1,879
Views
59
CrossRef citations to date
0
Altmetric
Short Communication

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

, , , &
Pages 125-135 | Received 30 Nov 2014, Accepted 26 Feb 2015, Published online: 21 May 2015

REFERENCES

  • Godsave SF, Wille H, Kujala P, Latawiec D, DeArmond SJ, Serban A, Prusiner SB, Peters PJ. Cryo-immunogold electron microscopy for prions: toward identification of a conversion site. J Neurosci 2008; 28(47):12489–99; PMID:19020041; http://dx.doi.org/10.1523/JNEUROSCI.4474-08.2008
  • Aguzzi A, Falsig J. Prion propagation, toxicity and degradation. Nat Neurosci 2012; 15(7):936–9; PMID:22735515; http://dx.doi.org/10.1038/nn.3120
  • Langevin C, Gousset K, Costanzo M, Richard-Le Goff O, Zurzolo C. Characterization of the role of dendritic cells in prion transfer to primary neurons. Biochem J 2010; 431(2):189–98; PMID:20670217; http://dx.doi.org/10.1042/BJ20100698
  • Arellano-Anaya ZE, Huor A, Leblanc P, Lehmann S, Provansal M, Raposo G, Andréoletti O, Vilette D. Prion strains are differentially released through the exosomal pathway. Cell Mol Life Sci 2014; 72:1185–96; Epub ahead of print; PMID:25227242; http://dx.doi.org/10.1007/s00018-014-1735-8
  • Gousset K, Schiff E, Langevin C, Marijanovic Z, Caputo A, Browman DT, Chenouard N, de Chaumont F, Martino A, Enninga J, et al. Prions hijack tunnelling nanotubes for intercellular spread. Nat Cell Biol 2009; 11(3):328–36; PMID:19198598; http://dx.doi.org/10.1038/ncb1841
  • Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science 2004; 303(5660):1007–10; PMID:14963329; http://dx.doi.org/10.1126/science.1093133
  • Gerdes HH, Carvalho RN. Intercellular transfer mediated by tunneling nanotubes. Curr Opin Cell Biol 2008; 20(4):470–5; PMID:18456488; http://dx.doi.org/10.1016/j.ceb.2008.03.005
  • Sowinski S, Alakoskela JM, Jolly C, Davis DM. Optimized methods for imaging membrane nanotubes between T cells and trafficking of HIV-1. Methods 2011; 53(1):27–33; PMID:20382227; http://dx.doi.org/10.1016/j.ymeth.2010.04.002
  • Abounit S, Zurzolo C. Wiring through tunneling nanotubes–from electrical signals to organelle transfer. J Cell Sci 2012; 125(Pt 5):1089–98; PMID:22399801; http://dx.doi.org/10.1242/jcs.083279
  • Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, et al. Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs. J Cell Biol 2014; 204(3):423–41; PMID:24493590; http://dx.doi.org/10.1083/jcb.201308028
  • Jeffrey M, McGovern G, Goodsir CM, Brown KL, Bruce ME. Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy. J Pathol 2000 191(3):323–32; PMID:10878556; http://dx.doi.org/10.1002/1096-9896(200007)191:3%3c323::AID-PATH629%3e3.0.CO;2-Z
  • Uchiyama K, Muramatsu N, Yano M, Usui T, Miyata H, Sakaguchi S. Prions disturb post-Golgi trafficking of membrane proteins. Nat Commun 2013; 4:1846; PMID:23673631; http://dx.doi.org/10.1038/ncomms2873
  • Marijanovic Z, Caputo A, Campana V, Zurzolo C. Identification of an intracellular site of prion conversion. PLoS Pathog 2009; 5(5):e1000426; PMID:19424437; http://dx.doi.org/10.1371/journal.ppat.1000426
  • Marzo L, Gousset K, Zurzolo C. Multifaceted roles of tunneling nanotubes in intercellular communication. Front Physiol 2012 Apr 10; 3:72; PMID:22514537; http://dx.doi.org/10.3389/fphys.2012.00072
  • Wang Y, Cui J, Sun X, Zhang Y. Tunneling-nanotube development in astrocytes depends on p53 activation. Cell Death Differ 2011; 18(4):732–42; PMID:21113142; http://dx.doi.org/10.1038/cdd.2010.147
  • Kadiu I, Gendelman HE. Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. J Neuroimmune Pharmacol 2011 Dec; 6(4):658–75; ; http://dx.doi.org/10.1007/s11481-011-9298-z
  • Hao M, Lin SX, Karylowski OJ, Wüstner D, McGraw TE, Maxfield FR. Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle. J Biol Chem 2002; 277(1):609–17; PMID:11682487; http://dx.doi.org/10.1074/jbc.M108861200
  • Sarnataro D, Campana V, Paladino S, Stornaiuolo M, Nitsch L, Zurzolo C. PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation. Mol Biol Cell 2004; 15:4031–42; PMID:15229281; http://dx.doi.org/10.1091/mbc.E03-05-0271
  • Marzo L, Marijanovic Z, Browman D, Chamoun Z, Caputo A, Zurzolo C. 4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy. J Cell Sci 2013; 126(Pt 6):1345–54; PMID:23418355; http://dx.doi.org/10.1242/jcs.114801
  • Schrock Y, Solis GP, Stuermer CA. Regulation of focal adhesion formation and filopodia extension by the cellular prion protein (PrPC). FEBS Lett 2009; 583(2):389–93; PMID:19116153; http://dx.doi.org/10.1016/j.febslet.2008.12.038
  • Gousset K, Marzo L, Commere PH, Zurzolo C. Myo10 is a key regulator of TNT formation in neuronal cells. J Cell Sci 2013; 126(Pt 19):4424–35; PMID:23886947; http://dx.doi.org/10.1242/jcs.129239
  • Bukoreshtliev NV, Wang X, Hodneland E, Gurke S, Barroso JF, Gerdes HH. Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells. FEBS Lett 2009; 583(9):1481–8; PMID:19345217; http://dx.doi.org/10.1016/j.febslet.2009.03.065
  • Kuznetsov IA, Kuznetsov AV. A minimal model of prion transport through a tunneling nanotube. Nanotube Ther 2012; 1:3–11, ISSN (Online) 2299-1026; PMID:23477810; http://dx.doi.org/10.2478/nanoth-2012-0002
  • Bach C, Gilch S, Rost R, Greenwood AD, Horsch M, Hajj GN, Brodesser S, Facius A, Schädler S, Sandhoff K, et al. Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. J Biol Chem 2009; 284(45):31260–9; PMID:19748890; http://dx.doi.org/10.1074/jbc.M109.004382
  • Lokar M, Kabaso D, Resnik N, Sepčić K, Kralj-Iglič V, Veranič P, Zorec R, Iglič A. The role of cholesterol-sphingomyelin membrane nanodomains in the stability of intercellular membrane nanotubes. Int J Nanomedicine 2012; 7:1891–902; PMID:22605937
  • Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997; 387(6633):569–72; PMID:9177342; http://dx.doi.org/10.1038/42408
  • Huttner WB, Zimmerberg J. Implications of lipid microdomains for membrane curvature, budding and fission. Curr Opin Cell Biol 2001; 13(4):478–84; PMID:11454455; http://dx.doi.org/10.1016/S0955-0674(00)00239-8
  • Linden R, Martins VR, Prado MA, Cammarota M, Izquierdo I, Brentani RR. Physiology of the prion protein. Physiol Rev 2008; 88(2):673–728; PMID:18391177; http://dx.doi.org/10.1152/physrev.00007.2007
  • Torres M, Castillo K, Armisén R, Stutzin A, Soto C, Hetz C. Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress. PLoS One 2010; 5(12):e15658; PMID:21209925; http://dx.doi.org/10.1371/journal.pone.0015658
  • Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, et al. Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice. Sci Transl Med 2013; 5(206):206ra138; PMID:24107777; http://dx.doi.org/10.1126/scitranslmed.3006767
  • Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 2012; 13(2):89–102; PMID:22251901; http://dx.doi.org/10.1038/nrm3270
  • Browman D, Zurzolo C. Not on the menu: autophagy-independent clearance of prions. Prion 2013; 7(4):286–90; PMID:23907058; http://dx.doi.org/10.4161/pri.25809
  • Gyllberg H, Löfgren K, Lindegren H, Bedecs K. Increased Src kinase level results in increased protein tyrosine phosphorylation in scrapie-infected neuronal cell lines. FEBS Lett 2006; 580(11):2603–8; PMID:16647068; http://dx.doi.org/10.1016/j.febslet.2006.03.092
  • de Chaumont F, Dallongeville S, Chenouard N, Hervé N, Pop S, Provoost T, Meas-Yedid V, Pankajakshan P, Lecomte T, Le Montagner Y, et al. Icy: an open bioimage informatics platform for extended reproducible research. Nat Methods 2012 Jun 28; 9(7):690–6; PMID:22743774; http://dx.doi.org/10.1038/nmeth.2075

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.