Vegetable Juices and Fibers Reduce Lipid Digestion or Absorption by Inhibiting Pancreatic Lipase, Cholesterol Solubility and Bile Acid Binding

References

• Adisakwattana, S., J. Intrawangso, A. Hemrid, B. Chanathong, K. Mäkynen, and J. Intrawangso. 2012. Extracts of edible plants inhibit pancreatic lipase, cholesterol esterase and cholesterol micellization, and bind bile acids. Food Technol. Biotechnol. 50:11–16.
   Web of Science ®Google Scholar
• Amran, A.A., Z. Zakaria, F. Othman, S. Das, S. Raj, and N.A. Nordin. 2010. Aqueous extract of Piper sarmentosum decreases atherosclerotic lesions in high cholesterolemic experimental rabbits. Lipids Health Dis. 9:44. doi:10.1186/1476-511X-9-44
   Web of Science ®Google Scholar
• Anderson, J.W. and T.J. Hanna. 1999. Impact of nondigestible carbohydrates on serum lipoproteins and risk for cardiovascular disease. J. Nutr. 129:1457S–1466S.
   Google Scholar
• Aubry, S., G. Aubert, T. Cresteil, and D. Crich. 2012. Synthesis and biological investigation of the beta-thiolactone and beta-lactam analogs of tetrahydrolipstatin. Org. Biomol. Chem. 10:2629–2632.
   PubMed Web of Science ®Google Scholar
• Baba, S.A. and S.A. Malik. 2015. Determination of total phenolic and flavonoid content, antimicrobial and antioxidant activity of a root extract of Arisaema jacquemontii Blume. J. Taibah Univ. Sci. 9:449–454.
   Web of Science ®Google Scholar
• Birari, R.B. and K.K. Bhutani. 2007. Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug Discov. Today 12:879–889.
   PubMed Web of Science ®Google Scholar
• Brown, A.W., J. Hang, P.H. Dussault, and T.P. Carr. 2010. Phytosterol ester constituents affect micellar cholesterol solubility in model bile. Lipids 45:855–862.
   PubMed Web of Science ®Google Scholar
• Coreta-Gomes, F.M., W.L. Vaz, E. Wasielewski, C.F. Geraldes, and M.J. Moreno. 2016. Quantification of cholesterol solubilized in dietary micelles: dependence on human bile salt variability and the presence of dietary food ingredients. Langmuir 32:4564–4574.
   PubMed Web of Science ®Google Scholar
• de la Garza, A.L., F.I. Milagro, N. Boque, J. Campion, and J.A. Martinez. 2011. Natural inhibitors of pancreatic lipase as new players in obesity treatment. Planta Med. 77:773–785.
   PubMed Web of Science ®Google Scholar
• De Smet, E., R.P. Mensink and J. Plat. 2012. Effects of plant sterols and stanols on intestinal cholesterol metabolism: suggested mechanisms from past to present. Mol. Nutr. Food Res. 56:1058–1072.
   PubMed Web of Science ®Google Scholar
• Heidrich, J.E., L.M. Contos, L.A. Hunsaker, L.M. Deck, and D.L. Vander Jagt. 2004. Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster. BMC Pharmacol. 4:5. doi:10.1186/1471-2210-4-5
   Google Scholar
• Kahlon, T.S., M.H. Chapman, and G.E. Smith. 2007. In vitro binding of bile acids by okra, beets, asparagus, eggplant, turnips, green beans, carrots, and cauliflower. Food Chem. 103:676–680.
   Web of Science ®Google Scholar
• Kahlon, T.S. and G.E. Smith. 2007. In vitro binding of bile acids by bananas, peaches, pineapple, grapes, pears, apricots and nectarines. Food Chem. 101:1046–1051.
   Web of Science ®Google Scholar
• Kahlon, T.S. and C.L. Woodruff. 2002. In vitro binding of bile acids by soy protein, pinto beans, black beans and wheat gluten. Food Chem. 79:425–429.
   Web of Science ®Google Scholar
• Kirana, C., P.F. Rogers, L.E. Bennett, M.Y. Abeywardena, and G.S. Patten. 2005. Naturally derived micelles for rapid in vitro screening of potential cholesterol-lowering bioactives. J. Agr. Food Chem. 53:4623–4627.
   PubMed Web of Science ®Google Scholar
• Limpeanchob, N., K. Trisat, A. Duangjai, W. Tiyaboonchai, S. Pongcharoen, and M. Sutheerawattananonda. 2010. Sericin reduces serum cholesterol in rats and cholesterol uptake into Caco-2 cells. J. Agr. Food Chem. 58:12519–12522.
   PubMed Web of Science ®Google Scholar
• McAloon, C.J., L.M. Boylan, T. Hamborg, N. Stallard, F. Osman, P.B. Lim, and S.A. Hayat. 2016. The changing face of cardiovascular disease 2000–2012: an analysis of the World Health Organisation global health estimates data. Int. J. Cardiol. 224:256–264.
   PubMed Web of Science ®Google Scholar
• Metzger, B.T., D.M. Barnes and J.D. Reed. 2007. Insoluble fraction of buckwheat (Fagopyrum esculentum Moench) protein possessing cholesterol-binding properties that reduce micelle cholesterol solubility and uptake by Caco-2 cells. J. Agr. Food Chem. 55:6032–6038.
   PubMed Web of Science ®Google Scholar
• Myers-Payne, S.C., D.Y. Hui, H.L. Brockman, and F. Schroeder. 1995. Cholesterol esterase: a cholesterol transfer protein. Biochemistry 34:3942–3947.
   PubMed Web of Science ®Google Scholar
• Nagaoka, S., A. Nakamura, H. Shibata, and Y. Kanamaru. 2010. Soystatin (VAWWMY), a novel bile acid-binding peptide, decreased micellar solubility and inhibited cholesterol absorption in rats. Biosci. Biotechnol. Biochem. 74: 1738–1741.
   Web of Science ®Google Scholar
• Nakai, M., Y. Fukui, S. Asami, Y. Toyoda-Ono, T. Iwashita, H. Shibata, T. Mitsunaga, F. Hashimoto, and Y. Kiso. 2005. Inhibitory effects of oolong tea polyphenols on pancreatic lipase in vitro. J. Agr. Food Chem. 53:4593–4598.
   PubMed Web of Science ®Google Scholar
• Ngamukote, S., K. Mäkynen, T. Thilawech, and S. Adisakwattana. 2011. Cholesterol-lowering activity of the major polyphenols in grape seed. Molecules 16:5054–5061.
   PubMed Web of Science ®Google Scholar
• Ogawa, K., S. Hirose, S. Nagaoka, and E. Yanase. 2016. Interaction between tea polyphenols and bile acid inhibits micellar cholesterol solubility. J. Agr. Food Chem. 64:204–209.
   PubMed Web of Science ®Google Scholar
• Otles, S. and S. Ozgoz. 2014. Health effects of dietary fiber. Acta Sci. Pol. Technol. Aliment. 13:191–202.
   PubMedGoogle Scholar
• Pietsch, M. and M. Gutschow. 2005. Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition. J. Med. Chem. 48:8270–8288.
   PubMed Web of Science ®Google Scholar
• Porter, J.L., J.S. Fordtran, C.A. Santa Ana, M. Emmett, L.R. Hagey, E.A. MacDonald, and A.F. Hofmann. 2003. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J. Lab. Clin. Med. 141:411–418.
   PubMed Web of Science ®Google Scholar
• Rosa Cde, O., C.A. Dos Santos, J.I. Leite, A.P. Caldas, and J. Bressan. 2015. Impact of nutrients and food components on dyslipidemias: what is the evidence? Adv. Nutr. 6:703–711.
   PubMed Web of Science ®Google Scholar
• Ruiz Ruiz, J.C., D.A. Betancur Ancona, and M.R. Segura Campos. 2014. Bioactive vegetable proteins and peptides in lipid-lowering; nutraceutical potential. Nutr. Hosp. 29:776–784.
   PubMed Web of Science ®Google Scholar
• Sengul, M., S. Ercisli, H. Yildiz, N. Gungor, A. Kavaz, and B. Çetin. 2011. Antioxidant, antimicrobial activity and total phenolic content within the aerial parts of Artemisia absinthum, Artemisia santonicum and Saponaria officinalis. Iran. J. Pharm. Res. 10:49–56.
   PubMed Web of Science ®Google Scholar
• van der Wulp, M.Y.M., H.J. Verkade, and A.K. Groen. 2013. Regulation of cholesterol homeostasis. Mol. Cell. Endocrinol. 368:1–16.
   PubMed Web of Science ®Google Scholar
• World Health Organization. 2016. Cardiovascular diseases. <http://www.who.int/mediacentre/factsheets/fs317/en/.>
   Google Scholar
• Yoshie-Stark, Y. and A. Wäsche. 2004. In vitro binding of bile acids by lupin protein isolates and their hydrolysates. Food Chem. 88:179–184.
   Web of Science ®Google Scholar
• Yoshikawa, M., H. Shimoda, N. Nishida, M. Takada, and H. Matsuda. 2002. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J. Nutr. 132: 1819–1824.
   PubMed Web of Science ®Google Scholar
• Young, S.C. and D.Y. Hui. 1999. Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells Biochem. J. 339:615–620.
   Google Scholar