KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2

References

• Shi H, Zhang Z, Wang X, et al. Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter. Nucleic Acids Res. 1999;27(24):4807–4815.
   PubMed Web of Science ®Google Scholar
• Dong JT, Chen C. Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci. 2009;66(16):2691–2706.
   PubMed Web of Science ®Google Scholar
• Guo P, Dong XY, Zhang X, et al. Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification. J Biol Chem. 2009;284(10):6071–6078.
   PubMed Web of Science ®Google Scholar
• Guo P, Dong XY, Zhao K, et al. Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta. J Biol Chem. 2009;284(41):28243–28252.
   PubMed Web of Science ®Google Scholar
• Yang Y, Tarapore RS, Jarmel MH, et al. p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle. 2012;11(21):4033–4039.
   PubMed Web of Science ®Google Scholar
• Nakajima Y, Akaogi K, Suzuki T, et al. Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERbeta and KLF5. Sci Signal. 2011;4(168):a22.
   Web of Science ®Google Scholar
• Chen C, Benjamin MS, Sun X, et al. KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer. 2006;118(6):1346–1355.
   PubMed Web of Science ®Google Scholar
• Zheng HQ, Zhou Z, Huang J, et al. Kruppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene. 2009;28(42):3702–3713.
   PubMed Web of Science ®Google Scholar
• Yang Y, Tetreault MP, Yermolina YA, et al. Kruppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. J Biol Chem. 2008;283(27):18812–18820.
   PubMed Web of Science ®Google Scholar
• Jia L, Zhou Z, Liang H, et al. KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2. Oncogene. 2016;35(16):2040–2051.
   PubMed Web of Science ®Google Scholar
• Du C, Gao Y, Xu S, et al. KLF5 promotes cell migration by up-regulating FYN in bladder cancer cells. FEBS Lett. 2016;590(3):408–418.
   PubMed Web of Science ®Google Scholar
• Yang Y, Nakagawa H, Tetreault MP, et al. Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Res. 2011;71(20):6475–6484.
   PubMed Web of Science ®Google Scholar
• McConnell BB, Kim SS, Yu K, et al. Kruppel-like factor 5 is important for maintenance of crypt architecture and barrier function in mouse intestine. Gastroenterology. 2011;141(4):1302–1313, 1311–1313.
   Web of Science ®Google Scholar
• Moreno-Bueno G, Peinado H, Molina P, et al. The morphological and molecular features of the epithelial-to-mesenchymal transition. Nat Protoc. 2009;4(11):1591–1613.
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871–890.
   PubMed Web of Science ®Google Scholar
• Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest. 2009;119(6):1429–1437.
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420–1428.
   PubMed Web of Science ®Google Scholar
• Shimamura T, Imoto S, Shimada Y, et al. A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition. PLoS One. 2011;6(6):e20804.
   PubMed Web of Science ®Google Scholar
• Yang Y, Goldstein BG, Chao HH, et al. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther. 2005;4(11):1216–1221.
   PubMed Web of Science ®Google Scholar
• Xia H, Wang C, Chen W, et al. Kruppel-like factor 5 transcription factor promotes microsomal prostaglandin E2 synthase 1 gene transcription in breast cancer. J Biol Chem. 2013;288(37):26731–26740.
   PubMed Web of Science ®Google Scholar
• Kuo PL, Hsu YL, Huang MS, et al. Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Kruppel-like factor 5 in areca nut-mediated airway remodeling. Toxicol Sci. 2011;121(1):177–190.
   PubMed Web of Science ®Google Scholar
• Bateman NW, Tan D, Pestell RG, et al. Intestinal tumor progression is associated with altered function of KLF5.J. Biol Chem. 2004;279(13):12093–12101.
   Web of Science ®Google Scholar
• Zhang B, Zhang Z, Xia S, et al. KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells. Mol Cell Biol. 2013;33(24):4919–4935.
   PubMed Web of Science ®Google Scholar
• David CJ, Huang YH, Chen M, et al. TGF-beta Tumor Suppression through a Lethal EMT. Cell. 2016;164(5):1015–1030.
   PubMed Web of Science ®Google Scholar
• Kim T, Veronese A, Pichiorri F, et al. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med. 2011;208(5):875–883.
   PubMed Web of Science ®Google Scholar
• Chou YS, Yang MH. Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy. J Chin Med Assoc. 2015;78(8):438–445.
   PubMed Web of Science ®Google Scholar
• Chang CJ, Chao CH, Xia W, et al. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011;13(3):317–323.
   PubMed Web of Science ®Google Scholar
• Di Gennaro A, Damiano V, Brisotto G, et al. A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness. Cell Death Differ. 2018;25(12):2165–2180.
   PubMed Web of Science ®Google Scholar
• Exposito-Villen AEAA, Franco D. Functional Role of Non-Coding RNAs during Epithelial-To-Mesenchymal Transition. Noncoding RNA. 2018;4(2):E14.
   PubMedGoogle Scholar
• Gregory PA, Bracken CP, Bert AG, et al. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle. 2008;7(20):3112–3118.
   PubMed Web of Science ®Google Scholar
• Kaller M, Hermeking H. Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer. Adv Exp Med Biol. 2016;937:71–92.
   PubMed Web of Science ®Google Scholar
• Geng L, Chaudhuri A, Talmon G, et al. MicroRNA-192 suppresses liver metastasis of colon cancer. Oncogene. 2014;33(46):5332–5340.
   PubMed Web of Science ®Google Scholar
• Wang B, Herman-Edelstein M, Koh P, et al. E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes. 2010;59(7):1794–1802.
   PubMed Web of Science ®Google Scholar
• Martin J, Dufour JF. Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol. 2008;14(11):1720–1733.
   PubMed Web of Science ®Google Scholar
• Guan YS, La Z, Yang L, et al. p53 gene in treatment of hepatic carcinoma: status quo. World J Gastroenterol. 2007;13(7):985–992.
   PubMed Web of Science ®Google Scholar
• Soussi T. p53 alterations in human cancer: more questions than answers. Oncogene. 2007;26(15):2145–2156.
   PubMed Web of Science ®Google Scholar