Advanced search
Publication Cover
Fly Volume 17, 2023 - Issue 1
Submit an article Journal homepage
1,864
Views
0
CrossRef citations to date
0
Altmetric
Research Paper

Downregulation of Plasma Membrane Ca2+ ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons

Brenda Erhardta Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;b Fundación Instituto Leloir, Buenos Aires, Argentina
,
Lia Frenkelc Laboratorio de Neurociencias del tiempo- iB3, Instituto de Biociencias, Biotecnología y Biología traslacional, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
,
María Silvina Marcorad Departamento de Química Biológica, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB)-CONICET, Buenos Aires, Argentina
,
María Isabel Faríasa Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;b Fundación Instituto Leloir, Buenos Aires, Argentina
,
Carina Cintia Ferraria Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;b Fundación Instituto Leloir, Buenos Aires, Argentina
,
Fernando Juan Pitossia Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;b Fundación Instituto Leloir, Buenos Aires, ArgentinaCorrespondence[email protected]
&
María Celeste Leala Instituto de Investigaciones Bioquímicas de Buenos Aires (IIBBA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina;b Fundación Instituto Leloir, Buenos Aires, ArgentinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4263-4047
ORCID Icon show all
Article: 2192457 | Received 12 Dec 2022, Accepted 13 Mar 2023, Published online: 22 Mar 2023

References

  • Mao Z, Davis RL. Eight different types of dopaminergic neurons innervate the drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Front Neural Circuits. 2009;3:5.
  • Brand AH, Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 1993;118(2):401–11.
  • Friggi-Grelin F, Coulom H, Meller M, et al. Targeted gene expression in drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase. J Neurobiol. 2003;54(4):618–627.
  • Qili L, Liu S, Kodama L, et al. Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in drosophila. Curr Biol. 2012;22(22):2114–2123.
  • Liu C, Yves Plaaais P, Yamagata N, et al. A subset of dopamine neurons signals reward for odour memory in drosophila. Nature. 2012;488(7412):512–516.
  • Pfeiffer BD, Jenett A, Hammonds AS, et al. Tools for neuroanatomy and neurogenetics in drosophila. Proc Natl Acad Sci USA. 2008;105(28):9715–9720.
  • Radostina L, Selcho M, Pfeuffer M, et al. Reward signaling in a recurrent circuit of dopaminergic neurons and peptidergic Kenyon cells. Nat Commun. 2019;10(1):1.
  • Riemensperger T, Raouf Issa A, Pech U, et al. A single dopamine pathway underlies progressive locomotor deficits in a drosophila model of Parkinson's disease. Cell Rep. 2013;5(4):952–960.
  • Erhardt B, Silvina Marcora M, Frenkel L, et al. Plasma membrane calcium ATPase downregulation in dopaminergic neurons alters cellular physiology and motor behaviour in drosophila melanogaster. Eur J Neurosci. 2021;54(6):5915–5931.
  • Birman S, Morgan B, Anzivino M, et al. A novel and major isoform of tyrosine hydroxylase in drosophila is generated by alternative RNA processing. J Biol Chem. 1994;269(42):26559–26567.
  • Linford NJ, Bilgir C, Jennifer R, et al. Measurement of lifespan in drosophila melanogaster. J Visualized Exp. 2013;JoVE(71). DOI:10.3791/50068
  • Schindelin J, Arganda-Carreras I, Frise E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9(7):676–682. DOI:10.1038/NMETH.2019
  • Nall AH, Shakhmantsir I, Cichewicz K, et al. Caffeine promotes wakefulness via dopamine signaling in drosophila. Sci Rep. 2016;6(February). DOI:10.1038/SREP20938
  • White KE, Humphrey DM, Hirth F. The dopaminergic system in the aging brain of drosophila. Front Neurosci. 2010;4:205.
  • Singh SR, Zeng X, Zheng Z, et al. The adult drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus). Cell Cycle (Georgetown, Tex). 2011;10(7):1109–1120.
  • Hansong D, Gerencser AA, Jasper H. Signal integration by Ca2+ regulates intestinal stem cell activity. Nature. 2015;528(7581):212–217.
  • Weaver LN, Tianlu M, Drummond-Barbosa D. Analysis of Gal4 expression patterns in adult drosophila females. G3 (Bethesda). 2020;10(11):4147–4158.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.