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Short Communications

Flow cytometric measurement of the cellular propagation of TDP-43 aggregation

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Pages 195-204 | Received 13 Jan 2017, Accepted 28 Mar 2017, Published online: 16 May 2017

REFERENCES

  • Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS. Nature Reviews 2001; 2:806-819; PMID:11715057; https://doi.org/10.1038/35097565
  • Chiti F, Dobson CM. Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem 2006; 75:333-66; PMID:16756495; https://doi.org/10.1146/annurev.biochem.75.101304.123901
  • Yerbury JJ, Ooi L, Dillin A, Saunders DN, Hatters DM, Beart PM, Cashman NR, Wilson MR, and Ecroyd H. Walking the tightrope: proteostasis and neurodegenerative disease. J Neurochem 2016; 137(4):489-505; PMID:26872075; https://doi.org/10.1111/jnc.13575
  • Bolognesi B, Kumita JR, Barros TP, Esbjorner EK, Luheshi LM, Crowther DC, Wilson MR, Dobson CM, Favrin G, Yerbury JJ. ANS binding reveals common features of cytotoxic amyloid species. ACS Chem Biol 2010; 5(8):735-40; PMID:20550130; https://doi.org/10.1021/cb1001203
  • Marciniuk K, Taschuk R, Napper S. Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapy. Clin Dev Immunol 2013; 2013:473706; PMID:24228054; https://doi.org/10.1155/2013/473706
  • Grad LI, Yerbury JJ, Turner BJ, Guest WC, Pokrishevsky E, O'Neill MA, Yanai A, Silverman JM, Zeineddine R, Corcoran L, et al. Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 2014; 111(9):3620-5; PMID:24550511; https://doi.org/10.1073/pnas.1312245111
  • Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol 2013; 74(1):20-38; PMID:23686809; https://doi.org/10.1002/ana.23937
  • Furukawa Y, Kaneko K, Watanabe S, Yamanaka K, Nukina N. A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions. J Biol Chem 2011; 286(21):18664-72; PMID:21454603;https://doi.org/10.1074/jbc.M111.231209
  • Nonaka T, Masuda-Suzukake M, Arai T, Hasegawa Y, Akatsu H, Obi T, Yoshida M, Murayama S, Mann DM, Akiyama H, et al. Prion-like properties of pathological TDP-43 aggregates from diseased brains. Cell Rep 2013; 4(1):124-34; PMID:23831027; https://doi.org/10.1016/j.celrep.2013.06.007
  • Smethurst P, Newcombe J, Troakes C, Simone R, Chen YR, Patani R, Sidle K. In vitro prion-like behaviour of TDP-43 in ALS. Neurobiol Dis 2016; 96:236-247; PMID:27590623
  • Feiler MS, Strobel B, Freischmidt A, Helferich AM, Kappel J, Brewer BM, Li D, Thal DR, Walther P, Ludolph AC, et al. TDP-43 is intercellularly transmitted across axon terminals. J Cell Biol 2015; 211(4):897-911; PMID:26598621; https://doi.org/10.1083/jcb.201504057
  • Shimonaka S, Nonaka T, Suzuki G, Hisanaga S, Hasegawa M. Templated Aggregation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Seeding with TDP-43 Peptide Fibrils. J Biol Chem 2016; 291(17):8896-907; PMID:26887947; https://doi.org/10.1074/jbc.M115.713552
  • Whiten DR, San Gil R, McAlary L, Yerbury JJ, Ecroyd H, Wilson MR. Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Sci Rep 2016; 6:31138; PMID:27516358; https://doi.org/10.1038/srep31138
  • Cashman NR, Durham HD, Blusztajn JK, Oda K, Tabira T, Shaw IT, Dahrouge S, Antel JP. Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev Dynam 1992; 194:209-221; https://doi.org/10.1002/aja.1001940306
  • Lee EB, Lee VMY, Trojanowski JQ. Gains or losses: Molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews Neuroscience 2012; 13(1):38-50
  • Buratti E, Baralle FE. Characterization and functional implications of the RNA binding properties of Nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9. J Biol Chem 2001; 276(39):36337-36343
  • Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. J Cell Sci 2006; 314:130-133
  • Farrawell NE, Lambert-Smith IA, Warraich ST, Blair IP, Saunders DN, Hatters DM, Yerbury JJ. Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions. Sci Rep 2015; 5:13416; PMID:26293199
  • Costanzo M, Abounit S, Marzo L, Danckaert A, Chamoun Z, Roux P, Zurzolo C. Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes. J Cell Sci 2013; 126(Pt 16):3678-85; PMID:23781027
  • Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Velde CV, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, et al. TARDBP Mutations in Individuals with Sporadic and Familial Amyotrophic Lateral Sclerosis. Nature Genetics 2008; 40(5):572-574; PMID:18372902
  • Sreedharan J, Blair LP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, et al. TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Journal of Cell Science 2008; 319:1668-1672
  • Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J Biol Chem 2009; 284(30):20329-39; PMID:19465477
  • Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, et al. SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Mol Neurodegener 2015; 10:57; PMID:26520394
  • Yerbury JJ. Protein aggregates stimulate macropinocytosis facilitating their propagation. Prion 2016; 10(2):119-26; PMID:26963158
  • Zeineddine R, and Yerbury JJ, The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases. Front Physiol 2015; 6:277; PMID:26528186

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