855
Views
7
CrossRef citations to date
0
Altmetric
Research Papers

In vitro neutralization of prions with PrPSc-specific antibodies

, , , , , & show all
Pages 292-303 | Received 15 May 2015, Accepted 08 Jul 2015, Published online: 18 Aug 2015

REFERENCES

  • Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-44; PMID:6801762; http://dx.doi.org/10.1126/science.6801762
  • Aguzzi A, Sigurdson C, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol 2008; 3:11-40; PMID:18233951; http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.154326
  • Geshwind MD. Clinical trials for prion disease: difficult challenges but hope for the future. Lancet Neurol (2009) 8:304-6.
  • Haley NJ, Hoover EA. Chronic Wasting Disease of Cervids: Current Knowledge and Future Perspectives. Annu Rev Anim Biosci 2014; 3:205–325; PMID:25387112
  • Sigurdsson EM, Brown DR, Daniels M, Kascsak RJ, Kascsak R, Carp R, Meeker HC, Frangione B, Wisniewski T. Immunization delays the onset of prion disease in mice. Am J Pathol 2002; 161:13-7; PMID:12107084; http://dx.doi.org/10.1016/S0002-9440(10)64151-X
  • Hanan E, Goren O, Eshkenazy M, Solomon B. Immunomodulation of the human prion peptide 106–126 aggregation. Biochem Biophys Res Commun 2001; 280:115-20; PMID:11162487; http://dx.doi.org/10.1006/bbrc.2000.4097
  • Koller MF, Grau T, Christen P. Induction of antibodies against murine full-length prion protein in wild-type mice. J Neuroimmunol 2002; 132:113-6; PMID:12417440; http://dx.doi.org/10.1016/S0165-5728(02)00316-8
  • Rosset MB, Ballerini C, Grégoire S, Metharom P, Carnaud C, Aucouturier P. Breaking immune tolerance to the prion protein using prion protein peptides plus oligodeoxynucleotide-CpG in mice. J Immunol 2004; 172:5168-74; PMID:15100253; http://dx.doi.org/10.4049/jimmunol.172.9.5168
  • Polymenidou M, Heppner FL, Pellicioli EC, Urich E, Miele G, Braun N, Wopfner F, Schätzl HM, Becher B, Aguzzi A. Humoral immune response to native eukaryotic prion protein correlates with antiprion protection. Proc Natl Acad Sci U S A 2004; 101(Suppl 2):14670-6; PMID:15292505; http://dx.doi.org/10.1073/pnas.0404772101
  • Schwarz A, Krätke O, Burwinkel M, Riemer C, Schultz J, Henklein P, Bamme T, Baier M. Immunisation with a synthetic prion protein-derived peptide prolongs survival times of mice orally exposed to the scrapie agent. Neurosci Lett 2003; 350:187-9; PMID:14550926; http://dx.doi.org/10.1016/S0304-3940(03)00907-8
  • Gilch S, Schätzl HM. Promising developments bringing prion diseases closer to therapy and prophylaxis. Trends Mol Med 2003; 9:367-9; PMID:13129701; http://dx.doi.org/10.1016/S1471-4914(03)00144-8
  • Goni F, Mathiason CK, Yim L, Wong K, Hayes-Klug J, Nalls A, Peyser D, Estevez V, Denkers N, Xu J, et al. Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease. Vaccine (2015) 33:726-33; PMID:25539804; http://dx.doi.org/10.1016/j.vaccine.2014.11.035
  • Cashman NR, Loertscher R, Nalbantoglu J, Shaw I, Kascsak RJ, Bolton DC, Bendheim PE. Cellular isoform of scrapie agent protein participates in lymphocyte activation. Cell (1990) 61:185-192; PMID:1969332; http://dx.doi.org/10.1016/0092-8674(90)90225-4
  • Huang L, Su X, Federoff HJ. Single-Chain Fragment Variable Passive Immunotherapies of Neurodegenerative diseases. Int. J. Mol. Sci. (2013) 14:19109-27; PMID:24048248; http://dx.doi.org/10.3390/ijms140919109
  • Solforosi L, Criado JR, McGavern DB, Wirz S, Sánchez-Alavez M, Sugama S, DeGiorgio LA, Volpe BT, Wiseman E, Abalos G, et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science 2004; 303:1514-6; PMID:14752167; http://dx.doi.org/10.1126/science.1094273
  • Sonati T, Reimann R, Falsig J, Baral P, O'Connor T, Hornemann S, Yaganoglu S, Li B, Herrmann U, Wieland B, et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature (2013) 501;102-6; PMID:23903654; http://dx.doi.org/10.1038/nature12402
  • Marciniuk K, Maattanen P, Taschuk R, Airey D, Potter A, Cashman N, Griebel P, Napper S. Development of a Multivalent, PrPSc-Specific Prion Vaccine through Rational Optimization of Three Disease-Specific Epitopes. Vaccine (2014) 32:1988-97; PMID:24486363; http://dx.doi.org/10.1016/j.vaccine.2014.01.027
  • Paramithiotis E, Pinard M, Lawton T, LaBoissiere S, Leathers VL, Zou W-Q, Estey LA, Lamontagne J, Lehto MT, Kondejewski LH, et al. A prion protein epitope selective for the pathologically misfolded conformation. Nat Med 2003; 9:893-9; PMID:12778138; http://dx.doi.org/10.1038/nm883
  • Guest W, Cashman N, Plotkin S. Structure-Based Prediction of Unstable Regions in Proteins: Applications to Protein Misfolding Diseases. Bull Am Phys Soc 2009; 54. Available at http://meetings.aps.org/link/BAPS.2009.MAR.A40.13
  • Gossert AD, Bonjour S, Lysek DA, Fiorito F, Wüthrich K. Prion protein NMR structures of elk and of mouse/elk hybrids. Proc Natl Acad Sci U S A 2005; 102:646-50; PMID:15647363; http://dx.doi.org/10.1073/pnas.0409008102
  • Soto C. Constraining the loop, releasing prion infectivity. Proc Natl Acad Sci U S A 2009; 106:10-1; PMID:19118191; http://dx.doi.org/10.1073/pnas.0811625106
  • Taschuk R, Marciniuk K, Maaattanen P, Madampage C, Hedlin P, Potter A, Lee J, Cashman N, Griebel P, Napper S. Safety, Specificity and Immunogenicity of a PrPSc-specific prion vaccine based on the YYR Disease-Specific Epitope. Prion Feb (2014) 7;8(1):51-9.
  • Hedlin PD, Cashman NR, Li L, Gupta J, Babiuk LA, Potter AA, Griebel P, Napper S. Design and Delivery of a cryptic (PrPC epitope for induction of PrP(Sc)-specific antibody responses. Vaccine (2009) 28:981-8; PMID:19925901; http://dx.doi.org/10.1016/j.vaccine.2009.10.134
  • Van der Merwe J, Aiken J, Westaway D, McKenzie D. The Standard Scrapie Cell Assay: Development, Utility and Prospects. Viruses, (2015) 7: 180-98; PMID:25602372; http://dx.doi.org/10.3390/v7010180
  • Maattanen P, Taschuk R, Ross L, Marciniuk K, Bertram L, Potter A, Cashman N, Napper S. PrPSc-specific antibodies do not induce prion disease or misfolding of PrPC in highly susceptible Tga20 mice. Prion. (2013) 5:434-9; http://dx.doi.org/10.4161/pri.26639
  • Bueler H, A Aguzzi, A Sailer, RA Greiner, P Autenried, M Aguet, C Weissmann. Mice devoid of PrP are resistant to scrapie. Cell 1993 73:1339-47; PMID:8100741; http://dx.doi.org/10.1016/0092-8674(93)90360-3
  • Feraudet C, Morel N, Simon S, Volland H, Frobert Y, Creminon C, Vilette D, Lehmann S, Grassi J. Screening of 145 Anti-PrP Monoclonal Antibodies for Their Capacity to Inhibit PrPSc Replication in Infected Cells. J Biol Chem (2005) 280: 11247-58; PMID:15618225; http://dx.doi.org/10.1074/jbc.M407006200
  • Liu H-N, Tjostheim S, Dasilva K, Taylor D, Zhao B, Rakhit R, et al. Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis. J Neurosci (2012) 32: 8791-9; PMID:22745481; http://dx.doi.org/10.1523/JNEUROSCI.5053-11.2012
  • Li L, Napper S, Cashman N. Immunotherapy for prion diseases: opportunities and obstacles. Immunotherapy (2010) 2:269-82; PMID:20635933; http://dx.doi.org/10.2217/imt.10.3
  • Hanan E, Priola S, Solomon B. Antiaggregating Antibody Raised Against Human PrP 106–126 Recognizes Pathological and Normal Isoforms of the Whole Prion Protein. Cell Molec Neurbiol (2001) 21: 693-703; http://dx.doi.org/10.1023/A:1015199904354
  • Pankiewicz J, Prelli F, Sy M, Kascsak R, Kascsak R, Spinner D, Carp R, Meeker H, Sadowski M, Wisniewski T. Clearance and prevention of prion infection in cell culture by anti-PrP antibodies. Eur J Neurosci 23: 2635-47; PMID:16817866; http://dx.doi.org/10.1111/j.1460-9568.2006.04805.x
  • Sadowski M, Pankiewicz J, Prelli F, Scholtzova H, Spinner D, Kascsak RB, Kascsak RJ, Wisniewski T. Anti-PrP Mab 6D11 suppresses PrPSc replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo. Neurobiol Dis. 34: 267-78; PMID:19385058; http://dx.doi.org/10.1016/j.nbd.2009.01.013

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.