1,107
Views
7
CrossRef citations to date
0
Altmetric
Research Paper

Adhesion structures in leukemia cells and their regulation by Src family kinases

, , , & ORCID Icon
Pages 286-298 | Received 21 Nov 2016, Accepted 16 Jun 2017, Published online: 18 Aug 2017

References

  • Guarino M. Src signaling in cancer invasion. J Cell Physiol 2010; 223:14-26; PMID:20049846
  • Huveneers S, Danen EH. Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci 2009; 122:1059-69; PMID:19339545; https://doi.org/10.1242/jcs.039446
  • Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol 2016; 212:349-64; PMID:26833789; https://doi.org/10.1083/jcb.201508080
  • del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP. Stretching single talin rod molecules activates vinculin binding. Science 2009; 323:638-41; PMID:19179532; https://doi.org/10.1126/science.1162912
  • Yao M, Goult BT, Klapholz B, Hu X, Toseland CP, Guo Y, Cong P, Sheetz MP, Yan J. The mechanical response of talin. Nat Commun 2016; 7:11966; PMID:27384267; https://doi.org/10.1038/ncomms11966
  • Teckchandani A, Cooper JA. The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells. Elife 2016; 5:pii: e17440; PMID:27656905; https://doi.org/10.7554/eLife.17440
  • Ingley E. Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal 2012; 10:21; PMID:22805580; https://doi.org/10.1186/1478-811X-10-21
  • Abram CL, Lowell CA. The diverse functions of Src family kinases in macrophages. Front Biosci 2008; 13:4426-50 [pii]; PMID:18508521; https://doi.org/10.2741/3015
  • He Y, Kapoor A, Cook S, Liu S, Xiang Y, Rao CV, Kenis PJ, Wang F. The non-receptor tyrosine kinase Lyn controls neutrophil adhesion by recruiting the CrkL-C3G complex and activating Rap1 at the leading edge. J Cell Sci 2011; 124:2153-64; PMID:21628423; https://doi.org/10.1242/jcs.078535
  • Orschell CM, Borneo J, Munugalavadla V, Ma P, Sims E, Ramdas B, Yoder MC, Kapur R. Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells. Exp Hematol 2008; 36:655-66; PMID:18346837; https://doi.org/10.1016/j.exphem.2008.01.002
  • Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin alphaIIbbeta3 and Lyn Kinase. PLoS One 2015; 10:e0135738; PMID:26291522; https://doi.org/10.1371/journal.pone.0135738
  • Penzes K, Baumann C, Szabadkai I, Orfi L, Keri G, Ullrich A, Torka R. Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells. Cancer Biol Ther 2014; 15:1571-82; PMID:25482942; https://doi.org/10.4161/15384047.2014.956634
  • Roseweir AK, Qayyum T, Lim Z, Hammond R, MacDonald AI, Fraser S, Oades GM, Aitchison M, Jones RJ, Edwards J. Nuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients. BMC Cancer 2016; 16:229, 016-2254-9; PMID:26984511; https://doi.org/10.1186/s12885-016-2254-9
  • Pham H, Birtolo C, Chheda C, Yang W, Rodriguez MD, Liu ST, Gugliotta G, Lewis MS, Cirulli V, Pandol SJ, et al. Essential role of lyn in Fibrosis. Front Physiol 2016; 7:387; PMID:27630579; https://doi.org/10.3389/fphys.2016.00387
  • Han J, Zhang G, Welch EJ, Liang Y, Fu J, Vogel SM, Lowell CA, Du X, Cheresh DA, Malik AB, et al. A critical role for Lyn kinase in strengthening endothelial integrity and barrier function. Blood 2013; 122:4140-9; PMID:24108461; https://doi.org/10.1182/blood-2013-03-491423
  • Hong H, Kitaura J, Xiao W, Horejsi V, Ra C, Lowell CA, Kawakami Y, Kawakami T. The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn. Blood 2007; 110:2511-9; PMID:17513616; https://doi.org/10.1182/blood-2007-01-066092
  • Obr A, Roselova P, Grebenova D, Kuzelova K. Real-time analysis of imatinib- and dasatinib-induced effects on chronic myelogenous leukemia cell interaction with fibronectin. PLoS One 2014; 9:e107367; PMID:25198091; https://doi.org/10.1371/journal.pone.0107367
  • Michaelis S, Wegener J, Robelek R. Label-free monitoring of cell-based assays: combining impedance analysis with SPR for multiparametric cell profiling. Biosens Bioelectron 2013; 49:63-70; PMID:23711901; https://doi.org/10.1016/j.bios.2013.04.042
  • Scielzo C, Bertilaccio MT, Simonetti G, Dagklis A, ten Hacken E, Fazi C, Muzio M, Caiolfa V, Kitamura D, Restuccia U, et al. HS1 has a central role in the trafficking and homing of leukemic B cells. Blood 2010; 116:3537-46; PMID:20530793; https://doi.org/10.1182/blood-2009-12-258814
  • Wegener J, Keese CR, Giaever I. Electric cell-substrate impedance sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces. Exp Cell Res 2000; 259:158-66; PMID:10942588; https://doi.org/10.1006/excr.2000.4919
  • Obr A, Roselova P, Grebenova D, Kuzelova K. Real-time monitoring of hematopoietic cell interaction with fibronectin fragment: The effect of histone deacetylase inhibitors. Cell Adh Migr 2013; 7:275-82; PMID:23567296; https://doi.org/10.4161/cam.24531
  • Prosper F, Verfaillie CM. Regulation of hematopoiesis through adhesion receptors. J Leukoc Biol 2001; 69:307-16; PMID:11261776
  • Martin-Henao GA, Quiroga R, Sureda A, Gonzalez JR, Moreno V, Garcia J. L-selectin expression is low on CD34+ cells from patients with chronic myeloid leukemia and interferon-a up-regulates this expression. Haematologica 2000; 85:139-46
  • Jin L, Tabe Y, Konoplev S, Xu Y, Leysath CE, Lu H, Kimura S, Ohsaka A, Rios MB, Calvert L, et al. CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells. Molecular Cancer Therapeutics 2008; 7:48-58; PMID:18202009; https://doi.org/10.1158/1535-7163.MCT-07-0042
  • Chen YY, Malik M, Tomkowicz BE, Collman RG, Ptasznik A. BCR-ABL1 alters SDF-1alpha-mediated adhesive responses through the beta2 integrin LFA-1 in leukemia cells. Blood 2008; 111:5182-6; PMID:18339898; https://doi.org/10.1182/blood-2007-10-117705
  • Daubon T, Rochelle T, Bourmeyster N, Genot E. Invadopodia and rolling-type motility are specific features of highly invasive p190(bcr-abl) leukemic cells. Eur J Cell Biol 2012; 91:978-87; PMID:22717125; https://doi.org/10.1016/j.ejcb.2012.04.006
  • Konig H, Holtz M, Modi H, Manley P, Holyoake TL, Forman SJ, Bhatia R. Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 2008; 22:748-55; PMID:18273048; https://doi.org/10.1038/sj.leu.2405086
  • Weisberg E, Wright RD, McMillin DW, Mitsiades C, Ray A, Barrett R, Adamia S, Stone R, Galinsky I, Kung AL, et al. Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells. Mol Cancer Ther 2008; 7:1121-9; PMID:18445657; https://doi.org/10.1158/1535-7163.MCT-07-2331
  • Becker PS. Dependence of acute myeloid leukemia on adhesion within the bone marrow microenvironment. ScientificWorldJournal 2012; 2012:856467; PMID:22346731; https://doi.org/10.1100/2012/856467
  • Brault L, Rovo A, Decker S, Dierks C, Tzankov A, Schwaller J. CXCR4-SERINE339 regulates cellular adhesion, retention and mobilization, and is a marker for poor prognosis in acute myeloid leukemia. Leukemia 2014; 28:566-76; PMID:23817178; https://doi.org/10.1038/leu.2013.201
  • Hanke M, Hoffmann I, Christophis C, Schubert M, Hoang VT, Zepeda-Moreno A, Baran N, Eckstein V, Wuchter P, Rosenhahn A, et al. Differences between healthy hematopoietic progenitors and leukemia cells with respect to CD44 mediated rolling versus adherence behavior on hyaluronic acid coated surfaces. Biomaterials 2014; 35:1411-9; https://doi.org/10.1016/j.biomaterials.2013.11.011
  • Gattazzo C, Martini V, Frezzato F, Trimarco V, Tibaldi E, Castelli M, Facco M, Zonta F, Brunati AM, Zambello R, et al. Cortactin, another player in the Lyn signaling pathway, is overexpressed and alternatively spliced in leukemic cells from patients with B-cell Chronic Lymphocytic Leukemia. Haematologica 2014; 99(6):1069-77; https://doi.org/10.3324/haematol.2013.090183
  • Li S. Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia. Leuk Lymphoma 2008; 49:19-26; PMID:18203007; https://doi.org/10.1080/10428190701713689
  • Hu Y, Liu Y, Pelletier S, Buchdunger E, Warmuth M, Fabbro D, Hallek M, Van Etten RA, Li S. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 2004; 36:453-61; PMID:15098032; https://doi.org/10.1038/ng1343
  • Dos Santos C, McDonald T, Ho YW, Liu H, Lin A, Forman SJ, Kuo YH, Bhatia R. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood 2013; 122:1900-13; PMID:23896410; https://doi.org/10.1182/blood-2012-11-466425
  • Gertz MA. New targets and treatments in multiple myeloma: Src family kinases as central regulators of disease progression. Leuk Lymphoma 2008; 49:2240-5; PMID:19052970; https://doi.org/10.1080/10428190802475311
  • Veldurthy A, Patz M, Hagist S, Pallasch CP, Wendtner CM, Hallek M, Krause G. The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood 2008; 112:1443-52; PMID:18550857; https://doi.org/10.1182/blood-2007-11-123984
  • ten Hacken E, Scielzo C, Bertilaccio MT, Scarfò L, Apollonio B, Barbaglio F, Stamatopoulos K, Ponzoni M, Ghia P, Caligaris-Cappio F. Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia. Blood 2013; 121:2264-73; PMID:23325840; https://doi.org/10.1182/blood-2012-09-457119
  • Horton ER, Byron A, Askari JA, Ng DH, Millon-Fremillon A, Robertson J, Koper EJ, Paul NR, Warwood S, Knight D, et al. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly. Nat Cell Biol 2015; 17:1577-87; PMID:26479319; https://doi.org/10.1038/ncb3257
  • Kaplan KB, Bibbins KB, Swedlow JR, Arnaud M, Morgan DO, Varmus HE. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J 1994; 13:4745-56; PMID:7525268
  • Fincham VJ, Frame MC. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 1998; 17:81-92; PMID:9427743; https://doi.org/10.1093/emboj/17.1.81
  • Jarvinen M, Ylanne J, Vartio T, Virtanen I. Tumor promoter and fibronectin induce actin stress fibers and focal adhesion sites in spreading human erythroleukemia (HEL) cells. Eur J Cell Biol 1987; 44:238-46; PMID:3319626
  • Ylanne J, Cheresh DA, Virtanen I. Localization of beta 1, beta 3, alpha 5, alpha v, and alpha IIb subunits of the integrin family in spreading human erythroleukemia cells. Blood 1990; 76:570-7; PMID:1696147
  • O'Laughlin-Bunner B, Radosevic N, Taylor ML, Shivakrupa DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 2001; 98:343-50; PMID:11435302; https://doi.org/10.1182/blood.V98.2.343
  • Tsuji-Takayama K, Kamiya T, Nakamura S, Matsuo Y, Adachi T, Tsubota T, Imanishi J, Minowada J. Establishment of multiple leukemia cell lines with diverse myeloid and/or megakaryoblastoid characteristics from a single Ph1 positive chronic myelogenous leukemia blood sample. Hum Cell 1994; 7:167-71; PMID:7873501
  • Kuzelova K, Pluskalova M, Brodska B, Otevrelova P, Elknerova K, Grebenova D, Hrkal Z. Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin. J Cell Biochem 2010; 109:184-95; PMID:19911379; https://doi.org/10.1002/jcb.22397

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.