . Biochem Pharmacol. 50:735–741.
  • Song M, Kellum JA, Kaldas H, Fink MP. 2004. Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated raw 264.7 cells. J Pharmacol Exp Ther. 308:307–316.
  • Volpin G, Cohen M, Assaf M, Meir T, Katz R, Pollack S. 2014. Cytokine levels (IL-4, IL-6, IL-8 and TGF-β) as potential biomarkers of systemic inflammatory response in trauma patients. Int Orthop. 38:1303–1309.
  • Xu C, Yang S, Zhu L, Cai X, Sheng Y, Zhu S, Xu J. 2014. Regulation of n-acetyl cysteine on gut redox status and major microbiota in weaned piglets. J Anim Sci. 92:1504–1511.
  • Yi D, Hou Y, Wang L, Ding B, Yang Z, Li J, Long M, Liu Y, Wu G. 2014. Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets. Br J Nutr. 111:46–54.
  • Zhu L, Cai X, Guo Q, Chen X, Zhu S, Xu J. 2013. Effect of n-acetyl cysteine on enterocyte apoptosis and intracellular signalling pathways' response to oxidative stress in weaned piglets. Br J Nutr. 110:1938–1947.
  • Zhu L, Zhao K, Chen X, Xu J. 2012. Impact of weaning and an antioxidant blend on intestinal barrier function and antioxidant status in pigs. J Anim Sci. 90:2581–2589.