Prion-like nanofibrils of small molecules (PriSM): A new frontier at the intersection of supramolecular chemistry and cell biology

REFERENCES

• Prusiner SB. Prions. Proc Natl Acad Sci U S A 1998; 95:13363–83; PMID:9811807; http://dx.doi.org/10.1073/pnas.95.23.13363
   PubMed Web of Science ®Google Scholar
• Liebman SW, Chernoff YO. Prions in yeast. Genetics 2012; 191:1041–72; PMID:22879407; http://dx.doi.org/10.1534/genetics.111.137760
   PubMed Web of Science ®Google Scholar
• Crow ET, Li L. Newly identified prions in budding yeast, and their possible functions. Semin Cell Dev Biol 2011; 22:452–9; PMID:21397710; http://dx.doi.org/10.1016/j.semcdb.2011.03.003
   PubMed Web of Science ®Google Scholar
• Bounhar Y, Zhang Y, Goodyer CG, LeBlanc A. Prion protein protects human neurons against Bax-mediated apoptosis. J Biol Chem 2001; 276:39145–9; PMID:11522774; http://dx.doi.org/10.1074/jbc.C100443200
   PubMed Web of Science ®Google Scholar
• Newby GA, Lindquist S. Blessings in disguise: biological benefits of prion-like mechanisms. Trends Cell Biol 2013; 23:251–9; PMID:23485338; http://dx.doi.org/10.1016/j.tcb.2013.01.007
   PubMed Web of Science ®Google Scholar
• Si K, Lindquist S, Kandel ER. In Brief. Nat Rev Neurosci 2004; 5:81–2
   Google Scholar
• Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ. MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 2011; 146:448–61; PMID:21782231; http://dx.doi.org/10.1016/j.cell.2011.06.041
   PubMed Web of Science ®Google Scholar
• Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P. Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell 2004; 15:5383–98; PMID:15371533; http://dx.doi.org/10.1091/mbc.E04-08-0715
   PubMed Web of Science ®Google Scholar
• Kuang Y, Long MJ, Zhou J, Shi J, Gao Y, Xu C, Hedstrom L, Xu B. Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics. J Biol Chem 2014; 289:29208–18; PMID:25157102; http://dx.doi.org/10.1074/jbc.M114.600288
   PubMedGoogle Scholar
• Gao Y, Long MJ, Shi J, Hedstrom L, Xu B. Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules. Chem Commun (Camb) 2012; 48:8404–6; PMID:22801479; http://dx.doi.org/10.1039/c2cc33631f
   PubMedGoogle Scholar
• Kuang Y, Xu B. Disruption of the dynamics of microtubules and selective inhibition of glioblastoma cells by nanofibers of small hydrophobic molecules. Angew Chem Int Ed Engl 2013; 52:6944–8; PMID:23686848; http://dx.doi.org/10.1002/anie.201302658
   PubMedGoogle Scholar
• Estroff LA, Hamilton AD. Water gelation by small organic molecules. Chem Rev 2004; 104:1201–18; PMID:15008620; http://dx.doi.org/10.1021/cr0302049
   PubMed Web of Science ®Google Scholar
• Yang Z, Liang G, Xu B. Enzymatic hydrogelation of small molecules. Acc Chem Res 2008; 41:315–26; PMID:18205323; http://dx.doi.org/10.1021/ar7001914
   PubMed Web of Science ®Google Scholar
• Kiyonaka S, Sada K, Yoshimura I, Shinkai S, Kato N, Hamachi I. Semi-wet peptide/protein array using supramolecular hydrogel. Nat Mater 2004; 3:58–64; PMID:14661016; http://dx.doi.org/10.1038/nmat1034
   PubMed Web of Science ®Google Scholar
• Kuang Y, Xu B. Disruption of the dynamics of microtubules and selective inhibition of glioblastoma cells by nanofibers of small hydrophobic molecules. Angew Chem Int Ed Engl 2013; 52:6944–8; PMID:23686848; http://dx.doi.org/10.1002/anie.201302658
   PubMedGoogle Scholar
• Kuang Y, Du X, Zhou J, Xu B. Supramolecular nanofibrils inhibit cancer progression in vitro and in vivo. Adv Healthc Mater 2014; 3:1217–21; PMID:24574174; http://dx.doi.org/10.1002/adhm.201300645
   PubMedGoogle Scholar
• Fishman WH, Inglis NR, Green S, Anstiss CL, Gosh NK, Reif AE, Rustigian R, Krant MJ, Stolbach LL. Immunology and biochemistry of Regan isoenzyme of alkaline phosphatase in human cancer. Nature 1968; 219:697–9; PMID:5691166; http://dx.doi.org/10.1038/219697a0
   PubMed Web of Science ®Google Scholar
• Fernley HN, Walker PG. Inhibition of alkaline phosphatase by L-phenylalanine. Biochem J 1970; 116:543–4; PMID:5435696
   PubMed Web of Science ®Google Scholar
• Shi J, Du X, Yuan D, Zhou J, Zhou N, Huang Y, Xu B. D-amino acids modulate the cellular response of enzymatic-instructed supramolecular nanofibers of small peptides. Biomacromolecules 2014; 15:3559–68; PMID:25230147; http://dx.doi.org/10.1021/bm5010355
   PubMed Web of Science ®Google Scholar
• Chu H, Pazgier M, Jung G, Nuccio SP, Castillo PA, de Jong MF, Winter MG, Winter SE, Wehkamp J, Shen B, et al. Human α-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets. Science 2012; 337:477–81; PMID:22722251; http://dx.doi.org/10.1126/science.1218831
   PubMed Web of Science ®Google Scholar
• Lo MC, Men H, Branstrom A, Helm J, Yao N, Goldman R, Walker S. A new mechanism of action proposed for ramoplanin. J Am Chem Soc 2000; 122:3540–1; http://dx.doi.org/10.1021/ja000182x
   Web of Science ®Google Scholar
• Yang L, Harroun TA, Weiss TM, Ding L, Huang HW. Barrel-stave model or toroidal model? A case study on melittin pores. Biophys J 2001; 81:1475–85; PMID:11509361; http://dx.doi.org/10.1016/S0006-3495(01)75802-X
   PubMed Web of Science ®Google Scholar
• Tanaka A, Fukuoka Y, Morimoto Y, Honjo T, Koda D, Goto M, Maruyama T. Cancer-cell death induced by the intracellular self-assembly of an enzyme-responsive supramolecular gelator. J Am Chem Soc 2015; 137:770–75; PMID:25521540
   PubMedGoogle Scholar
• Pires RA. Controlling Cancer Cell Fate using Localized Biocatalytic Self-Assembly of an Aromatic Carbohydrate Amphiphile. J Am Chem Soc 2015; 137:579–79; PMID:25539667
   PubMedGoogle Scholar
• Yang ZM, Gu HW, Fu DG, Gao P, Lam JK, Xu B. Enzymatic formation of supramolecular hydrogels. Adv Mater 2004; 16:1440–4; http://dx.doi.org/10.1002/adma.200400340
   Web of Science ®Google Scholar
• Shi J, Du X, Huang Y, Zhou J, Yuan D, Wu D, Zhang Y, Haburcak R, Epstein IR, Xu B. Ligand-Receptor Interaction Catalyzes the Aggregation of Small Molecules To Induce Cell Necroptosis. J Am Chem Soc 2015; 137:26–9; PMID:25522243; http://dx.doi.org/10.1021/ja5100417
   PubMedGoogle Scholar
• Zorn JA, Wille H, Wolan DW, Wells JA. Self-Assembling Small Molecules Form Nanofibrils That Bind Procaspase-3 To Promote Activation. J Am Chem Soc 2011; 133:19630–3; PMID:22066605; http://dx.doi.org/10.1021/ja208350u
   PubMed Web of Science ®Google Scholar
• Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, et al. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol 2014; 10:969–76; PMID:25262416; http://dx.doi.org/10.1038/nchembio.1639
   PubMed Web of Science ®Google Scholar
• Du X, Zhou J, Guvench O, Sangiorgi FO, Li X, Zhou N, Xu B. Supramolecular assemblies of a conjugate of nucleobase, amino acids, and saccharide act as agonists for proliferation of embryonic stem cells and development of zygotes. Bioconjug Chem 2014; 25:1031–5; PMID:24798034; http://dx.doi.org/10.1021/bc500187m
   PubMedGoogle Scholar
• Zhao F, Heesters BA, Chiu I, Gao Y, Shi J, Zhou N, Carroll MC, Xu B. L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials. Org Biomol Chem 2014; 12:6816–9; PMID:25078446; http://dx.doi.org/10.1039/C4OB01362J
   PubMedGoogle Scholar
• Xing B, Yu CW, Chow KH, Ho PL, Fu D, Xu B. Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: a potential candidate for biomaterials. J Am Chem Soc 2002; 124:14846–7; PMID:12475316; http://dx.doi.org/10.1021/ja028539f
   PubMed Web of Science ®Google Scholar
• Newcomb CJ, Sur S, Ortony JH, Lee OS, Matson JB, Boekhoven J, Yu JM, Schatz GC, Stupp SI. Cell death versus cell survival instructed by supramolecular cohesion of nanostructures. Nat Commun 2014; 5:3321; PMID:24531236; http://dx.doi.org/10.1038/ncomms4321
   PubMedGoogle Scholar
• Svensson M, Hakansson A, Mossberg AK, Linse S, Svanborg C. Conversion of α-lactalbumin to a protein inducing apoptosis. Proc Natl Acad Sci U S A 2000; 97:4221–6; PMID:10760289; http://dx.doi.org/10.1073/pnas.97.8.4221
   PubMed Web of Science ®Google Scholar
• Chiti F, Dobson CM. Amyloid formation by globular proteins under native conditions. Nat Chem Biol 2009; 5:15–22; PMID:19088715; http://dx.doi.org/10.1038/nchembio.131
   PubMed Web of Science ®Google Scholar
• McGovern SL, Caselli E, Grigorieff N, Shoichet BK. A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem 2002; 45:1712–22; PMID:11931626; http://dx.doi.org/10.1021/jm010533y
   PubMed Web of Science ®Google Scholar
• Macdonald JC, Whitesides GM. Solid-State Structures of Hydrogen-Bonded Tapes Based on Cyclic Secondary Diamides. Chem Rev 1994; 94:2383–420; http://dx.doi.org/10.1021/cr00032a007
   Web of Science ®Google Scholar
• Lehn J-M. From Molecular to Supramolecular Chemistry. Supramolecular Chemistry: Wiley-VCH Verlag GmbH & Co. KGaA 2006:1–9.
   Google Scholar
• Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Munch J, Baker D, Eisenberg D. Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature 2011; 475:96–100; PMID:21677644; http://dx.doi.org/10.1038/nature10154
   PubMed Web of Science ®Google Scholar
• Liang C, Ni R, Smith JE, Childers WS, Mehta AK, Lynn DG. Kinetic intermediates in amyloid assembly. J Am Chem Soc 2014; 136:15146–9; PMID:25313920; http://dx.doi.org/10.1021/ja508621b
   PubMedGoogle Scholar
• Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57–70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
   PubMed Web of Science ®Google Scholar
• Cooper MA, Shlaes D. Fix the antibiotics pipeline. Nature 2011; 472:32; PMID:21475175; http://dx.doi.org/10.1038/472032a
   PubMed Web of Science ®Google Scholar
• Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, et al. Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels. Cell 2012; 149:753–67; PMID:22579281; http://dx.doi.org/10.1016/j.cell.2012.04.017
   PubMed Web of Science ®Google Scholar