789
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

BMP2 rescues deficient cell migration in Tgfbr3−/− epicardial cells and requires Src kinase

, &
Pages 259-268 | Received 01 Jul 2015, Accepted 07 Nov 2015, Published online: 10 Mar 2016

References

  • Mu H, Ohashi R, Lin P, Yao Q, Chen C. Cellular and molecular mechanisms of coronary vessel development. Vasc Med 2005; 10(1):37-44; http://dx.doi.org/10.1191/1358863x05vm584ra
  • Kalman F, Viragh S, Modis L. Cell surface glycoconjugates and the extracellular matrix of the developing mouse embryo epicardium. Anat Embryol (Berl) 1995; 191(5):451-64; http://dx.doi.org/10.1007/BF00304430
  • Munoz-Chapuli R, Macias D, Gonzalez-Iriarte M, Carmona R, Atencia G, Perez-Pomares JM. The epicardium and epicardial-derived cells: multiple functions in cardiac development. Rev Esp Cardiol 2002; 55(10):1070-82; http://dx.doi.org/10.1016/S0300-8932(02)76758-4
  • Perez-Pomares JM, de la Pompa JL. Signaling during epicardium and coronary vessel development. Circ Res 2011; 109(12):1429-42; http://dx.doi.org/10.1161/CIRCRESAHA.111.245589
  • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al. Heart disease and stroke statistics–2013 update: a report from the American Heart Association. Circulation 2013; 127(1):e6-e245; PMID:23239837; http://dx.doi.org/10.1161/CIR.0b013e31828124ad
  • Azhar M, Schultz Jel J, Grupp I, Dorn GW,2nd, Meneton P, Molin DG, Gittenberger-de Groot AC, Doetschman T. Transforming growth factor beta in cardiovascular development and function. Cytokine Growth Factor Rev 2003; 14(5):391-407; PMID:12948523; http://dx.doi.org/10.1016/S1359-6101(03)00044-3
  • Doetschman T, Barnett JV, Runyan RB, Camenisch TD, Heimark RL, Granzier HL, Conway SJ, Azhar M. Transforming growth factor beta signaling in adult cardiovascular diseases and repair. Cell Tissue Res 2012; 347(1):203-23; PMID:21953136; http://dx.doi.org/10.1007/s00441-011-1241-3
  • Hill CR, Sanchez NS, Love JD, Arrieta JA, Hong CC, Brown CB, Austin AF, Barnett JV. BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFbeta receptor to promote invasion. Cell Signal 2012; 24(5):1012-22; PMID:22237159; http://dx.doi.org/10.1016/j.cellsig.2011.12.022
  • Lopez-Casillas F, Wrana JL, Massague J. Betaglycan presents ligand to the TGF beta signaling receptor. Cell 1993; 73(7):1435-44; PMID:8391934; http://dx.doi.org/10.1016/0092-8674(93)90368-Z
  • Zhang YE. Non-Smad pathways in TGF-beta signaling. Cell Res 2009; 19(1):128-39; http://dx.doi.org/10.1038/cr.2008.328
  • Compton LA, Potash DA, Brown CB, Barnett JV. Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res 2007; 101(8):784-91;http://dx.doi.org/10.1161/CIRCRESAHA.107.152082
  • Shin D, Shin CH, Tucker J, Ober EA, Rentzsch F, Poss KD, Hammerschmidt M, Mullins MC, Stainier DY. Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 2007; 134(11):2041-50; PMID:17507405; http://dx.doi.org/10.1242/dev.000281
  • Weber H, Symes CE, Walmsley ME, Rodaway AR, Patient RK. A role for GATA5 in Xenopus endoderm specification. Development 2000; 127(20):4345-60
  • Dale L, Jones CM. BMP signalling in early Xenopus development. Bioessays 1999; 21(9):751-60; http://dx.doi.org/10.1002/(SICI)1521-1878(199909)21:9%3c751::AID-BIES6%3e3.0.CO;2-I
  • Nakajima Y, Yamagishi T, Hokari S, Nakamura H. Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec 2000; 258(2):119-27;http://dx.doi.org/10.1002/(SICI)1097-0185(20000201)258:2%3c119::AID-AR1%3e3.0.CO;2-U
  • Delot EC. Control of endocardial cushion and cardiac valve maturation by BMP signaling pathways. Mol Genet Metab 2003; 80(1-2):27-35; http://dx.doi.org/10.1016/j.ymgme.2003.07.004
  • Townsend TA, Robinson JY, Deig CR, Hill CR, Misfeldt A, Blobe GC, et al. BMP-2 and TGFbeta2 shared pathways regulate endocardial cell transformation. Cells Tissues Organs 2011; 194(1):1-12; PMID:21212630; http://dx.doi.org/10.1159/000322035
  • Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T. BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart. Dev Cell 2010; 19(2):307-16; http://dx.doi.org/10.1016/j.devcel.2010.07.017
  • Sanchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV. The cytoplasmic domain of TGFbetaR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol 2011; 358(2):331-43; PMID:21871877; http://dx.doi.org/10.1016/j.ydbio.2011.08.008
  • Bjorge JD, Jakymiw A, Fujita DJ. Selected glimpses into the activation and function of Src kinase. Oncogene 2000 Nov 20; 19(49):5620-35; http://dx.doi.org/10.1038/sj.onc.1203923
  • Hutcheson JD, Ryzhova LM, Setola V, Merryman WD. 5-HT(2B) antagonism arrests non-canonical TGF-beta1-induced valvular myofibroblast differentiation. J Mol Cell Cardiol 2012 Nov; 53(5):707-14; http://dx.doi.org/10.1016/j.yjmcc.2012.08.012
  • Wong WK, Knowles JA, Morse JH. Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension. Am J Respir Cell Mol Biol 2005 Nov; 33(5):438-46; http://dx.doi.org/10.1165/rcmb.2005-0103OC
  • Allison P, Espiritu D, Barnett JV, Camenisch TD. Type III TGFbeta receptor and Src direct hyaluronan-mediated invasive cell motility. Cell Signal 2015 Mar; 27(3):453-9; PMID:25499979; http://dx.doi.org/10.1016/j.cellsig.2014.11.037
  • Jin H, Pi J, Huang X, Huang F, Shao W, Li S, Chen Y, Cai J. BMP2 promotes migration and invasion of breast cancer cells via cytoskeletal reorganization and adhesion decrease: an AFM investigation. Appl Microbiol Biotechnol 2012; 93(4):1715-23; PMID:22270235; http://dx.doi.org/10.1007/s00253-011-3865-3
  • Gamell C, Osses N, Bartrons R, Ruckle T, Camps M, Rosa JL, Ventura F. BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity. J Cell Sci 2008; 121(Pt 23):3960-70; PMID:19001503; http://dx.doi.org/10.1242/jcs.031286
  • Austin AF, Compton LA, Love JD, Brown CB, Barnett JV. Primary and immortalized mouse epicardial cells undergo differentiation in response to TGFbeta. Dev Dyn 2008; 237(2):366-76; http://dx.doi.org/10.1002/dvdy.21421
  • Sollome JJ, Thavathiru E, Camenisch TD, Vaillancourt RR. HER2/HER3 regulates extracellular acidification and cell migration through MTK1 (MEKK4). Cell Signal 2014; 26(1):70-82; http://dx.doi.org/10.1016/j.cellsig.2013.08.043
  • Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J. Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system. Cell 1991; 67(4):785-95; http://dx.doi.org/10.1016/0092-8674(91)90073-8
  • Camenisch TD, Spicer AP, Brehm-Gibson T, Biesterfeldt J, Augustine ML, Calabro A, Jr, Kubalak S, Klewer SE, McDonald JA. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J Clin Invest 2000; 106(3):349-60; PMID:10930438; http://dx.doi.org/10.1172/JCI10272
  • Craig EA, Austin AF, Vaillancourt RR, Barnett JV, Camenisch TD. TGFbeta2-mediated production of hyaluronan is important for the induction of epicardial cell differentiation and invasion. Exp Cell Res 2010; 316(20):3397-405; http://dx.doi.org/10.1016/j.yexcr.2010.07.006
  • Sanchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV. The cytoplasmic domain of TGFbetaR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior. Dev Biol 2011; 358(2):331-43; PMID:21871877; http://dx.doi.org/10.1016/j.ydbio.2011.08.008
  • Krause C, Guzman A, Knaus P. Noggin. Int J Biochem Cell Biol 2011; 43(4):478-81; http://dx.doi.org/10.1016/j.biocel.2011.01.007
  • Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112(4):453-65; http://dx.doi.org/10.1016/S0092-8674(03)00120-X
  • Kirkbride KC, Townsend TA, Bruinsma MW, Barnett JV, Blobe GC. Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor. J Biol Chem 2008; (283), 7628-7637; PMID:18184661; http://dx.doi.org/10.1074/jbc.M704883200

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.