Involvement of Rho GAP GRAF1 in maintenance of epithelial phenotype

References

• Lim J, Thiery JP. Epithelial-mesenchymal transitions: insights from development. Development 2012; 139:3471-86; PMID:22949611; https://doi.org/10.1242/dev.071209
   PubMed Web of Science ®Google Scholar
• Hay ED. An overview of epithelio-mesenchymal transformation. Acta Anat 1995; 154:8-20.
   PubMedGoogle Scholar
• Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002; 3:155-66; PMID:11994736; https://doi.org/10.1038/nrm757
   PubMed Web of Science ®Google Scholar
• Savagner P. The epithelial–mesenchymal transition (EMT) phenomenon. Ann Oncol 2010; 21(Supplement 7):89-92.
   Web of Science ®Google Scholar
• Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 2005; 132:3151-61; PMID:15983400; https://doi.org/10.1242/dev.01907
   PubMed Web of Science ®Google Scholar
• Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2:442-54; PMID:12189386; https://doi.org/10.1038/nrc822
   PubMed Web of Science ®Google Scholar
• Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switcing. J Cell Sci 2008; 121:727-35; PMID:18322269; https://doi.org/10.1242/jcs.000455
   PubMed Web of Science ®Google Scholar
• Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol 1999; 147:631-44; PMID:10545506; https://doi.org/10.1083/jcb.147.3.631
   PubMed Web of Science ®Google Scholar
• Hulit J, Suyama K, Chung S, Keren R, Agiostratidou G, Shan W, Dong X. N-cadherin signaling potentiates mammary tumor metastasis via enhanced extracellular signal regulated kinase activation. Cancer Res 2007; 67:3106-16; PMID:17409417; https://doi.org/10.1158/0008-5472.CAN-06-3401
   PubMed Web of Science ®Google Scholar
• Parri M, Chiarugi P. Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal 2010; 8:23; PMID:20822528; https://doi.org/10.1186/1478-811X-8-23
   PubMed Web of Science ®Google Scholar
• Lawson CD, Burridge K. The on-off relationship of Rho and Rac during integrin mediated adhesion and cell migration. Small GTPases 2014; 5:e27958; PMID:24607953; https://doi.org/10.4161/sgtp.27958
   PubMedGoogle Scholar
• Aznar S, Fernandez-Valeron P, Espina C, Lacal JC. Rho GTPases: potential candidates for anticancer therapy. Cancer Lett 2004; 206:181-91; PMID:15013523; https://doi.org/10.1016/j.canlet.2003.08.035
   PubMed Web of Science ®Google Scholar
• Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002; 2:133-42; PMID:12635176; https://doi.org/10.1038/nrc725
   PubMed Web of Science ®Google Scholar
• Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer 1999; 81:682-7; PMID:10328216; https://doi.org/10.1002/(SICI)1097-0215(19990531)81:5%3c682::AID-IJC2%3e3.0.CO;2-B
   PubMed Web of Science ®Google Scholar
• McHenry PR, Vargo-Gogola T. Pleiotropic Functions of Rho GTPase Signaling: a Trojan Horse or Achilles' heel for breast cancer treatment? Curr Drug Targets 2010; 11(9):1043-58; PMID:20545614; https://doi.org/10.2174/138945010792006852
   PubMed Web of Science ®Google Scholar
• Hildebrand JD, Taylor JM, Parsons JT. An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol Cell Biol 1996; 16(6):3169.
   PubMed Web of Science ®Google Scholar
• Lundmark R, Doherty GJ, Howes MT, Cortese K, Vallis Y, Parton RG, McMahon HT. The GTPase-activating protein GRAF1regulates the CLIC/GEEC endocytic pathway. Curr Biol 2008; 18:1802-8
   PubMed Web of Science ®Google Scholar
• Francis MK, Holst MR, Vidal-Quadras M, Henriksson S, Santarella-Mellwig R, Sandblad L, Lundmark R. Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1. J Cell Sci 2015; 128:4183-95; PMID:26446261; https://doi.org/10.1242/jcs.174417
   PubMed Web of Science ®Google Scholar
• Huret JL, Le Minor S, Dorkeld F, Dessen P, Bernheim A. Atlas of genetics and cytogenetics in oncology and haematology, an interactive database. Nucleic Acids Res 2000; 28:1; PMID:10592167; https://doi.org/10.1093/nar/28.1.349
   PubMed Web of Science ®Google Scholar
• Sarrio D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G, Palacios J. Epithelial-Mesenchymal transition in breast cancer relates to the Basal-like Phenotype. Cancer Res 2008; 68:989-97; PMID:18281472; https://doi.org/10.1158/0008-5472.CAN-07-2017
   PubMed Web of Science ®Google Scholar
• Fogg VC, Liu CJ, Margolis B. Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells. J Cell Sci 2005; 118(Pt 13):2859-69; PMID:15976445; https://doi.org/10.1242/jcs.02412
   PubMed Web of Science ®Google Scholar
• Geiger B, Bershadsky A, Pankov R, Yamada KM. Transmembrane crosstalk between the extracellular matrix–cytoskeleton crosstalk. Nat Rev Mol Cell Biol 2001; 2(11):793-805; PMID:11715046; https://doi.org/10.1038/35099066
   PubMed Web of Science ®Google Scholar
• Geiger B, Yamada KM. Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 2011; 3(5); PMID:21441590; https://doi.org/10.1101/cshperspect.a005033
   PubMed Web of Science ®Google Scholar
• Geiger B, Spatz JP, Bershadsky AD. Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol 2009; 10:21-33; PMID:19197329; https://doi.org/10.1038/nrm2593
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. Clin Invest 2009; 119(6):1420-8; https://doi.org/10.1172/JCI39104
   Google Scholar
• Ben-Ze'ev A. Differential control of cytokeratins and vimentin synthesis by cell-cell contact and cell spreading in cultured epithelial cells. J Cell Biol 1984; 99:1424-33; https://doi.org/10.1083/jcb.99.4.1424
   PubMed Web of Science ®Google Scholar
• Thiery JP, Sleeman JP. Complex networks orchestrate epithelial–mesenchymal transitions. Nat Rev 2006; 7(2):131-42; PMID:16493418; https://doi.org/10.1038/nrm1835
   PubMedGoogle Scholar
• Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA. Utilization of the soft agar colony formation assay to identify inhibitors of tumorigenicity in breast cancer cells. J Vis Exp 2015; (99):e52727; PMID:26067809
   PubMed Web of Science ®Google Scholar
• Borkhardt A, Bojesen S, Haas AO, Fuchs U, Bartelheimer B, Loncarevic IF, Rainer M, Bohle RM, Harbott J, Repp R, et al. The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q. Proc Nat Acad Sci 2000; 97:9168-73; PMID:10908648; https://doi.org/10.1073/pnas.150079597
   PubMed Web of Science ®Google Scholar
• Qian J, Qian Z, Lin J, Yao DM, Chen Q, Li Y, Ji RB, Yang J, Xiao GF, Wang YL. Abnormal methylation of GRAF promoter Chinese patients with acute myeloid leukemia. Leuk Res 2011; 35(6):783-6; PMID:21074269; https://doi.org/10.1016/j.leukres.2010.10.013
   PubMedGoogle Scholar
• Chung CY, Lee S, Briscoe C, Ellsworth C, Firtel RA. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci 2000; 97(10):5225-30; PMID:10805781; https://doi.org/10.1073/pnas.97.10.5225
   PubMed Web of Science ®Google Scholar
• Radisky CD. Epithelial-mesenchymal transition. J Cell Sci 2005; 118:4325-6; PMID:16179603; https://doi.org/10.1242/jcs.02552
   PubMed Web of Science ®Google Scholar
• Roxanis I. Occurrence and significance of epithelial-mesenchymal transition in breast cancer. J Clin Pathol 2013; 66(6):517-21.
   PubMed Web of Science ®Google Scholar
• Ye X, Weinberg RA. Epithelial-Mesenchymal plasticity: a central regulator of cancer progression. Trends Cell Biol 2015; 25(11):675-86; PMID:26437589; https://doi.org/10.1016/j.tcb.2015.07.012
   PubMed Web of Science ®Google Scholar
• Baulida J, García de Herreros A. Snail1-driven plasticity of epithelial and mesenchymal cells sustains cancer malignancy. Biochim Biophys Acta 2015; 1856(1):55-61; PMID:26050961
   PubMed Web of Science ®Google Scholar
• Yao F, Kausalya JP, Sia YY, Teo AS, Lee WH, Ong AG, Zhang Z, Tan JH, Li G, Bertrand D, et al. Recurrent fusion genes in gastric cancer: CLDN18-ARHGAP26 induces loss of epithelial integrity. Cell Rep 2015; 12(2):272-85; PMID:26146084; https://doi.org/10.1016/j.celrep.2015.06.020
   PubMed Web of Science ®Google Scholar
• Popescu NC, Goodison S. Deleted in liver cancer-1 (DLC-1): An emerging metastasis suppressor gene. Mol Diagn Ther 2014; 18(3):293-302; PMID:24519699; https://doi.org/10.1007/s40291-014-0086-3
   PubMed Web of Science ®Google Scholar
• Kim TY, Vigil D, Der CJ, Juliano RL. Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev 2009; 28(1–2):77-83; PMID:19221866; https://doi.org/10.1007/s10555-008-9167-2
   PubMed Web of Science ®Google Scholar
• Barras D, Widmann C. GAP-independent functions of DLC1 in metastasis. Cancer Metastasis Rev 2014; 33(1):87-100; PMID:24338004; https://doi.org/10.1007/s10555-013-9458-0
   PubMed Web of Science ®Google Scholar
• Braun AC, Olayioye MA. Rho regulation: DLC proteins in space and time. Cell Signal 2015; 27(8):1643-51; PMID:25889896; https://doi.org/10.1016/j.cellsig.2015.04.003
   PubMed Web of Science ®Google Scholar
• Liu S, Goldstein RH, Scepansky EM, Rosenblatt M. Inhibition of Rho-Associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 2009; 69:8742-51; PMID:19887617; https://doi.org/10.1158/0008-5472.CAN-09-1541
   PubMed Web of Science ®Google Scholar
• Diz-Muñoz A, Fletcher DA, Weiner OD. Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol 2013; 23(2):47-53; https://doi.org/10.1016/j.tcb.2012.09.006
   PubMed Web of Science ®Google Scholar
• Gauthier NC, Masters TA, Sheetz MP. Mechanical feedback between membrane tension and dynamics. Trends Cell Biol 2012; 22(10):527-35; PMID:22921414; https://doi.org/10.1016/j.tcb.2012.07.005
   PubMed Web of Science ®Google Scholar
• Simunovic M, Voth GA. Membrane tension controls the assembly of curvature-generating proteins. Nat Commun 2015; 6:7219; PMID:26008710; https://doi.org/10.1038/ncomms8219
   PubMed Web of Science ®Google Scholar
• Simunovic M, Voth GA, Callan-Jones A, Bassereau P. When physics takes over: BAR proteins and membrane curvature. Trends Cell Biol 2015; 25(12):780-92; PMID:26519988; https://doi.org/10.1016/j.tcb.2015.09.005
   PubMed Web of Science ®Google Scholar
• Carramusa L, Ballestrem C, Zilberman Y, Bershadsky AD. Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. J Cell Sci 2007; 120(Pt 21):3870-82.
   PubMed Web of Science ®Google Scholar
• Brinkley BR, Beall PT, Wible LJ, Mace ML, Turner DS, Cailleau RM. Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. Cancer Res 1980; 40:3118-29; PMID:7000337
   PubMed Web of Science ®Google Scholar