550
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Dsg2 ectodomain organization increases throughout desmosome assembly

ORCID Icon, ORCID Icon, ORCID Icon, , & ORCID Icon
Pages 1-13 | Received 25 Apr 2023, Accepted 18 Mar 2024, Published online: 02 Apr 2024

References

  • Shafraz O, Rübsam M, Stahley SN, et al. E-cadherin binds to desmoglein to facilitate desmosome assembly. Elife. 2018;7. doi: 10.7554/eLife.37629
  • Stahley SN, Bartle EI, Atkinson CE, et al. Molecular organization of the desmosome as revealed by direct stochastic optical reconstruction microscopy. J Cell Sci. 2016;129(15):2897–2904. doi: 10.1242/jcs.185785
  • Getsios S, Huen AC, Green KJ. Working out the strength and flexibility of Desmosomes. Nat Rev Mol Cell Biol. 2004;5(4):271–281. doi: 10.1038/nrm1356
  • Brasch J, Harrison OJ, Honig B, et al. Thinking outside the cell: how cadherins drive adhesion. Trends Cell Biol. 2012;22:299–310. doi: 10.1016/j.tcb.2012.03.004
  • Dusek RL, Godsel LM, Green KJ. Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. J Dermatol Sci. 2007;45(1):7–21. doi: 10.1016/j.jdermsci.2006.10.006
  • Garrod D, Chidgey M. Desmosome structure, composition and function. Biochim Biophys Acta. 2008;1778(3):572–587. doi: 10.1016/j.bbamem.2007.07.014
  • Broussard JA, Getsios S, Green KJ. Desmosome regulation and signaling in disease. Cell Tissue Res. 2015;360(3):501–512. doi: 10.1007/s00441-015-2136-5
  • Godsel LM, Hsieh SN, Amargo EV, et al. Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Bio. 2005;171(6):1045–1059. doi: 10.1083/jcb.200510038
  • Nekrasova O, Green KJ. Desmosome assembly and dynamics. Trends Cell Biol. 2013;23(11):537–546. doi: 10.1016/j.tcb.2013.06.004
  • Yin T, Green KJ. Regulation of desmosome assembly and adhesion. Semin Cell Dev Biol. 2004;15(6):665–677. doi: 10.1016/S1084-9521(04)00091-6
  • Nekrasova OE, Amargo EV, Smith WO, et al. Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes. J Cell Bio. 2011;195(7):1185–1203. doi: 10.1083/jcb.201106057
  • Gosavi P, Kundu ST, Khapare N, et al. E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell Mol Life Sci. 2011;68(8):1439–1454. doi: 10.1007/s00018-010-0531-3
  • Godsel LM, Dubash AD, Bass-Zubek AE, et al. Plakophilin 2 couples actomyosin remodeling to Desmosomal plaque assembly via RhoA. Mol Biol Cell. 2010;21(16):2844–2859. doi: 10.1091/mbc.e10-02-0131
  • Bass-Zubek AE, Hobbs RP, Amargo EV, et al. Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Bio. 2008;181(4):605–613. doi: 10.1083/jcb.200712133
  • Beggs R, Rao TC, Dean WF, et al. Desmosomes undergo dynamic architectural changes during assembly and maturation tissue barriers. Tissue Barr. 2022;10(4). doi: 10.1080/21688370.2021.2017225
  • Dean WF, Mattheyses AL. Defining domain-specific orientational order in the desmosomal cadherins. Biophys J. 2022;121(22):4325–4341. doi: 10.1016/j.bpj.2022.10.009
  • Sikora M, Ermel UH, Seybold A, et al. Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography. Proc Natl Acad Sci USA. 2020;117(44):27132–27140. doi: 10.1073/pnas.2004563117
  • Al-Amoudi A, Castano-Diez D, Devos DP, et al. The three-dimensional molecular structure of the desmosomal plaque. Proc Natl Acad Sci USA. 2011;108(16):6480–6485. doi: 10.1073/pnas.1019469108
  • Al-Amoudi A, Diez DC, Betts MJ, et al. The molecular architecture of cadherins in native epidermal desmosomes. Nature. 2007;450(7171):832–837. doi: 10.1038/nature05994
  • Rayns DG, Simpson FO, Ledingham JM. Ultrastructure of desmosomes in mammalian intercalated disc; appearances after lanthanum treatment. J Cell Bio. 1969;42(1):322. doi: 10.1083/jcb.42.1.322
  • Garrod DR, Berika MY, Bardsley WF, et al. Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure. J Cell Sci. 2005;118(Pt 24):5743–5754. doi: 10.1242/jcs.02700
  • Abbe E. Beiträge zur Theorie des Mikroskops und der mikroskopischen wahrnehmung. Archiv für mikroskopische Anatomie. 1873;9(1):413–468. doi: 10.1007/BF02956173
  • Jeong D, Kim D. Recent developments in correlative super-resolution fluorescence microscopy and Electron microscopy. Mol Cells. 2022;45(1):41–50. doi: 10.14348/molcells.2021.5011
  • Axelrod D. Carbocyanine dye orientation in red cell membrane studied by microscopic fluorescence polarization. Biophys J. 1979;26(3):557–573. doi: 10.1016/S0006-3495(79)85271-6
  • Bartle EI, Rao TC, Beggs RR, et al. Protein exchange is reduced in calcium-independent epithelial junctions. J Cell Bio. 2020;219(6). doi: 10.1083/jcb.201906153
  • Bartle EI, Urner TM, Raju SS, et al. Desmoglein 3 order and dynamics in desmosomes determined by fluorescence polarization microscopy. Biophys J. 2017;113(11):2519–2529. doi: 10.1016/j.bpj.2017.09.028
  • Kampmann M, Atkinson CE, Mattheyses AL, et al. Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. Nat Struct Mol Biol. 2011;18(6):643–649. doi: 10.1038/nsmb.2056
  • Mattheyses AL, Kampmann M, Atkinson CE, et al. Fluorescence anisotropy reveals order and disorder of protein domains in the nuclear pore complex. Biophys J. 2010;99(6):1706–1717. doi: 10.1016/j.bpj.2010.06.075
  • DeMay BS, Noda N, Gladfelter AS, et al. Rapid and quantitative imaging of excitation polarized fluorescence reveals ordered septin dynamics in live yeast. Biophys J. 2011;101(4):985–994. doi: 10.1016/j.bpj.2011.07.008
  • Nordenfelt P, Moore TI, Mehta SB, et al. Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. Nat Commun. 2017;8(1):2047. doi: 10.1038/s41467-017-01848-y
  • Nakai N, Sato K, Tani T, et al. Genetically encoded orientation probes for F-actin for fluorescence polarization microscopy. Microscopy (Oxf). 2019;68(5):359–368. doi: 10.1093/jmicro/dfz022
  • Otsu N. A threshold selection method from gray-level histograms. IEEE Trans Syst Man Cybern. 1979;9(1):62–66. doi: 10.1109/TSMC.1979.4310076
  • Berens P. CircStat: a MATLAB toolbox for circular statistics. J Stat Soft. 2009;31(10). doi: 10.18637/jss.v031.i10
  • Delva E, Tucker DK, Kowalczyk AP. The desmosome. Cold Spring Harbor Perspect Biol. 2009;1(2). doi: 10.1101/cshperspect.a002543
  • Green K, Getsios S, Troyanovsky S, et al. Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harbor Perspect Biol. 2010;2(2). doi: 10.1101/cshperspect.a000125
  • Stahley S, Saito M, Faundez V, et al. Desmosome assembly and disassembly are membrane raft-dependent. PloS One. 2014;9(1):e87809. doi: 10.1371/journal.pone.0087809
  • Roberts BJ, Pashaj A, Johnson KR, et al. Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton. Exp Cell Res. 2011;317(20):2814–2822. doi: 10.1016/j.yexcr.2011.09.003
  • Pasdar M, Li Z. Disorganization of microfilaments and intermediate filaments interferes with the assembly and stability of desmosomes in MDCK epithelial cells. Cell Motility. 1993;26(2):163–180. doi: 10.1002/cm.970260207
  • Ishii K, Norvell SM, Bannon LJ, et al. Assembly of desmosomal cadherins into desmosomes is isoform dependent. J Invest Dermatol. 2001;117(1):26–35. doi: 10.1046/j.0022-202x.2001.01400.x
  • Schäfer S, Koch PJ, Franke WW. Identification of the ubiquitous human desmoglein, dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res. 1994;211(2):391–399. doi: 10.1006/excr.1994.1103
  • Hegazy M, Perl AL, Svoboda SA, et al. Desmosomal cadherins in health and disease. Annu Rev Pathol Mech Dis. 2022;17(1):47–72. doi: 10.1146/annurev-pathol-042320-092912